LOCUS       NM_022867               1768 bp    mRNA    linear   ROD 16-FEB-2025
DEFINITION  Rattus norvegicus microtubule-associated protein 1 light chain 3
            beta (Map1lc3b), mRNA.
ACCESSION   NM_022867
VERSION     NM_022867.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1768)
  AUTHORS   Shyu,K.G., Wang,B.W., Pan,C.M., Fang,W.J. and Lin,C.M.
  TITLE     Exosomal MALAT1 from macrophages treated with high levels of
            glucose upregulates LC3B expression via miR-204-5p downregulation
  JOURNAL   J Chin Med Assoc 87 (6), 581-589 (2024)
   PUBMED   38651895
  REMARK    GeneRIF: Exosomal MALAT1 from macrophages treated with high levels
            of glucose upregulates LC3B expression via miR-204-5p
            downregulation.
REFERENCE   2  (bases 1 to 1768)
  AUTHORS   Shi,G., Zhang,Z., Ma,S., Li,Y., Du,S., Chu,Y., Li,Y., Tang,X.,
            Yang,Y., Chen,Z., Wang,Z. and Wu,H.
  TITLE     Hepatic interferon regulatory factor 8 expression mediates liver
            ischemia/reperfusion injury in mice
  JOURNAL   Biochem Pharmacol 192, 114728 (2021)
   PUBMED   34400126
REFERENCE   3  (bases 1 to 1768)
  AUTHORS   Zheng,Q., Shen,H., Tong,Z., Cheng,L., Xu,Y., Feng,Z., Liao,S.,
            Hu,X., Pan,Z., Mao,Z. and Wang,Y.
  TITLE     A thermosensitive, reactive oxygen species-responsive,
            MR409-encapsulated hydrogel ameliorates disc degeneration in rats
            by inhibiting the secretory autophagy pathway
  JOURNAL   Theranostics 11 (1), 147-163 (2021)
   PUBMED   33391467
  REMARK    GeneRIF: A thermosensitive, reactive oxygen species-responsive,
            MR409-encapsulated hydrogel ameliorates disc degeneration in rats
            by inhibiting the secretory autophagy pathway.
            Erratum:[Theranostics. 2024 Sep 12;14(15):5982-5983. doi:
            10.7150/thno.103020.. PMID: 39346549]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1768)
  AUTHORS   Andres-Alonso,M., Ammar,M.R., Butnaru,I., Gomes,G.M., Acuna
            Sanhueza,G., Raman,R., Yuanxiang,P., Borgmeyer,M., Lopez-Rojas,J.,
            Raza,S.A., Brice,N., Hausrat,T.J., Macharadze,T., Diaz-Gonzalez,S.,
            Carlton,M., Failla,A.V., Stork,O., Schweizer,M., Gundelfinger,E.D.,
            Kneussel,M., Spilker,C., Karpova,A. and Kreutz,M.R.
  TITLE     SIPA1L2 controls trafficking and local signaling of TrkB-containing
            amphisomes at presynaptic terminals
  JOURNAL   Nat Commun 10 (1), 5448 (2019)
   PUBMED   31784514
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1768)
  AUTHORS   Tang,B., Kang,P., Guo,J., Zhu,L., Xu,Q., Gao,Q., Zhang,H. and
            Wang,H.
  TITLE     [Effects of mitochondrial aldehyde dehydrogenase 2 on
            autophagy-associated proteins in neonatal rat myocardial
            fibroblasts cultured in high glucose]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 39 (5), 523-527 (2019)
   PUBMED   31140414
  REMARK    GeneRIF: Mitochondrial ALDH2 inhibits the proliferation of neonatal
            rat cardiac fibroblasts induced by high glucose, and the effect is
            possibly mediated by the up-regulation of autophagy-related
            proteins Beclin-1 and LC3B.
REFERENCE   6  (bases 1 to 1768)
  AUTHORS   Seidenbecher,C.I., Landwehr,M., Smalla,K.H., Kreutz,M.,
            Dieterich,D.C., Zuschratter,W., Reissner,C., Hammarback,J.A.,
            Bockers,T.M., Gundelfinger,E.D. and Kreutz,M.R.
  TITLE     Caldendrin but not calmodulin binds to light chain 3 of MAP1A/B: an
            association with the microtubule cytoskeleton highlighting
            exclusive binding partners for neuronal Ca(2+)-sensor proteins
  JOURNAL   J Mol Biol 336 (4), 957-970 (2004)
   PUBMED   15095872
  REMARK    GeneRIF: Data show that caldendrin specifically associates with the
            microtubule cytoskeleton via an interaction with the microtubule
            componentlight chain 3 (Mpl3).
REFERENCE   7  (bases 1 to 1768)
  AUTHORS   Navarro-Lerida,I., Martinez Moreno,M., Roncal,F., Gavilanes,F.,
            Albar,J.P. and Rodriguez-Crespo,I.
  TITLE     Proteomic identification of brain proteins that interact with
            dynein light chain LC8
  JOURNAL   Proteomics 4 (2), 339-346 (2004)
   PUBMED   14760703
REFERENCE   8  (bases 1 to 1768)
  AUTHORS   Bergman,M.R., Cheng,S., Honbo,N., Piacentini,L., Karliner,J.S. and
            Lovett,D.H.
  TITLE     A functional activating protein 1 (AP-1) site regulates matrix
            metalloproteinase 2 (MMP-2) transcription by cardiac cells through
            interactions with JunB-Fra1 and JunB-FosB heterodimers
  JOURNAL   Biochem J 369 (Pt 3), 485-496 (2003)
   PUBMED   12371906
REFERENCE   9  (bases 1 to 1768)
  AUTHORS   Kabeya,Y., Mizushima,N., Ueno,T., Yamamoto,A., Kirisako,T.,
            Noda,T., Kominami,E., Ohsumi,Y. and Yoshimori,T.
  TITLE     LC3, a mammalian homologue of yeast Apg8p, is localized in
            autophagosome membranes after processing
  JOURNAL   EMBO J 19 (21), 5720-5728 (2000)
   PUBMED   11060023
  REMARK    Erratum:[EMBO J. 2003 Sep 1;22(17):4577]
REFERENCE   10 (bases 1 to 1768)
  AUTHORS   Mann,S.S. and Hammarback,J.A.
  TITLE     Molecular characterization of light chain 3. A microtubule binding
            subunit of MAP1A and MAP1B
  JOURNAL   J Biol Chem 269 (15), 11492-11497 (1994)
   PUBMED   7908909
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY392036.1.
            
            On Jan 21, 2004 this sequence version replaced NM_022867.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY392036.1, BC083556.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1768
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..1768
                     /gene="Map1lc3b"
                     /gene_synonym="LC3B; Map1lc3; Mpl3; zbs559"
                     /note="microtubule-associated protein 1 light chain 3
                     beta"
                     /db_xref="GeneID:64862"
                     /db_xref="RGD:621315"
     exon            1..116
                     /gene="Map1lc3b"
                     /gene_synonym="LC3B; Map1lc3; Mpl3; zbs559"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..454
                     /gene="Map1lc3b"
                     /gene_synonym="LC3B; Map1lc3; Mpl3; zbs559"
                     /note="microtubule-associated proteins 1A/1B light chain
                     3B; MAP1A/MAP1B LC3 B; MAP1A/1B light chain 3 B;
                     autophagy-related protein LC3 B; MAP1 light chain 3-like
                     protein 2; autophagy-related ubiquitin-like modifier LC3
                     B; MAP1A/MAP1B light chain 3 B"
                     /codon_start=1
                     /product="microtubule-associated protein 1 light chain 3
                     beta"
                     /protein_id="NP_074058.2"
                     /db_xref="GeneID:64862"
                     /db_xref="RGD:621315"
                     /translation="MPSEKTFKQRRSFEQRVEDVRLIREQHPTKIPVIIERYKGEKQL
                     PVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESE
                     RDEDGFLYMVYASQETFGTALAV"
     exon            117..172
                     /gene="Map1lc3b"
                     /gene_synonym="LC3B; Map1lc3; Mpl3; zbs559"
                     /inference="alignment:Splign:2.1.0"
     exon            173..279
                     /gene="Map1lc3b"
                     /gene_synonym="LC3B; Map1lc3; Mpl3; zbs559"
                     /inference="alignment:Splign:2.1.0"
     exon            280..1744
                     /gene="Map1lc3b"
                     /gene_synonym="LC3B; Map1lc3; Mpl3; zbs559"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgcgggttg aggagacaca caagggaagt gatcgtcgcg ggaaccagat cgtctgaccc
       61 aggacccccg cgcgccatgc cgtccgagaa gaccttcaaa cagcgccgga gcttcgaaca
      121 aagagtggaa gatgtccggc tcatccggga gcagcacccc accaagatcc cagtgattat
      181 agagcgatac aagggtgaga agcagctgcc cgtcctggac aagaccaagt tccttgtacc
      241 tgatcacgtg aatatgagcg aactcatcaa gataattaga aggcgcctgc agctcaatgc
      301 taaccaagcc ttcttcctcc tggtgaatgg gcacagcatg gtgagtgtgt ccacacccat
      361 ctctgaagtg tacgagagcg agagagatga agacggcttc ctgtacatgg tctatgcctc
      421 ccaggagacg ttcgggacag cactggctgt gtaagactag aacaatacct aatgtttgtt
      481 aagcccctac caaggcaaaa agggacgtta ccagcggaag ctggtcagct caccacccca
      541 cagatcagaa cgtaggcacc cacgtagggg attagaaact atctcagcca gaaactgagt
      601 gccatgcaag tgcatttggc ttggaaactc atctaaacta gactatcctg tgttcaaact
      661 ttagtttaaa aataaaatac tttgcatcct aagttgccaa taaaaagacc aagttatttt
      721 gacattttct ccctagtagg gacttgaaat agaagagcag tgtcaggggc ggcctcttcc
      781 tgggacctgc tgccttctct aaaagggctt ctactcagag aagtccctgg aaacagtccc
      841 tcgcccaggt tgcctagcag aggtctccag agggctctgg ctttgcccga aacaggtcag
      901 gtgtatagga catagctcta aggacccaca tgggccctgg tcctgaaccc cagccatttc
      961 acctcagcag tgtgggacgc tcacccgctg ctgtgtagac attaccacat gcaccactgc
     1021 tcagaggcca gttccaaccc tgtccagggg ttgcttggtc cagcttctta agaaactgca
     1081 aggtgttttt ctcctggttt ggacttctct ggtccatgcc tgcttcaggt gtgcaatgct
     1141 ggccttcccg tgcagctgtc cagtggaagg ctgaagtcca agtgcactcg ccttgtacgt
     1201 ggttcacacc tacttgtcag tgcacaccca cagtctttgt aagggcggtt ctgacagctg
     1261 ttggggtttc cccatttcat gccagtacat acatgtcagc tctgaaggca acagcaacag
     1321 gaagagagcc atgcttgtga cagacataca gccacttcca actaaagcaa gcctctgctt
     1381 cctgctacct gcatggagcc cactgtgaca ctcagaccat ccccggtcac tcactcgtgt
     1441 ctgagaatct cagtgagagc tgcctctgtc acggacggaa gccaacacag ccacctctcg
     1501 acctggctcc ccacagcacc caccctccct gcatgcagct gtccctgcta acccccaatg
     1561 ttatgttaca ctgtgtaaat ccccactgct gccgtgtgtg ggttgtgtac gtcgtcatgt
     1621 ccctggttta taactatggt gcggtcggga aggattcctg taatgctgct ctaagatgct
     1681 gctcaggcag ccattgtagg acacctgtac tctgatgcac taagtcaata aaggcacaac
     1741 tggaaaaaaa aaaaaaaaaa aaaaaaaa
//
