LOCUS       NM_001100674            2356 bp    mRNA    linear   ROD 01-JUL-2024
DEFINITION  Rattus norvegicus mitogen activated protein kinase kinase 3
            (Map2k3), mRNA.
ACCESSION   NM_001100674 XM_001077724 XM_239239
VERSION     NM_001100674.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2356)
  AUTHORS   Li,L., Zhang,Z., Kuai,X., Deng,J., Qiu,Z., Wang,Z. and Jiang,H.
  TITLE     MKK3 depletion attenuates intestinal injury after traumatic
            hemorrhagic shock by restoring mitochondrial function
  JOURNAL   Mol Biol Rep 51 (1), 776 (2024)
   PUBMED   38904879
  REMARK    GeneRIF: MKK3 depletion attenuates intestinal injury after
            traumatic hemorrhagic shock by restoring mitochondrial function.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2356)
  AUTHORS   Liu,Z., Lv,Y., Zhang,Y., Liu,F., Zhu,L., Pan,S., Qiu,C., Guo,Y.,
            Yang,T. and Wang,J.
  TITLE     Matrine-Type Alkaloids Inhibit Advanced Glycation End Products
            Induced Reactive Oxygen Species-Mediated Apoptosis of Aortic
            Endothelial Cells In Vivo and In Vitro by Targeting MKK3 and
            p38MAPK Signaling
  JOURNAL   J Am Heart Assoc 6 (12), e007441 (2017)
   PUBMED   29197828
  REMARK    GeneRIF: Matrine-type alkaloids exert endothelial protective
            effects against advanced glycation end products induced reactive
            oxygen species-mediated apoptosis by targeting MKK3/6/p38MAPK
            signaling and enhancing their phosphorylation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2356)
  AUTHORS   Bassi,R., Burgoyne,J.R., DeNicola,G.F., Rudyk,O., DeSantis,V.,
            Charles,R.L., Eaton,P. and Marber,M.S.
  TITLE     Redox-dependent dimerization of p38alpha mitogen-activated protein
            kinase with mitogen-activated protein kinase kinase 3
  JOURNAL   J Biol Chem 292 (39), 16161-16173 (2017)
   PUBMED   28739872
  REMARK    GeneRIF: Data suggest that Mapk14/p38alpha is activated and forms
            cystine disulfide-bound heterodimer with Map2k3/Mkk3 in
            cardiomyocytes and isolated hearts during oxidative stress
            (exposure to hydrogen peroxide). (Mapk14, mitogen-activated protein
            kinase 14; Mkk3 = mitogen-activated protein kinase kinase 3)
REFERENCE   4  (bases 1 to 2356)
  AUTHORS   Huang,D., Li,X., Sun,L., Huang,P., Ying,H., Wang,H., Wu,J. and
            Song,H.
  TITLE     Regulation of Hippo signalling by p38 signalling
  JOURNAL   J Mol Cell Biol 8 (4), 328-337 (2016)
   PUBMED   27402810
REFERENCE   5  (bases 1 to 2356)
  AUTHORS   MacNeil,A.J., Jiao,S.C., McEachern,L.A., Yang,Y.J., Dennis,A.,
            Yu,H., Xu,Z., Marshall,J.S. and Lin,T.J.
  TITLE     MAPK kinase 3 is a tumor suppressor with reduced copy number in
            breast cancer
  JOURNAL   Cancer Res 74 (1), 162-172 (2014)
   PUBMED   24233520
REFERENCE   6  (bases 1 to 2356)
  AUTHORS   Guan,Z., Buckman,S.Y., Springer,L.D. and Morrison,A.R.
  TITLE     Both p38alpha(MAPK) and JNK/SAPK pathways are important for
            induction of nitric-oxide synthase by interleukin-1beta in rat
            glomerular mesangial cells
  JOURNAL   J Biol Chem 274 (51), 36200-36206 (1999)
   PUBMED   10593906
REFERENCE   7  (bases 1 to 2356)
  AUTHORS   Lu,H.T., Yang,D.D., Wysk,M., Gatti,E., Mellman,I., Davis,R.J. and
            Flavell,R.A.
  TITLE     Defective IL-12 production in mitogen-activated protein (MAP)
            kinase kinase 3 (Mkk3)-deficient mice
  JOURNAL   EMBO J 18 (7), 1845-1857 (1999)
   PUBMED   10202148
REFERENCE   8  (bases 1 to 2356)
  AUTHORS   Wysk,M., Yang,D.D., Lu,H.T., Flavell,R.A. and Davis,R.J.
  TITLE     Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for
            tumor necrosis factor-induced cytokine expression
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3763-3768 (1999)
   PUBMED   10097111
REFERENCE   9  (bases 1 to 2356)
  AUTHORS   Kim,S.O., Irwin,P., Katz,S. and Pelech,S.L.
  TITLE     Expression of mitogen-activated protein kinase pathways during
            postnatal development of rat heart
  JOURNAL   J Cell Biochem 71 (2), 286-301 (1998)
   PUBMED   9779826
REFERENCE   10 (bases 1 to 2356)
  AUTHORS   Moriguchi,T., Toyoshima,F., Gotoh,Y., Iwamatsu,A., Irie,K.,
            Mori,E., Kuroyanagi,N., Hagiwara,M., Matsumoto,K. and Nishida,E.
  TITLE     Purification and identification of a major activator for p38 from
            osmotically shocked cells. Activation of mitogen-activated protein
            kinase kinase 6 by osmotic shock, tumor necrosis factor-alpha, and
            H2O2
  JOURNAL   J Biol Chem 271 (43), 26981-26988 (1996)
   PUBMED   8900184
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DY311082.1, BC160839.1 and BC100095.1.
            
            On or before Sep 4, 2008 this sequence version replaced
            XM_239239.3, XM_001077724.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC160839.1, SRR8487227.141314.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               DY311082.1         1-130
            131-2232            BC160839.1         1-2102
            2233-2356           BC100095.1         1352-1475
FEATURES             Location/Qualifiers
     source          1..2356
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..2356
                     /gene="Map2k3"
                     /gene_synonym="Mek3; Mkk3"
                     /note="mitogen activated protein kinase kinase 3"
                     /db_xref="GeneID:303200"
                     /db_xref="RGD:1306620"
     exon            1..211
                     /gene="Map2k3"
                     /gene_synonym="Mek3; Mkk3"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..1206
                     /gene="Map2k3"
                     /gene_synonym="Mek3; Mkk3"
                     /note="dual specificity mitogen-activated protein kinase
                     kinase 3-like"
                     /codon_start=1
                     /product="dual specificity mitogen-activated protein
                     kinase kinase 3"
                     /protein_id="NP_001094144.1"
                     /db_xref="GeneID:303200"
                     /db_xref="RGD:1306620"
                     /translation="MESPAASPPASLPQTKGKSKRKRDLRISCVSKPPVSNPTPPRNL
                     DSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQ
                     EQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLEKNMK
                     IPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDS
                     VAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQ
                     QLKQVVEEPSPQLPADQFSPEFVDFTSQCLRKNPAERMSYLELMEHPFFTLHKTKKTD
                     IAAFVKEILGEDS"
     exon            212..278
                     /gene="Map2k3"
                     /gene_synonym="Mek3; Mkk3"
                     /inference="alignment:Splign:2.1.0"
     exon            279..327
                     /gene="Map2k3"
                     /gene_synonym="Mek3; Mkk3"
                     /inference="alignment:Splign:2.1.0"
     exon            328..441
                     /gene="Map2k3"
                     /gene_synonym="Mek3; Mkk3"
                     /inference="alignment:Splign:2.1.0"
     exon            442..561
                     /gene="Map2k3"
                     /gene_synonym="Mek3; Mkk3"
                     /inference="alignment:Splign:2.1.0"
     exon            562..678
                     /gene="Map2k3"
                     /gene_synonym="Mek3; Mkk3"
                     /inference="alignment:Splign:2.1.0"
     exon            679..730
                     /gene="Map2k3"
                     /gene_synonym="Mek3; Mkk3"
                     /inference="alignment:Splign:2.1.0"
     exon            731..858
                     /gene="Map2k3"
                     /gene_synonym="Mek3; Mkk3"
                     /inference="alignment:Splign:2.1.0"
     exon            859..936
                     /gene="Map2k3"
                     /gene_synonym="Mek3; Mkk3"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1076
                     /gene="Map2k3"
                     /gene_synonym="Mek3; Mkk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1122
                     /gene="Map2k3"
                     /gene_synonym="Mek3; Mkk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..2343
                     /gene="Map2k3"
                     /gene_synonym="Mek3; Mkk3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgtggcgcc gcccgcctcg gacgcttgga actgtcgcgt ctgtgtcgcc tgtcgcccat
       61 cgcctgccgc cgctgccagc caccagcaac catgagcgcg cccggccccg gtgtagtctg
      121 ctgtcctcta gattagtgct ctcctccgcg acggtccgca gcatggagtc gcccgccgcc
      181 agcccgccgg ccagcttgcc tcagaccaaa ggaaaatcca aaaggaaaag ggatttacgg
      241 atatcctgtg tgtccaagcc acccgtgtcc aaccccacac ccccccggaa cctggactcc
      301 cggaccttca tcactatcgg agacagaaac ttcgaagtgg aggctgatga cttggtgacc
      361 atctcagagc tgggccgcgg agcctatggg gtggtggaga aggtgcggca tgctcagagt
      421 ggtaccatca tggctgtcaa gcgcatccgg gccactgtga actcacagga gcagaaacgt
      481 ctgcttatgg acctagacat caacatgcgc actgtcgact gcttctatac tgtcaccttc
      541 tatggtgccc tctttagaga gggggatgtg tggatctgca tggaactcat ggacacgtcc
      601 ctggataagt tctaccggaa ggtgctagag aagaacatga aaattccgga agacattctg
      661 ggggagattg ctgtatccat cgtgcgggcc ctggagcacc tacacagcaa gctgtctgtg
      721 atccacagag atgtgaagcc ttccaatgtc ctcatcaaca aagaggggca cgtgaagatg
      781 tgcgactttg gcatcagtgg ctacctggtg gactctgtgg caaagacaat ggatgctggc
      841 tgcaagcctt acatggcccc tgagaggatc aaccctgagc tgaatcagaa gggctacaac
      901 gtcaagtctg atgtctggag ccttggcatc accatgattg agatggccat tctgcgattc
      961 ccttacgagt cttgggggac accgttccag cagctgaagc aggtggtgga ggagccatcc
     1021 ccacagctcc cagcagacca gttctcccct gagtttgtgg acttcacaag ccagtgcctc
     1081 aggaagaatc ctgcggaacg catgagctac ctggagctga tggaacaccc gttcttcacc
     1141 ttgcacaaaa ctaagaagac ggacattgct gcctttgtga aggagatcct gggagaggat
     1201 tcatagggac tggcccagga ccccactggt ctgccagcat ccatacacct gtgctggggc
     1261 agcacttacc tacaaccata agctactgcc attctggtcc tgggcattcg aggaattaag
     1321 gggctgttcc tgtttgtctc gcaactagct gtcccaagtg ccaaagaatc agacctcagg
     1381 ggctcccagc caggccatat gtgcccacag tgcctctgct gttgctgctc ccagggtctc
     1441 aggcctctac ccaagggatg aatttggagg ggcctgtgta ccccagcaaa tgctgttgct
     1501 tcttgaagag caggcagctg gtgcctctgt ggacagccta tagccttgtt atggacctgg
     1561 atgccatcca ggttgtatat atattctaaa tcacaactga atgaatggac tttgtacact
     1621 atggcctgga tcagggacat ctctatcctg tctcaggtgc tgaggacaca ctgtggggat
     1681 gagccatgtg aatcccctaa gactttcctg ggagatatgt tgagctgccc aaggccttca
     1741 cccagcactg gccaggtctc tgaggggcac actgccctca gatagcccct ggttaccacc
     1801 tctggtggta tctgcctttc tttttaaact attatctttg ttgccttttg ctttgtgggt
     1861 gtcgctggtt tttcttgcat ggtttggagc tgatcactta accctgggta ccagcaggtt
     1921 cacagcgctc aggctgcagt ctgcaggcac acagcgctca ggctgcagtc tgcaggcacg
     1981 gtccttaggc tgcagtctgc aggcacacag tgctcaggct gcagtctgca ggcacacagc
     2041 gctcaggctg cagtctgcag gcacggtcct taggctgcag tctgcaggca cacagcgctc
     2101 aggctgcagt ctgcaggatg gctcaagctc tttgctcaag accacacggg agctctacca
     2161 actgtccagg tgtgaccagc tcatggaagc taataggttt actttggtgg tgtttttaaa
     2221 aaaaaaaaaa aagaagagga agaaaatata tttttgtgaa gtaagacctg cctattccag
     2281 ccttttccca ggcaggaacc tattgctgtt ttaattaaaa aacaaaccaa aaaaaaaaaa
     2341 aaaaaaaaaa aaaaaa
//
