LOCUS       NM_001395098            3440 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus mitogen activated protein kinase kinase kinase 10
            (Map3k10), mRNA.
ACCESSION   NM_001395098 XM_006228576
VERSION     NM_001395098.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3440)
  AUTHORS   Wilhelm,M., Kukekov,N.V., Schmit,T.L., Biagas,K.V., Sproul,A.A.,
            Gire,S., Maes,M.E., Xu,Z. and Greene,L.A.
  TITLE     Sh3rf2/POSHER protein promotes cell survival by ring-mediated
            proteasomal degradation of the c-Jun N-terminal kinase scaffold
            POSH (Plenty of SH3s) protein
  JOURNAL   J Biol Chem 287 (3), 2247-2256 (2012)
   PUBMED   22128169
REFERENCE   2  (bases 1 to 3440)
  AUTHORS   Pedraza,N., Rafel,M., Navarro,I., Encinas,M., Aldea,M. and
            Gallego,C.
  TITLE     Mixed lineage kinase phosphorylates transcription factor E47 and
            inhibits TrkB expression to link neuronal death and survival
            pathways
  JOURNAL   J Biol Chem 284 (47), 32980-32988 (2009)
   PUBMED   19801649
REFERENCE   3  (bases 1 to 3440)
  AUTHORS   Varjosalo,M., Bjorklund,M., Cheng,F., Syvanen,H., Kivioja,T.,
            Kilpinen,S., Sun,Z., Kallioniemi,O., Stunnenberg,H.G., He,W.W.,
            Ojala,P. and Taipale,J.
  TITLE     Application of active and kinase-deficient kinome collection for
            identification of kinases regulating hedgehog signaling
  JOURNAL   Cell 133 (3), 537-548 (2008)
   PUBMED   18455992
REFERENCE   4  (bases 1 to 3440)
  AUTHORS   Zhong,J. and Kyriakis,J.M.
  TITLE     Dissection of a signaling pathway by which pathogen-associated
            molecular patterns recruit the JNK and p38 MAPKs and trigger
            cytokine release
  JOURNAL   J Biol Chem 282 (33), 24246-24254 (2007)
   PUBMED   17584736
REFERENCE   5  (bases 1 to 3440)
  AUTHORS   Johnson,G.L. and Nakamura,K.
  TITLE     The c-jun kinase/stress-activated pathway: regulation, function and
            role in human disease
  JOURNAL   Biochim Biophys Acta 1773 (8), 1341-1348 (2007)
   PUBMED   17306896
  REMARK    Review article
REFERENCE   6  (bases 1 to 3440)
  AUTHORS   Ganguly,A., Oo,T.F., Rzhetskaya,M., Pratt,R., Yarygina,O.,
            Momoi,T., Kholodilov,N. and Burke,R.E.
  TITLE     CEP11004, a novel inhibitor of the mixed lineage kinases,
            suppresses apoptotic death in dopamine neurons of the substantia
            nigra induced by 6-hydroxydopamine
  JOURNAL   J Neurochem 88 (2), 469-480 (2004)
   PUBMED   14690535
REFERENCE   7  (bases 1 to 3440)
  AUTHORS   Eckey,M., Tenbaum,S.P., Munoz,A. and Baniahmad,A.
  TITLE     Mixed lineage kinase 2 enhances trans-repression of Alien and
            nuclear receptors
  JOURNAL   Mol Cell Endocrinol 213 (1), 71-78 (2003)
   PUBMED   15062575
REFERENCE   8  (bases 1 to 3440)
  AUTHORS   Xu,Z., Maroney,A.C., Dobrzanski,P., Kukekov,N.V. and Greene,L.A.
  TITLE     The MLK family mediates c-Jun N-terminal kinase activation in
            neuronal apoptosis
  JOURNAL   Mol Cell Biol 21 (14), 4713-4724 (2001)
   PUBMED   11416147
REFERENCE   9  (bases 1 to 3440)
  AUTHORS   Savinainen,A., Garcia,E.P., Dorow,D., Marshall,J. and Liu,Y.F.
  TITLE     Kainate receptor activation induces mixed lineage kinase-mediated
            cellular signaling cascades via post-synaptic density protein 95
  JOURNAL   J Biol Chem 276 (14), 11382-11386 (2001)
   PUBMED   11152698
REFERENCE   10 (bases 1 to 3440)
  AUTHORS   Liu,Y.F., Dorow,D. and Marshall,J.
  TITLE     Activation of MLK2-mediated signaling cascades by
            polyglutamine-expanded huntingtin
  JOURNAL   J Biol Chem 275 (25), 19035-19040 (2000)
   PUBMED   10801775
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jun 3, 2021 this sequence version replaced XM_006228576.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.2088.1,
                                           SRR26643293.2158.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1017              JAXUCZ010000001.1  92100660-92101676   c
            1018-1198           JAXUCZ010000001.1  92095967-92096147   c
            1199-1347           JAXUCZ010000001.1  92092014-92092162   c
            1348-1523           JAXUCZ010000001.1  92091476-92091651   c
            1524-1770           JAXUCZ010000001.1  92090269-92090515   c
            1771-1887           JAXUCZ010000001.1  92088533-92088649   c
            1888-2041           JAXUCZ010000001.1  92086044-92086197   c
            2042-2154           JAXUCZ010000001.1  92085837-92085949   c
            2155-2835           JAXUCZ010000001.1  92084833-92085513   c
            2836-3440           JAXUCZ010000001.1  92083376-92083980   c
FEATURES             Location/Qualifiers
     source          1..3440
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..3440
                     /gene="Map3k10"
                     /gene_synonym="Mlk2"
                     /note="mitogen activated protein kinase kinase kinase 10"
                     /db_xref="GeneID:308463"
                     /db_xref="RGD:1308381"
     exon            1..1017
                     /gene="Map3k10"
                     /gene_synonym="Mlk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             336..3158
                     /gene="Map3k10"
                     /gene_synonym="Mlk2"
                     /EC_number="2.7.11.25"
                     /note="mixed-lineage kinase 2; mitogen-activated protein
                     kinase kinase kinase 10-like"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase
                     10"
                     /protein_id="NP_001382027.1"
                     /db_xref="GeneID:308463"
                     /db_xref="RGD:1308381"
                     /translation="MEEEEGAAAREWGATPAGPVWTAVFDYEAVGDEELTLRRGDRVQ
                     VLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPAAPAAPTDLQLPQEIPFHELQLEE
                     IIGVGGFGKVYRALWRGEEVAVKAARLDPERDPAVTAEQVRQEARLFGALQHPNIIAL
                     RGACLSPPNLCLVMEYARGGALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPI
                     IHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIR
                     LSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFAR
                     LLEECWDPDPHGRPDFGSILKQLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFDDLR
                     TKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMSQLSQEKP
                     RVRKRKGNFKRSRLLKLREGSSHISLPSGFEHKITVQASPTLDKRKGSDGASPPASPS
                     IIPRLRAIRLTPVDCGSSGGSGTWSRSGPPKKEELVGGKKKGRTWGPSSTLQKERAGG
                     EERLKALGEGSKQWSSSAPNLGKSPKHTPMAPGFASLNEMEEFAEADEGNNVPPSPYS
                     TPSYLKVPLPAEASPCAQPPWEPPAATPSRPGHGARRRCDLALLGCATLLSAVGLGAD
                     VAEARAGDGEEQRGWLDGLFFPRPGRFPRGLSPTGRPGGRREETAPGFGLAPSATLVS
                     LSSVSDCNSTRSLLRSDSDEAAPTAPSPPPSLLPPSPSTNPLVDVELESFKKDPRQSL
                     TPTHVTAAHAVSRGHRRTPSDGALRQREPPELTNHGPRDPLDFPRLPDPQALFPTRRR
                     PLEFPGRPTTLTFAPRPRPAASRPRLDPWKLVSFGRTLSISPPSRPDTPESPGPLSVQ
                     PTLLDMDMEGQSQDNTVPLCGAYGSH"
     exon            1018..1198
                     /gene="Map3k10"
                     /gene_synonym="Mlk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1347
                     /gene="Map3k10"
                     /gene_synonym="Mlk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1523
                     /gene="Map3k10"
                     /gene_synonym="Mlk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1770
                     /gene="Map3k10"
                     /gene_synonym="Mlk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1887
                     /gene="Map3k10"
                     /gene_synonym="Mlk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..2041
                     /gene="Map3k10"
                     /gene_synonym="Mlk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2154
                     /gene="Map3k10"
                     /gene_synonym="Mlk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2835
                     /gene="Map3k10"
                     /gene_synonym="Mlk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2836..3440
                     /gene="Map3k10"
                     /gene_synonym="Mlk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgcttg ctgccctcgg cctcggcctc cgccggcggg ccccgctcaa cccggccctc
       61 cttgcgccct gacatctttg gggacaggtg aacctatcgc cagatctgca tagccagatc
      121 cgagggaacg gtcctgtctt ttgaaaaagg tgtattttag gttttttttt ttttaattcc
      181 ttcgctccag tggaggccct tcccccagcc atggtcctca ggagcccccc ggggtcccca
      241 gggactgtct cccatcccgg cctcctggct tcgtgctcag cattccgcgg gcagcctgcg
      301 tgaagcggcc ccccgcagcc cccggcccct cccccatgga ggaggaggag ggggcggcgg
      361 ccagagagtg gggcgcgacc cccgcggggc cagtgtggac cgccgtgttc gactacgagg
      421 cggtgggcga cgaggagctg accctgcgga gaggcgatcg cgtccaggtg ctttcccagg
      481 actgtgcggt gtctggagat gagggctggt ggacagggca gctgcccagc ggccgagtgg
      541 gcgtcttccc cagcaactac gtggcccccg ctgcacccgc tgcacccaca gacctccagc
      601 tgccacagga gatccccttt cacgagctgc agctggagga gatcatcggt gtggggggct
      661 ttggcaaggt ctaccgcgcc ttatggcgtg gagaggaagt agcggtcaag gccgcccggc
      721 tggaccctga acgggaccca gcagtgacag cggagcaggt gcgccaggag gcccggctct
      781 ttggagccct tcagcacccc aacatcattg ccctgagggg cgcctgcctc agccccccaa
      841 acctctgcct ggtgatggaa tatgctcggg gaggtgcatt gagcagggta ctggcaggtc
      901 gccgggtccc ccctcatgtg ctggtcaact gggctgtgca ggtggcacgg ggcatgaact
      961 atctgcacaa tgatgcccct gtacccatca ttcaccggga cctcaagtcc atcaacatcc
     1021 taattctgga ggccattgag aaccacaacc tcgctgacac ggtgctcaag atcacagact
     1081 tcggccttgc ccgagagtgg cacaagacga ccaaaatgag tgcggcgggg acctacgcct
     1141 ggatggctcc tgaggttatc cgcctctccc tcttctccaa aagcagcgat gtctggagct
     1201 tcggggttct tctttgggag ctgctgaccg gggaggtccc ctaccgagaa atcgacgcct
     1261 tggccgtggc ttacggtgtg gctatgaaca agctgacgct acccatcccc tccacgtgcc
     1321 ccgagccctt tgcccgccta ctggaggaat gctgggaccc agaccctcat gggcgaccag
     1381 attttggcag catcttgaag cagctggagg tcatcgagca gtcagccctg ttccagatgc
     1441 cactggagtc cttccactca ctgcaggaag actggaagct ggagattcag catatgttcg
     1501 atgaccttcg gaccaaggag aaggaattgc gcagccgtga agaagagctg ttgcgggccg
     1561 cacaggagca gcgttttcag gaagagcagc tgcggcggcg ggagcaggag ctggccgagc
     1621 gagagatgga cattgtagaa cgtgaactgc acctgctcat gagccagctg agccaggaga
     1681 agcccagggt ccgcaaacgc aagggcaact tcaaacgcag ccgcttgctc aagctacggg
     1741 aaggcagcag ccacatcagc ctgccctccg gatttgaaca caagatcact gtccaggcct
     1801 cccccaccct ggacaagagg aaaggatctg atggggccag ccctcctgcc agccccagca
     1861 tcattccccg gctgagggcc attcgcttga cccccgtaga ctgtggcagc agcggtggca
     1921 gtggaacatg gagccgcagt gggccaccaa aaaaggaaga actggttggg ggcaagaaga
     1981 aaggcaggac gtggggtccc agttctactt tacaaaagga gcgggccgga ggagaggaga
     2041 ggctcaaggc cctgggggaa ggaagcaagc agtggtcctc gagcgccccc aacctgggca
     2101 aatcccctaa gcacaccccc atggccccag gcttcgccag cctcaatgag atggaagaat
     2161 ttgcggaggc agatgaaggc aacaacgtgc ccccttcccc ctactccacc ccgtcctacc
     2221 tcaaggtgcc tctgcccgcc gaggcctctc cttgtgctca gccgccttgg gagccgccgg
     2281 ctgcgacccc ctcccggccg ggacacggag ctcggaggcg ctgtgatctg gctctgctgg
     2341 gctgcgccac gctgctgagt gcggtgggcc tgggcgccga cgttgccgag gcacgggccg
     2401 gggatggtga ggagcagcgg ggctggctgg acggtctctt cttcccacgg cccggccgct
     2461 tccctcgggg tctcagcccg acagggcgcc caggaggtcg ccgcgaagag acagccccag
     2521 gctttggcct ggcaccctcg gccaccctgg tgtctttatc ttctgtatct gattgcaact
     2581 ctacgcgctc attgctgcgc tctgacagtg atgaggctgc ccccactgcg ccctccccgc
     2641 cgccttctct gctcccgccc tcacctagca ccaatcctct tgtggacgta gagctggaga
     2701 gcttcaagaa ggacccccgg cagtcgctca cgcccaccca cgtcactgcg gcccacgctg
     2761 tgagccgtgg acacagacgg acaccatcgg atggggctct gagacagcgg gagcctccag
     2821 agctcaccaa ccacggtcct cgagatccct tggacttccc tcgactgccc gacccccagg
     2881 ccctgttccc tacccgacgc cggcccctgg agttccctgg ccgtcccacc accctcacct
     2941 ttgccccaag accccggcca gctgccagcc gcccccgtct ggacccctgg aaactggtct
     3001 cctttggccg gacactcagc atctcgcctc caagcaggcc agacactcca gagagccctg
     3061 ggcccctcag cgtgcagccc acgctgctgg acatggacat ggagggtcag agccaggaca
     3121 atacagtgcc cctgtgtggg gcctatggct ctcactgaga cctgcccacc accgcccgcc
     3181 tgggcagcca tgaatgtagc gccccaggct ccgccacagc ccaccatttg ccaaggtggg
     3241 ggaggccctg ggcaggatac tcactctatt tattggggaa ggggggaggg gaggacactt
     3301 aagttattcc tttgtacccc aggttgtgga gctctgggcc caacctgctg tggggagagg
     3361 gtgggcaggg atactcaggg acaggacatt gtgggggatt tggcacaaaa cgcagcatta
     3421 aaggtaaccc ctgcccccta
//
