LOCUS       NM_199500                969 bp    mRNA    linear   ROD 16-FEB-2025
DEFINITION  Rattus norvegicus microtubule-associated protein 1 light chain 3
            alpha (Map1lc3a), mRNA.
ACCESSION   NM_199500 XM_342550
VERSION     NM_199500.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 969)
  AUTHORS   Guerrina,N., Aloufi,N., Shi,F., Prasade,K., Mehrotra,C.,
            Traboulsi,H., Matthews,J., Eidelman,D.H., Hamid,Q. and Baglole,C.J.
  TITLE     The aryl hydrocarbon receptor reduces LC3II expression and controls
            endoplasmic reticulum stress
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 320 (3), L339-L355 (2021)
   PUBMED   33236922
  REMARK    GeneRIF: The aryl hydrocarbon receptor reduces LC3II expression and
            controls endoplasmic reticulum stress.
REFERENCE   2  (bases 1 to 969)
  AUTHORS   Okada,T. and Ogura,T.
  TITLE     Scanning Electron-Assisted Dielectric Microscopy Reveals
            Autophagosome Formation by LC3 and ATG12 in Cultured Mammalian
            Cells
  JOURNAL   Int J Mol Sci 22 (4), 1834 (2021)
   PUBMED   33673233
  REMARK    GeneRIF: Scanning Electron-Assisted Dielectric Microscopy Reveals
            Autophagosome Formation by LC3 and ATG12 in Cultured Mammalian
            Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 969)
  AUTHORS   Babuta,M., Furi,I., Bala,S., Bukong,T.N., Lowe,P., Catalano,D.,
            Calenda,C., Kodys,K. and Szabo,G.
  TITLE     Dysregulated Autophagy and Lysosome Function Are Linked to Exosome
            Production by Micro-RNA 155 in Alcoholic Liver Disease
  JOURNAL   Hepatology 70 (6), 2123-2141 (2019)
   PUBMED   31090940
REFERENCE   4  (bases 1 to 969)
  AUTHORS   Chino,H., Hatta,T., Natsume,T. and Mizushima,N.
  TITLE     Intrinsically Disordered Protein TEX264 Mediates ER-phagy
  JOURNAL   Mol Cell 74 (5), 909-921 (2019)
   PUBMED   31006538
REFERENCE   5  (bases 1 to 969)
  AUTHORS   Wu,X., Qin,Y., Zhu,X., Liu,D., Chen,F., Xu,S., Zheng,D., Zhou,Y.
            and Luo,J.
  TITLE     Increased expression of DRAM1 confers myocardial protection against
            ischemia via restoring autophagy flux
  JOURNAL   J Mol Cell Cardiol 124, 70-82 (2018)
   PUBMED   30144448
  REMARK    Erratum:[J Mol Cell Cardiol. 2019 Feb;127:277. doi:
            10.1016/j.yjmcc.2018.12.009.. PMID: 30660099]
REFERENCE   6  (bases 1 to 969)
  AUTHORS   Tanida,I., Ueno,T. and Kominami,E.
  TITLE     LC3 conjugation system in mammalian autophagy
  JOURNAL   Int J Biochem Cell Biol 36 (12), 2503-2518 (2004)
   PUBMED   15325588
  REMARK    Review article
REFERENCE   7  (bases 1 to 969)
  AUTHORS   Tanida,I., Sou,Y.S., Ezaki,J., Minematsu-Ikeguchi,N., Ueno,T. and
            Kominami,E.
  TITLE     HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three
            human Atg8 homologues and delipidates microtubule-associated
            protein light chain 3- and GABAA receptor-associated
            protein-phospholipid conjugates
  JOURNAL   J Biol Chem 279 (35), 36268-36276 (2004)
   PUBMED   15187094
REFERENCE   8  (bases 1 to 969)
  AUTHORS   Seidenbecher,C.I., Landwehr,M., Smalla,K.H., Kreutz,M.,
            Dieterich,D.C., Zuschratter,W., Reissner,C., Hammarback,J.A.,
            Bockers,T.M., Gundelfinger,E.D. and Kreutz,M.R.
  TITLE     Caldendrin but not calmodulin binds to light chain 3 of MAP1A/B: an
            association with the microtubule cytoskeleton highlighting
            exclusive binding partners for neuronal Ca(2+)-sensor proteins
  JOURNAL   J Mol Biol 336 (4), 957-970 (2004)
   PUBMED   15095872
REFERENCE   9  (bases 1 to 969)
  AUTHORS   He,H., Dang,Y., Dai,F., Guo,Z., Wu,J., She,X., Pei,Y., Chen,Y.,
            Ling,W., Wu,C., Zhao,S., Liu,J.O. and Yu,L.
  TITLE     Post-translational modifications of three members of the human
            MAP1LC3 family and detection of a novel type of modification for
            MAP1LC3B
  JOURNAL   J Biol Chem 278 (31), 29278-29287 (2003)
   PUBMED   12740394
REFERENCE   10 (bases 1 to 969)
  AUTHORS   Kabeya,Y., Mizushima,N., Ueno,T., Yamamoto,A., Kirisako,T.,
            Noda,T., Kominami,E., Ohsumi,Y. and Yoshimori,T.
  TITLE     LC3, a mammalian homologue of yeast Apg8p, is localized in
            autophagosome membranes after processing
  JOURNAL   EMBO J 19 (21), 5720-5728 (2000)
   PUBMED   11060023
  REMARK    Erratum:[EMBO J. 2003 Sep 1;22(17):4577]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM063664.1, FM046244.1, FM036735.1 and FM053631.1.
            
            On Feb 22, 2012 this sequence version replaced NM_199500.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY206668.1, BC086389.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                FM063664.1         1-32
            33-477              FM046244.1         1-445
            478-614             FM036735.1         263-399
            615-969             FM053631.1         69-423
FEATURES             Location/Qualifiers
     source          1..969
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..969
                     /gene="Map1lc3a"
                     /gene_synonym="LC3-I; LC3-II; LC3A"
                     /note="microtubule-associated protein 1 light chain 3
                     alpha"
                     /db_xref="GeneID:362245"
                     /db_xref="RGD:735183"
     exon            1..215
                     /gene="Map1lc3a"
                     /gene_synonym="LC3-I; LC3-II; LC3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..541
                     /gene="Map1lc3a"
                     /gene_synonym="LC3-I; LC3-II; LC3A"
                     /note="microtubule-associated proteins 1A/1B light chain
                     3A; MAP1A/MAP1B LC3 A; MAP1A/1B light chain 3 A;
                     autophagy-related protein LC3 A; MAP1 light chain 3-like
                     protein 1; autophagy-related ubiquitin-like modifier LC3
                     A; MAP1A/MAP1B light chain 3 A"
                     /codon_start=1
                     /product="microtubule-associated protein 1 light chain 3
                     alpha"
                     /protein_id="NP_955794.1"
                     /db_xref="GeneID:362245"
                     /db_xref="RGD:735183"
                     /translation="MPSDRPFKQRRSFADRCKEVQQIRDQHPSKIPVIIERYKGEKQL
                     PVLDKTKFLVPDHVNMSELVKIIRRRLQLNPTQAFFLLVNQHSMVSVSTPIADIYEQE
                     KDEDGFLYMVYASQETFGF"
     exon            216..271
                     /gene="Map1lc3a"
                     /gene_synonym="LC3-I; LC3-II; LC3A"
                     /inference="alignment:Splign:2.1.0"
     exon            272..378
                     /gene="Map1lc3a"
                     /gene_synonym="LC3-I; LC3-II; LC3A"
                     /inference="alignment:Splign:2.1.0"
     exon            379..969
                     /gene="Map1lc3a"
                     /gene_synonym="LC3-I; LC3-II; LC3A"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgtgacctga cgtcacccag gcgagttacc tcccgcagcc gccaccgccg ggctcagcgc
       61 gagccccgca gcccttgagc tcgagccccg gagcccccgg cgcgccgaac cgcagccgca
      121 tccctgagcc gcgcgccccg gagcccccgg ctgcgcgccc cgccgggccc gcgcgatgcc
      181 ctccgaccgg cctttcaagc agcggcgcag cttcgccgac cgctgtaagg aggtgcagca
      241 gatccgtgac cagcacccca gcaagatccc ggtgatcatc gagcgctaca agggtgagaa
      301 gcagctgcct gtcctggata agaccaagtt tctggtccca gaccatgtta acatgagcga
      361 gttggtcaag atcatccggc gccgcctgca actcaacccc acgcaggcct tcttcctgct
      421 ggtgaaccag cacagcatgg tgagtgtatc cacacccatc gctgacatct atgaacagga
      481 gaaggatgaa gacggattcc tctacatggt ctatgcctcc caagaaacct tcggcttctg
      541 agtcaagagg aggggtgggg ggtggctggg agttctggtc aggttctccc cagggaggtc
      601 ctgcctccta aactaagcta tttcggcccc gggtggatta ggcagagatg tgacaccccc
      661 tccccccagg taggggccac cagccagcat accaagtcct gggtaggtcc tgggccagtc
      721 ttgttaggct tgctcttttg ggtgctggct gggttgggag tgggtgggga gcagcatccc
      781 tgccccgtgg ggtttgtctt ttttttaggc ccttgcctgt ctacccatct tgcccctcat
      841 ccacctgagg ctttgccccc tgacaggacc tgccccaccc ctgaaaggct ggctcccctt
      901 gtcctgacat ggtatgtgga tctgtggtca tttcctctgc agaataaaga ttgctcaggc
      961 ctgcctggc
//
