LOCUS       NM_013198               2389 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Rattus norvegicus monoamine oxidase B (Maob), mRNA.
ACCESSION   NM_013198
VERSION     NM_013198.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2389)
  AUTHORS   Merce,A.P., Ionica,L.N., Bina,A.M., Popescu,S., Lighezan,R.,
            Petrescu,L., Borza,C., Sturza,A., Muntean,D.M. and Cretu,O.M.
  TITLE     Monoamine oxidase is a source of cardiac oxidative stress in obese
            rats: the beneficial role of metformin
  JOURNAL   Mol Cell Biochem 478 (1), 59-67 (2023)
   PUBMED   35723772
  REMARK    GeneRIF: Monoamine oxidase is a source of cardiac oxidative stress
            in obese rats: the beneficial role of metformin.
REFERENCE   2  (bases 1 to 2389)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 2389)
  AUTHORS   Nakamura,Y., Arawaka,S., Sato,H., Sasaki,A., Shigekiyo,T.,
            Takahata,K., Tsunekawa,H. and Kato,T.
  TITLE     Monoamine Oxidase-B Inhibition Facilitates alpha-Synuclein
            Secretion In Vitro and Delays Its Aggregation in rAAV-Based Rat
            Models of Parkinson's Disease
  JOURNAL   J Neurosci 41 (35), 7479-7491 (2021)
   PUBMED   34290084
  REMARK    GeneRIF: Monoamine Oxidase-B Inhibition Facilitates alpha-Synuclein
            Secretion In Vitro and Delays Its Aggregation in rAAV-Based Rat
            Models of Parkinson's Disease.
REFERENCE   4  (bases 1 to 2389)
  AUTHORS   Cho,H.U., Kim,S., Sim,J., Yang,S., An,H., Nam,M.H., Jang,D.P. and
            Lee,C.J.
  TITLE     Redefining differential roles of MAO-A in dopamine degradation and
            MAO-B in tonic GABA synthesis
  JOURNAL   Exp Mol Med 53 (7), 1148-1158 (2021)
   PUBMED   34244591
  REMARK    GeneRIF: Redefining differential roles of MAO-A in dopamine
            degradation and MAO-B in tonic GABA synthesis.
REFERENCE   5  (bases 1 to 2389)
  AUTHORS   Huang,G., Zhu,F., Chen,Y., Chen,S., Liu,Z., Li,X., Gan,L., Zhang,L.
            and Yu,Y.
  TITLE     A spectrophotometric assay for monoamine oxidase activity with 2,
            4-dinitrophenylhydrazine as a derivatized reagent
  JOURNAL   Anal Biochem 512, 18-25 (2016)
   PUBMED   27503749
  REMARK    GeneRIF: Benzylamine and serotonin oxidation were catalyzed by
            MAO-B and MAO-A, respectively, to aldehydes. These were derivatized
            with DNPH, and the corresponding quinones were further formed by
            adding NaOH. These DNPH derivatives with large conjugated
            structures were directly measured spectrophotometrically at 465 nm
            and 425 nm
REFERENCE   6  (bases 1 to 2389)
  AUTHORS   Falk,E.M., Cook,V.J., Nichols,D.E. and Sprague,J.E.
  TITLE     An antisense oligonucleotide targeted at MAO-B attenuates rat
            striatal serotonergic neurotoxicity induced by MDMA
  JOURNAL   Pharmacol Biochem Behav 72 (3), 617-622 (2002)
   PUBMED   12175458
REFERENCE   7  (bases 1 to 2389)
  AUTHORS   Tsugeno,Y. and Ito,A.
  TITLE     A key amino acid responsible for substrate selectivity of monoamine
            oxidase A and B
  JOURNAL   J Biol Chem 272 (22), 14033-14036 (1997)
   PUBMED   9162023
REFERENCE   8  (bases 1 to 2389)
  AUTHORS   Costa,P., Checkoway,H., Levy,D., Smith-Weller,T., Franklin,G.M.,
            Swanson,P.D. and Costa,L.G.
  TITLE     Association of a polymorphism in intron 13 of the monoamine oxidase
            B gene with Parkinson disease
  JOURNAL   Am J Med Genet 74 (2), 154-156 (1997)
   PUBMED   9129714
REFERENCE   9  (bases 1 to 2389)
  AUTHORS   Sherif,F., Gottfries,C.G., Alafuzoff,I. and Oreland,L.
  TITLE     Brain gamma-aminobutyrate aminotransferase (GABA-T) and monoamine
            oxidase (MAO) in patients with Alzheimer's disease
  JOURNAL   J Neural Transm Park Dis Dement Sect 4 (3), 227-240 (1992)
   PUBMED   1627256
REFERENCE   10 (bases 1 to 2389)
  AUTHORS   Ito,A., Kuwahara,T., Inadome,S. and Sagara,Y.
  TITLE     Molecular cloning of a cDNA for rat liver monoamine oxidase B
  JOURNAL   Biochem Biophys Res Commun 157 (3), 970-976 (1988)
   PUBMED   2974701
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M23601.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M23601.1, FQ210326.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2389
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq11"
     gene            1..2389
                     /gene="Maob"
                     /note="monoamine oxidase B"
                     /db_xref="GeneID:25750"
                     /db_xref="RGD:3041"
     exon            1..109
                     /gene="Maob"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1626
                     /gene="Maob"
                     /EC_number="1.4.3.4"
                     /EC_number="1.4.3.21"
                     /note="MAO-B; monoamine oxidase type B"
                     /codon_start=1
                     /product="amine oxidase [flavin-containing] B"
                     /protein_id="NP_037330.1"
                     /db_xref="GeneID:25750"
                     /db_xref="RGD:3041"
                     /translation="MSNKCDVIVVGGGISGMAAAKLLHDCGLSVVVLEARDCVGGRTY
                     TIRNKNVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHFVKGKSYAFRGP
                     FPPVWNPITYLDYNNLWRTMDEMGQEIPSDAPWKAPLAEEWDYMTMKELLDKICWTNS
                     TKQIATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFIGGSGQVS
                     ERIKDILGDRVKLERPVIHIDQTGENVVVKTLNHEIYEAKYVISAIPPVLGMKIHHSP
                     PLPILRNQLITRVPLGSVIKCMVYYKEPFWRKKDFCGTMVIEGEEAPIAYTLDDTKPD
                     AGCAAIMGFILAHKARKLVRLTKEERLRKLCELYAKVLNSQEALQPVHYEEKNWCEEQ
                     YSGGCYTAYFPPGILTQYGRVLRQPVGKIFFAGTETASHWSGYMEGAVEAGERAAREI
                     LHAIGKIPEDEIWQPEPESVDVPARPITNTFLERHLPSVPGLLKLLGLTTILSATALG
                     FLAHKKGLFVRF"
     exon            110..204
                     /gene="Maob"
                     /inference="alignment:Splign:2.1.0"
     exon            205..342
                     /gene="Maob"
                     /inference="alignment:Splign:2.1.0"
     exon            343..447
                     /gene="Maob"
                     /inference="alignment:Splign:2.1.0"
     exon            448..539
                     /gene="Maob"
                     /inference="alignment:Splign:2.1.0"
     exon            540..681
                     /gene="Maob"
                     /inference="alignment:Splign:2.1.0"
     exon            682..831
                     /gene="Maob"
                     /inference="alignment:Splign:2.1.0"
     exon            832..991
                     /gene="Maob"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1088
                     /gene="Maob"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1142
                     /gene="Maob"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1200
                     /gene="Maob"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1298
                     /gene="Maob"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1410
                     /gene="Maob"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1473
                     /gene="Maob"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..2389
                     /gene="Maob"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctcaggca gaggtccaga ctcagtggaa gcagaggaga gagcctgaaa cctggcgagc
       61 accatgagca acaaatgcga tgtgatcgtg gtggggggcg gcatctcagg tatggcagca
      121 gccaaacttt tgcatgactg tggcctcagt gtggtggttc tggaagcacg agactgtgtg
      181 ggaggcagga cttacacaat taggaataaa aatgttaaat atgtggacct tggaggatct
      241 tatgttgggc cgacccagaa tcgtatctta cgattggcca aagagctagg attggagacc
      301 tataaagtga atgaagttga gcggctgatc cactttgtaa agggaaaatc atatgccttc
      361 aggggcccat tcccaccagt gtggaatcca atcacttacc tagattataa caacctctgg
      421 agaacaatgg atgagatggg ccaagagatt cccagtgatg ctccatggaa ggcacccctt
      481 gctgaagagt gggactacat gacaatgaaa gagttgctag ataagatctg ctggaccaac
      541 tctacaaagc agattgccac actctttgtg aacctatgtg taactgcgga gacccatgag
      601 gtttctgcac tgtggttcct gtggtatgtg aagcagtgtg ggggtacaac cagaatcata
      661 tcaacaacca atggaggaca ggagaggaaa tttattggtg gatctggtca agtgagtgag
      721 cggataaagg atatccttgg ggacagagtg aagctggaga ggccggtgat ccacattgac
      781 cagacaggag aaaatgttgt tgtgaaaacc ctaaaccatg aaatatatga ggctaaatat
      841 gtgattagtg ccatcccacc tgttttgggc atgaagattc accatagtcc tcctctgccc
      901 attctaagaa accagctgat tactcgtgtg cctttgggtt cagttattaa gtgcatggtt
      961 tattataaag aacccttctg gaggaaaaag gatttctgtg gaaccatggt tattgaagga
     1021 gaggaagctc caattgcgta cacattggat gataccaagc cagatgcagg ctgtgctgct
     1081 ataatgggat ttatccttgc tcacaaagct agaaaactgg tacgccttac taaagaagaa
     1141 agactgagga agctctgtga gctatacgcg aaagttctga actctcaaga agctctgcag
     1201 ccagtccatt atgaagagaa gaactggtgt gaggagcagt actccggggg ctgctacaca
     1261 gcctacttcc ctcctggcat cttgacccag tatggaaggg ttctacgcca gccagtgggc
     1321 aagattttct ttgcaggcac cgagacagct tcacattgga gtggctacat ggagggggct
     1381 gtagaggctg gagagagagc tgccagagag attcttcatg ccattgggaa gattccagag
     1441 gatgaaattt ggcagccaga accagaatct gtggatgtcc cagcaagacc cattaccaac
     1501 accttcctgg agagacactt gccttctgta ccaggtctac taaagctgct tggattgacc
     1561 accatcttgt cagcaacagc tcttggtttc ctggcccaca aaaagggtct gtttgtacgt
     1621 ttctaaagat gggctttagg accatatcca caggtttctc attcagtgtg tcacaaaagc
     1681 ttttggaagg agttgggata aaaatctgac aaaggtgcag agattatgga gtgagaaagc
     1741 acagtaactt ggtctccatt ttggctatct tttagcatcg ctgtggtcca ctcattttca
     1801 actttcctgc actctgaata ttgagaacag atacacaggc tctctcacaa cctacctgcc
     1861 ctatgcacat agttgttttt caaaacccta tgcctttgtg cttgtctttc ttctggtgtg
     1921 ttaggtcctc acctatatca agttcttcat cattgtacct agaatcctgt cttgttagaa
     1981 ccagaaggca ttagacactg tagcttattg tctactttag agttaaataa accaaatgca
     2041 acagaagtga aatctaacca cacaaggcct acacaaagct actggtattt gggtgactgg
     2101 aacacaagct gatgcttttc tcacctccca aggttcattc ccctgtgatc ctcctccacc
     2161 ttatgtcata gtcattcacg gatcattgtt cttgtggatt tactctgtat taactggtat
     2221 tgtgttactc agtagattct tctaggcttg ctattttgtg tagtgttgcc agctgattct
     2281 aatttttctt gagaatggga gtcttgtctt tgtcatttct tttttgcatc ttccagtatg
     2341 cttccactca tagatttaag acatgcttaa ataattaaaa ataaagctg
//
