LOCUS       NM_013066               5736 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus microtubule-associated protein 2 (Map2), mRNA.
ACCESSION   NM_013066 XM_346853
VERSION     NM_013066.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5736)
  AUTHORS   Zhao,H., Liu,Z.D., Zhang,Y.B., Gao,X.Y., Wang,C., Liu,Y. and
            Wang,X.F.
  TITLE     NEP1-40 promotes myelin regeneration via upregulation of GAP-43 and
            MAP-2 expression after focal cerebral ischemia in rats
  JOURNAL   Mol Med Rep 24 (6) (2021)
   PUBMED   34643252
  REMARK    GeneRIF: NEP140 promotes myelin regeneration via upregulation of
            GAP43 and MAP2 expression after focal cerebral ischemia in rats.
            Erratum:[Mol Med Rep. 2023 Mar;27(3):58. doi:
            10.3892/mmr.2023.12945. PMID: 36695184]
REFERENCE   2  (bases 1 to 5736)
  AUTHORS   Hung,T.W., Wu,K.J., Wang,Y.S., Bae,E.K., Song,Y., Yoon,J. and
            Yu,S.J.
  TITLE     Human Milk Oligosaccharide 2'-Fucosyllactose Induces
            Neuroprotection from Intracerebral Hemorrhage Stroke
  JOURNAL   Int J Mol Sci 22 (18), 9881 (2021)
   PUBMED   34576050
  REMARK    GeneRIF: Human Milk Oligosaccharide 2'-Fucosyllactose Induces
            Neuroprotection from Intracerebral Hemorrhage Stroke.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5736)
  AUTHORS   Xu,C., Lu,H., Li,F. and Su,G.
  TITLE     Protein Expression Profile on Differentiation of Bone Marrow
            Mesenchymal Stem Cells into Retinal Ganglion-Like Cells
  JOURNAL   J Comput Biol 27 (8), 1329-1336 (2020)
   PUBMED   31841640
  REMARK    GeneRIF: Protein Expression Profile on Differentiation of Bone
            Marrow Mesenchymal Stem Cells into Retinal Ganglion-Like Cells.
REFERENCE   4  (bases 1 to 5736)
  AUTHORS   Yu,Q., Li,X., Li,Y., Fu,J. and Xiao,Z.
  TITLE     Effects of combined electroacupuncture and exercise training on
            motor function and microtubule-associated protein 2 expression in
            the middle and late stages of cerebral infarction in rats
  JOURNAL   Acupunct Med 38 (3), 175-180 (2020)
   PUBMED   31996007
  REMARK    GeneRIF: Effects of combined electroacupuncture and exercise
            training on motor function and microtubule-associated protein 2
            expression in the middle and late stages of cerebral infarction in
            rats.
REFERENCE   5  (bases 1 to 5736)
  AUTHORS   Kim,Y., Jang,Y.N., Kim,J.Y., Kim,N., Noh,S., Kim,H., Queenan,B.N.,
            Bellmore,R., Mun,J.Y., Park,H., Rah,J.C., Pak,D.T.S. and Lee,K.J.
  TITLE     Microtubule-associated protein 2 mediates induction of long-term
            potentiation in hippocampal neurons
  JOURNAL   FASEB J 34 (5), 6965-6983 (2020)
   PUBMED   32237183
  REMARK    GeneRIF: Microtubule-associated protein 2 mediates induction of
            long-term potentiation in hippocampal neurons.
REFERENCE   6  (bases 1 to 5736)
  AUTHORS   Kindler,S., Schulz,B., Goedert,M. and Garner,C.C.
  TITLE     Molecular structure of microtubule-associated protein 2b and 2c
            from rat brain
  JOURNAL   J Biol Chem 265 (32), 19679-19684 (1990)
   PUBMED   2174050
REFERENCE   7  (bases 1 to 5736)
  AUTHORS   Kindler,S., Schwanke,B., Schulz,B. and Garner,C.C.
  TITLE     Complete cDNA sequence encoding rat high and low molecular weight
            MAP2
  JOURNAL   Nucleic Acids Res 18 (9), 2822 (1990)
   PUBMED   2339070
REFERENCE   8  (bases 1 to 5736)
  AUTHORS   Doll,T., Papandrikopoulou,A. and Matus,A.
  TITLE     Nucleotide and amino acid sequences of embryonic rat MAP2c
  JOURNAL   Nucleic Acids Res 18 (2), 361 (1990)
   PUBMED   2326166
REFERENCE   9  (bases 1 to 5736)
  AUTHORS   Ferreira,A., Busciglio,J. and Caceres,A.
  TITLE     Microtubule formation and neurite growth in cerebellar macroneurons
            which develop in vitro: evidence for the involvement of the
            microtubule-associated proteins, MAP-1a, HMW-MAP2 and Tau
  JOURNAL   Brain Res Dev Brain Res 49 (2), 215-228 (1989)
   PUBMED   2509111
REFERENCE   10 (bases 1 to 5736)
  AUTHORS   Marechal,D., Delapierre,D. and Dresse,A.
  TITLE     Cloning and partial sequencing of a new rat brain specific cDNA
  JOURNAL   Arch Int Physiol Biochim 96 (5), 231-236 (1988)
   PUBMED   2474284
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X54100.1.
            
            [WARNING] On Jul 22, 2024 this sequence was replaced by
            NM_013066.2.
            
            On Jan 12, 2005 this sequence version replaced XM_346853.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X54100.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..5736
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q32"
     gene            1..5736
                     /gene="Map2"
                     /gene_synonym="MAP2R; Mtap2"
                     /note="microtubule-associated protein 2"
                     /db_xref="GeneID:25595"
                     /db_xref="RGD:3044"
     exon            1..79
                     /gene="Map2"
                     /gene_synonym="MAP2R; Mtap2"
                     /inference="alignment:Splign:2.1.0"
     exon            80..364
                     /gene="Map2"
                     /gene_synonym="MAP2R; Mtap2"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..5580
                     /gene="Map2"
                     /gene_synonym="MAP2R; Mtap2"
                     /note="MAP-2; microtubule-associated protein 2C"
                     /codon_start=1
                     /product="microtubule-associated protein 2"
                     /protein_id="NP_037198.1"
                     /db_xref="GeneID:25595"
                     /db_xref="RGD:3044"
                     /translation="MADERKDEGKAPHWTSASLTEAAAHPHSPEMKDQGGSGEGLSRS
                     ANGFPYREEEEGAFGEHGSQGTYSDTKENGINGELTSADRETAEEVSARIVQVVTAEA
                     VAVLKGEQEKEAQHKDQPAALPLAAEETVNLPPSPPPSPASEQTAALEEASKMEFPEQ
                     QKLPSSFAEPLDKEETEFKMQSKPGEDFEHAALVPQPDTSKTPQDKKDPQDMEGEKSP
                     ASPFAQTFGTNLEDIKQITEPSITVPSIGLSAEPLAPKDQKDWFIEMPVESKKDEWGL
                     AAPISPGPLTPMREKDVLEDIPRWEGKQFDSPMPSPFHSGSFTLPLDTVKDERVTEGS
                     QPFAPVFFQSDDKMSLQDTSGSATSKESSKDEEPQKDKADKVADVPVSEATTVLGDVH
                     SPAVEGFVGENISGEEKGTTDQEKKETSTPSVQEPTLTETEPQTKLEETSKVSIEETV
                     AKEEESLKLKDDKAGVIQTSTEHSFSKEDQKGEEQTIEALKQDSFPISLEQAVTDAAM
                     ATKTLEKVTSEPEAVSEKREIQGLFEEDIADKSKLEGAGSATVAEVEMPFYEDKSGMS
                     KYFETSALKEDVTRSTGLGSDYYELSDSRGNAQESLDTVSPKNQQDEKELLAKASQPS
                     PPAHEAGYSTLAQSYTSDHPSELPEEPSSPQERMFTIDPKVYGEKRDLHSKNKDDLTL
                     SRSLGLGGRSAIEQRSMSINLPMSCLDSIALGFNFGRGHDLSPLASDILTNTSGTMDE
                     GDDYLPPTTPAVEKIPCFPIESKEEEDKTEQAKVTGGQTTQVETSSESPFPAKEYYKN
                     GTVMAPDLPEMLDLAGTRSRLASVSADAEVARRKSVPSEAVVAESSTGLPPVADDSQP
                     VKPDSQLEDMGYCVFNKYTVPLPSPVQDSENLSGESGSFYEGTDDKVRRDLATDLSLI
                     EVKLAAAGRVKDEFTAEKEASPPSSADKSGLSREFDQDRKANDKLDTVLEKSEEHVDS
                     KEHAKESEEVGDKVELFGLGVTYEQTSAKELITTKETAPERAEKGLSSVPEVAEVETT
                     TKADQGLDVAAKKDDQSPLDIKVSDFGQMASGMSVDAGKTIELKFEVDQQLTLSSEAP
                     QETDSFMGIESSHVKDGAKVSETEVKEKVAKPDLVHQEAVDKEESYESSGEHESLTME
                     SLKPDEGKKETSPETSLIQDEVALKLSVEIPCPPPVSEADSSIDEKAEVQMEFIQLPK
                     EESTETPDIPAIPSDVTQPQPEAVVSEPAEVRGEEEEIEAEGEYDKLLFRSDTLQITD
                     LLVPGSREEFVETCPGEHKGVVESVVTIEDDFITVVQTTTDEGELGSHSVRFAAPVQP
                     EEERRPYPHDEELEVLMAAEAQAEPKDGSPDAPATPEKEEVPFSEYKTETYDDYKDET
                     TIDDSIMDADSLWVDTQDDDRSILTEQLETIPKEERAEKEARRPSLEKHRKEKPFKTG
                     RGRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKSEVQAHSPSRKLILKPAIK
                     YTRPTHLSCVKRKTTATSGESAQAPSAFKQAKDKVTDGITKSPEKRSSLPRPSSILPP
                     RRGVSGDREENSFSLNSSISSARRTTRSEPIRRAGKSGTSTPTTPGSTAITPGTPPSY
                     SSRTPGTPGTPSYPRTPGTPKFGILVPSEKKVAIIRTPPKSPATPKQLRLINQPLPDL
                     KNVKSKIGSTDNIKYQPKGGQVQIVTKKIDLSHVTSKCGSLKNIRHRPGGGRVKIESV
                     KLDFKEKAQAKVGSLDNAHHVPGGGNVKIDSQKLNFREHAKARVDHGAEIITQSPSRS
                     SVASPRRLSNVSSSGSINLLESPQLATLAEDVTAALAKQGL"
     exon            365..478
                     /gene="Map2"
                     /gene_synonym="MAP2R; Mtap2"
                     /inference="alignment:Splign:2.1.0"
     exon            479..556
                     /gene="Map2"
                     /gene_synonym="MAP2R; Mtap2"
                     /inference="alignment:Splign:2.1.0"
     exon            557..4288
                     /gene="Map2"
                     /gene_synonym="MAP2R; Mtap2"
                     /inference="alignment:Splign:2.1.0"
     exon            4289..4495
                     /gene="Map2"
                     /gene_synonym="MAP2R; Mtap2"
                     /inference="alignment:Splign:2.1.0"
     exon            4496..4630
                     /gene="Map2"
                     /gene_synonym="MAP2R; Mtap2"
                     /inference="alignment:Splign:2.1.0"
     exon            4631..4692
                     /gene="Map2"
                     /gene_synonym="MAP2R; Mtap2"
                     /inference="alignment:Splign:2.1.0"
     exon            4693..4837
                     /gene="Map2"
                     /gene_synonym="MAP2R; Mtap2"
                     /inference="alignment:Splign:2.1.0"
     exon            4838..5169
                     /gene="Map2"
                     /gene_synonym="MAP2R; Mtap2"
                     /inference="alignment:Splign:2.1.0"
     exon            5170..5251
                     /gene="Map2"
                     /gene_synonym="MAP2R; Mtap2"
                     /inference="alignment:Splign:2.1.0"
     exon            5252..5364
                     /gene="Map2"
                     /gene_synonym="MAP2R; Mtap2"
                     /inference="alignment:Splign:2.1.0"
     exon            5365..5731
                     /gene="Map2"
                     /gene_synonym="MAP2R; Mtap2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaagaaaga agccagaaca taccaccagc cctttgagta tacaacataa caaacgtcat
       61 tactttacaa cttgattagg agacagtaca gagatctgaa ggatggctga cgagaggaaa
      121 gacgaaggaa aggcaccaca ctggacatca gcctcactca cagaggcagc tgcacacccc
      181 cactcgccag agatgaagga ccagggtggc tcaggggaag ggctgagccg cagcgccaat
      241 ggatttccat acagagagga ggaggaaggc gcctttgggg agcacgggtc acagggcacc
      301 tattcagata ccaaagagaa cgggatcaac ggagagctga cctcagctga cagagaaaca
      361 gcagaggaag tgtctgcaag gatagttcaa gtagtcacag ctgaagctgt agcagtcctg
      421 aaaggtgaac aagagaagga ggcccaacac aaggatcagc ctgcagctct gcctttagca
      481 gctgaagaaa cagttaatct gccaccttcc ccaccaccat cgccagcatc agaacaaaca
      541 gctgcactgg aagaagcctc gaagatggaa ttccctgagc agcagaaatt gccttcctca
      601 ttcgctgagc ctttagacaa ggaggaaacg gagtttaaga tgcaaagtaa gcctggtgaa
      661 gactttgaac atgctgcctt agttcctcag ccggacacaa gtaaaactcc ccaggataaa
      721 aaggatcccc aagacatgga aggagaaaag tcgcctgcca gtccatttgc gcagactttc
      781 ggtaccaacc tggaagacat aaaacagatc acagaaccaa gcataacagt acctagcatt
      841 ggcctctccg cagagcccct agctccaaaa gatcagaaag actggttcat cgaaatgccc
      901 gtggaatcaa agaaggatga atggggttta gctgccccaa tatctcctgg ccccttgaca
      961 cccatgaggg aaaaagatgt gctggaggat atcccaagat gggaaggaaa gcagtttgac
     1021 tctcccatgc ctagcccctt ccacagtgga agtttcactc ttcccttaga tactgtgaaa
     1081 gatgagagag tcacagaagg gtcacaaccc tttgcccctg tcttcttcca atcagatgac
     1141 aaaatgtctc tgcaggacac cagtggttca gctacttcca aagagagttc taaagatgag
     1201 gagccacaga aagataaagc agacaaagtg gcagatgttc ctgtctcaga agctaccact
     1261 gtactgggag atgttcacag tccagctgtg gaaggctttg tcggggagaa catttcagga
     1321 gaagaaaagg gtaccacaga tcaagagaaa aaagagactt cgacacccag tgtacaggaa
     1381 cctacactca ctgaaactga accacagaca aagcttgaag agacatcaaa ggtttccatc
     1441 gaagaaactg tggcaaaaga agaggaatcc ttgaaattaa aagatgataa agcaggtgta
     1501 attcagactt ccaccgagca ttctttctcc aaagaagacc agaaaggcga agaacagaca
     1561 atcgaagcat taaaacaaga ctcctttcct ataagtctag aacaggcagt tacagatgca
     1621 gccatggcca ccaagacctt ggaaaaggtt acgtctgagc cagaggcagt aagtgaaaag
     1681 agagaaatcc agggactttt tgaagaggat atagctgaca agagtaagct cgaaggcgct
     1741 gggtctgcaa cagtagccga ggttgagatg ccattttatg aagataaatc agggatgtcc
     1801 aagtactttg aaacatctgc attgaaagaa gatgtgacca gaagcactgg gttgggcagt
     1861 gattactacg agctgagtga ctcaagagga aatgcccagg aatctcttga tactgtatct
     1921 cccaagaacc aacaagatga aaaggaactt ctggcaaaag cttcccagcc tagtcctcca
     1981 gcacacgaag cagggtacag cactcttgcc cagagttata catctgatca tccgtccgag
     2041 ttacctgaag aaccaagttc tcctcaagaa agaatgttca ctattgaccc caaagtttat
     2101 ggggagaaaa gggaccttca tagtaagaac aaagatgatc tgacacttag tcgaagcttg
     2161 gggctgggcg gaaggtctgc aatagaacag agaagcatgt ccattaactt gcctatgtct
     2221 tgccttgatt ctattgccct tgggtttaac tttggccggg gccatgatct ttcccctctg
     2281 gcttctgata ttctaaccaa cactagcgga acgatggatg aaggagatga ttacctgccc
     2341 cccaccacac ctgcagtgga gaagattcct tgctttccaa tagagagcaa agaggaagaa
     2401 gataagacag agcaagcaaa agtgactgga gggcaaacta cccaagttga aacatcctcc
     2461 gagtcaccct tcccagccaa agaatattac aaaaatggca ctgtcatggc ccctgacctg
     2521 cctgagatgc tagatctagc agggaccagg tccagattag cttctgtgag tgcagatgct
     2581 gaggttgcca ggaggaaatc agtcccatcg gaggctgtgg ttgcagagag cagtactggt
     2641 ttgccacctg ttgctgatga cagccaaccc gtaaaaccag acagtcaact tgaagacatg
     2701 gggtactgtg tgttcaacaa gtacacagtc cctctcccat cgccagttca agacagtgag
     2761 aatttgtcag gagagagtgg ttcgttttat gaaggaaccg atgacaaagt ccgtagagat
     2821 ttggccactg acctttcact aattgaggta aaacttgcag ctgctggaag agtcaaagat
     2881 gaattcactg ctgagaaaga ggcatctcca ccctcttctg ctgacaaatc aggactgagt
     2941 agggagtttg accaagacag gaaagctaat gacaagctgg atactgtcct agaaaagagc
     3001 gaagagcatg ttgattcaaa agaacatgcc aaggagtcag aagaggttgg ggataaagta
     3061 gagctcttcg gattaggtgt aacctatgag caaacctctg ccaaagaact gataacaact
     3121 aaagaaacag cacctgagag agcagagaaa ggtctcagtt cagtgccaga ggtagctgag
     3181 gtagaaacaa ccacaaaagc tgaccaaggt ctagatgttg ctgccaagaa agatgatcag
     3241 agtccattag atataaaagt cagtgacttt ggacagatgg cttctgggat gagtgtagat
     3301 gctgggaaaa ccatagagct taagttcgag gttgatcagc agctgactct ctcatccgaa
     3361 gcacctcagg aaacagattc attcatgggt attgagtcca gccacgtgaa ggatggtgcc
     3421 aaagtcagtg aaacagaagt caaagagaag gtggcaaagc ctgacttggt gcatcaggag
     3481 gctgtggaca aagaagagtc ctatgagtct agtggtgagc atgaaagcct caccatggag
     3541 tccctgaagc ctgatgaggg caagaaagaa acatctccag agacatcact gatacaagat
     3601 gaagttgccc tcaaactgtc tgtagaaatc ccttgcccac ctccagtttc cgaagctgat
     3661 tcatccattg atgagaaggc ggaggtccag atggaattta ttcagctgcc aaaggaagag
     3721 agcacagaga ctccggatat acctgccata ccttctgatg tcacccagcc acagcctgaa
     3781 gcagttgtgt ccgaaccagc agaggttcga ggtgaggaag aagagatcga agctgaggga
     3841 gaatatgaca aactgctctt ccgctcagac accctccaga tcaccgacct gcttgttcca
     3901 ggaagtaggg aggagtttgt ggagacctgc ccaggggagc acaaaggtgt ggttgagtcc
     3961 gtggtaacca tcgaggatga tttcatcact gtagtacaaa ccacgactga tgagggagag
     4021 ttgggatccc acagtgtgcg ctttgcagct ccagttcagc ctgaggaaga aaggagacca
     4081 taccctcatg atgaagagct tgaagtactg atggcagcag aagcccaggc agagcccaag
     4141 gatggctctc cagatgctcc agctacccct gagaaagaag aggttccatt ctcagaatat
     4201 aaaacagaaa cctacgacga ttacaaagat gagaccacca ttgatgactc cattatggat
     4261 gccgacagcc tgtgggtgga cactcaagat gatgatagaa gcatcttgac agagcagtta
     4321 gaaactattc ctaaagagga gagagctgag aaggaagctc ggagaccgtc tctcgagaaa
     4381 catagaaaag aaaaaccttt taaaactggg agaggcagaa tttccactcc tgaaagaaaa
     4441 gtagctaaaa aggaacctag cacggtctcc agggatgaag tgagaaggaa aaaagcagtt
     4501 tataagaagg ctgaacttgc taaaaaatca gaagttcagg cccactctcc ttccaggaaa
     4561 ctcattttaa aacctgctat caaatacact agaccaactc atctctcctg tgttaagcgg
     4621 aaaaccacag caacaagtgg tgaatcagct caggctccca gtgcgtttaa acaggcgaag
     4681 gacaaagtca ctgatggaat aaccaagagc ccagaaaaac gttcttccct cccaagacct
     4741 tcctccatcc tccctcctcg caggggcgta tcaggagaca gggaggagaa ctcgttctct
     4801 ctgaacagct ccatctcttc agcacgacgg accaccaggt cagaaccaat tcgcagagca
     4861 ggaaaaagcg gcacctcaac acctactacc cctggatcta ctgcaatcac ccctggcact
     4921 cctccaagct actcttcacg taccccaggc acccctggaa ccccgagcta tcccaggaca
     4981 ccaggaaccc ccaaatttgg catcttggtg cccagtgaga agaaagttgc catcattcgc
     5041 actcctccaa agtccccagc tactcccaag cagcttcggc tcattaacca acctctgcca
     5101 gacctgaaga acgtcaagtc caaaatcgga tcaaccgaca acatcaaata ccagcctaag
     5161 gggggtcagg tacaaattgt tactaagaag atagacttaa gccatgtgac ttccaaatgt
     5221 ggctctctaa agaacatccg tcacaggcca ggtggtggac gcgtgaagat tgagagtgta
     5281 aagctggatt tcaaggagaa ggcccaagct aaagttggct cacttgacaa tgctcaccat
     5341 gtacctggag gtggtaacgt gaagattgac agccaaaagc tgaacttccg agagcatgca
     5401 aaggcccgcg tcgaccacgg ggctgagatc atcacacagt cgccaagcag gtcaagcgtg
     5461 gcgtctcccc ggcgactcag caatgtctcc tcttctggaa gcatcaacct gctcgaatcc
     5521 cctcagctgg ccactttggc tgaggacgtc actgcggcgc tcgctaagca gggcttgtga
     5581 atccttctca tctagcactg aagtaccatt taggcatgag ctcttggcag gagtgggctc
     5641 tgagcaggtg tcatattcat tctttacaaa ccatagataa ataatctcat cccccaactg
     5701 tagtaattgt tacaatttta tataaaaaaa aaaaaa
//
