LOCUS       NM_133283               1368 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus mitogen activated protein kinase kinase 2
            (Map2k2), mRNA.
ACCESSION   NM_133283
VERSION     NM_133283.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1368)
  AUTHORS   Zhao,E., Chen,S. and Dang,Y.
  TITLE     Development and External Validation of a Novel Immune
            Checkpoint-Related Gene Signature for Prediction of Overall
            Survival in Hepatocellular Carcinoma
  JOURNAL   Front Mol Biosci 7, 620765 (2021)
   PUBMED   33553243
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1368)
  AUTHORS   Lavoie,H., Sahmi,M., Maisonneuve,P., Marullo,S.A., Thevakumaran,N.,
            Jin,T., Kurinov,I., Sicheri,F. and Therrien,M.
  TITLE     MEK drives BRAF activation through allosteric control of KSR
            proteins
  JOURNAL   Nature 554 (7693), 549-553 (2018)
   PUBMED   29433126
REFERENCE   3  (bases 1 to 1368)
  AUTHORS   Chen,J., Cui,X., Li,L., Qu,J., Raj,J.U. and Gou,D.
  TITLE     MiR-339 inhibits proliferation of pulmonary artery smooth muscle
            cell by targeting FGF signaling
  JOURNAL   Physiol Rep 5 (18) (2017)
   PUBMED   28947594
REFERENCE   4  (bases 1 to 1368)
  AUTHORS   He,H., Yao,M., Zhang,W., Tao,B., Liu,F., Li,S., Dong,Y., Zhang,C.,
            Meng,Y., Li,Y., Hu,G., Luo,C., Zong,H. and Lu,Y.
  TITLE     MEK2 is a prognostic marker and potential chemo-sensitizing target
            for glioma patients undergoing temozolomide treatment
  JOURNAL   Cell Mol Immunol 13 (5), 658-668 (2016)
   PUBMED   26189368
REFERENCE   5  (bases 1 to 1368)
  AUTHORS   Tabur,S., Oztuzcu,S., Oguz,E., Demiryurek,S., Dagli,H.,
            Alasehirli,B., Ozkaya,M. and Demiryurek,A.T.
  TITLE     Evidence for elevated (LIMK2 and CFL1) and suppressed (ICAM1, EZR,
            MAP2K2, and NOS3) gene expressions in metabolic syndrome
  JOURNAL   Endocrine 53 (2), 465-470 (2016)
   PUBMED   26956845
REFERENCE   6  (bases 1 to 1368)
  AUTHORS   Catling,A.D., Schaeffer,H.J., Reuter,C.W., Reddy,G.R. and
            Weber,M.J.
  TITLE     A proline-rich sequence unique to MEK1 and MEK2 is required for raf
            binding and regulates MEK function
  JOURNAL   Mol Cell Biol 15 (10), 5214-5225 (1995)
   PUBMED   7565670
REFERENCE   7  (bases 1 to 1368)
  AUTHORS   Duan,R.D., Zheng,C.F., Guan,K.L. and Williams,J.A.
  TITLE     Activation of MAP kinase kinase (MEK) and Ras by cholecystokinin in
            rat pancreatic acini
  JOURNAL   Am J Physiol 268 (6 Pt 1), G1060-G1065 (1995)
   PUBMED   7611406
REFERENCE   8  (bases 1 to 1368)
  AUTHORS   Zheng,C.F. and Guan,K.L.
  TITLE     Cloning and characterization of two distinct human extracellular
            signal-regulated kinase activator kinases, MEK1 and MEK2
  JOURNAL   J Biol Chem 268 (15), 11435-11439 (1993)
   PUBMED   8388392
REFERENCE   9  (bases 1 to 1368)
  AUTHORS   Wu,J., Harrison,J.K., Vincent,L.A., Haystead,C., Haystead,T.A.,
            Michel,H., Hunt,D.F., Lynch,K.R. and Sturgill,T.W.
  TITLE     Molecular structure of a protein-tyrosine/threonine kinase
            activating p42 mitogen-activated protein (MAP) kinase: MAP kinase
            kinase
  JOURNAL   Proc Natl Acad Sci U S A 90 (1), 173-177 (1993)
   PUBMED   8380494
REFERENCE   10 (bases 1 to 1368)
  AUTHORS   Wu,J., Michel,H., Rossomando,A., Haystead,T., Shabanowitz,J.,
            Hunt,D.F. and Sturgill,T.W.
  TITLE     Renaturation and partial peptide sequencing of mitogen-activated
            protein kinase (MAP kinase) activator from rabbit skeletal muscle
  JOURNAL   Biochem J 285 (Pt 3) (Pt 3), 701-705 (1992)
   PUBMED   1379797
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 27, 2020 this sequence version replaced NM_133283.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L14936.1, FQ215833.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               JAXUCZ010000007.1  9260680-9260798     c
            120-330             JAXUCZ010000007.1  9258129-9258339     c
            331-477             JAXUCZ010000007.1  9250187-9250333     c
            478-555             JAXUCZ010000007.1  9247254-9247331     c
            556-607             JAXUCZ010000007.1  9246498-9246549     c
            608-732             JAXUCZ010000007.1  9246303-9246427     c
            733-946             JAXUCZ010000007.1  9245977-9246190     c
            947-1011            JAXUCZ010000007.1  9244381-9244445     c
            1012-1073           JAXUCZ010000007.1  9243539-9243600     c
            1074-1119           JAXUCZ010000007.1  9242890-9242935     c
            1120-1368           JAXUCZ010000007.1  9241449-9241697     c
FEATURES             Location/Qualifiers
     source          1..1368
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1368
                     /gene="Map2k2"
                     /gene_synonym="Prkmk2"
                     /note="mitogen activated protein kinase kinase 2"
                     /db_xref="GeneID:58960"
                     /db_xref="RGD:61888"
     exon            1..119
                     /gene="Map2k2"
                     /gene_synonym="Prkmk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..1230
                     /gene="Map2k2"
                     /gene_synonym="Prkmk2"
                     /EC_number="2.7.12.2"
                     /note="MEK2; MAPKK 2; MAPK/ERK kinase 2; MAP kinase kinase
                     2; ERK activator kinase 2; MEK 2"
                     /codon_start=1
                     /product="dual specificity mitogen-activated protein
                     kinase kinase 2"
                     /protein_id="NP_579817.1"
                     /db_xref="GeneID:58960"
                     /db_xref="RGD:61888"
                     /translation="MLARRKPVLPALTINPTIAEGPSPTSEGASEAHLVDLQKKLEEL
                     DLDEQQRKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKARHRPSGLIMARKL
                     IHLEIKPAVRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK
                     EAKRIPEDILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQ
                     LIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVELAIGRYPIPPPDAKELE
                     ASFGRPVVDGADGEPHSVSPRPRPPGRPISGHGMDSRPAMAIFELLDYIVNEPPPKLP
                     SGVFSSDFQEFVNKCLIKNPAERADLKLLTNHAFIKRSEGEDVDFAGWLCRTLRLKQP
                     STPTRTAV"
     exon            120..330
                     /gene="Map2k2"
                     /gene_synonym="Prkmk2"
                     /inference="alignment:Splign:2.1.0"
     exon            331..477
                     /gene="Map2k2"
                     /gene_synonym="Prkmk2"
                     /inference="alignment:Splign:2.1.0"
     exon            478..555
                     /gene="Map2k2"
                     /gene_synonym="Prkmk2"
                     /inference="alignment:Splign:2.1.0"
     exon            556..607
                     /gene="Map2k2"
                     /gene_synonym="Prkmk2"
                     /inference="alignment:Splign:2.1.0"
     exon            608..732
                     /gene="Map2k2"
                     /gene_synonym="Prkmk2"
                     /inference="alignment:Splign:2.1.0"
     exon            733..946
                     /gene="Map2k2"
                     /gene_synonym="Prkmk2"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1011
                     /gene="Map2k2"
                     /gene_synonym="Prkmk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1073
                     /gene="Map2k2"
                     /gene_synonym="Prkmk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1119
                     /gene="Map2k2"
                     /gene_synonym="Prkmk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1368
                     /gene="Map2k2"
                     /gene_synonym="Prkmk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgccgccg ccggccgcag agccctgatg ctggcccgga ggaagccggt gttaccggcg
       61 ctcaccatca accctaccat cgctgagggc ccgtccccca ccagcgaggg cgcctccgag
      121 gcacacctgg tggacctcca gaagaagttg gaagagctgg acctggatga acagcagagg
      181 aagcggctgg aggccttcct tacccagaag gccaaggttg gtgagctcaa ggacgacgac
      241 tttgagagaa tctcagaact gggtgcaggc aatggcggcg tggtcacaaa ggcccggcat
      301 aggccctctg gcctcatcat ggccagaaag ctgatccacc tggagatcaa gccagctgtc
      361 cgcaaccaga tcatccggga gctgcaggtg ctgcatgagt gcaactcacc gtacatcgtg
      421 ggcttttatg gggccttcta cagcgacggc gagatcagca tctgcatgga gcacatggac
      481 ggtggctcac tggaccaggt actgaaggag gccaagcgca ttcccgagga catcttaggg
      541 aaggtcagca ttgcggtgct ccggggcctg gcgtacctcc gcgagaagca ccagatcatg
      601 catagagatg tgaagccctc caacattctg gtgaactctc gtggagagat taagctgtgc
      661 gacttcggag tgagcggcca gttgattgac tccatggcca actcatttgt agggacacgc
      721 tcctacatgt ccccagaacg gctgcagggc acccactact ctgtgcagtc ggacatctgg
      781 agcatggggc tgtcgctggt ggagctggcc atcgggaggt accccatccc cccacctgat
      841 gccaaggaac tagaggccag ctttggccgg cctgtggtgg acggggcaga tggagagccc
      901 catagtgtct caccgcggcc ccggccccct ggacgcccca tcagtggtca tgggatggac
      961 agccgaccag ccatggccat ctttgagctg ctggactaca tagtgaatga gccacctccc
     1021 aagctgccca gtggtgtgtt cagctcagac ttccaggagt ttgtgaataa atgtctcatt
     1081 aagaacccag cagagcgtgc agacctcaag ctgctgacga accatgcctt catcaaacgc
     1141 tctgaggggg aggacgtgga cttcgctggc tggctatgca gaaccctgcg gctgaagcag
     1201 cccagcacac ccacgcgtac tgcagtgtga cagccatcgc tcagcagtct gtgtccttgt
     1261 ccctgtgggc acagcggccg cctttgggga cagcagtggt gtgtgttgtg gcaggggacc
     1321 tgtgcctgtg catttggaaa agcaaacaaa gtggagaaag agagaaaa
//
