LOCUS       NM_001013150            3536 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus mitogen-activated protein kinase kinase kinase 11
            (Map3k11), mRNA.
ACCESSION   NM_001013150 XM_219517
VERSION     NM_001013150.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3536)
  AUTHORS   Xing,B., Li,Q.J., Li,H., Chen,S.S., Cui,Z.Y., Ma,J. and Zhang,Z.W.
  TITLE     miR-140-5p aggravates hypoxia-induced cell injury via regulating
            MLK3 in H9c2 cells
  JOURNAL   Biomed Pharmacother 103, 1652-1657 (2018)
   PUBMED   29864954
  REMARK    GeneRIF: miR-140-5p aggravated hypoxia-induced cell injury
            partially through up-regulation of MLK3.
REFERENCE   2  (bases 1 to 3536)
  AUTHORS   Sato-Kunisada,R., Yoshida,N., Nakamura,S., Uchiyama,H. and
            Matsumoto,H.
  TITLE     Enhanced Expression of miR-199b-5p Promotes Proliferation of
            Pancreatic beta-Cells by Down-Regulation of MLK3
  JOURNAL   Microrna 5 (1), 57-65 (2016)
   PUBMED   27280801
  REMARK    GeneRIF: data suggest that the up-regulation of miR-199b-5p
            enhances proliferation of beta-cells at least in part through
            down-regulation of Mixed lineage kinase-3.
REFERENCE   3  (bases 1 to 3536)
  AUTHORS   Zhu,Q.J., Xu,Y., Du,C.P. and Hou,X.Y.
  TITLE     SUMOylation of the kainate receptor subunit GluK2 contributes to
            the activation of the MLK3-JNK3 pathway following kainate
            stimulation
  JOURNAL   FEBS Lett 586 (9), 1259-1264 (2012)
   PUBMED   22483987
REFERENCE   4  (bases 1 to 3536)
  AUTHORS   Hu,S.Q., Ye,J.S., Zong,Y.Y., Sun,C.C., Liu,D.H., Wu,Y.P., Song,T.
            and Zhang,G.Y.
  TITLE     S-nitrosylation of mixed lineage kinase 3 contributes to its
            activation after cerebral ischemia
  JOURNAL   J Biol Chem 287 (4), 2364-2377 (2012)
   PUBMED   22123824
  REMARK    GeneRIF: the activation of MLK3 during the early stages of
            ischemia/reperfusion is modulated by S-nitrosylation and provides a
            potential new approach for stroke therapy whereby the
            post-translational modification machinery is targeted.
REFERENCE   5  (bases 1 to 3536)
  AUTHORS   Wang,Q., Yin,X.H., Liu,Y. and Zhang,G.Y.
  TITLE     K252a suppresses neuronal cells apoptosis through inhibiting the
            translocation of Bax to mitochondria induced by the MLK3/JNK
            signaling after transient global brain ischemia in rat hippocampal
            CA1 subregion
  JOURNAL   J Recept Signal Transduct Res 31 (4), 307-313 (2011)
   PUBMED   21726169
  REMARK    GeneRIF: Data suggest that K252a induced neuroprotection against
            ischemia/reperfusion in rat hippocampal CA1 subregion via
            inhibiting the mitochondrial Bax apoptosis pathway induced by
            JNK/MLK3 activation.
REFERENCE   6  (bases 1 to 3536)
  AUTHORS   Xu,Z., Maroney,A.C., Dobrzanski,P., Kukekov,N.V. and Greene,L.A.
  TITLE     The MLK family mediates c-Jun N-terminal kinase activation in
            neuronal apoptosis
  JOURNAL   Mol Cell Biol 21 (14), 4713-4724 (2001)
   PUBMED   11416147
REFERENCE   7  (bases 1 to 3536)
  AUTHORS   Leung,I.W. and Lassam,N.
  TITLE     The kinase activation loop is the key to mixed lineage kinase-3
            activation via both autophosphorylation and hematopoietic
            progenitor kinase 1 phosphorylation
  JOURNAL   J Biol Chem 276 (3), 1961-1967 (2001)
   PUBMED   11053428
REFERENCE   8  (bases 1 to 3536)
  AUTHORS   Leung,I.W. and Lassam,N.
  TITLE     Dimerization via tandem leucine zippers is essential for the
            activation of the mitogen-activated protein kinase kinase kinase,
            MLK-3
  JOURNAL   J Biol Chem 273 (49), 32408-32415 (1998)
   PUBMED   9829970
REFERENCE   9  (bases 1 to 3536)
  AUTHORS   Teramoto,H., Coso,O.A., Miyata,H., Igishi,T., Miki,T. and
            Gutkind,J.S.
  TITLE     Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the
            c-Jun N-terminal kinase/stress-activated protein kinase pathway. A
            role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel
            member of the mixed lineage kinase family
  JOURNAL   J Biol Chem 271 (44), 27225-27228 (1996)
   PUBMED   8910292
REFERENCE   10 (bases 1 to 3536)
  AUTHORS   Gallo,K.A., Mark,M.R., Scadden,D.T., Wang,Z., Gu,Q. and
            Godowski,P.J.
  TITLE     Identification and characterization of SPRK, a novel src-homology 3
            domain-containing proline-rich kinase with serine/threonine kinase
            activity
  JOURNAL   J Biol Chem 269 (21), 15092-15100 (1994)
   PUBMED   8195146
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081952.1.
            
            On Apr 20, 2005 this sequence version replaced XM_219517.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081952.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3536
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..3536
                     /gene="Map3k11"
                     /gene_synonym="Mlk-3; Mlk3; RHOE"
                     /note="mitogen-activated protein kinase kinase kinase 11"
                     /db_xref="GeneID:309168"
                     /db_xref="RGD:1359261"
     exon            1..1177
                     /gene="Map3k11"
                     /gene_synonym="Mlk-3; Mlk3; RHOE"
                     /inference="alignment:Splign:2.1.0"
     CDS             436..2988
                     /gene="Map3k11"
                     /gene_synonym="Mlk-3; Mlk3; RHOE"
                     /EC_number="2.7.11.25"
                     /note="mixed lineage kinase 3"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase
                     11"
                     /protein_id="NP_001013168.1"
                     /db_xref="GeneID:309168"
                     /db_xref="RGD:1359261"
                     /translation="MEPLKNLFLKSPLGSWNGSGSGGGGGSGGVRPEGSPKATAAYAN
                     PVWTALFDYEPNGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVS
                     RGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAE
                     SVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVN
                     WAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIEGDDMEHKTLKITDFGLAREWH
                     KTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYG
                     VAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDS
                     FHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWE
                     LEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQAS
                     PGLDRRRNVFEVGAGDSPTFPRFRAIQLEPAESGQTWGRQSPRRLDDSSNGERRACWA
                     WGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSPEPEEP
                     RRSGPTERGNSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGLSRERGESPTAPPPA
                     QMASPCPPDLPSTPLIHLSQATPDARGPLTPAPLLLDLGVSSGQPSAKSPRREETRGR
                     TVSPPPGISRSAPGTPGTPRSPPLGLISRPRPSPLRNRIDPWSFVSAGPRPSPLPSPQ
                     PAPRRAPWTLFPDSDPFWDSPPANPFRGGSQDCRTQTKDVGAQAPWAPEAGP"
     exon            1178..1358
                     /gene="Map3k11"
                     /gene_synonym="Mlk-3; Mlk3; RHOE"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1507
                     /gene="Map3k11"
                     /gene_synonym="Mlk-3; Mlk3; RHOE"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1683
                     /gene="Map3k11"
                     /gene_synonym="Mlk-3; Mlk3; RHOE"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1927
                     /gene="Map3k11"
                     /gene_synonym="Mlk-3; Mlk3; RHOE"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2041
                     /gene="Map3k11"
                     /gene_synonym="Mlk-3; Mlk3; RHOE"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2177
                     /gene="Map3k11"
                     /gene_synonym="Mlk-3; Mlk3; RHOE"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..2269
                     /gene="Map3k11"
                     /gene_synonym="Mlk-3; Mlk3; RHOE"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..2650
                     /gene="Map3k11"
                     /gene_synonym="Mlk-3; Mlk3; RHOE"
                     /inference="alignment:Splign:2.1.0"
     exon            2651..3512
                     /gene="Map3k11"
                     /gene_synonym="Mlk-3; Mlk3; RHOE"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgagaaga ggtagcttcg gctctattgg agactttctc ttacctcttg tatctcaaga
       61 caacaaccag agtccaggcg ccgaccctgg caggccccac cttacagtag gcgggcgctg
      121 gagccaggtt cccaggacta cttcgggacc gagggactca ctgccgctcc aattcagcca
      181 tggtgaggcg ccggaggcca gtgggcccca cccctccagc ctgaccacac tgccctcggt
      241 gccctcctcc agaagcccga gatgcggggg gccgggaggc gacactcctg gctccccaga
      301 gaggcgtggg tctggggctg agggccaggg cccggatgcc caggttccgg cactagggcc
      361 tcacaagcca ccgggggtgg ataccacggg cacccgaaga aggtccccca cacattccaa
      421 cgccggctcc ctgccatgga gcccttgaag aacctcttcc tcaagagccc gctggggtca
      481 tggaacggca gtggcagtgg gggcggtggg ggttctggtg gagtccggcc agaggggtcc
      541 ccgaaggcaa cagcagctta tgccaaccct gtctggacag ccctgttcga ctatgagccc
      601 aatgggcagg acgaactagc cctgaggaag ggcgaccgtg tggaggtgct gtccagggat
      661 gcagccatct caggagatga aggctggtgg gcgggccagg tgggtggcca ggtgggcatt
      721 tttccatcca actatgtatc tcggggtgga ggcccacccc cctgtgaggt ggccagcttc
      781 caggagctgc gactggagga ggtgatcggc atcggtggct tcggcaaggt ctaccgtggc
      841 agctggcgag gggagctggt ggctgtgaaa gcagctcgac aggatcctga tgaggacatc
      901 agtgtaacag ctgagagtgt tcgacaggag gcccggcttt ttgccatgct ggcacatccc
      961 aacatcattg ccctcaaagc tgtgtgcctg gaggagccaa acctatgcct ggtgatggag
     1021 tatgcagctg gtggacctct tagccgtgcc ctggctggtc ggcgggtgcc cccccatgtg
     1081 ctggtcaact gggctgtgca gattgcccga gggatgcact acctgcactg tgaggctcta
     1141 gtgcctgtga tacaccgaga cctgaagtcc aacaacattc tgctgctgca gcccattgaa
     1201 ggtgacgaca tggagcacaa gaccctaaag attactgact ttggcctcgc ccgagagtgg
     1261 cacaaaacca cacagatgag tgctgcgggg acctatgcgt ggatggctcc tgaggttatc
     1321 aaggcatcta ccttctccaa gggcagcgat gtctggagct ttggggtgct gctgtgggaa
     1381 ctgctgactg gggaggtacc ctaccgtggt atcgactgtc ttgcggtagc ctatggtgtg
     1441 gctgtaaaca agttaacatt acccatccca tccacttgcc ctgagccctt cgcacaactc
     1501 atggctgact gctgggcaca ggacccccac cgcaggcccg acttcgcctc catcctgcag
     1561 cagttggaag ctctagaggc tcaggtgctg agggagatgc cacgggactc cttccattcc
     1621 atgcaggagg gctggaaacg cgagatccag ggcctttttg atgagctgcg ggccaaggaa
     1681 aaggaactac tgagccgcga ggaggaactg acgcgcgcag cacgcgagca gcggtcccag
     1741 gcagagcagc tgcgacggcg cgagcacctg ctggcgcagt gggagctgga ggtgttcgag
     1801 cgcgagctga cactgctgct acagcaggtg gaccgagaac ggccacacgt gcgccgccga
     1861 cgcggcacct tcaagcggag caagctccga gcgagggatg gcggagaacg catcagcatg
     1921 cccctggact tcaaacatcg catcactgtg caggcctctc caggacttga ccggaggaga
     1981 aatgtgttcg aggttggggc tggggactcg cccaccttcc ctcggttccg agctatccag
     2041 ttggaacctg cagaatcagg ccagacttgg ggtcgccagt cccctagacg tcttgacgat
     2101 tcaagcaatg gagagaggcg tgcttgctgg gcctggggtc ccagttcccc caagcctggg
     2161 gaggcccaga atgggaggag aaggtcccgc atggatgaag ccacgtggta cctagattca
     2221 gatgactcat ccccattagg gtctccttct actcccccag cactcaacgg taatcctcca
     2281 aggcctagcc ctgagccaga ggagccacgg cggtctgggc ccacagaacg gggcaatagc
     2341 tctgggacgc ctaaactgat ccaacgtgca ttgctccggg ggaccgctct gctggcttcc
     2401 ctaggccttg gccgagacct gcagcctcca ggaggcctga gccgtgaacg tggagagtcc
     2461 ccgacagcac caccccctgc acagatggct tcaccctgtc cacctgacct gccctccacc
     2521 ccgctcatcc acctctcaca agcaacacct gatgcccgtg gaccactcac ccctgcaccc
     2581 ttattgctgg acctaggtgt ttcctctggc cagccatcag ccaagagccc tcggcgggaa
     2641 gagacacgtg gaagaactgt ttcacctcca ccaggaatat cacgctctgc tcctggcacc
     2701 cctggaaccc ctcgctcacc acctttgggc ctcatcagcc gacctcggcc atcaccactc
     2761 cgtaaccgta ttgacccatg gagcttcgtg tcagctgggc cacggccttc acccctgccc
     2821 tctccacagc ctgcaccccg acgggcacca tggaccttat tcccagactc agatcccttc
     2881 tgggactccc cacctgccaa ccccttccgg ggaggctccc aggactgcag gacgcagacc
     2941 aaagatgtgg gtgctcaggc gccatgggca ccagaagcag ggccctgagt gggccagacc
     3001 ataccccctg cgctccagct gcctcagagg aggcatagca tacactggaa gaggagccag
     3061 gaaggcctct gtggctgcct tggtttcccc cagggaccct gaccctttgg cggtcaggaa
     3121 cactacactg cacagaaagc cttcacactg gatgggggct acaccccaca tgcctacaaa
     3181 ctgtaggtcc ccctgattta cctgccccac tggggcctga cactgtacct agctggttag
     3241 gaggaccaga gcctgtctca gggaattgcc ccccaaggag tggtgcaggg agggggtcca
     3301 ggggaaaggg gctgacctca ggtgtcacca gcacttttga ccaagtcctg ttactgtggc
     3361 ccctgtctcc aaggcctagt tcctggaccc cctaccctgg aggttattgg agccggggct
     3421 ctctgggtgc ctttctactg ccccagccaa ggttggagcc ttggcctggg gagccaatga
     3481 agccaaataa acttgtaagc tgtctcccca aaaaaaaaaa aaaaaaaaaa aaaaaa
//
