LOCUS       NM_001030023            1924 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus mitogen activated protein kinase kinase 4
            (Map2k4), mRNA.
ACCESSION   NM_001030023 XM_220604
VERSION     NM_001030023.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1924)
  AUTHORS   Yao,H., Gao,Y., Han,J., Wang,Y., Cai,J., Rui,Y. and Ge,X.
  TITLE     MKK4 Knockdown Plays a Protective Role in Hemorrhagic Shock-Induced
            Liver Injury through the JNK Pathway
  JOURNAL   Oxid Med Cell Longev 2022, 5074153 (2022)
   PUBMED   36164393
  REMARK    GeneRIF: MKK4 Knockdown Plays a Protective Role in Hemorrhagic
            Shock-Induced Liver Injury through the JNK Pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1924)
  AUTHORS   Rui,T., Zhang,X., Feng,S., Huang,H., Zhan,S., Xie,H., Zhou,L.,
            Ling,Q. and Zheng,S.
  TITLE     The Similar Effects of miR-512-3p and miR-519a-2-5p on the
            Promotion of Hepatocellular Carcinoma: Different Tunes Sung With
            Equal Skill
  JOURNAL   Front Oncol 10, 1244 (2020)
   PUBMED   32850377
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1924)
  AUTHORS   Lu,J., Zhou,N., Yang,P., Deng,L. and Liu,G.
  TITLE     MicroRNA-27a-3p Downregulation Inhibits Inflammatory Response and
            Hippocampal Neuronal Cell Apoptosis by Upregulating
            Mitogen-Activated Protein Kinase 4 (MAP2K4) Expression in Epilepsy:
            In Vivo and In Vitro Studies
  JOURNAL   Med Sci Monit 25, 8499-8508 (2019)
   PUBMED   31710596
  REMARK    GeneRIF: Findings indicated that miR-27a-3p inhibitor protected
            against epilepsy-induced inflammatory response and hippocampal
            neuronal apoptosis by targeting MAP2K4.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1924)
  AUTHORS   Hu,G., Zhao,X., Wang,C., Geng,Y., Zhao,J., Xu,J., Zuo,B., Zhao,C.,
            Wang,C. and Zhang,X.
  TITLE     MicroRNA-145 attenuates TNF-alpha-driven cartilage matrix
            degradation in osteoarthritis via direct suppression of MKK4
  JOURNAL   Cell Death Dis 8 (10), e3140 (2017)
   PUBMED   29072705
  REMARK    GeneRIF: MKK4 overexpression enhanced TNF-alpha-mediated signaling
            activation and transcription of downstream catabolic genes, and
            consequently worsened cartilage degradation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1924)
  AUTHORS   Wu,X., Gong,Z., Sun,L., Ma,L. and Wang,Q.
  TITLE     MicroRNA-802 plays a tumour suppressive role in tongue squamous
            cell carcinoma through directly targeting MAP2K4
  JOURNAL   Cell Prolif 50 (3) (2017)
   PUBMED   28319306
REFERENCE   6  (bases 1 to 1924)
  AUTHORS   Choukroun,G., Hajjar,R., Kyriakis,J.M., Bonventre,J.V.,
            Rosenzweig,A. and Force,T.
  TITLE     Role of the stress-activated protein kinases in endothelin-induced
            cardiomyocyte hypertrophy
  JOURNAL   J Clin Invest 102 (7), 1311-1320 (1998)
   PUBMED   9769323
REFERENCE   7  (bases 1 to 1924)
  AUTHORS   Flood,D.G., Finn,J.P., Walton,K.M., Dionne,C.A., Contreras,P.C.,
            Miller,M.S. and Bhat,R.V.
  TITLE     Immunolocalization of the mitogen-activated protein kinases p42MAPK
            and JNK1, and their regulatory kinases MEK1 and MEK4, in adult rat
            central nervous system
  JOURNAL   J Comp Neurol 398 (3), 373-392 (1998)
   PUBMED   9714150
REFERENCE   8  (bases 1 to 1924)
  AUTHORS   Auer,K.L., Contessa,J., Brenz-Verca,S., Pirola,L., Rusconi,S.,
            Cooper,G., Abo,A., Wymann,M.P., Davis,R.J., Birrer,M. and Dent,P.
  TITLE     The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which
            agonists stimulate DNA synthesis in primary cultures of rat
            hepatocytes
  JOURNAL   Mol Biol Cell 9 (3), 561-573 (1998)
   PUBMED   9487126
REFERENCE   9  (bases 1 to 1924)
  AUTHORS   Mizukami,Y., Yoshioka,K., Morimoto,S. and Yoshida,Ki.
  TITLE     A novel mechanism of JNK1 activation. Nuclear translocation and
            activation of JNK1 during ischemia and reperfusion
  JOURNAL   J Biol Chem 272 (26), 16657-16662 (1997)
   PUBMED   9195981
REFERENCE   10 (bases 1 to 1924)
  AUTHORS   Moriguchi,T., Kawasaki,H., Matsuda,S., Gotoh,Y. and Nishida,E.
  TITLE     Evidence for multiple activators for stress-activated protein
            kinase/c-Jun amino-terminal kinases. Existence of novel activators
  JOURNAL   J Biol Chem 270 (22), 12969-12972 (1995)
   PUBMED   7768885
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Oct 27, 2022 this sequence version replaced NM_001030023.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.39791.1,
                                           SRR26643291.28034.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               JAXUCZ010000010.1  50946878-50947039   c
            163-265             JAXUCZ010000010.1  50916072-50916174   c
            266-440             JAXUCZ010000010.1  50893083-50893257   c
            441-560             JAXUCZ010000010.1  50877039-50877158   c
            561-680             JAXUCZ010000010.1  50869182-50869301   c
            681-732             JAXUCZ010000010.1  50867120-50867171   c
            733-860             JAXUCZ010000010.1  50864648-50864775   c
            861-938             JAXUCZ010000010.1  50850171-50850248   c
            939-1087            JAXUCZ010000010.1  50847404-50847552   c
            1088-1133           JAXUCZ010000010.1  50845756-50845801   c
            1134-1924           JAXUCZ010000010.1  50844034-50844824   c
FEATURES             Location/Qualifiers
     source          1..1924
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..1924
                     /gene="Map2k4"
                     /gene_synonym="MKK4; Sek1"
                     /note="mitogen activated protein kinase kinase 4"
                     /db_xref="GeneID:287398"
                     /db_xref="RGD:1307040"
     exon            1..162
                     /gene="Map2k4"
                     /gene_synonym="MKK4; Sek1"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..1247
                     /gene="Map2k4"
                     /gene_synonym="MKK4; Sek1"
                     /note="SAPK/ERK kinase 1; MAP2K4delta"
                     /codon_start=1
                     /product="dual specificity mitogen-activated protein
                     kinase kinase 4"
                     /protein_id="NP_001025194.1"
                     /db_xref="GeneID:287398"
                     /db_xref="RGD:1307040"
                     /translation="MAAPSPSGGGGSGGGGGTPGPIGPPASGHPAVSSMQGKRKALKL
                     NFANPPVKSTARFTLNPNTTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKD
                     LGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIV
                     QFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLK
                     ENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPS
                     ASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREF
                     SPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERTVEVACYVCKILDQMPATPSS
                     PMYVD"
     exon            163..265
                     /gene="Map2k4"
                     /gene_synonym="MKK4; Sek1"
                     /inference="alignment:Splign:2.1.0"
     exon            266..440
                     /gene="Map2k4"
                     /gene_synonym="MKK4; Sek1"
                     /inference="alignment:Splign:2.1.0"
     exon            441..560
                     /gene="Map2k4"
                     /gene_synonym="MKK4; Sek1"
                     /inference="alignment:Splign:2.1.0"
     exon            561..680
                     /gene="Map2k4"
                     /gene_synonym="MKK4; Sek1"
                     /inference="alignment:Splign:2.1.0"
     exon            681..732
                     /gene="Map2k4"
                     /gene_synonym="MKK4; Sek1"
                     /inference="alignment:Splign:2.1.0"
     exon            733..860
                     /gene="Map2k4"
                     /gene_synonym="MKK4; Sek1"
                     /inference="alignment:Splign:2.1.0"
     exon            861..938
                     /gene="Map2k4"
                     /gene_synonym="MKK4; Sek1"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1087
                     /gene="Map2k4"
                     /gene_synonym="MKK4; Sek1"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1133
                     /gene="Map2k4"
                     /gene_synonym="MKK4; Sek1"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1924
                     /gene="Map2k4"
                     /gene_synonym="MKK4; Sek1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcttgctg cattgcagcc gccgcggcgc cgctcggctc ctcatttcca acaatggcgg
       61 ctccgagccc gagcggcggc ggcggctccg ggggcggtgg cggcaccccg gggcccatcg
      121 ggcctccagc ttctggccac ccggcggtca gcagcatgca gggtaaacgc aaagccctga
      181 agttgaattt tgcaaatcca cctgtcaaat cgacagcacg gtttactctg aatcctaata
      241 ccacaggagt ccagaaccca cacatagaga gactgagaac ccacagcatt gagtcatcag
      301 gaaaactgaa gatctcccct gaacaacact gggatttcac tgcagaggac ttgaaagacc
      361 ttggagaaat tggacgagga gcttatggtt ctgtcaacaa aatggtccac aaaccaagtg
      421 ggcagataat ggcagttaaa agaatacgat caactgtgga tgaaaaagaa caaaaacaac
      481 ttctcatgga tttggatgta gtgatgcgga gtagtgattg cccatacatt gttcagttct
      541 atggtgcact cttcagagag ggcgactgtt ggatctgtat ggagctcatg tctacctcgt
      601 tcgataagtt ttacaaatat gtatatagtg tgttagatga tgtgatcccg gaagagatct
      661 taggcaaaat cactttagca actgtgaaag cactaaacca cttaaaagaa aacttgaaaa
      721 ttattcacag agacatcaaa ccttccaata ttcttctgga caggagtgga aatataaagc
      781 tctgtgactt cggcatcagt ggacagctcg tggactctat tgccaagacg agagatgctg
      841 gctgtaggcc gtatatggca cctgaaagaa tagacccaag tgcatcaaga caagggtatg
      901 atgtccgctc tgatgtctgg agtttgggga tcacattgta cgagttggcc acaggccgat
      961 ttccttatcc aaagtggaat agtgtatttg atcagctaac acaagtggtg aaaggagacc
     1021 ctccccagct gagtaattcc gaagaaaggg agttctcccc cagtttcatc aactttgtca
     1081 acttgtgcct tacgaaggac gagtccaaaa ggccaaagta caaagagctt ctgaaacatc
     1141 cctttatttt gatgtatgaa gaacgtactg tagaggtcgc atgctatgtt tgtaaaatcc
     1201 tggatcagat gccagctact cccagctctc ccatgtatgt cgactgatac tgctgctaca
     1261 tcagactcta gaaaaaaggg ctgagaggaa gcaagacgta aagagttttc atcctgtatc
     1321 acagtgtttt tattgctcgc ccagacacca tgtgcaataa gattggtgtt cgtttccatc
     1381 atgtctgtat acttctgtca cctcgaatgt gcatccctgt aatacctgac tgatcacagt
     1441 gttagtgctg gtcacagaga cctcatcctg ctctttgtga tgaacatatt catgacgtgt
     1501 ggaagtcagt acgatcaagt tgttgactgt gattagatca caccttaaat tcatttctag
     1561 actcaaaacc tggagacgca gctactggag tggcgttttg tgagccttcc gaaggctgga
     1621 aagacacagt catggatgta ctatatctga acatagagac ctgggcttga gtgagaagag
     1681 cttgcacagc cagtgagaca cattgccttc tgcagctggg agacaaagga aggatttcct
     1741 tttttcacca agtgcaatag atttgctgat ctgatactct gttcctttac agtcacagtc
     1801 gatgttgggg gatcgatgtg ctcagccaaa ttccctgttc aaaacatgtt aaattagaat
     1861 taatctatct ttaccaaaac ctatgttgct ttcagagagg tgaacattaa acgctgagac
     1921 agga
//
