LOCUS       NM_001401064             848 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus mesencephalic astrocyte-derived neurotrophic
            factor (Manf), mRNA.
ACCESSION   NM_001401064 XM_006243775
VERSION     NM_001401064.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 848)
  AUTHORS   Zhou,C., Han,D., Fang,H., Huang,D., Cai,H., Shen,Y., Shen,Y. and
            Liu,J.
  TITLE     Deletion of mesencephalic astrocyte-derived neurotrophic factor
            delays and damages the development of white pulp in spleen
  JOURNAL   Immunobiology 229 (1), 152778 (2024)
   PUBMED   38159526
  REMARK    GeneRIF: Deletion of mesencephalic astrocyte-derived neurotrophic
            factor delays and damages the development of white pulp in spleen.
REFERENCE   2  (bases 1 to 848)
  AUTHORS   Ko,J.A., Komatsu,K., Okumichi,H. and Kiuchi,Y.
  TITLE     Functional analysis of mesencephalic astrocyte-derived neurotrophic
            factor in retinal ganglion cells under oxidative stress
  JOURNAL   Cell Biochem Funct 39 (1), 98-106 (2021)
   PUBMED   32613670
  REMARK    GeneRIF: Functional analysis of mesencephalic astrocyte-derived
            neurotrophic factor in retinal ganglion cells under oxidative
            stress.
REFERENCE   3  (bases 1 to 848)
  AUTHORS   Belayev,L., Hong,S.H., Freitas,R.S., Menghani,H., Marcell,S.J.,
            Khoutorova,L., Mukherjee,P.K., Reid,M.M., Oria,R.B. and Bazan,N.G.
  TITLE     DHA modulates MANF and TREM2 abundance, enhances neurogenesis,
            reduces infarct size, and improves neurological function after
            experimental ischemic stroke
  JOURNAL   CNS Neurosci Ther 26 (11), 1155-1167 (2020)
   PUBMED   32757264
  REMARK    GeneRIF: DHA modulates MANF and TREM2 abundance, enhances
            neurogenesis, reduces infarct size, and improves neurological
            function after experimental ischemic stroke.
REFERENCE   4  (bases 1 to 848)
  AUTHORS   Li,T., Xu,W., Gao,L., Guan,G., Zhang,Z., He,P., Xu,H., Fan,L.,
            Yan,F. and Chen,G.
  TITLE     Mesencephalic astrocyte-derived neurotrophic factor affords
            neuroprotection to early brain injury induced by subarachnoid
            hemorrhage via activating Akt-dependent prosurvival pathway and
            defending blood-brain barrier integrity
  JOURNAL   FASEB J 33 (2), 1727-1741 (2019)
   PUBMED   30211660
  REMARK    GeneRIF: Mesencephalic astrocyte-derived neurotrophic factor showed
            not only transient but also long-lasting neuroprotective properties
REFERENCE   5  (bases 1 to 848)
  AUTHORS   Bai,M., Vozdek,R., Hnizda,A., Jiang,C., Wang,B., Kuchar,L., Li,T.,
            Zhang,Y., Wood,C., Feng,L., Dang,Y. and Ma,D.K.
  TITLE     Conserved roles of C. elegans and human MANFs in sulfatide binding
            and cytoprotection
  JOURNAL   Nat Commun 9 (1), 897 (2018)
   PUBMED   29497057
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 848)
  AUTHORS   Lindholm,P., Peranen,J., Andressoo,J.O., Kalkkinen,N., Kokaia,Z.,
            Lindvall,O., Timmusk,T. and Saarma,M.
  TITLE     MANF is widely expressed in mammalian tissues and differently
            regulated after ischemic and epileptic insults in rodent brain
  JOURNAL   Mol Cell Neurosci 39 (3), 356-371 (2008)
   PUBMED   18718866
REFERENCE   7  (bases 1 to 848)
  AUTHORS   Piepoli,A., Gentile,A., Valvano,M.R., Barana,D., Oliani,C.,
            Cotugno,R., Quitadamo,M., Andriulli,A. and Perri,F.
  TITLE     Lack of association between UGT1A7, UGT1A9, ARP, SPINK1 and CFTR
            gene polymorphisms and pancreatic cancer in Italian patients
  JOURNAL   World J Gastroenterol 12 (39), 6343-6348 (2006)
   PUBMED   17072959
REFERENCE   8  (bases 1 to 848)
  AUTHORS   Shridhar,V., Rivard,S., Wang,X., Shridhar,R., Paisley,C.,
            Mullins,C., Beirnat,L., Dugan,M., Sarkar,F., Miller,O.J.,
            Vaitkevicius,V.K. and Smith,D.I.
  TITLE     Mutations in the arginine-rich protein gene (ARP) in pancreatic
            cancer
  JOURNAL   Oncogene 14 (18), 2213-2216 (1997)
   PUBMED   9174057
REFERENCE   9  (bases 1 to 848)
  AUTHORS   Shridhar,R., Shridhar,V., Rivard,S., Siegfried,J.M.,
            Pietraszkiewicz,H., Ensley,J., Pauley,R., Grignon,D., Sakr,W.,
            Miller,O.J. and Smith,D.I.
  TITLE     Mutations in the arginine-rich protein gene, in lung, breast, and
            prostate cancers, and in squamous cell carcinoma of the head and
            neck
  JOURNAL   Cancer Res 56 (24), 5576-5578 (1996)
   PUBMED   8971156
REFERENCE   10 (bases 1 to 848)
  AUTHORS   Shridhar,V., Rivard,S., Shridhar,R., Mullins,C., Bostick,L.,
            Sakr,W., Grignon,D., Miller,O.J. and Smith,D.I.
  TITLE     A gene from human chromosomal band 3p21.1 encodes a highly
            conserved arginine-rich protein and is mutated in renal cell
            carcinomas
  JOURNAL   Oncogene 12 (9), 1931-1939 (1996)
   PUBMED   8649854
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Feb 1, 2022 this sequence version replaced XM_006243775.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166980.1, FQ232064.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840111, SAMN12840115
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               JAXUCZ010000008.1  116430135-116430259 c
            126-253             JAXUCZ010000008.1  116429398-116429525 c
            254-395             JAXUCZ010000008.1  116428461-116428602 c
            396-848             JAXUCZ010000008.1  116427053-116427505 c
FEATURES             Location/Qualifiers
     source          1..848
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..848
                     /gene="Manf"
                     /gene_synonym="Armet"
                     /note="mesencephalic astrocyte-derived neurotrophic
                     factor"
                     /db_xref="GeneID:315989"
                     /db_xref="RGD:1307252"
     exon            1..125
                     /gene="Manf"
                     /gene_synonym="Armet"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..580
                     /gene="Manf"
                     /gene_synonym="Armet"
                     /note="arginine-rich protein; arginine-rich, mutated in
                     early stage tumors"
                     /codon_start=1
                     /product="mesencephalic astrocyte-derived neurotrophic
                     factor precursor"
                     /protein_id="NP_001387993.1"
                     /db_xref="GeneID:315989"
                     /db_xref="RGD:1307252"
                     /translation="MWATRGLAVALALSVLPDSRALRPGDCEVCISYLGRFYQDLKDR
                     DVTFSPATIEEELIKFCREARGKENRLCYYIGATDDAATKIINEVSKPLAHHIPVEKI
                     CEKLKKKDSQICELKYDKQIDLSTVDLKKLRVKELKKILDDWGEMCKGCAEKSDYIRK
                     INELMPKYAPKAASARTDL"
     exon            126..253
                     /gene="Manf"
                     /gene_synonym="Armet"
                     /inference="alignment:Splign:2.1.0"
     exon            254..395
                     /gene="Manf"
                     /gene_synonym="Armet"
                     /inference="alignment:Splign:2.1.0"
     exon            396..848
                     /gene="Manf"
                     /gene_synonym="Armet"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attcgcgcgg cggcggcggt ggtggcgact gccgagaagg atgtgggcta cgcgcgggct
       61 ggcggtagcg ctggccctga gcgttctgcc tgacagtcgg gcgctacggc caggcgactg
      121 cgaagtttgt atttcttatc tggggagatt ttaccaggac ctcaaagaca gggatgtcac
      181 attttcacca gccactattg aagaagaact tataaagttc tgccgggaag caagaggcaa
      241 agaaaatcgg ttgtgctact acattggagc cacagatgat gccgccacca agatcatcaa
      301 tgaggtatcg aagcctctgg cccaccatat ccctgtggag aagatctgtg agaagctgaa
      361 gaagaaagac agccagatct gcgagctaaa atacgacaag cagattgacc tgagcacagt
      421 ggacctgaag aagctccggg tgaaagagct gaagaaaatc ctggacgatt ggggggagat
      481 gtgcaaaggc tgtgcagaga agtctgacta tatccggaag ataaatgaac tcatgcctaa
      541 atatgccccc aaggcggcca gcgcacggac tgatctgtag tctgcccagt tcctgctgca
      601 ccggagggaa acagcagttc atctgtctct tccccaaaca accattttgt aatttatttt
      661 ttaagtgggc tcctgacaat gagatgtgaa gcctggagct ctcctgatga tgatgttggc
      721 tctgccgtgc ccccctcacc cccccatccc caagtgggga ggaatttact tccttctttt
      781 gctggtttac tctaggactt caaagtttgt ctgggatttt tttattaaag aaaaaaattg
      841 tctttgga
//
