LOCUS       NM_030995              10112 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus microtubule-associated protein 1A (Map1a), mRNA.
ACCESSION   NM_030995 XM_346662 XM_347365
VERSION     NM_030995.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 10112)
  AUTHORS   Cai,B., Shao,N., Ye,T., Zhou,P., Si,W., Song,H., Wang,G. and Kou,J.
  TITLE     Phosphorylation of MAP 1A regulates hyperphosphorylation of Tau in
            Alzheimer's disease model
  JOURNAL   Neuropathol Appl Neurobiol 49 (5), e12934 (2023)
   PUBMED   37705167
  REMARK    GeneRIF: Phosphorylation of MAP 1A regulates hyperphosphorylation
            of Tau in Alzheimer's disease model.
REFERENCE   2  (bases 1 to 10112)
  AUTHORS   Hallam,R.D., Buchner-Duby,B., Stykel,M.G., Coackley,C.L. and
            Ryan,S.D.
  TITLE     Intracellular Accumulation of alpha-Synuclein Aggregates Promotes
            S-Nitrosylation of MAP1A Leading to Decreased NMDAR-Evoked Calcium
            Influx and Loss of Mature Synaptic Spines
  JOURNAL   J Neurosci 42 (50), 9473-9487 (2022)
   PUBMED   36414406
  REMARK    GeneRIF: Intracellular Accumulation of alpha-Synuclein Aggregates
            Promotes S-Nitrosylation of MAP1A Leading to Decreased NMDAR-Evoked
            Calcium Influx and Loss of Mature Synaptic Spines.
REFERENCE   3  (bases 1 to 10112)
  AUTHORS   Tortosa,E., Adolfs,Y., Fukata,M., Pasterkamp,R.J., Kapitein,L.C.
            and Hoogenraad,C.C.
  TITLE     Dynamic Palmitoylation Targets MAP6 to the Axon to Promote
            Microtubule Stabilization during Neuronal Polarization
  JOURNAL   Neuron 94 (4), 809-825 (2017)
   PUBMED   28521134
REFERENCE   4  (bases 1 to 10112)
  AUTHORS   Gumy,L.F., Katrukha,E.A., Grigoriev,I., Jaarsma,D., Kapitein,L.C.,
            Akhmanova,A. and Hoogenraad,C.C.
  TITLE     MAP2 Defines a Pre-axonal Filtering Zone to Regulate KIF1- versus
            KIF5-Dependent Cargo Transport in Sensory Neurons
  JOURNAL   Neuron 94 (2), 347-362 (2017)
   PUBMED   28426968
REFERENCE   5  (bases 1 to 10112)
  AUTHORS   Takei,Y., Kikkawa,Y.S., Atapour,N., Hensch,T.K. and Hirokawa,N.
  TITLE     Defects in Synaptic Plasticity, Reduced NMDA-Receptor Transport,
            and Instability of Postsynaptic Density Proteins in Mice Lacking
            Microtubule-Associated Protein 1A
  JOURNAL   J Neurosci 35 (47), 15539-15554 (2015)
   PUBMED   26609151
REFERENCE   6  (bases 1 to 10112)
  AUTHORS   Oudega,M., Touri,F., Deenen,M.G., Riederer,B.M. and Marani,E.
  TITLE     Microtubule-associated protein 1a is involved in the early
            development of the rat spinal cord
  JOURNAL   Neurosci Lett 246 (2), 81-84 (1998)
   PUBMED   9627185
REFERENCE   7  (bases 1 to 10112)
  AUTHORS   Mann,S.S. and Hammarback,J.A.
  TITLE     Molecular characterization of light chain 3. A microtubule binding
            subunit of MAP1A and MAP1B
  JOURNAL   J Biol Chem 269 (15), 11492-11497 (1994)
   PUBMED   7908909
REFERENCE   8  (bases 1 to 10112)
  AUTHORS   Langkopf,A., Hammarback,J.A., Muller,R., Vallee,R.B. and
            Garner,C.C.
  TITLE     Microtubule-associated proteins 1A and LC2. Two proteins encoded in
            one messenger RNA
  JOURNAL   J Biol Chem 267 (23), 16561-16566 (1992)
   PUBMED   1379599
REFERENCE   9  (bases 1 to 10112)
  AUTHORS   Ferreira,A., Busciglio,J. and Caceres,A.
  TITLE     Microtubule formation and neurite growth in cerebellar macroneurons
            which develop in vitro: evidence for the involvement of the
            microtubule-associated proteins, MAP-1a, HMW-MAP2 and Tau
  JOURNAL   Brain Res Dev Brain Res 49 (2), 215-228 (1989)
   PUBMED   2509111
REFERENCE   10 (bases 1 to 10112)
  AUTHORS   Benjamin,S., Cambray-Deakin,M.A. and Burgoyne,R.D.
  TITLE     Effect of hypothyroidism on the expression of three
            microtubule-associated proteins (1A, 1B and 2) in developing rat
            cerebellum
  JOURNAL   Neuroscience 27 (3), 931-939 (1988)
   PUBMED   3252178
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Dec 5, 2020 this sequence version replaced NM_030995.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M83196.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                JAXUCZ010000003.1  128722695-128722774
            81-163              JAXUCZ010000003.1  128725830-128725912
            164-304             JAXUCZ010000003.1  128726148-128726288
            305-8408            JAXUCZ010000003.1  128726508-128734611
            8409-8629           JAXUCZ010000003.1  128734751-128734971
            8630-10112          JAXUCZ010000003.1  128735156-128736638
FEATURES             Location/Qualifiers
     source          1..10112
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..10112
                     /gene="Map1a"
                     /gene_synonym="Mtap1a"
                     /note="microtubule-associated protein 1A"
                     /db_xref="GeneID:25152"
                     /db_xref="RGD:3042"
     exon            1..80
                     /gene="Map1a"
                     /gene_synonym="Mtap1a"
                     /inference="alignment:Splign:2.1.0"
     exon            81..163
                     /gene="Map1a"
                     /gene_synonym="Mtap1a"
                     /inference="alignment:Splign:2.1.0"
     exon            164..304
                     /gene="Map1a"
                     /gene_synonym="Mtap1a"
                     /inference="alignment:Splign:2.1.0"
     exon            305..8408
                     /gene="Map1a"
                     /gene_synonym="Mtap1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             455..8785
                     /gene="Map1a"
                     /gene_synonym="Mtap1a"
                     /note="MAP-1A"
                     /codon_start=1
                     /product="microtubule-associated protein 1A"
                     /protein_id="NP_112257.2"
                     /db_xref="GeneID:25152"
                     /db_xref="RGD:3042"
                     /translation="MDGVAEFSEYVSETVDVPSPFDLLEPPTSGGFLKLSKPCCYIFP
                     GGRGDSALFAVNGFNILVDGGSDRKSCFWKLVRHLDRIDSVLLTHIGADNLPGINGLL
                     QRKVAELEEEQSQGSSSYSDWVKNLISPELGVVFFNVPDKLRLPDASRKAKRSIEEAC
                     LTLQHLNRLGIQAEPLYRVVSNTIEPLTLFHKMGVGRLDMYVLNPVKDSKEMQFLMQK
                     WAGNSKAKTGIVLANGKEAEISVPYLTSITALVVWLPANPTEKIVRVLFPGNAPQNKI
                     LEGLEKLRHLDFLRYPVATQKDLAAGAVPANLKPSKIKHRADSKESLKAAPKTAVSKL
                     AKREEVLEEGAKEARSELAKELAKTEKKAKEPSEKPPEKPSKSERVRGESSEALKAEK
                     RRLIKDKAGKKHLKEKISKLEEKKDKEKKEIKKERKELKKEEGRKEEKKDAKKDEKRK
                     DTKPEVKKLSKPDLKPFTPEVRKTLYKAKAPGRVKVDKGRAARGEKELSSEPRTPPAQ
                     KGAAPPAAVSGHRELALSSPEDLTQDFEELKREERGLLAEQRDTGLGEKPLPADATEQ
                     GHPSAAIQVTQPSGPVLEGEHVEREKEVVPDSPGDKGSTNRGPDSGAEVEKEKETWEE
                     RKQREAELGPENTAAREESEAEVKEDVIEKAELEEMEETHPSDEEGEETKAESFYQKH
                     TQEALKASPKSREALGGRDLGFQGKAPEKETASFLSSLATPAGATEHVSYIQDETIPG
                     YSETEQTISDEEIHDEPDERPAPPRFPTSTYDLSGPEGPGPFEASQAADSAVPASSSK
                     TYGAPETELTYPPNMVAAPLAEEEHVSSATSITECDKLSSFATSVAEDQSVASLTAPQ
                     TEETGKSSLLLDTVTSIPSSRTEATQGLDYVPSAGTISPTSSLEEDKGFKSPPCEDFS
                     VTGESEKKGETVGRGLSGEKAVGKEEKYVVTSEKLSGQYAAVFGAPGHTLPPGEPALG
                     EVEERCLSPDDSTVKMASPPPSGPPSAAHTPFHQSPVEDKSEPRDFQEDSWGETKHSP
                     GVSKEDSEEQTVKPGPEEGTSEEGKGPPTRSPQAQDTPVSIAGGQTGCTIQLLPEQDK
                     AIVFETGEAGSILGAGTLPGEVRTSTEEATEPQKDEVLRFTDQSLSPEDAESLSVLSV
                     VSPDTTKQEATPRSPCSLKEQQPHKDLWPMVSPEDTQSLSFSEESPSKETSLDISSKQ
                     LSPESLGTLQFGELNLGKEERGPVMKAEDDSCHLAPVSIPEPHRATVSPSTDETPAGT
                     LPGGSFSHSALSVDRKHSPGEITGPGGHFMTSDSSLTKSPESLSSPAMEDLAVEWEGK
                     APGKEKEPELKSETRQQKGQILPEKVAVVEQDLIIHQKDGALDEENKPGRQQDKTPEQ
                     KGRDLDEKDTAAELDKGPEPKEKDLDREDQGQRAGPPAEKDKASEQRDTDLQQTQATE
                     PRDRAQERRDSEEKDKSLELRDRTPEEKDRILVQEDRAPEHSIPEPTQTDRAPDRKGT
                     DDKEQKEEASEEKEQVLEQKDWALGKEGETLDQEARTAEQKDETLKEDKTQGQKSSFV
                     EDKTTTSKETVLDQKSAEKADSVEQQDGAALEKTRALGLEESPAEGSKAREQEKKYWK
                     EQDVVQGWRETSPTRGEPVGGQKEPVPAWEGKSPEQEVRYWRDRDITLQQDAYWRELS
                     CDRKVWFPHELDGQGARPRYCEERESTFLDEGPDEQEITPLQHTPRSPWTSDFKDFQE
                     PLPQKGLEVERWLAESPVGLPPEEEDKLTRSPFEIISPPASPPEMTGQRVPSAPGQES
                     PVPDTESTAPMRNEPTTPSWLAEIPPWVPKDRPLPPAPLSPAPAPPTPAPEPHTPVPF
                     SWGLAEYDSVVAAVQEGAAELEGGPYSPLGKDYRKAEGEREGEGGAGAPDSSSFSPKV
                     PEAGESLATRDTEQTEPEQREPTPYPDERSFQYADIYEQMMLTGLGPACPTREPPLGA
                     SGDWPPHLSTKEEAAGCNTSAEKETSSPASPQNLQSDTPAFSYASLAGPAVPPRQEPD
                     PGPNVEPSITPPAVPPRAPISLSKDLSPPLNGSTVSCSPDRRTPSPKETGRGHWDDGT
                     NDSDLEKGAREQPEKETRSPSPHHPMPMGHSSLWPETEAYSSLSSDSHLGSVRPSLDF
                     PASAFGFSSLQPAPPQLPSPAEPRSAPCGSLAFSGDRALALVPGTPTRTRHDEYLEVT
                     KAPSLDSSLPQLPSPSSPGGPLLSNLPRPASPALSEGSSSEATTPVISSVAERFPPGL
                     EAAEQSAEGLGSGKESAAHSLWDLTPLSPAPSASLDLAPAPAPAPAPAPAPGLPGDLG
                     DGTLPCRPECTGELTKKPSPFLSPSGDHEANGPGETSLNPPGFVTATAEKEEAEAPHA
                     WERGSWPEGAERSSRPDTLLSSEQPLRPGKSSGGPPCSLSSEVEAGPQGCATDPRPHC
                     GELSPSFLNPPLPPSTDDSDLSTEEARLAGKGGRRRVGRPGATGGPCPMADETPPTSA
                     SDSGSSQSDSDVPPETEECPSITAEAALDSDEDGDFLPVDKAGGVSGTHHPRPGHDPP
                     PTPLPDPRPSPPRPDVCMADPEGLSSESGRVERLREKGRPGRRAPGRAKPASPARRLD
                     IRGKRSPTPGKGPVDRTSRTVPRPRSTPSQVTSAEEKDGHSPMSKGLVNGLKAGSTAL
                     GSKGGSGPPVYVDLAYIPNHCSGKTADQDFFRRVRASYYVVSGNDPANGEPSRAVLDA
                     LLEGKAQWGENLQVTLIPTHDTEVTREWYQQTHEQQQQLNVLVLASSSTVVMQDESFP
                     ACKIEF"
     exon            8409..8629
                     /gene="Map1a"
                     /gene_synonym="Mtap1a"
                     /inference="alignment:Splign:2.1.0"
     exon            8630..10112
                     /gene="Map1a"
                     /gene_synonym="Mtap1a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agactcttcc ctgaagctgc cgggctaagg ctaaggccag agccaatgcc tccatgaggg
       61 gctccctccc acaccccggg gccagaggac cctctgccac cagagtgaga tcctcgagac
      121 catcatccta gtcaacccca gtgcagacag tatcagctca gaggttcacc atcttctcag
      181 cagcccatca gctcacaaac tcctgatcct gagtggacaa actttagaac ctgagggaga
      241 ccttatccta cagagtggta cctactcata tcaaaacttt gcccaggtcc ttcacaaacc
      301 tgagattgcc cagttgctta gcaacagaga cccggagatc caggccttcc tcactgtttc
      361 ctgcttaggg gagggtgact ggagccacct gggactgtcc agttcccaag agaccttgca
      421 cctccggcta aatcctgagc ctgtgctacc caccatggat ggtgtggctg agttctccga
      481 gtatgtctct gagactgtgg atgtgccatc cccctttgac ctgcttgaac cgcccacctc
      541 aggaggcttc ctcaagctct ctaagccttg ctgctacatc tttcctggtg gccgtgggga
      601 ctctgctctc tttgctgtca atggctttaa catcctggtg gatggcggtt cggatcgcaa
      661 gtcctgcttc tggaagctgg tgcggcacct ggaccgcatc gactccgtgc tgctcacaca
      721 cattggggct gacaatctgc cgggcatcaa cggcctcctg cagcgcaagg tggcagagct
      781 agaggaggag cagtcccagg gctccagcag ctacagcgac tgggtgaaga acctcatctc
      841 ccctgagctt ggagttgtgt tcttcaacgt gcctgataag ctccggctgc ccgacgcctc
      901 ccgcaaggcc aagcgcagca ttgaagaggc ctgtctcact cttcagcact taaaccgcct
      961 aggcatccaa gccgagcctc tgtatcgtgt agtcagcaac accatcgagc cactgaccct
     1021 cttccacaaa atgggtgtgg gtaggctgga catgtatgtc ctcaaccccg tcaaggacag
     1081 taaggagatg cagttcctca tgcagaagtg ggcaggcaat agtaaagcca agacaggcat
     1141 tgtactggcc aatgggaagg aggcagagat ctctgtcccc tacctgacct ccatcactgc
     1201 tctggtggta tggctcccag ccaaccctac tgagaagatt gtgcgtgttc ttttcccggg
     1261 aaatgctccc cagaacaaga tcttggaggg cttggaaaag cttcggcacc tggactttct
     1321 gcgctaccct gtggcaacgc agaaggacct ggctgctggg gccgtgcccg ccaacttgaa
     1381 acccagcaaa atcaaacatc gggctgacag caaggagagc ctcaaagctg ctcccaagac
     1441 agcagtgagc aagctggcca aacgggagga agtgttggaa gagggggcca aggaggcccg
     1501 ctcagagctg gccaaggagt tagccaagac agaaaagaaa gcaaaagaac cgtctgagaa
     1561 gcccccagaa aaaccctcca agtccgaaag ggtgaggggc gagtccagcg aagcgctgaa
     1621 ggccgagaaa cggaggctga tcaaggacaa ggccggcaag aagcacctga aggaaaagat
     1681 ttcaaagcta gaggagaaga aggacaagga gaaaaaggag atcaagaagg aaaggaagga
     1741 gctcaagaag gaggaaggga gaaaggaaga gaaaaaggat gccaaaaagg acgaaaagag
     1801 gaaagatacc aaaccagagg tcaagaaact ctccaagcca gacctgaagc cttttacccc
     1861 tgaggtccgt aagaccctct acaaagccaa ggcccctggc agggtcaagg tggacaaagg
     1921 ccgagccgcc cgtggagaaa aggagttgtc ttctgagccc cggacacccc cagcccagaa
     1981 gggggctgct ccgcctgcag ctgtcagtgg gcacagagag ttggccttgt cctcaccaga
     2041 ggacctcaca caggactttg aggagttgaa gcgtgaggag agaggtttgc tggctgaaca
     2101 aagagatacg gggctgggtg agaaaccact ccctgcagat gccacagagc aggggcaccc
     2161 gagcgcagcc atccaggtga ctcaaccctc tggccctgtg ctggagggag aacatgtgga
     2221 aagggagaaa gaggtagtcc cagactcccc aggggataaa gggagcacaa acagaggccc
     2281 agactctggg gctgaggtcg agaaagagaa agaaacctgg gaggaaagga agcagagaga
     2341 agcagagctg ggcccagaga acactgcggc cagggaggag agcgaagctg aggtaaagga
     2401 ggatgtgatc gaaaaggccg agttagagga aatggaggag actcatcctt cagatgagga
     2461 gggggaagag acaaaggctg agagctttta tcagaaacat acgcaggaag ccctaaaggc
     2521 tagcccaaag agcagagagg ctcttggcgg ccgggacctg gggttccagg gcaaggcacc
     2581 cgagaaggag acagcatcat tcctaagcag tttggccaca cctgcgggag ccactgaaca
     2641 cgtctcttac attcaggatg agacaatccc tggctactca gagactgagc agactatttc
     2701 agatgaggag atccatgatg agccagatga acgcccagcg ccgcccagat ttcctacgag
     2761 tacctatgac ctctctgggc ctgaaggtcc tggccccttt gaagccagcc aggctgcaga
     2821 tagtgctgtt ccagcctcct cgagcaaaac ttatggggca cctgagactg aactcaccta
     2881 ccctcccaac atggtcgccg cccctctggc tgaagaggaa catgtgtcct cagccacgtc
     2941 aatcaccgag tgtgacaaac tctcttcctt tgccacatcg gtggctgagg accaatctgt
     3001 ggcttcactc acagctcccc agacggagga gacaggcaag agctccctgt tgctcgacac
     3061 tgtcacgagt atcccctctt cccgcactga agccacccag ggcctggact atgtgccgtc
     3121 agctggtacc atctccccca cctcttccct ggaagaagac aagggcttca agtcaccacc
     3181 ctgtgaggat ttctctgtga ccggggagtc ggagaagaaa ggagagactg tggggagagg
     3241 cttgagcggg gagaaggctg tggggaagga ggaaaaatat gtagtgacgt ctgagaaact
     3301 gtccggtcag tatgctgctg tgtttggtgc ccctggacac accctacccc cgggggaacc
     3361 agccctcgga gaagtggagg aacggtgcct cagcccagat gacagcacgg tgaagatggc
     3421 ttctcctcca ccatctggcc cacccagtgc tgcccacacg ccctttcacc agtctccagt
     3481 ggaagacaag tctgagccgc gagactttca ggaagattcc tggggagaaa caaagcattc
     3541 tccaggtgtg agcaaggaag actctgaaga gcagacggtg aagccagggc ccgaggaggg
     3601 cacttcagaa gaggggaagg gacctcctac caggagcccc caagcccagg acacgcctgt
     3661 gagcattgct gggggtcaga ctggctgtac tatccaactc ttaccagaac aagacaaagc
     3721 catagtgttt gagactggag aggcaggttc gattctagga gcagggaccc tccctggaga
     3781 agtgaggaca tcaactgaag aagccactga acctcagaaa gatgaggtac ttcgctttac
     3841 tgatcaaagc ctttcccctg aagatgcaga gtctctgtct gtcctcagtg tggtctcccc
     3901 agacactacc aaacaagagg ccactcccag gtctccctgc agcctgaaag agcagcagcc
     3961 gcacaaagac ctttggccaa tggtgtctcc agaagacacc cagtcacttt ctttctcaga
     4021 agagagtcct agcaaggaga cctctctgga tatctcttct aagcagctct ctccagaaag
     4081 ccttggcacc ctccagtttg gagaactgaa cctaggaaag gaagaaaggg ggcctgtgat
     4141 gaaggcagaa gacgattctt gccacctagc tcctgtgtct attccagagc cacacagggc
     4201 cacagtgtca cctagcacag atgagacccc tgctgggact ttacctggtg gctctttttc
     4261 tcactctgca ctgtcagtcg ataggaagca ctcacctggg gagatcacgg gccctggtgg
     4321 acactttatg acatctgata gctccctcac caagagtccc gagtctttgt caagtcccgc
     4381 catggaagat ctggccgtgg agtgggaagg taaagctcca gggaaggaga aagaacctga
     4441 gctaaagagt gaaacccgac agcaaaaggg ccagattctg ccggagaagg ttgctgttgt
     4501 cgagcaggac ttgatcatac atcagaaaga cggggctctg gatgaggaga acaaacctgg
     4561 aaggcagcag gataagactc cagaacagaa aggcagagac ttggacgaaa aggacacggc
     4621 tgcagagctg gacaaaggcc cagaacccaa agaaaaagac ttagaccggg aggaccaggg
     4681 ccagagagca gggcctccag cagagaagga caaggcctca gaacaaaggg acacagacct
     4741 gcaacagacc caggccacag aaccaagaga cagagcacaa gagcgcagag attcagaaga
     4801 aaaggacaag agtttagagc tgagagatag gactcctgaa gagaaagata gaatattagt
     4861 acaggaagac agggctccag agcacagcat ccctgaacca acacagacag acagagctcc
     4921 agatcgcaaa ggcacggatg ataaagaaca gaaggaggag gcctcagaag agaaagaaca
     4981 ggttttagaa caaaaagact gggccctagg aaaggagggt gagaccttgg accaagaggc
     5041 cagaactgct gaacagaaag atgagaccct aaaagaggac aaaactcagg gacagaagag
     5101 ctctttcgtc gaagataaaa ccacaacatc aaaagagacg gtccttgacc aaaagtctgc
     5161 agagaaggcc gacagtgtgg agcagcagga tggagccgcc ctggagaaga ccagagcttt
     5221 ggggctggaa gagagcccag cagagggaag caaggctcga gagcaggaaa agaaatactg
     5281 gaaggaacag gatgtggtcc agggatggcg agaaacatct ccaaccaggg gagagccagt
     5341 gggaggccag aaagagcctg ttccagcctg ggagggcaag tctcctgagc aagaagtccg
     5401 gtattggagg gacagagaca taacactaca gcaggatgca tactggaggg agctaagctg
     5461 tgacaggaag gtctggttcc cccatgagct agatggccaa ggagcccgtc cacggtactg
     5521 tgaggaacgt gaaagcactt ttcttgatga ggggccagat gaacaagaaa taacccccct
     5581 gcagcacact ccccggagtc cctggacctc ggatttcaag gatttccagg agcccctgcc
     5641 acagaagggg ctggaagtag agcgctggct tgctgagtca ccagttggcc tgccaccaga
     5701 ggaagaggac aaactgacac gctcgccctt tgagatcatc tcccctccag catccccacc
     5761 tgagatgact ggacagaggg ttccttcagc tccaggacaa gagagccctg tcccagacac
     5821 tgagtccaca gcacccatga ggaatgaacc taccacccct tcatggctag ctgagatccc
     5881 accttgggta cctaaggaca ggcctctgcc tcctgcaccc ctctccccag ctccagctcc
     5941 cccaacacct gccccagagc cacatactcc tgtgcccttc tcctggggct tagctgaata
     6001 tgacagtgtg gtggctgccg tgcaggaggg ggcagcggag ctggaaggcg gcccatactc
     6061 cccactcggg aaggactatc gaaaagctga aggggaaagg gaaggagagg gtggggctgg
     6121 agctcctgac agcagctcct tcagtccaaa ggtcccagag gctggtgaga gccttgccac
     6181 cagggacact gagcagactg agccagagca gagagagccc acaccctatc ccgatgagag
     6241 aagctttcag tatgcagaca tctatgaaca gatgatgctt actggactgg gccctgcttg
     6301 ccccaccagg gagcctccac tgggggcatc cggggactgg cccccacacc tctcaaccaa
     6361 ggaggaggct gctggctgca atacttctgc agagaaggag acttcctccc ctgcctcgcc
     6421 ccaaaacctc caatctgaca ctccagcttt cagctacgca tctctggcag gacccgctgt
     6481 acctcccagg caagaaccgg atccaggacc caatgtggag cccagcatca cccctcccgc
     6541 agtgccccct cgcgccccta tctccctgag caaagacctg agtccccctc ttaatggaag
     6601 cactgtgagc tgcagcccgg acaggaggac cccatcccca aaggaaacgg gccgaggtca
     6661 ctgggatgat ggtaccaatg actcagacct ggagaagggg gcccgggaac agcccgagaa
     6721 agagactcgg tccccaagtc cccatcaccc catgcctatg ggccactcct cactgtggcc
     6781 tgaaaccgag gcatacagca gcctttcctc agactcacac ctaggatctg tccgtccaag
     6841 tctggacttc cctgcttcag cctttggctt ctcctccttg cagcctgctc cccctcagct
     6901 gccctctcca gctgaacccc gctccgcacc ctgtggctca cttgccttct ctggggaccg
     6961 agctctggcc ttggttccag gaactccaac cagaacccga catgatgagt acctggaagt
     7021 gaccaaggca cccagcctgg attcctcact gccccaactc ccatcaccca gctctcctgg
     7081 gggccctctt ctctctaacc tgcccagacc tgcctcgcca gccttgtctg aagggtcctc
     7141 ttctgaggct accacgcctg tgatttcaag tgtggccgaa cgcttccctc caggtctcga
     7201 ggcagctgaa cagagtgctg aaggactggg ctcaggaaaa gagtcggctg cccacagcct
     7261 ctgggacctc actcccctga gcccagctcc ctcagcttca ctggacttgg ctccagctcc
     7321 agctccagct ccagctccag ctccagctcc aggcctgcct ggagacttgg gcgatggtac
     7381 cctgccctgc cgccctgagt gcacagggga actcaccaag aagccaagcc ccttcctgag
     7441 cccctctgga gatcatgaag ccaatggccc aggagaaacc agccttaatc ccccagggtt
     7501 tgtcacagcc acggcagaaa aagaagaggc tgaagcccct catgcttggg aacgagggtc
     7561 ctggcctgag ggagctgaga ggagctcccg gccggataca cttctctcat ctgagcagcc
     7621 actgcgtcct gggaagagct ccgggggccc accctgcagt ctttcttctg aagtcgaggc
     7681 tggacctcag ggatgtgcta cggatccccg cccccactgc ggggagcttt ccccctcatt
     7741 cctgaaccct cctctgcctc catccacaga tgacagtgac ctttccacgg aagaagctcg
     7801 gctggcagga aaaggaggga ggcgccgggt agggaggcca ggggccacgg gaggtccatg
     7861 ccctatggct gatgagacac cccccacatc agccagcgac tcaggctcct cacagtcaga
     7921 ttctgatgtc ccaccagaaa ctgaggagtg tccatccatc acagctgagg cagccctcga
     7981 ctcagatgaa gatggggact tcttgcctgt ggacaaagct gggggagtta gcggaactca
     8041 ccatcccaga cctggccatg acccaccccc aaccccccta ccagaccccc gcccatcccc
     8101 tccacgaccg gatgtttgca tggctgaccc tgaggggctc agctcagagt cggggagggt
     8161 tgagagacta cgagaaaagg gacgacctgg ccgtagggcc cctggccggg ccaagcctgc
     8221 atctcctgct aggcggttgg atattcgggg aaaacggtca cctactcctg gcaaagggcc
     8281 tgtagatcga acatctcgta ctgtaccccg accacggagc actccaagcc aggtcacctc
     8341 agcagaagaa aaggatggtc acagtcccat gtccaaaggc ttagtcaatg gcctcaaggc
     8401 aggatcaaca gccttgggct ccaagggtgg ttccggccct cctgtgtatg tggatcttgc
     8461 ctatatccca aatcactgca gcggcaagac tgcggatcag gacttcttcc gccgagtacg
     8521 tgcgtcctac tatgtggtca gtggaaatga ccctgccaat ggcgagccaa gccgggctgt
     8581 gctggatgcc ctgctggaag gcaaggccca gtggggggag aaccttcagg tgactctgat
     8641 tcccactcat gacacggagg tgactcgtga gtggtatcag cagacacatg aacagcagca
     8701 gcagctgaat gtcctggtcc tggcgagcag cagcactgtg gtgatgcagg acgagtcctt
     8761 tccagcctgc aagattgagt tctgaatgac ccatgctccc ttccccaagg atccactcct
     8821 acagttcatt tagagaatgg ctactgctga gtcctctggg gttgagggaa gtagagctgg
     8881 gcaggggcca tgtcatatta ttaggctaag cggaaggtcc tgtccttccc ctcctctctc
     8941 cctgggggtt tcaaaaccaa aggcaatgag ggggcataca aaatcatgaa aggttatctg
     9001 atgcccaaaa cccctagagc cactccctct cctagcactg ccaaatgctg gtcttgcacg
     9061 aggatgggtt tcagacagca cactcctccc catggaggaa gatttaacac cctctccccc
     9121 agaacctcat tatttatttg gcattccaga aaggattgct gataatgtat atgatgcagg
     9181 gaaggccact gttagtaagg tgccagagct gcgccctttc ttccatctcc cagtccctag
     9241 ccaccagagt ctgggttcca tcagcgacct ggggacatgt ggctactata ctgtcttatt
     9301 gcttccctca atatctgaat gtctcaatcc aaaacttgaa gctctttaga ccaagaacta
     9361 gggagaggaa aaaggagctc atctctcagc ccctgcttca taccacttac agccttgggc
     9421 tgtacccaga ccaggctacc tgggcagcac aacgggcaag gagagccccc aaccccagtc
     9481 gctccaagca cccctatcac ttagtcttca cctaccccat ttcaataagc ctcattcctt
     9541 ctcatcccct gcttggcttc tctgcatgtg gtcatctgct atggcctggt gtgtaatggg
     9601 tttaaaaaaa gccactgcct gacatccaca tccactttag ccatgtgtga ctccctcaac
     9661 attccaatcc tctaccatcc tgcagctgaa atgggaacac tggctgcctc tctaaaccta
     9721 aactcttgga tagagtttct gggaggtgga ggctggacta gagacctggg gagggggatg
     9781 ggagggagga ggggagagaa gagaagaagc tatagtttaa ctcctccaga gtgaagacag
     9841 gctgagcatt ctactacagg acagggcctc accccaagca agccagtgag cagcccagcc
     9901 agaccctgct ggactgagaa acccagctgc tgacagaccc tgggacttgc cttctttgcc
     9961 aagtcaaggg gaaaccaaaa ggagcttccc tcctattctt cctagctccc ctccctgccc
    10021 tgcgctctgc tcctccccac acttccctgc tacagtccca gttgctgtaa cagccacctc
    10081 cactctaaca ataaaccaag ttcattgcgg tc
//
