LOCUS       NM_001401207            3472 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus mitogen activated protein kinase kinase 7
            (Map2k7), transcript variant 2, mRNA.
ACCESSION   NM_001401207 XM_006248768
VERSION     NM_001401207.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3472)
  AUTHORS   Chang,C.L., Chen,K.H., Sung,P.H., Chiang,J.Y., Huang,C.R.,
            Chen,H.H. and Yip,H.K.
  TITLE     Combined high energy of extracorporeal shock wave and 5-FU
            effectively suppressed the proliferation and growth of tongue
            squamous cell carcinoma
  JOURNAL   Biomed Pharmacother 142, 112036 (2021)
   PUBMED   34411913
REFERENCE   2  (bases 1 to 3472)
  AUTHORS   Ruiz,E.J., Lan,L., Diefenbacher,M.E., Riising,E.M., Da Costa,C.,
            Chakraborty,A., Hoeck,J.D., Spencer-Dene,B., Kelly,G., David,J.P.,
            Nye,E., Downward,J. and Behrens,A.
  TITLE     JunD, not c-Jun, is the AP-1 transcription factor required for
            Ras-induced lung cancer
  JOURNAL   JCI Insight 6 (13), e124985 (2021)
   PUBMED   34236045
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3472)
  AUTHORS   Chen,C., Chen,S., Cao,H., Wang,J., Wen,T., Hu,X. and Li,H.
  TITLE     Prognostic significance of autophagy-related genes within
            esophageal carcinoma
  JOURNAL   BMC Cancer 20 (1), 797 (2020)
   PUBMED   32831056
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3472)
  AUTHORS   Luo,M.S., Huang,G.J. and Liu,H.B.
  TITLE     An autophagy-related model of 4 key genes for predicting prognosis
            of patients with laryngeal cancer
  JOURNAL   Medicine (Baltimore) 99 (30), e21163 (2020)
   PUBMED   32791689
REFERENCE   5  (bases 1 to 3472)
  AUTHORS   Ray,D., Yun,Y.C., Idris,M., Cheng,S., Boot,A., Iain,T.B.H.,
            Rozen,S.G., Tan,P. and Epstein,D.M.
  TITLE     A tumor-associated splice-isoform of MAP2K7 drives
            dedifferentiation in MBNL1-low cancers via JNK activation
  JOURNAL   Proc Natl Acad Sci U S A 117 (28), 16391-16400 (2020)
   PUBMED   32601196
REFERENCE   6  (bases 1 to 3472)
  AUTHORS   Trotter,L., Panton,W., Hajimohamadreza,I., Petalidis,L., Ward,R.,
            Fleming,Y., Armstrong,C.G., Cohen,P., Karran,E.H. and Kinloch,R.A.
  TITLE     Mitogen-activated protein kinase kinase 7 is activated during low
            potassium-induced apoptosis in rat cerebellar granule neurons
  JOURNAL   Neurosci Lett 320 (1-2), 29-32 (2002)
   PUBMED   11849756
REFERENCE   7  (bases 1 to 3472)
  AUTHORS   Butterfield,L., Zentrich,E., Beekman,A. and Heasley,L.E.
  TITLE     Stress- and cell type-dependent regulation of transfected c-Jun
            N-terminal kinase and mitogen-activated protein kinase kinase
            isoforms
  JOURNAL   Biochem J 338 (Pt 3) (Pt 3), 681-686 (1999)
   PUBMED   10051439
REFERENCE   8  (bases 1 to 3472)
  AUTHORS   Tournier,C., Whitmarsh,A.J., Cavanagh,J., Barrett,T. and Davis,R.J.
  TITLE     The MKK7 gene encodes a group of c-Jun NH2-terminal kinase kinases
  JOURNAL   Mol Cell Biol 19 (2), 1569-1581 (1999)
   PUBMED   9891090
REFERENCE   9  (bases 1 to 3472)
  AUTHORS   Foltz,I.N., Gerl,R.E., Wieler,J.S., Luckach,M., Salmon,R.A. and
            Schrader,J.W.
  TITLE     Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly
            conserved c-Jun N-terminal kinase/stress-activated protein kinase
            (JNK/SAPK) activated by environmental stresses and physiological
            stimuli
  JOURNAL   J Biol Chem 273 (15), 9344-9351 (1998)
   PUBMED   9535930
REFERENCE   10 (bases 1 to 3472)
  AUTHORS   Yao,Z., Diener,K., Wang,X.S., Zukowski,M., Matsumoto,G., Zhou,G.,
            Mo,R., Sasaki,T., Nishina,H., Hui,C.C., Tan,T.H., Woodgett,J.P. and
            Penninger,J.M.
  TITLE     Activation of stress-activated protein kinases/c-Jun N-terminal
            protein kinases (SAPKs/JNKs) by a novel mitogen-activated protein
            kinase kinase
  JOURNAL   J Biol Chem 272 (51), 32378-32383 (1997)
   PUBMED   9405446
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Feb 4, 2022 this sequence version replaced XM_006248768.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.27586.1,
                                           SRR26360190.2787622.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-210               JAXUCZ010000012.1  7389267-7389476
            211-258             JAXUCZ010000012.1  7391121-7391168
            259-400             JAXUCZ010000012.1  7393782-7393923
            401-467             JAXUCZ010000012.1  7394032-7394098
            468-581             JAXUCZ010000012.1  7394219-7394332
            582-701             JAXUCZ010000012.1  7394426-7394545
            702-809             JAXUCZ010000012.1  7394703-7394810
            810-989             JAXUCZ010000012.1  7394902-7395081
            990-1070            JAXUCZ010000012.1  7395168-7395248
            1071-1213           JAXUCZ010000012.1  7395333-7395475
            1214-1259           JAXUCZ010000012.1  7395997-7396042
            1260-3472           JAXUCZ010000012.1  7396165-7398377
FEATURES             Location/Qualifiers
     source          1..3472
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p12"
     gene            1..3472
                     /gene="Map2k7"
                     /gene_synonym="JNKK; Jnkk2; Mapkk7; Mek7; Mkk7"
                     /note="mitogen activated protein kinase kinase 7"
                     /db_xref="GeneID:363855"
                     /db_xref="RGD:1560043"
     exon            1..210
                     /gene="Map2k7"
                     /gene_synonym="JNKK; Jnkk2; Mapkk7; Mek7; Mkk7"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1394
                     /gene="Map2k7"
                     /gene_synonym="JNKK; Jnkk2; Mapkk7; Mek7; Mkk7"
                     /EC_number="2.7.12.2"
                     /note="isoform 2 is encoded by transcript variant 2; dual
                     specificity mitogen-activated protein kinase kinase 7; JNK
                     kinase 2; MAPK/ERK kinase 7; MAP kinase kinase 7;
                     JNK-activating kinase 2; c-Jun N-terminal kinase kinase 2;
                     MEK 7; JNKK 2; MAPKK 7"
                     /codon_start=1
                     /product="dual specificity mitogen-activated protein
                     kinase kinase 7 isoform 2"
                     /protein_id="NP_001388136.1"
                     /db_xref="GeneID:363855"
                     /db_xref="RGD:1560043"
                     /translation="MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPIIV
                     ITLSPAPAPSQRAALQLPLANDGGSRSPSSESSPQHPTPPSRPRHMLGLPSTLFTPRS
                     MESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGH
                     IIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTC
                     AEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLC
                     DFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATG
                     QFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLE
                     HSFIKHYETLEVDVASWFKDVMAKTESPRTSGVLSQHHLPFFR"
     exon            211..258
                     /gene="Map2k7"
                     /gene_synonym="JNKK; Jnkk2; Mapkk7; Mek7; Mkk7"
                     /inference="alignment:Splign:2.1.0"
     exon            259..400
                     /gene="Map2k7"
                     /gene_synonym="JNKK; Jnkk2; Mapkk7; Mek7; Mkk7"
                     /inference="alignment:Splign:2.1.0"
     exon            401..467
                     /gene="Map2k7"
                     /gene_synonym="JNKK; Jnkk2; Mapkk7; Mek7; Mkk7"
                     /inference="alignment:Splign:2.1.0"
     exon            468..581
                     /gene="Map2k7"
                     /gene_synonym="JNKK; Jnkk2; Mapkk7; Mek7; Mkk7"
                     /inference="alignment:Splign:2.1.0"
     exon            582..701
                     /gene="Map2k7"
                     /gene_synonym="JNKK; Jnkk2; Mapkk7; Mek7; Mkk7"
                     /inference="alignment:Splign:2.1.0"
     exon            702..809
                     /gene="Map2k7"
                     /gene_synonym="JNKK; Jnkk2; Mapkk7; Mek7; Mkk7"
                     /inference="alignment:Splign:2.1.0"
     exon            810..989
                     /gene="Map2k7"
                     /gene_synonym="JNKK; Jnkk2; Mapkk7; Mek7; Mkk7"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1070
                     /gene="Map2k7"
                     /gene_synonym="JNKK; Jnkk2; Mapkk7; Mek7; Mkk7"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1213
                     /gene="Map2k7"
                     /gene_synonym="JNKK; Jnkk2; Mapkk7; Mek7; Mkk7"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1259
                     /gene="Map2k7"
                     /gene_synonym="JNKK; Jnkk2; Mapkk7; Mek7; Mkk7"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..3472
                     /gene="Map2k7"
                     /gene_synonym="JNKK; Jnkk2; Mapkk7; Mek7; Mkk7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcctagcgc aggcgcagtg cggtgtttgt ctacccggga ctgacgggtg gcctggcggt
       61 gagcggcggc agcggcggcg gggaagatgg cggcgtcctc cctggagcaa aagctgtccc
      121 gcctggaggc caagctgaag caggagaatc gtgaggcccg caggaggatc gacctcaacc
      181 tggatataag cccacagcgg cccaggccca ttattgtgat cactctaagc cctgctcctg
      241 ccccgtccca gcgagcagcc ttgcagctcc cactggccaa cgatgggggc agccgctcac
      301 catcctcaga gagctcccca cagcacccta cgccccccag ccggccccgc cacatgctgg
      361 ggctcccgtc aaccttgttc acacctcgca gtatggagag catcgagatt gaccaaaagc
      421 tgcaggagat catgaagcag acagggtacc tgactatcgg gggccagcgt tatcaggcag
      481 aaatcaatga cttggagaac ctgggagaga tgggcagtgg tacctgtggt caggtgtgga
      541 agatgcggtt ccggaagaca ggccacatca ttgctgttaa gcaaatgcgg cgctcgggga
      601 acaaggaaga gaataagcgc atcctaatgg acctggacgt agtactcaag agccacgact
      661 gcccctacat tgttcagtgc tttggtacct tcatcaccaa cacggacgtc tttattgcca
      721 tggagctcat gggcacgtgt gcggagaagc tgaagaaacg gatgcagggc cccatcccag
      781 agcgaatcct tggcaagatg accgtggcga ttgtgaaagc attgtactat ctgaaggaga
      841 agcatggggt catccatcgt gatgtcaaac cctccaacat cctgctggat gagcggggtc
      901 agatcaagct ctgtgacttt ggcatcagtg gccgccttgt tgactccaaa gccaaaacac
      961 ggagtgctgg ctgtgctgcc tatatggctc ctgagcgcat tgacccgcca gaccccacca
     1021 agccagacta tgacatccgg gccgatgtgt ggagcctggg catctcactg gtggagctgg
     1081 caacaggaca gttcccctat aagaactgca agacggactt tgaggtcctc accaaagtcc
     1141 tacaggaaga gcccccgctc ctgcctggtc acatgggctt ctcaggggac ttccagtcat
     1201 ttgtcaaaga ctgccttact aaagaccaca ggaagagacc aaagtataac aaactacttg
     1261 aacacagctt catcaagcac tatgagacac tcgaagtgga tgtcgcgtcc tggtttaagg
     1321 acgtcatggc aaagaccgag tccccaagga ctagtggagt cctgagccaa caccatctgc
     1381 ccttcttcag gtagcctcat ggcagcggcc agccccacaa gggcccaggg gcagggccac
     1441 aggcccccct ctcccacctg gccaacccag ctgcccatca ggggacctgg gacctggacg
     1501 actgccaagg actgaggaca gaaagtaggg ggtacccgtc cacctgactc cccgcccacc
     1561 agctgtggac gaaggggcgt gctggttcct aatcctgcca gctgtgtgaa ccccacccca
     1621 cccgccccga cagacactgt gaacggaaga cagcaggcca tgagcagact cactatttat
     1681 tcaatcataa cctctgggct ggggtgaccc ccaggggcag agagaaagcc ccttgtcccc
     1741 atcccccaaa ctcccagtgt ctgtcccctc caccttctct cacacacgtg cttgctctcc
     1801 atctctcctt ctatctccct ccctatctcc ctccctcttc ccctttctgg tttccctgtg
     1861 tccccgcccc agcctctgcc tttctcctgc ctcagcctgg cccagccact ctaccctcag
     1921 tggaagcccc ggttcaccta ggcttcctta agtctttgac ccaggatggc tttgtgggca
     1981 ttgtgactgc agccaaaccg gttgctgtct ctgtgtctgt ctgtctctct ttgatctcag
     2041 ggggtccttt tggagtttat tgtattttac tgtacttggt gggggtgtgt gtttgggggg
     2101 gttgtcctca tgggtgtgtc ggtaccttca gaaactttac caaagtaatg tttagctgct
     2161 tgtggtgggc cccctctcct ccactgcctc aggcactggg ggttggactg cttgcttctc
     2221 cttgtcattt ctggcctagg agaggccagg ctcctttggg ggaccctccc atggggctgg
     2281 gaactgctta cagttcgggg ttaagtagaa gagctcaggt gtcacagagg gagaccgggg
     2341 gcctcagcca cacaggtggc cttcagggaa ggtgtgtgag ggatgcgctg gagagtagca
     2401 ggtagtaggg agggaacaga caggagtcag tgacaggagt aatgccaagg ggcaggaggg
     2461 gttctgagaa gtcagggatt aagagtgaag ggagtagatg cggaggtctg agcatgtgta
     2521 tcagggacaa gacggacagg cttgagtgca ggggaggcca gggtattggt atgtaaagtg
     2581 acttacccgg acatgcccct gagcatccct tagctcacct agagctggcc agctgcaacc
     2641 caacttgtag cctggactag accaggcgtc tgtcccgtcc actgtcctgc agtggccagg
     2701 acagagtggg gtctgtctcc tttttgttgg tgatgcatgc aattcaagtg gacaagagaa
     2761 caatataaca aaacaattta caaccacaaa agccagcacc aaagttgcga aaccttgctg
     2821 gatgtagctg acgcagctgt aggcttcggt gacactgtgg ctcttctctt agccattcag
     2881 ttgactcatc ttcatcctac tcacacaatg ccgcatgttt caattgtaat agcagtcatc
     2941 ttttctgcgg gcagggcgcc ctctctcctt atctatctcc tgtgttgggg agatggagtg
     3001 aagtagggat agaatagaaa gcccagccca cccttaccat tctgaggcta gccaagtctc
     3061 gtcggtagcc tttgtgtgta cttaggtcac atggctggtc ccagggccag cacaggccca
     3121 agactgggcc tcatggtttt atttttattt aactttattt tctatgtgtg tgtgtcttgt
     3181 gtctgtctgt ctgtctcgtc ttgtctttgt ctactgccct ctagtgttaa gtgggagcct
     3241 ggaggagtct cccacttccc taccttttcc caagtccttc cctctgtcac cagccatccc
     3301 tctggcccag gcagagtggg tcttgggcag gtagggacct ggagtggcct gatcccaccc
     3361 tctgacctcc tcctcaggcc accagtgttg ccctcttccc tttttaaaac aaaataccct
     3421 tgtttgtaaa tccttagacg cttgagaata aaacccttcc cttttcttct ga
//
