LOCUS       NM_001033987            2357 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus mitogen activated protein kinase kinase 5
            (Map2k5), transcript variant 1, mRNA.
ACCESSION   NM_001033987 XM_579403
VERSION     NM_001033987.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2357)
  AUTHORS   Stankiewicz,T.R., Ramaswami,S.A., Bouchard,R.J., Aktories,K. and
            Linseman,D.A.
  TITLE     Neuronal apoptosis induced by selective inhibition of Rac GTPase
            versus global suppression of Rho family GTPases is mediated by
            alterations in distinct mitogen-activated protein kinase signaling
            cascades
  JOURNAL   J Biol Chem 290 (15), 9363-9376 (2015)
   PUBMED   25666619
  REMARK    GeneRIF: Data indicate that NSC23766-mediated Rac inhibition
            induces cerebellar granule neurons (CGNs) apoptosis through
            deactivation of prosurvival MAP Kinase Kinase 5 MEK5/ERK5 kinase
            signaling.
REFERENCE   2  (bases 1 to 2357)
  AUTHORS   Woo,C.H., Le,N.T., Shishido,T., Chang,E., Lee,H., Heo,K.S.,
            Mickelsen,D.M., Lu,Y., McClain,C., Spangenberg,T., Yan,C.,
            Molina,C.A., Yang,J., Patterson,C. and Abe,J.
  TITLE     Novel role of C terminus of Hsc70-interacting protein (CHIP)
            ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction
            via regulating ERK5-mediated degradation of inducible cAMP early
            repressor
  JOURNAL   FASEB J 24 (12), 4917-4928 (2010)
   PUBMED   20724525
REFERENCE   3  (bases 1 to 2357)
  AUTHORS   Ohnesorge,N., Viemann,D., Schmidt,N., Czymai,T., Spiering,D.,
            Schmolke,M., Ludwig,S., Roth,J., Goebeler,M. and Schmidt,M.
  TITLE     Erk5 activation elicits a vasoprotective endothelial phenotype via
            induction of Kruppel-like factor 4 (KLF4)
  JOURNAL   J Biol Chem 285 (34), 26199-26210 (2010)
   PUBMED   20551324
REFERENCE   4  (bases 1 to 2357)
  AUTHORS   Haines,J.D., Fang,J., Mushynski,W.E. and Almazan,G.
  TITLE     Mitogen-activated protein kinase activated protein kinase 2 (MK2)
            participates in p38 MAPK regulated control of oligodendrocyte
            differentiation
  JOURNAL   Glia 58 (11), 1384-1393 (2010)
   PUBMED   20607863
  REMARK    GeneRIF: The p38-mitogen-activated protein kinase activated protein
            kinase 2 (MK2) pathway is a component of the signaling cascade
            regulating oligodendrocyte differentiation.
REFERENCE   5  (bases 1 to 2357)
  AUTHORS   Gerits,N., Shiryaev,A., Kostenko,S., Klenow,H., Shiryaeva,O.,
            Johannessen,M. and Moens,U.
  TITLE     The transcriptional regulation and cell-specific expression of the
            MAPK-activated protein kinase MK5
  JOURNAL   Cell Mol Biol Lett 14 (4), 548-574 (2009)
   PUBMED   19484198
  REMARK    GeneRIF: Several binding motifs for heat shock factor are dispersed
            in the mouse and rat promoter, and temperature shock transiently
            enhanced the MAP-kinase-activated kinase 5 transcript levels.
REFERENCE   6  (bases 1 to 2357)
  AUTHORS   Thomas,J.A., Haudek,S.B., Koroglu,T., Tsen,M.F., Bryant,D.D.,
            White,D.J., Kusewitt,D.F., Horton,J.W. and Giroir,B.P.
  TITLE     IRAK1 deletion disrupts cardiac Toll/IL-1 signaling and protects
            against contractile dysfunction
  JOURNAL   Am J Physiol Heart Circ Physiol 285 (2), H597-H606 (2003)
   PUBMED   12860565
  REMARK    Erratum:[Am J Physiol Heart Circ Physiol. 2004 Jan;286(1):H477]
REFERENCE   7  (bases 1 to 2357)
  AUTHORS   Mehta,P.B., Jenkins,B.L., McCarthy,L., Thilak,L., Robson,C.N.,
            Neal,D.E. and Leung,H.Y.
  TITLE     MEK5 overexpression is associated with metastatic prostate cancer,
            and stimulates proliferation, MMP-9 expression and invasion
  JOURNAL   Oncogene 22 (9), 1381-1389 (2003)
   PUBMED   12618764
REFERENCE   8  (bases 1 to 2357)
  AUTHORS   Watson,F.L., Heerssen,H.M., Bhattacharyya,A., Klesse,L., Lin,M.Z.
            and Segal,R.A.
  TITLE     Neurotrophins use the Erk5 pathway to mediate a retrograde survival
            response
  JOURNAL   Nat Neurosci 4 (10), 981-988 (2001)
   PUBMED   11544482
  REMARK    Erratum:[Nat Neurosci 2002 Oct;5(10):1017]
REFERENCE   9  (bases 1 to 2357)
  AUTHORS   Nicol,R.L., Frey,N., Pearson,G., Cobb,M., Richardson,J. and
            Olson,E.N.
  TITLE     Activated MEK5 induces serial assembly of sarcomeres and eccentric
            cardiac hypertrophy
  JOURNAL   EMBO J 20 (11), 2757-2767 (2001)
   PUBMED   11387209
REFERENCE   10 (bases 1 to 2357)
  AUTHORS   English,J.M., Vanderbilt,C.A., Xu,S., Marcus,S. and Cobb,M.H.
  TITLE     Isolation of MEK5 and differential expression of alternatively
            spliced forms
  JOURNAL   J Biol Chem 270 (48), 28897-28902 (1995)
   PUBMED   7499418
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC078860.1.
            
            On Oct 9, 2005 this sequence version replaced XM_579403.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078860.1, U37462.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2357              BC078860.1         1-2357
FEATURES             Location/Qualifiers
     source          1..2357
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2357
                     /gene="Map2k5"
                     /gene_synonym="Mek5"
                     /note="mitogen activated protein kinase kinase 5"
                     /db_xref="GeneID:29568"
                     /db_xref="RGD:61890"
     exon            1..734
                     /gene="Map2k5"
                     /gene_synonym="Mek5"
                     /inference="alignment:Splign:2.1.0"
     CDS             600..1946
                     /gene="Map2k5"
                     /gene_synonym="Mek5"
                     /EC_number="2.7.12.2"
                     /note="isoform a is encoded by transcript variant 1; dual
                     specificity mitogen-activated protein kinase kinase 5;
                     MAPKK 5; MAPK/ERK kinase 5; MAP kinase kinase 5; MEK 5"
                     /codon_start=1
                     /product="dual specificity mitogen-activated protein
                     kinase kinase 5 isoform a"
                     /protein_id="NP_001029159.1"
                     /db_xref="GeneID:29568"
                     /db_xref="RGD:61890"
                     /translation="MLWLALGPFRAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDV
                     LDVIGQVLPEATTTAFEYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPL
                     QIFPRACKPPGERNIHGLKVNTRAGPSQHTSPVVSDSLPSNSLKKSSAELRKILANGQ
                     MNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYK
                     CDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKIPEHVLGRIAVAVVKGLTYLWS
                     LKILHRDVKPSNMLVNTSGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYG
                     IHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPLGEFSEPF
                     VHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNATVVSMWVCRALEERRSQQGPP"
     exon            735..783
                     /gene="Map2k5"
                     /gene_synonym="Mek5"
                     /inference="alignment:Splign:2.1.0"
     exon            784..851
                     /gene="Map2k5"
                     /gene_synonym="Mek5"
                     /inference="alignment:Splign:2.1.0"
     exon            852..921
                     /gene="Map2k5"
                     /gene_synonym="Mek5"
                     /inference="alignment:Splign:2.1.0"
     exon            922..962
                     /gene="Map2k5"
                     /gene_synonym="Mek5"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1030
                     /gene="Map2k5"
                     /gene_synonym="Mek5"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1079
                     /gene="Map2k5"
                     /gene_synonym="Mek5"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1144
                     /gene="Map2k5"
                     /gene_synonym="Mek5"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1184
                     /gene="Map2k5"
                     /gene_synonym="Mek5"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1253
                     /gene="Map2k5"
                     /gene_synonym="Mek5"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1335
                     /gene="Map2k5"
                     /gene_synonym="Mek5"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1397
                     /gene="Map2k5"
                     /gene_synonym="Mek5"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1446
                     /gene="Map2k5"
                     /gene_synonym="Mek5"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1520
                     /gene="Map2k5"
                     /gene_synonym="Mek5"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1571
                     /gene="Map2k5"
                     /gene_synonym="Mek5"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1643
                     /gene="Map2k5"
                     /gene_synonym="Mek5"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1673
                     /gene="Map2k5"
                     /gene_synonym="Mek5"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1700
                     /gene="Map2k5"
                     /gene_synonym="Mek5"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1733
                     /gene="Map2k5"
                     /gene_synonym="Mek5"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1795
                     /gene="Map2k5"
                     /gene_synonym="Mek5"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1841
                     /gene="Map2k5"
                     /gene_synonym="Mek5"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..2279
                     /gene="Map2k5"
                     /gene_synonym="Mek5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccgccacc ttcgccgccg ggacgagggc ctcagtcggc cgatcccgca cgcgccgcac
       61 tctccggttc cggctgcggc ctgggacccg ccccctgacc ccgcggccct gagccctcct
      121 gcctggtgga gggctggcgg caccggtgca cctccgaaac agccccgacc cagcccgcgg
      181 cgccgggcca cgctcccctt gcccaccgag ccgctcagga aggcaggacc ctagtcgctg
      241 tatctgcctt aaaccaggcc gttgctccgt tgtctcctct tactcacgag gactacaaaa
      301 tacttgtggg ttctgttttg tccacttttg taactccagg accttccgct ctctgctaat
      361 tcctcttggc ccatacccct tccccagtgc atcctccccc agagacactc catacgacct
      421 gggcctggtt cagggcctgc aagctccctc ctgatcgccc ctcttcactt ctccccacct
      481 tcctgctccc tatttatcgc ctgtcttctg tctatcattc cccttgtcac ttcttggggc
      541 tcctaagtag gggccagtcg gtactccttg ccgcaggatg tgagaccctt taacctgtaa
      601 tgctgtggct ggcccttggc ccctttcgtg ccatggagaa ccaggtgctg gtgattcgga
      661 tcaagattcc aaatagtggc gcggtggact ggaccgtgca ctccgggccg cagttactct
      721 tcagggacgt gctggatgtg ataggccagg ttctgcctga agcaacgacg acagcctttg
      781 aatatgaaga tgaagatggt gataggatta cagtaagaag tgacgaagag atgaaggcaa
      841 tgctgtccta ctattattcc acagtaatgg aacagcaagt aaatggccag ctaatagagc
      901 cgctgcagat ctttccaaga gcctgcaagc ctcctgggga acggaacata catggcctga
      961 aggtgaatac acgggctgga ccatctcagc acaccagccc tgtggtctca gattcacttc
     1021 caagcaatag cttgaagaag tcctcggctg aactgagaaa gatactggcc aacggccaga
     1081 tgaatgaaca agacatacgg tatcgagaca cccttggtca tggcaacgga ggcacagtct
     1141 acaaagcata tcatgtccca agtgggaaaa tcttagctgt aaaggttatt ctgttagaca
     1201 tcacactgga gcttcagaag cagatcatgt ctgagttgga aattctttat aagtgtgact
     1261 catcgtatat cataggattt tacggggcat tttttgtaga aaacaggatt tcgatttgta
     1321 cagaattcat ggatgggggg tctttggatg tatataggaa aattccagag cacgtcctcg
     1381 gaagaattgc agtagcagtt gttaaaggcc ttacctatct gtggagttta aagattttac
     1441 acagagatgt gaagccttcc aacatgcttg taaacacaag cggacaggtc aagctgtgtg
     1501 acttcggcgt gagcacccag ctggtgaatt ctatagccaa gacgtatgtt ggaacaaatg
     1561 cttatatggc acccgaaagg atttcaggag agcagtatgg gatccattcc gacgtgtgga
     1621 gcttagggat ctctttcatg gagcttgctc ttgggaggtt tccatatcct cagattcaga
     1681 aaaaccaggg atctttaatg cctctccagc ttctgcagtg cattgttgat gaggattcgc
     1741 cggtccttcc gcttggagag ttctcggagc cgtttgtaca tttcatcact cagtgcatga
     1801 ggaagcagcc caaggaaaga ccagcgcccg aggagctgat gggtcaccca ttcatcgtgc
     1861 agttcaatga cggaaacgcc actgtggtgt ccatgtgggt ttgccgagct ctggaggaga
     1921 gacggagcca gcaggggccc ccatgagacc tcagcaggac actgaccacc caggaccagg
     1981 catcaaggtc acaacaagcc gtgacccctc tgtctgctgc ctgattggga agagatgtac
     2041 tgggcacagc ctcctgcttt caccttctac cttacctggg agtcttcaag aaggctggcc
     2101 tctgccgaac ccctcaccac tggtagggag gaggcactga caatggcagg tggagatggt
     2161 gcagggttgg ggtgatgagg ttatggaacc tcctctggcc ccaccctcat ctctccctac
     2221 tgttgtaaag ggtcagccta tcagcagcac tgatgggaat aaagtattac tgctttggaa
     2281 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2341 aaaaaaaaaa aaaaaaa
//
