LOCUS       NM_019217              11884 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus microtubule-associated protein 1B (Map1b), mRNA.
ACCESSION   NM_019217 XM_001061557 XM_215469
VERSION     NM_019217.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 11884)
  AUTHORS   Sole,L., Wagnon,J.L., Akin,E.J., Meisler,M.H. and Tamkun,M.M.
  TITLE     The MAP1B Binding Domain of Nav1.6 Is Required for Stable
            Expression at the Axon Initial Segment
  JOURNAL   J Neurosci 39 (22), 4238-4251 (2019)
   PUBMED   30914445
  REMARK    GeneRIF: This work confirms a new biological role of MAP1B in the
            regulation of sodium channel localization
REFERENCE   2  (bases 1 to 11884)
  AUTHORS   Palenzuela,R., Gutierrez,Y., Draffin,J.E., Lario,A., Benoist,M. and
            Esteban,J.A.
  TITLE     MAP1B Light Chain Modulates Synaptic Transmission via AMPA Receptor
            Intracellular Trapping
  JOURNAL   J Neurosci 37 (41), 9945-9963 (2017)
   PUBMED   28904092
  REMARK    GeneRIF: MAP1B restricts the access of AMPARs to dendritic spines
            and the postsynaptic membrane, contributing to downregulating
            synaptic transmission
REFERENCE   3  (bases 1 to 11884)
  AUTHORS   Tortosa,E., Adolfs,Y., Fukata,M., Pasterkamp,R.J., Kapitein,L.C.
            and Hoogenraad,C.C.
  TITLE     Dynamic Palmitoylation Targets MAP6 to the Axon to Promote
            Microtubule Stabilization during Neuronal Polarization
  JOURNAL   Neuron 94 (4), 809-825 (2017)
   PUBMED   28521134
REFERENCE   4  (bases 1 to 11884)
  AUTHORS   Gumy,L.F., Katrukha,E.A., Grigoriev,I., Jaarsma,D., Kapitein,L.C.,
            Akhmanova,A. and Hoogenraad,C.C.
  TITLE     MAP2 Defines a Pre-axonal Filtering Zone to Regulate KIF1- versus
            KIF5-Dependent Cargo Transport in Sensory Neurons
  JOURNAL   Neuron 94 (2), 347-362 (2017)
   PUBMED   28426968
REFERENCE   5  (bases 1 to 11884)
  AUTHORS   Liu,Y., Lee,J.W. and Ackerman,S.L.
  TITLE     Mutations in the microtubule-associated protein 1A (Map1a) gene
            cause Purkinje cell degeneration
  JOURNAL   J Neurosci 35 (11), 4587-4598 (2015)
   PUBMED   25788676
REFERENCE   6  (bases 1 to 11884)
  AUTHORS   Fawcett,J.W., Mathews,G., Housden,E., Goedert,M. and Matus,A.
  TITLE     Regenerating sciatic nerve axons contain the adult rather than the
            embryonic pattern of microtubule associated proteins
  JOURNAL   Neuroscience 61 (4), 789-804 (1994)
   PUBMED   7838378
REFERENCE   7  (bases 1 to 11884)
  AUTHORS   Zauner,W., Kratz,J., Staunton,J., Feick,P. and Wiche,G.
  TITLE     Identification of two distinct microtubule binding domains on
            recombinant rat MAP 1B
  JOURNAL   Eur J Cell Biol 57 (1), 66-74 (1992)
   PUBMED   1639092
REFERENCE   8  (bases 1 to 11884)
  AUTHORS   Rienitz,A., Grenningloh,G., Hermans-Borgmeyer,I., Kirsch,J.,
            Littauer,U.Z., Prior,P., Gundelfinger,E.D., Schmitt,B. and Betz,H.
  TITLE     Neuraxin, a novel putative structural protein of the rat central
            nervous system that is immunologically related to
            microtubule-associated protein 5
  JOURNAL   EMBO J 8 (10), 2879-2888 (1989)
   PUBMED   2555150
REFERENCE   9  (bases 1 to 11884)
  AUTHORS   Schoenfeld,T.A., McKerracher,L., Obar,R. and Vallee,R.B.
  TITLE     MAP 1A and MAP 1B are structurally related microtubule associated
            proteins with distinct developmental patterns in the CNS
  JOURNAL   J Neurosci 9 (5), 1712-1730 (1989)
   PUBMED   2470876
REFERENCE   10 (bases 1 to 11884)
  AUTHORS   Benjamin,S., Cambray-Deakin,M.A. and Burgoyne,R.D.
  TITLE     Effect of hypothyroidism on the expression of three
            microtubule-associated proteins (1A, 1B and 2) in developing rat
            cerebellum
  JOURNAL   Neuroscience 27 (3), 931-939 (1988)
   PUBMED   3252178
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CB610210.1,
            X60370.1, BF286433.1, CF977184.1, BG665276.1, CB579120.1,
            CB583564.1, BG378086.1, CB810012.1, CB584802.1, CA510735.1,
            CB580055.1, CA510940.1, CO393350.1, CB576609.1, AA925503.1 and
            CA503854.1.
            
            On or before Oct 28, 2007 this sequence version replaced
            XM_215469.4, XM_001061557.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN14984024
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-558               CB610210.1         1-558
            559-1166            X60370.1           110-717
            1167-1455           BF286433.1         322-610
            1456-1945           CF977184.1         219-708
            1946-4456           X60370.1           1494-4004
            4457-5029           BG665276.1         1-573
            5030-5520           CB579120.1         76-566
            5521-6504           X60370.1           5066-6049
            6505-6960           CB583564.1         100-555
            6961-7550           X60370.1           6506-7095
            7551-7975           BG378086.1         17-441              c
            7976-8311           CB810012.1         46-381
            8312-8660           CB584802.1         244-592
            8661-9299           CA510735.1         61-699
            9300-9909           CB580055.1         4-613
            9910-10298          CA510940.1         263-651
            10299-10952         CO393350.1         12-665
            10953-11430         CB576609.1         162-639
            11431-11848         AA925503.1         17-434              c
            11849-11884         CA503854.1         1-36                c
FEATURES             Location/Qualifiers
     source          1..11884
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..11884
                     /gene="Map1b"
                     /gene_synonym="Mtap1b"
                     /note="microtubule-associated protein 1B"
                     /db_xref="GeneID:29456"
                     /db_xref="RGD:3043"
     exon            1..348
                     /gene="Map1b"
                     /gene_synonym="Mtap1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..7550
                     /gene="Map1b"
                     /gene_synonym="Mtap1b"
                     /note="MAP-1B; neuraxin"
                     /codon_start=1
                     /product="microtubule-associated protein 1B"
                     /protein_id="NP_062090.1"
                     /db_xref="GeneID:29456"
                     /db_xref="RGD:3043"
                     /translation="MATVVVEATEPEPSGSIGNPAATTSPSLSHRFLDSKFYLLVVVG
                     ETVTEEHLRRAIGNIELGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVPGQKILHH
                     RSDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQ
                     NFIEIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSAS
                     ILPEMEGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFA
                     VNGFNMLINGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEE
                     RSQGSTSNSDWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSTEEACFTLQYLNKLS
                     MKPEPLFRSVGNAIEPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQWTGTNKDKAE
                     LILPNGQEVDIPISYLTSVSSLIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHL
                     DFLKQPLATQKDLTGQVSTPPVKQVKLKQRADSRESLKPATKPLSSKSVRKESKEEAP
                     EATKASQVEKTPKVESKEKVIVKKDKPGKVESKPSVTEKEVPSKEEQSPVKAEVAEKA
                     ATESKPKVTKDKVVKKEIKTKPEEKKEEKPKKEVAKKEDKTPLKKDEKPKKEEAKKEI
                     KKEIKKEEKKELKKEVKKETPLKDAKKEVKKDEKKEVKKEEKEPKKEIKKISKDIKKS
                     TPLSDTKKPAALKPKVAKKEEPTKKEPIAAGKLKDKGKVKVIKKEGKTTEAAATAVGT
                     AAVAAAAGVAASGPAKELEAERSLMSSPEDLTKDFEELKAEEIDVAKDIKPQLELIED
                     EEKLKETEPGEAYVIQKETEVSKGSAESPDEGITTTEGEGECEQTPEELEPVEKQGVD
                     DIEKFEDEGAGFEESSEAGDYEEKAETEEAEEPEEDGEDNVSGSASKHSPTEDEEIAK
                     AEADVHIKEKRESVASGDDRAEEDMDEALEKGEAEQSEEEGEEEEDKAEDAREEDHEP
                     DKTEAEDYVMAVVDKAAEAGVTEDQYDFLGTPAKQPGVQSPSREPASSIHDETLPGGS
                     ESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPRDVMTDETNNEET
                     ESPSQEFVNITKYESSLYSQEYSKPVVASFNGLSDGSKTDATDGRDYNASASTISPPS
                     SMEEDKFSKSALRDAYRPEETDVKTGAELDIKDVSDERLSPAKSPSLSPSPPSPIEKT
                     PLGERSVNFSLTPNEIKASAEGEATAVVSPGVTQAVVEEHCASPEEKTLEVVSPSQSV
                     TGSAGHTPYYQSPTDEKSSHLPTEVTENAQAVPVSFEFTEAKDENERSSISPMDEPVP
                     DSESPIEKVLSPLRSPPLIGSESAYEDFLSADDKALGRRSESPFEGKNGKQGFSDKES
                     PVSDLTSDLYQDKQEEKSAGFIPIKEDFSPEKKASDAEIMSSQSALALDERKLGGDGS
                     PTQVDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAEDTYSHMEGVASVSTASVAT
                     SSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTFQETEMSPSKEECPRPM
                     SISPPDFSPKTAKSRTPVQDHRSEQSSMSIEFGQESPEHSLAMDFSRQSPDHPTVGAG
                     MLHITENGPTEVDYSPSDIQDSSLSHKIPPTEEPSYTQDNDLSELISVSQVEASPSTS
                     SAHTPSQIASPLQEDTLSDVVPPRDMSLYASLASEKVQSLEGEKLSPKSDISPLTPRE
                     SSPTYSPGFSDSTSGAKESTAAYQTSSSPPIDAAAAEPYGFRSSMLFDTMQHHLALSR
                     DLTTSSVEKDNGGKTPGDFNYAYQKPESTTESPDEEDYDYESHEKTIQAHDVGGYYYE
                     KTERTIKSPCDSGYSYETIEKTTKTPEDGGYSCEITEKTTRTPEEGGYSYEISEKTTR
                     TPEVSGYTYEKTERSRRLLDDISNGYDDTEDGGHTLGDCSYSYETTEKITSFPESESY
                     SYETTTKTTRSPDTSAYCYETMEKITKTPQASTYSYETSDRCYTPERKSPSEARQDVD
                     LCLVSSCEFKHPKTELSPSFINPNPLEWFAGEEPTEESEKPLTQSGGAPPPSGGKQQG
                     RQCDETPPTSVSESAPSQTDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKH
                     MDPPPAPMQDRSPSPRHPDVSMVDPEALAIEQNLGKALKKDLKEKAKTKKPGTKTKSS
                     SPVKKGDGKSKPSAASPKPGALKESSDKVSRVASPKKKESVEKAMKTTTTPEVKATRG
                     EEKDKETKNAANASASKSVKTATAGPGTTKTAKSSTVPPGLPVYLDLCYIPNHSNSKN
                     VDVEFFKRVRSSYYVVSGNDPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVM
                     REWYQETHEKQQDLNIMVLASSSTVVMQDESFPACKIEL"
     exon            349..450
                     /gene="Map1b"
                     /gene_synonym="Mtap1b"
                     /inference="alignment:Splign:2.1.0"
     exon            451..533
                     /gene="Map1b"
                     /gene_synonym="Mtap1b"
                     /inference="alignment:Splign:2.1.0"
     exon            534..674
                     /gene="Map1b"
                     /gene_synonym="Mtap1b"
                     /inference="alignment:Splign:2.1.0"
     exon            675..7155
                     /gene="Map1b"
                     /gene_synonym="Mtap1b"
                     /inference="alignment:Splign:2.1.0"
     exon            7156..7394
                     /gene="Map1b"
                     /gene_synonym="Mtap1b"
                     /inference="alignment:Splign:2.1.0"
     exon            7395..11866
                     /gene="Map1b"
                     /gene_synonym="Mtap1b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgcaggga gagagcggag ggggaggcga cgcgcgccgg gaggaggggg gacgcagtgg
       61 gcggagcgga gacagcacct tcggagataa tcctttctcc tgccgcagag cagaggagcg
      121 gcgggagagg aacacttctc ccaggcttta gcagagccgg caggatggcg accgtggtgg
      181 tggaagccac cgagccggag ccatcgggca gcatcggcaa cccggcggcg accacctcgc
      241 ccagcctgtc gcaccgcttc ctagacagca agttctactt gctggtggtg gtcggcgaga
      301 cggtgaccga agagcacctg aggcgtgcca tcggcaacat cgagctgggg atccgatcgt
      361 gggacacaaa cctgatcgag tgcaacttgg accaagagct caaacttttc gtgtctcgac
      421 actccgcgag attctctcct gaagttccag gacaaaagat cctccatcac cgaagtgacg
      481 tcttagaaac tgtagttctg atcaaccctt cggatgaagc agtcagcacc gaggtgcgtt
      541 tgatgatcac tgacgccgcc cgccataaac tgctggtgct caccggacag tgctttgaga
      601 acactggaga gctcatcctc cagtcaggct ctttctcctt ccagaacttc atagagattt
      661 tcaccgacca agagattggg gagctcctaa gcaccaccca tcctgccaac aaagccagcc
      721 tcaccctctt ctgccctgag gaaggagact ggaagaactc caaccttgac agacacaatc
      781 tccaagactt catcaacatc aagctcaact cagcttctat cttgccagaa atggagggac
      841 tttctgagtt caccgagtac ctctcggagt ctgtcgaagt cccctccccc tttgacatcc
      901 tggagccccc gacctcgggc ggatttctga agctctccaa gccttgttgt tacatttttc
      961 cggggggccg cggggactct gccctgttcg cagtgaacgg attcaacatg ctcattaacg
     1021 gaggatcaga aagaaagtcc tgcttctgga agctcattcg gcacttggac cgggtggact
     1081 ccatcctgct cacccacatt ggggatgaca acttgcccgg gatcaacagc atgttgcaac
     1141 gcaagattgc agagctggaa gaggagcggt cccagggctc caccagcaac agtgactgga
     1201 tgaaaaacct catctcccct gacttggggg ttgtgtttct caatgtacct gaaaatctga
     1261 aaaacccaga acccaacatc aagatgaaga gaagtacaga agaagcatgc ttcaccctcc
     1321 agtacctaaa caaactgtcc atgaaaccag agcctttatt tagaagtgta ggcaatgcca
     1381 ttgagcctgt catcctgttc caaaaaatgg gagtgggtaa actggagatg tacgtgctta
     1441 acccagtcaa aagcagcaag gaaatgcagt atttcatgca gcagtggact ggaaccaaca
     1501 aagacaaggc tgaacttatc ctgcccaatg gtcaagaagt agacatcccg atttcctacc
     1561 tgacttccgt ctcgtctttg attgtgtggc acccagccaa ccctgctgag aaaatcatcc
     1621 gggttctgtt tcctggaaac agcacccagt acaacatcct agaagggctg gaaaaactca
     1681 aacatctaga cttcctaaag cagccactgg ccacccaaaa agatctcact ggccaggtgt
     1741 ccaccccccc agtgaaacag gtcaagttga aacagcgggc tgacagccga gagagtctga
     1801 agccagccac aaaaccactt tccagtaaat cagtgaggaa ggagtccaaa gaggaggccc
     1861 ctgaagccac aaaagccagc caagtggaaa aaacacccaa agttgaaagc aaagagaaag
     1921 tgatagtgaa aaaagacaag ccaggaaagg tagaaagtaa gccatcggtg acggaaaagg
     1981 aggtgcccag caaagaggag cagtcgcccg tcaaagctga ggtggctgag aaggcggcca
     2041 cggagagcaa acccaaagtc accaaagaca aagtggtaaa aaaggaaata aagacaaaac
     2101 ccgaagaaaa gaaagaggag aagcccaaga aggaagtggc taaaaaggaa gacaaaactc
     2161 ccctcaagaa agacgagaag cccaaaaagg aagaggcgaa gaaggagatc aagaaagaaa
     2221 tcaaaaagga agagaaaaag gagctgaaga aagaggtgaa gaaggaaacg cccctgaagg
     2281 acgccaagaa ggaggtgaag aaagacgaga agaaagaagt taaaaaggaa gagaaggaac
     2341 ccaaaaagga gattaagaag atctccaagg acataaagaa atccactcct ctgtcagaca
     2401 caaagaaacc ggctgcattg aaaccaaaag tagcaaagaa agaagagccc accaagaagg
     2461 agcctattgc tgctgggaaa ctcaaggaca aggggaaggt caaagtcatt aaaaaggaag
     2521 gcaagaccac agaggccgct gccacagctg ttggcactgc tgccgtggct gcagcagccg
     2581 gagtagcggc cagcggtcct gccaaagaac ttgaagctga gcggtccctc atgtcgtccc
     2641 ctgaggatct aaccaaggac tttgaggagc taaaggctga ggagatcgat gtagcgaagg
     2701 acatcaagcc tcagctggag ctcattgaag atgaagagaa actgaaggaa accgagccgg
     2761 gagaagccta cgtcattcag aaagagacgg aagtcagcaa aggttctgct gagtcacctg
     2821 atgaagggat caccaccact gagggggaag gggagtgcga gcaaaccccc gaggagctgg
     2881 agccagttga gaagcagggc gtggatgaca tcgagaagtt cgaggatgaa ggcgctggtt
     2941 ttgaagaatc ctcagaggcc ggagactacg aagagaaggc agaaactgag gaggccgagg
     3001 agccggaaga agacggggaa gacaatgtga gcgggagcgc ctcgaagcac agccccacag
     3061 aagacgaaga aatcgctaag gctgaggcgg acgtacacat caaggagaag agggagtctg
     3121 tggccagcgg cgatgaccgg gccgaagaag acatggatga agcgcttgag aaaggagaag
     3181 ctgaacagtc tgaggaggag ggtgaggagg aggaggacaa agcagaggac gccagagagg
     3241 aagaccatga gcccgacaaa actgaggctg aagattatgt gatggctgtg gttgacaagg
     3301 ccgcggaggc cggagtcacc gaggatcagt atgatttcct ggggacaccg gccaagcaac
     3361 ctggagtcca gtctcctagc cgagaacccg cgtcttcaat tcatgatgag accctacccg
     3421 gaggctccga gagcgaggcc actgcttcag atgaggagaa tcgagaagac cagcctgagg
     3481 aattcactgc tacctccgga tatactcagt ccaccatcga gatatctagt gagccgactc
     3541 caatggatga gatgtccact cctcgagatg tgatgaccga cgagaccaac aatgaggaga
     3601 cagagtcccc gtctcaggag ttcgtgaaca ttaccaaata cgagtcttcg ctgtactctc
     3661 aggagtactc caaacctgtg gttgcatcat tcaatggatt gtcagacggg tcaaagacag
     3721 acgccactga cggtagggat tacaacgctt ccgcctccac catatcacca ccttcgtcca
     3781 tggaagaaga caaattcagc aagtctgctc ttcgtgacgc ttaccgccca gaagagacgg
     3841 acgtgaaaac cggtgccgag ttggacatca aagatgtttc ggatgagaga cttagcccag
     3901 ccaagagtcc atccctgagt ccttctccac catcacccat agagaagact cccctgggtg
     3961 aacgtagcgt gaatttctct ctgacaccca acgagatcaa agcctctgca gagggagagg
     4021 caacagcagt agtgtccccc ggagtgaccc aagcagtagt tgaagaacac tgtgccagtc
     4081 ctgaggagaa gaccttggag gtagtgtcac cgtctcagtc tgtgacaggc agtgcgggcc
     4141 acacacctta ctaccaatct cccaccgacg aaaagtccag tcacctacct acagaagtca
     4201 ctgagaacgc gcaggcagtc ccggtgagct ttgaattcac tgaggccaaa gatgagaacg
     4261 agaggtcgtc catcagcccc atggatgaac ctgtgcctga ctcagagtct cctatcgaga
     4321 aagttctgtc tccgttacgc agccctcccc ttattggatc cgagtccgca tatgaagact
     4381 tcctgagtgc ggatgacaag gctcttggca gacgttcaga aagccccttt gaagggaaga
     4441 atggaaagca aggcttctca gacaaagaaa gcccagtttc tgacctgact tccgatcttt
     4501 accaagacaa gcaggaagag aaaagcgcgg gcttcatacc gataaaggaa gactttagtc
     4561 cagaaaagaa agccagcgat gctgaaatca tgagttctca atcagctctg gctttggatg
     4621 aaaggaaact gggaggagat ggatctccaa cgcaagtaga tgtcagtcag tttggctctt
     4681 tcaaagaaga caccaagatg tccatttcgg aaggcaccgt ttcagacaag tccgccacgc
     4741 ctgtggatga gggcgtggcc gaagacacct attcacacat ggaaggtgtg gcctcagtgt
     4801 caaccgcctc tgtggctacc agctcgtttc cagagccaac cacagatgac gtgtctcctt
     4861 ctctccacgc tgaagtgggc tctccacatt ccacagaggt ggatgactcc ctgtcggtgt
     4921 cggtggtgca aacaccaact actttccagg aaacagaaat gtctccgtct aaagaagagt
     4981 gcccaagacc aatgtcgatt tctcctcctg acttctcccc taagacagcc aaatccagga
     5041 caccagttca agatcaccga tccgaacagt cttcaatgtc tattgaattc ggtcaggaat
     5101 cccccgagca ttctcttgct atggacttta gtcggcagtc tccagaccac cctactgtgg
     5161 gtgctggtat gcttcacatc accgaaaatg ggccaactga ggtggactac agtccctccg
     5221 atatccagga ctctagtttg tcacataaga ttccgccgac agaagagcca tcctacaccc
     5281 aggataatga tctgtccgag ctcatctctg tgtctcaggt ggaggcttcc ccatccacct
     5341 cttctgctca cactccttct cagatagcct ctcctcttca ggaagacact ctctctgatg
     5401 tcgttcctcc cagagatatg tccttatatg cctcgcttgc gtctgagaaa gtgcagagcc
     5461 tggaaggaga gaaactctct ccaaaatccg atatttctcc gctcacccct cgagagtcct
     5521 cacctacata ttcacctggc ttttcagatt ctacctctgg agctaaagag agtacagcgg
     5581 cttaccaaac ctcctcttcc ccaccaatag atgcagcagc cgcagagccc tacggcttcc
     5641 gctcctcaat gttatttgat acaatgcagc atcacctggc cttgagtaga gatttgacca
     5701 catctagtgt ggagaaggac aatggaggga agacacccgg tgactttaac tatgcctatc
     5761 aaaagcccga gagcaccacc gaatccccag atgaagaaga ttatgactat gaatctcacg
     5821 agaaaaccat ccaggcccac gatgtgggtg gttactacta tgagaagaca gagagaacca
     5881 taaaatcccc atgtgacagt ggatactcct atgagaccat tgagaagacc accaagaccc
     5941 cagaagatgg tggctactcc tgtgaaatta ccgagaaaac cactcggacc cctgaagagg
     6001 gcgggtactc gtatgagatc agcgagaaga caacacgaac ccctgaagta agtggctaca
     6061 cctatgagaa gaccgagagg tccagaaggc tcctcgatga cattagcaat ggctacgatg
     6121 acactgagga tggtggccac acacttggcg actgtagcta ttcctacgaa accactgaga
     6181 aaattaccag ctttcctgaa tctgaaagct attcctatga gacaactaca aaaacaacac
     6241 ggagtccaga cacctctgca tactgttacg agaccatgga gaagatcacc aagaccccac
     6301 aggcatccac atactcctat gagacctcag accgatgcta cactccagaa aggaagtccc
     6361 cctcggaggc acgccaggat gttgacttgt gtctggtgtc ctcctgtgaa ttcaagcatc
     6421 ccaagaccga gctctcacct tccttcatta atccaaaccc tctcgagtgg tttgctgggg
     6481 aagagcccac tgaagaatct gagaagcctc tcactcagtc tggaggagcc cccccacctt
     6541 caggaggaaa acaacagggc agacaatgcg atgaaactcc acccacctca gtcagtgagt
     6601 cagctccatc ccagacggac tctgatgttc ccccagagac agaagagtgc ccctccatca
     6661 cagctgatgc caacattgac tctgaagatg agtcagaaac catccccaca gacaaaacgg
     6721 ttacgtacaa acacatggac ccgcctccag cccccatgca agaccgaagc ccttctcctc
     6781 gccaccctga tgtgtccatg gtggatccag aggccttggc tattgagcag aacctaggca
     6841 aggctctgaa aaaggatctg aaggagaagg ccaagaccaa gaaaccaggc acaaagacca
     6901 agtcctcttc acctgtcaaa aagggtgatg ggaagtccaa gccttcagca gcttccccca
     6961 aaccaggagc cttgaaggaa tcctctgaca aggtgtccag agtggcttct cccaagaaga
     7021 aagagtctgt ggagaaagct atgaagacca ccaccactcc tgaggtcaaa gccacacgag
     7081 gggaagagaa ggacaaggaa actaagaatg cagccaatgc ttctgcatcc aagtcagtga
     7141 agactgcaac agcaggacca ggaaccacta agacggccaa gtcgtccacc gtgcctcccg
     7201 gcctccctgt gtatttggac ctctgctata ttcccaacca cagcaacagt aagaatgtcg
     7261 atgttgagtt tttcaagaga gtgaggtcat cttactacgt ggtgagtggg aacgaccctg
     7321 ccgcggagga gcccagccgg gctgtcctgg atgccttgtt ggaagggaag gctcagtggg
     7381 gaagcaacat gcaggtgact ctgatcccaa cacatgactc tgaggtgatg agggagtggt
     7441 accaggagac ccacgagaag cagcaagacc tcaacatcat ggtcctagca agcagtagta
     7501 cagtggtcat gcaagacgag tccttccctg catgcaagat agaactgtag aaaccgcagc
     7561 cgaccacacc acaggatttg aactgtgttt ccagaaattc ctgaatttga aactaccttt
     7621 tcttaaacgt ccattcatct aattacgtca ctgaacaagg acctgccaga tgctatacag
     7681 tgtcatggtg atgcaaatca ctgatatttc tcaatttttg ccgaccgcta aggaaagtaa
     7741 ccatattccc acaatagatt tcaagttact gcaaaattac ctacccccgt tcatctctgc
     7801 tgaaatacgt ggaagccagg cactcgcaca cccaactgac ttctgctagg tattggcatt
     7861 tatcttagag agagaaagag agagggaaag agagtcagcg ggaggggagg gagagcggcg
     7921 ggagagaggg acaaagagac tgccggagag agagagagtg agagtgagag aggaagaatc
     7981 agaaagaaaa agaatgcaag acaaaaaagg tagagagttc tgatgagatg cccagggaga
     8041 aagagtgggc aggatggggt atagagaaga caccagcaac tgggtctgcg ttttcccaga
     8101 ccacagcgat tcattctgtg gtctacacag gtggagtttt ccattttcac cagagtcatc
     8161 agaaagagtc gatctcctaa agcttgtttc taaagaacag gaaggacgaa gcctgtcacg
     8221 agggcatgag atttttcacg ccttaattaa atgcctttgc tataaaggct gcccacgcat
     8281 aatgtagcaa gtgtaggctg gagaagcgag tggttggagc cccgttcaga actctcagac
     8341 ttttcaaaca cgtgagtagg ttgatctaag gcatgctccc agcatttgtc tacccaagtc
     8401 cacatcgagt caacccgcat gcagcaacac ccaaggccac cccagttaac tgaagcaaat
     8461 accaaagcag ttgggagaac atatgggaga cattttgcct taggaagtga cttgaatgta
     8521 caaagttacc cgatgcactt attttttaac gtgagacggc aagtttttaa aacatccgtg
     8581 taggattgta gatactccag gcgaaggagc atgcggggag ggaaggtact agaaactcgt
     8641 ctgactggcc caacagttta gtgcagagtc atgcttggtg aacgtcacca cttctgatgt
     8701 acccgtggcc tctcagccag ataagttgca ccctaagtag cttctttaac gcttcaagtt
     8761 taagactgaa atggcttctc taatcagaac cagggaaaca atgaatctca cggtggaagg
     8821 ggttctcggc aagtgtacag tgtctgcctt cctttgtctt gcattgacta ttttaatttt
     8881 tccattaatt ccaacacgtg ggaacacatg tacagaagat tttttttttt agatacatga
     8941 gaacttttca tagatgaact ttctaacgaa tgttttcatt tacagaaaaa tgcaaagaaa
     9001 aatttgaagc gatggtcttt ttttttaatt attattttaa gtgttttgta agacaaaaaa
     9061 attgaagttt tttgaggttc tggaaagatt tgaagcctga tattgaagtc gtgatgatat
     9121 ttatttaaaa acccgtcact actggaaacg gtggtacctc ccaccctttg actctcatat
     9181 tatgaaagtg tgagtccgtg ctgtttgaga gtgggtaggt ggcagggtag gctactgttc
     9241 agggtttcac agtgctattc cctcctcctt tcaagatttt ttcaccgtga ggtggaagag
     9301 ccaagttcag aagcacccta gcgccagctt gcttgggcct tttctggaaa acattcattg
     9361 aaagaaataa cagattgaaa acaaatgaat tctcagctcc tacgttcacc atgtagagag
     9421 ttcagacaca atgtccgtca ctgtcatcac tgaaccacaa actcgtaacg ccagatcatg
     9481 aggaaatctt tcgccaagtt tcaaacggca gatccatgta ccaggggttc agagttggca
     9541 atcttctcag tgacagccat gacagctcgt tcacgctgag tttcctgcag actcttaaga
     9601 tctccggagt agtgaacaat gacctcattt tattttctat gttagttatt tatttcaaaa
     9661 gttacatttt agtttacttt tcgtctgtga agtctatgtt tcgcactgct gtttactctg
     9721 agggtttaac aatatttctc cagggtcccc tcaccgagga cccatgcagt ctacttaatg
     9781 ctgtgaatca cattttccaa atgtttaatt ttttaaagaa aattaatatt ctatttttgt
     9841 taggcgtctc taggaatgca gcttttattt attttcctat ttctttccaa ctcgtaaaag
     9901 ccacacatta aaggtacaga aatgtcctat atggtggaag agacattgag aacggagttc
     9961 attgagtgtc agctcacttg tttctcactt caggcaagct gaacacacac aagatggcaa
    10021 tctcatggta gctgttgggt tggtccacac aatacactca aagagaaaca gtttctagcc
    10081 ttcttgccaa atccagacct ctggttgact tttctttcct aaaagatgga gttactgccc
    10141 agttctacag cttaaattta tttagccttt tatattattt tgttttaaag atgcaaagac
    10201 cttagaagaa ccatagccag ccttcagtta taaccactcg accccatacg tcttattgtt
    10261 tatacagaat ccgatgggga aaacactttt ttttttcaaa actgtcactg atccactggc
    10321 tgtgattcct acacaatctg gcagcaccat cctgacccct gtcctcagtg atggccatgt
    10381 agccgaggac accagggtga agtacattgg ctttgcaggt agctcctgat ctcccaggca
    10441 cccctcctac ctgtgtggct gatctgatct tgcttgttcc atacatacac aattagttta
    10501 gaggtagcca ccacgatgga ctatgtacat ttgtggtgag agctcaaaac cgacacagac
    10561 ttctagaaga tttgtgcata caatccttga tccaattgta tagattgact atttgagtgg
    10621 aaggcgtttc caccctgttt aaatgatgga attctattgt gctagcactc ccgatcatga
    10681 cccttttggt agtatttgta aacaaaattc tacagagact aaatcttaga gataatcctc
    10741 catttcaatt ttaatcaatt ctgtcctcct tttttccaaa ccccgaaccc catgcatgct
    10801 ttcccagtct tgtgatggga ctggacacag tgaccgaccc cctcgcctca aacaccattt
    10861 tccatggaat tcaaaagaaa aaaatttttt ttcttaacct tacatatcat agtgaatggt
    10921 ttccccggtg tatatgaatg ttttaagtgt ttccaatagc ttatgaaatt taggagcttt
    10981 ctaatactcg ttttataaat ttaatcattt gctaatggaa attttaccac ctcccatttg
    11041 tgttacaaat cttagctcct ggagcggcac tacaattcag gagttgtttt ttctcacctc
    11101 ctctgtcatt tgtcacagga ggtccctgct tggcaatgac atttgtgagt taggataatg
    11161 acgttccttc tctccttttt ttttcctttc atacttcaga tttaggagaa aaagattctg
    11221 tttccacgtg agaggaactg taagctttta tcacgtaacc agctgaacaa cacaccaaaa
    11281 gcagcctagg gatgagcacc gcgctttggt agcgattagg ttttattcac ctggtattaa
    11341 aactattcac tatttcaaaa atccggaact tttaagaatt catttcaaag gcagcatcaa
    11401 aaactgaaaa ggaagggaaa aaaaaacaac agctaataat cggcttctcc gcacgcgtgg
    11461 agctcgcgaa actggagccc cggagaagtg gctctgctca gccgcccgcc cacgccgcgg
    11521 cggtccttgc tttccccgca tgcgcccgca ggcagcgtgc agtcctaagc ccggctgtgg
    11581 agaagctcac tctctctctt gttctgaatg gtgtttgtgt cggtctgcct ctgtgtatgg
    11641 tattatgtct tataatcctg catcacttcc atcctatcca gtcatatcta atgtagaaaa
    11701 attagtttcc agtgaaagta atatgtagtg cttttatggt atttgtgtgc aatatcccct
    11761 cttctattga ggatatttga tgtaaaggaa aaaaaaaaag aaaaaagaaa ctgagttcca
    11821 caataaaata caaagtggca aaagttcact tgtgtgttga gacatcaaaa aaaaaaaaaa
    11881 aaaa
//
