LOCUS       NM_013055               3754 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus mitogen activated protein kinase kinase kinase 12
            (Map3k12), mRNA.
ACCESSION   NM_013055
VERSION     NM_013055.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3754)
  AUTHORS   Tenenbaum,M., Plaisance,V., Boutry,R., Pawlowski,V., Jacovetti,C.,
            Sanchez-Parra,C., Ezanno,H., Bourry,J., Beeler,N., Pasquetti,G.,
            Gmyr,V., Dalle,S., Kerr-Conte,J., Pattou,F., Hirai,S.I.,
            Regazzi,R., Bonnefond,A., Froguel,P. and Abderrahmani,A.
  TITLE     The Map3k12 (Dlk)/JNK3 signaling pathway is required for pancreatic
            beta-cell proliferation during postnatal development
  JOURNAL   Cell Mol Life Sci 78 (1), 287-298 (2021)
   PUBMED   32189007
  REMARK    GeneRIF: The Map3k12 (Dlk)/JNK3 signaling pathway is required for
            pancreatic beta-cell proliferation during postnatal development.
REFERENCE   2  (bases 1 to 3754)
  AUTHORS   Huang,Y.A., Zhou,B., Wernig,M. and Sudhof,T.C.
  TITLE     ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription
            and Abeta Secretion
  JOURNAL   Cell 168 (3), 427-441 (2017)
   PUBMED   28111074
REFERENCE   3  (bases 1 to 3754)
  AUTHORS   Chen,M., Geoffroy,C.G., Wong,H.N., Tress,O., Nguyen,M.T.,
            Holzman,L.B., Jin,Y. and Zheng,B.
  TITLE     Leucine Zipper-bearing Kinase promotes axon growth in mammalian
            central nervous system neurons
  JOURNAL   Sci Rep 6, 31482 (2016)
   PUBMED   27511108
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3754)
  AUTHORS   Holland,S.M., Collura,K.M., Ketschek,A., Noma,K., Ferguson,T.A.,
            Jin,Y., Gallo,G. and Thomas,G.M.
  TITLE     Palmitoylation controls DLK localization, interactions and activity
            to ensure effective axonal injury signaling
  JOURNAL   Proc Natl Acad Sci U S A 113 (3), 763-768 (2016)
   PUBMED   26719418
  REMARK    GeneRIF: These findings explain how DLK specifically mediates nerve
            injury responses and reveal a novel cellular mechanism that ensures
            the specificity of neuronal kinase signaling.
REFERENCE   5  (bases 1 to 3754)
  AUTHORS   Itoh,T., Horiuchi,M., Ikeda,R.H. Jr., Xu,J., Bannerman,P.,
            Pleasure,D., Penninger,J.M., Tournier,C. and Itoh,A.
  TITLE     ZPK/DLK and MKK4 form the critical gateway to axotomy-induced
            motoneuron death in neonates
  JOURNAL   J Neurosci 34 (32), 10729-10742 (2014)
   PUBMED   25100604
REFERENCE   6  (bases 1 to 3754)
  AUTHORS   Ganguly,A., Oo,T.F., Rzhetskaya,M., Pratt,R., Yarygina,O.,
            Momoi,T., Kholodilov,N. and Burke,R.E.
  TITLE     CEP11004, a novel inhibitor of the mixed lineage kinases,
            suppresses apoptotic death in dopamine neurons of the substantia
            nigra induced by 6-hydroxydopamine
  JOURNAL   J Neurochem 88 (2), 469-480 (2004)
   PUBMED   14690535
REFERENCE   7  (bases 1 to 3754)
  AUTHORS   Hirai,S., Kawaguchi,A., Hirasawa,R., Baba,M., Ohnishi,T. and
            Ohno,S.
  TITLE     MAPK-upstream protein kinase (MUK) regulates the radial migration
            of immature neurons in telencephalon of mouse embryo
  JOURNAL   Development 129 (19), 4483-4495 (2002)
   PUBMED   12223406
  REMARK    GeneRIF: MUK/DLK/ZPK, and JNK activity increase potently and
            temporally in newly generated neurons in developing mouse
            telencephalon during radial migration
REFERENCE   8  (bases 1 to 3754)
  AUTHORS   Mata,M., Merritt,S.E., Fan,G., Yu,G.G. and Holzman,L.B.
  TITLE     Characterization of dual leucine zipper-bearing kinase, a mixed
            lineage kinase present in synaptic terminals whose phosphorylation
            state is regulated by membrane depolarization via calcineurin
  JOURNAL   J Biol Chem 271 (28), 16888-16896 (1996)
   PUBMED   8663324
REFERENCE   9  (bases 1 to 3754)
  AUTHORS   Hirai,S., Izawa,M., Osada,S., Spyrou,G. and Ohno,S.
  TITLE     Activation of the JNK pathway by distantly related protein kinases,
            MEKK and MUK
  JOURNAL   Oncogene 12 (3), 641-650 (1996)
   PUBMED   8637721
REFERENCE   10 (bases 1 to 3754)
  AUTHORS   Holzman,L.B., Merritt,S.E. and Fan,G.
  TITLE     Identification, molecular cloning, and characterization of dual
            leucine zipper bearing kinase. A novel serine/threonine protein
            kinase that defines a second subfamily of mixed lineage kinases
  JOURNAL   J Biol Chem 269 (49), 30808-30817 (1994)
   PUBMED   7983011
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D49785.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D49785.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3754
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..3754
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; PK; Zpk"
                     /note="mitogen activated protein kinase kinase kinase 12"
                     /db_xref="GeneID:25579"
                     /db_xref="RGD:3988"
     exon            1..240
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; PK; Zpk"
                     /inference="alignment:Splign:2.1.0"
     exon            241..327
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; PK; Zpk"
                     /inference="alignment:Splign:2.1.0"
     exon            328..416
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; PK; Zpk"
                     /inference="alignment:Splign:2.1.0"
     exon            417..895
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; PK; Zpk"
                     /inference="alignment:Splign:2.1.0"
     CDS             451..3117
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; PK; Zpk"
                     /EC_number="2.7.11.25"
                     /note="dual leucine zipper kinase; MAPK-upstream kinase;
                     mixed lineage kinase; leucine-zipper protein kinase; dual
                     leucine zipper bearing kinase; Zipper (leucine) protein
                     kinase; Mitogen activated protein kinase 12 (Zipper
                     (leucine) protein kinase)"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase
                     12"
                     /protein_id="NP_037187.1"
                     /db_xref="GeneID:25579"
                     /db_xref="RGD:3988"
                     /translation="MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTP
                     TQCVLRDVVPLGGQGGGGPSPSPGGEPPPEPFANSVLQLHEQDTGGPGGATGSPESRA
                     SRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILD
                     LQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPC
                     YCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNML
                     ITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLW
                     ELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNRKPRNRPSFRQ
                     ILLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRRE
                     ELRHALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKSH
                     TSRSLLHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKA
                     PPSPGRSRRGKTRHRKASAKGSCGDLPGLRAALPPHEPGGLGSPGGLGVGPTAWDASP
                     PALRGLHHDLLLRKMSSSSPDLLSAALGARGRGATGGARDPGSPPPPQGDTPPSEGSA
                     PGSTSPDSPGGAKGEPPPPVGPGEGVGLLGTGREGTTGRGGSRAGYQHLTPAALLYRA
                     AVTRSQKRGISSEEEEGEVDSEVELPPSQRWPQGPNMRQSLSTFSSENPSDVEEGTAS
                     EPSPSGTPEVGSTNTDERPDERSDDMCSQGSEIPLDLPTSEVVPERETSSLPMQHQDD
                     QGPNPEDSDCDSTELDNSNSIDALPPPASLPP"
     exon            896..1079
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; PK; Zpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1271
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; PK; Zpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1430
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; PK; Zpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1589
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; PK; Zpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1698
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; PK; Zpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1808
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; PK; Zpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1925
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; PK; Zpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2063
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; PK; Zpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2688
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; PK; Zpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2689..2759
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; PK; Zpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2760..3021
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; PK; Zpk"
                     /inference="alignment:Splign:2.1.0"
     exon            3022..3754
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; PK; Zpk"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3754
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; PK; Zpk"
ORIGIN      
        1 ttggaaggag cgggagttca agtcgagtgg gaacggggct tagagtagtg ggtggggggc
       61 caaaagctgg ggctgacacc cgtgcacctg agctccactc gagcatcgcc ggtgacagct
      121 ctccaggtcc agtggagggc aacgggggga ggaggggagg aggaggagga ggcgggagca
      181 gcatccggag ccgagctgca gcagcgccgc cttttgtgct gcggccgcgg agcccccgag
      241 ggccttggat cccctggaac tggagttata ggggttgtga gcatcatgtg gatgctggga
      301 atggaacccc agtcatctcg aagaacaccc aggctggcct gaaactcact gtgaagccag
      361 agatgacctt ggacttctga gcctctcacc tccattcctg agtgctggga ctgctgggcc
      421 cgctactcag cacacctggc tccagaggcc atggcctgcc tccatgaaac ccgaacaccc
      481 tccccttcct ttggaggctt tgtgtctact ctaagtgagg cctccatgcg aaagctggat
      541 ccagacactt cagactgcac ccctgagaag gacctgacac ctacccaatg tgtacttcga
      601 gatgttgtgc ctctcggtgg gcagggtgga ggagggccca gcccctcccc aggtggagag
      661 cctcctccag agccttttgc caatagtgtc ctgcagctac atgagcagga tacaggtggg
      721 ccagggggag ccaccgggtc acctgagagt cgagcatcta gggttcgagc tgatgaggta
      781 cgtctgcagt gccagagtgg cagtggcttc cttgaaggtc tttttggctg cctgcgccct
      841 gtctggacaa tgattggcaa agcctactcc acagagcaca agcaacagca ggaagacctt
      901 tgggaagtcc cctttgagga aatcctggac ctgcagtggg taggctcagg ggctcagggt
      961 gccgttttcc tgggacgctt tcatggggag gaggtagctg tgaagaaggt tcgagacctc
     1021 aaggagaccg acatcaagca tcttcgaaaa ctgaagcacc ccaacatcat cactttcaag
     1081 ggtgtttgca cacaggcccc gtgctactgc atcctcatgg agttctgtgc ccaaggacag
     1141 ctgtatgagg tgctcagggc gggccgcccc gttaccccct ccttgctggt tgactggtcc
     1201 atgggcatcg ctggaggcat gaattaccta cacctgcaca aaatcatcca cagagacctg
     1261 aagtcaccca acatgctaat cacatacgac gatgtggtga agatctcaga ctttggcact
     1321 tccaaggagc tgagtgacaa gagcaccaag atgtcctttg cagggacagt agcctggatg
     1381 gctcctgaag tgatcagaaa tgaacctgtg tctgagaagg ttgacatctg gtcctttggg
     1441 gtggtgcttt gggaattact gactggagag attccctaca aagatgtaga ctcctcagcc
     1501 atcatctggg gtgtgggaag caacagtctt cacctgcctg taccctctag ctgcccagac
     1561 ggctttaaaa ttctgcttcg ccagtgctgg aacagaaaac ctcggaaccg cccatcattc
     1621 cgacagatct tgctgcacct ggacatcgcc tcggctgatg tgctctctac accccaggag
     1681 acttacttta aatcccaggc agagtggcgg gaagaagtaa aactgcactt tgaaaagatt
     1741 aagtcagaag ggacctgtct gcaccgccta gaagaggaac tggtgatgcg gagaagggag
     1801 gagctcagac atgccctgga catcagggag cactatgagc gcaagttgga gagagctaac
     1861 aacttgtaca tggaactgaa tgccctcatg ttgcaactag aactcaaaga gagggaattg
     1921 ctcaggcgag agcaagcttt agaaaggagg tgtcctggtc tactgaagtc acacacgtcc
     1981 cgaagcctcc tacatggaaa cacgatggag aagctcatca agaaaaggaa tgtgccacag
     2041 aaactgtcac cccatagcaa aaggccagat attctcaaga cagagtcttt gctacctaaa
     2101 ctagatgcag ccctaagtgg ggtggggctt cctggttgtc ctaaggcccc cccttcacct
     2161 gggaggagtc gtcgtggcaa gacccgtcac cgaaaggcca gcgccaaggg cagctgtgga
     2221 gacctgcctg ggcttcgtgc agctttgcca ccccatgagc ctggaggact aggaagccca
     2281 ggaggcctag gagtgggccc tacagcttgg gatgcctccc cccctgctct ccgtggactc
     2341 caccatgacc ttctacttcg gaagatgtct tcatcatccc cagacctgtt atcagcagca
     2401 ctgggagccc gaggccgagg ggcaacaggg ggagctcggg atcctggctc accacctcca
     2461 ccccagggtg atactcctcc aagtgaggga tcagctcctg gttccaccag cccagattca
     2521 cctgggggag ctaaagggga accacctcca ccagtagggc ctggagaagg tgtggggctg
     2581 ctgggaactg gaagggaagg gactacaggc cggggaggaa gccgggctgg gtaccagcac
     2641 ttgacccccg ctgcgctgct gtacagggct gctgtgactc gtagtcagaa acgtggtatc
     2701 tcatctgaag aggaagaagg agaggtcgac agtgaagtag agctaccccc aagtcaaagg
     2761 tggcctcagg gcccgaacat gcgtcagtca ctatctacgt tcagctcaga gaacccatca
     2821 gatgtggagg aaggtacagc tagtgagcct tccccaagtg gcacaccgga agttggcagc
     2881 accaacactg atgagcgacc agatgaacgg tctgatgaca tgtgctcaca gggttcagaa
     2941 atcccactgg acctacctac ttcagaggtg gtccctgaac gtgaaaccag ctccttgccc
     3001 atgcaacacc aggatgacca gggccccaat cctgaggact cagactgtga cagcactgaa
     3061 ttggacaact ccaacagcat tgatgccttg ccgcccccag cctcccttcc tccatgaaag
     3121 acactcttat tccttgtaca tagagaaata tttatataaa taatatatat gcgccacata
     3181 atcaacagat agacggggct ttcttagccg taagtcaggc ttcagagtga acgacgcccc
     3241 tgaccaatta agttctaggg acactggcag ctgtggaaat gactccaagt actaccctag
     3301 agctgtaagg aaaggacacc ggtcccttct tgcttcaccc cattccttat gttgaacaag
     3361 caagtaggca tagaaaagcc aggcttgtct ctacactgtc tgtccctaaa catggggggc
     3421 aggaagagga ttcacttaaa actgcacttt tattttccgt ttactgttta cacattttgc
     3481 acttgggagg agggaaacta aggctgggtc ctaggtcctc cctctgaggt ttctcaggtg
     3541 gcaatgtaac tcatttcttt gttcctgttt ctctgccaaa gccctggctt tgggcccaga
     3601 ggcaagttag aagattaata gcatgtgatg gctcaggctg aagaactggg tgctggttaa
     3661 gtccccgctg ttatctggtg cctggtaggg gtggggactg tcatattgta acccctgtga
     3721 acaaccctga aatataacca ctccatgcag gccc
//
