LOCUS       NM_080785               4645 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Rattus norvegicus mannosidase, endo-alpha (Manea), mRNA.
ACCESSION   NM_080785 XM_006237960 XM_346733
VERSION     NM_080785.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4645)
  AUTHORS   Jensen,K.P., Stein,M.B., Kranzler,H.R., Yang,B.Z., Farrer,L.A. and
            Gelernter,J.
  TITLE     The alpha-endomannosidase gene (MANEA) is associated with panic
            disorder and social anxiety disorder
  JOURNAL   Transl Psychiatry 4 (1), e353 (2014)
   PUBMED   24473444
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4645)
  AUTHORS   Farrer,L.A., Kranzler,H.R., Yu,Y., Weiss,R.D., Brady,K.T.,
            Anton,R., Cubells,J.F. and Gelernter,J.
  TITLE     Association of variants in MANEA with cocaine-related behaviors
  JOURNAL   Arch Gen Psychiatry 66 (3), 267-274 (2009)
   PUBMED   19255376
REFERENCE   3  (bases 1 to 4645)
  AUTHORS   Yu,Y., Kranzler,H.R., Panhuysen,C., Weiss,R.D., Poling,J.,
            Farrer,L.A. and Gelernter,J.
  TITLE     Substance dependence low-density whole genome association study in
            two distinct American populations
  JOURNAL   Hum Genet 123 (5), 495-506 (2008)
   PUBMED   18438686
REFERENCE   4  (bases 1 to 4645)
  AUTHORS   Stehli,J., Torossi,T. and Ziak,M.
  TITLE     Triple arginines in the cytoplasmic tail of endomannosidase are not
            essential for type II membrane topology and Golgi localization
  JOURNAL   Cell Mol Life Sci 65 (10), 1609-1619 (2008)
   PUBMED   18425413
  REMARK    GeneRIF: The presence of positively charged amino acids in the
            cytoplasmic tail is critical for Golgi localization of rat
            endomannosidase.
REFERENCE   5  (bases 1 to 4645)
  AUTHORS   Torossi,T., Fan,J.Y., Sauter-Etter,K., Roth,J. and Ziak,M.
  TITLE     Endomannosidase processes oligosaccharides of alpha1-antitrypsin
            and its naturally occurring genetic variants in the Golgi apparatus
  JOURNAL   Cell Mol Life Sci 63 (16), 1923-1932 (2006)
   PUBMED   16871372
  REMARK    GeneRIF: Endomannosidase does not discriminate the folding state og
            substrate and provides a back-up mechanism for completion of
            N-glycosylation of endoplasmic reticulum-escaped glucosylated
            glycoproteins.
REFERENCE   6  (bases 1 to 4645)
  AUTHORS   Hamilton,S.R., Li,H., Wischnewski,H., Prasad,A.,
            Kerley-Hamilton,J.S., Mitchell,T., Walling,A.J., Davidson,R.C.,
            Wildt,S. and Gerngross,T.U.
  TITLE     Intact {alpha}-1,2-endomannosidase is a typical type II membrane
            protein
  JOURNAL   Glycobiology 15 (6), 615-624 (2005)
   PUBMED   15677381
  REMARK    GeneRIF: We have cloned two novel endomannosidase sequences from
            rat and human cDNA libraries [and] confirm that endomannosidase is
            a type II membrane protein, like the majority of other secretory
            pathway glycosylation enzymes
REFERENCE   7  (bases 1 to 4645)
  AUTHORS   Spiro,M.J., Bhoyroo,V.D. and Spiro,R.G.
  TITLE     Molecular cloning and expression of rat liver
            endo-alpha-mannosidase, an N-linked oligosaccharide processing
            enzyme
  JOURNAL   J Biol Chem 272 (46), 29356-29363 (1997)
   PUBMED   9361017
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On or before Sep 1, 2022 this sequence version replaced
            XM_006237960.3, NM_080785.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ223109.1, SRR26360172.363068.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-272               JAXUCZ010000005.1  45014813-45015084   c
            273-854             JAXUCZ010000005.1  45008145-45008726   c
            855-964             JAXUCZ010000005.1  45004365-45004474   c
            965-1041            JAXUCZ010000005.1  44997328-44997404   c
            1042-4645           JAXUCZ010000005.1  44992937-44996540   c
FEATURES             Location/Qualifiers
     source          1..4645
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q21"
     gene            1..4645
                     /gene="Manea"
                     /gene_synonym="Enman"
                     /note="mannosidase, endo-alpha"
                     /db_xref="GeneID:140808"
                     /db_xref="RGD:620327"
     exon            1..272
                     /gene="Manea"
                     /gene_synonym="Enman"
                     /inference="alignment:Splign:2.1.0"
     exon            273..854
                     /gene="Manea"
                     /gene_synonym="Enman"
                     /inference="alignment:Splign:2.1.0"
     CDS             311..1699
                     /gene="Manea"
                     /gene_synonym="Enman"
                     /EC_number="3.2.1.130"
                     /note="rEndo; endomannosidase; endo-alpha mannosidase;
                     endo-alpha-D-mannosidase"
                     /codon_start=1
                     /product="glycoprotein endo-alpha-1,2-mannosidase"
                     /protein_id="NP_542963.2"
                     /db_xref="GeneID:140808"
                     /db_xref="RGD:620327"
                     /translation="MAKFRRRTCIILSLFIVFIFSLMMGLKMLWPNAASFGPPFGLDL
                     LPELRPPNTHLENKADFQRSDRIDMETNTKDLKGAGVTVHPPRASEVNLEELPPLNYF
                     VHAFYYSWYGNPQFDGKYVHWNHPVLEHWDPRIAKNYPQGRHSPPDDIGSSFYPELGS
                     YSSRDPSVIETHMKQMRSASIGVLALSWYPPDASDENGEATDYLVPTILDKAHKYNLK
                     VTFHIEPYSNRDDQNMHQNVKYIIDKYGNHPAFYRYKTRMGHSLPMFYIYDSYITKPK
                     TWANLLTPSGSQSVRGSPYDGLFIALLVEEKHKYDILQSGFDGIYTYFATNGFTYGSS
                     HQNWNKLKSFCEKNNMIFIPSVGPGYIDTSIRPWNTQNTRNRINGKYYEVGLSAALQT
                     QPSLISITSFNEWHEGTQIEKAVPKRTANTVYLDYRPHKPSLYLEITRKWSEKYSKER
                     MTYALDQQLPAS"
     exon            855..964
                     /gene="Manea"
                     /gene_synonym="Enman"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1041
                     /gene="Manea"
                     /gene_synonym="Enman"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..4645
                     /gene="Manea"
                     /gene_synonym="Enman"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccccgcgc tgtcctttgg gaggcgggac tttggggcct gtggcgagca ctgtcagcga
       61 taacagaact cgcgattctt tcggccagac gcgggttagc agttgggtgg tcccggtgcc
      121 aaggcccaca gggactccgc agctatcacc tgcgtgcttg cccgtcagcc aatcgtgggc
      181 cccctgactg cggcaccctt tgaccccggg ccttcaggaa tccagtcccg ctcagcccag
      241 cagcccggct ccgcgccggt ccccgcctct agcaaagcgt ttactagatt ggagtgtaaa
      301 gtatgtcatc atggcaaaat tccgaagaag gacctgcatc attttgtcac tttttattgt
      361 atttattttc tctctgatga tgggcttaaa gatgctgtgg ccaaacgcag catcctttgg
      421 acctccgttt ggacttgacc tccttccaga actccgtcca ccgaataccc acttggaaaa
      481 caaagccgac ttccaaagga gtgatcgaat cgacatggaa acaaacacca aggatttgaa
      541 aggggctggt gtgactgtgc acccacccag agcctctgag gtgaacctgg aagaactgcc
      601 tccactgaac tattttgtac atgcatttta ttacagttgg tatggaaacc cacagttcga
      661 tggtaaatac gtacactgga accatccagt cctggaacac tgggacccta gaatagccaa
      721 gaactatcca caaggaagac atagtcctcc agatgacatt ggctccagtt tttatcctga
      781 gttaggaagt tacagctccc gagacccttc tgtcatagaa actcacatga aacaaatgcg
      841 ctcagcctcc attggagtac tggccctgtc ttggtaccca cctgatgcaa gtgacgagaa
      901 tggagaagct actgattact tggtaccaac tattttggat aaagctcata aatataatct
      961 gaaggtcact tttcacatag aaccatatag caatcgagat gaccaaaaca tgcatcaaaa
     1021 tgtgaagtat attatagaca agtatggaaa ccatccagcc ttttataggt acaagaccag
     1081 gatggggcat tctctaccca tgttttatat ctatgattct tatatcacaa agcctaaaac
     1141 atgggccaat ctattaacac cctcaggatc tcagagtgtt cgcggttctc cttatgatgg
     1201 cttgtttatt gcacttctag tagaagaaaa gcataaatac gatattcttc aaagtggttt
     1261 tgatggaatt tacacatatt ttgccacaaa tggctttaca tatggctcat ctcatcagaa
     1321 ttggaataaa ctgaaatcat tttgtgaaaa gaacaacatg atatttatcc caagtgtagg
     1381 cccaggatac atagatacaa gcatccgtcc atggaacact cagaacaccc ggaacagaat
     1441 caatgggaaa tattatgaag ttggactaag cgctgcactc cagacccagc ccagtttaat
     1501 ctccatcacc tctttcaatg agtggcatga agggactcaa atcgaaaagg ctgtccccaa
     1561 aagaactgct aacacggtat acctggatta ccggcctcat aagccaagtc tttacctaga
     1621 aataactcga aaatggtctg aaaaatacag taaggaaaga atgacgtatg cattggatca
     1681 acagctgcct gcttcataat gtacctctta tagtctgtca agactcctag cttcagtcaa
     1741 cacactatat tatgagctat gaaaactgtc aaaatcaatg tgtgcttgct actgtaacct
     1801 ttatcagtta tttcattttt actttttaaa agattcattt ttctacaatg gacagtacct
     1861 tacagaaaca tctaacaaga taagttctgt cagtaacatt cctgatggta tagttttctg
     1921 aatttctgac tattattgaa atcttaatgg agttgccttg tttttgtttc acattaagaa
     1981 aatgattgta ttacattaca aaaagcagct aacagctaat gttcaggtaa gtcatacttg
     2041 tattctgggt ccaaagacat aggagtatgt acatgttagg tacatctggc aacagaagtt
     2101 cagacctaaa ggacagtaag tgaatgtgct tcatttctgg actctttggt gaagtttgtt
     2161 aatattcaga gtctggttgg cttcccctgg tgatccagct cacttttcaa gtttgttgtg
     2221 aacacagacc tgtttaagta aaaagtcctt ttatcacatt tttctgtttc tgttagccat
     2281 ggtctgttga agaatgcctg tgtaggcatc catcagtgtc agtgttcgaa gactcgggtg
     2341 cctatggtgc taagtgcttt tgcatgttga atgctcctgg attgttctgc tgaactaaaa
     2401 actagaaaca ataggtagtt tgttaaatgt tcatgactgt ttctaatata tgagaaaaat
     2461 aattgtttaa gagtggttaa aatttaatgt tcaccagaga ctactgaacg gactttgaaa
     2521 ggataatgtt aatactcaaa agtgttttcc tttcaatatt ttaatttaat tttactgtaa
     2581 tacagaaaat ttgcatatca cttcaaaaat agagatactt ttaaagtaac atcatgtatt
     2641 tcagtaatgt cctcacttta atgtcttacc cttatatagt ggctattggt ttaaaaagaa
     2701 agttaagtta gtgatccata gctgtcaagt ggttacaaat tggtaagttc tatgctaaaa
     2761 ataaattttt gtaaaaagtg aaaataaaaa ttgactgaat tcaatattta taattaaaat
     2821 agaaaaaaac agcccagcta gtatacataa ttttacacaa ctgttatttc ttagttctac
     2881 agcgagaatc atttaagtaa cactaacaag catgcctgtc ttcatagcct atagacattg
     2941 agaaacaagt aagttctgga atttatctta aaatacagag cagagaggac acagcttgat
     3001 ggtaagggtg agtgatatgt gagaaaagtt cttgttgtgc aagtatgagg gcctgagtct
     3061 gaacacctag aactcacata aacatgagct cagtagcata catgttttat tccacagctc
     3121 ctgcagtgta gacaagacag agcccaggag tgtaggaacc agttagcctt ctgtaggtag
     3181 cagcaaagaa gagatcctgt ctcaaacatg gtgggaagca aaggtcaaca ggcaaggtca
     3241 cttggacatt caaacccacc tcatgtcata ttcagtctcc ctcttactct tgaatgtttg
     3301 cagataccca cacagagctt ttttaagact tatttttaaa ataatgcttg tagactaaag
     3361 tgtttttcag gagttacact aactttatta aattaaaatt ttctatttgt aagaaaattc
     3421 ttaggacata aaaattatga gaataatagt ctgatttttc cagataaatt gtaagaatga
     3481 ttaagtgtaa tattttgata ttacacatct ccattggaat aaggagaaat ataacctata
     3541 gatttttttc tttgctttgc tactacatta aagctaatta tcaatacata gttatatagt
     3601 atatgttgtt ttcttcattc tttatattgc attttatatt tgagtccacc atgacaaaaa
     3661 gtggatgtta tgaaacaatt ctgatattaa gaaacagtct gcgaaaataa gatcaagcaa
     3721 ctgtcagtaa gaactttcac agcagacagc tcaccctagc tgttcccagt acttctccac
     3781 cccatcagta gtcagaactt aaaattagac agatgctatc tttaaagaat gtctgtctaa
     3841 caaatcactg agctatcttt tcataagaat tactagttga taattatata aataaccata
     3901 gtcacctctg tggtttccac aaccaaatat tcagccaact aaggatcaaa atacttggga
     3961 acaaaagtcc atttgtatat aacaaacatg tttagtgtgt ttccatccca taagccagat
     4021 agtataacta ccatttatat ttttctaggt attataaata agctgagaga gtttaaagta
     4081 tacctgaaga tcattgtgtg gtatattcca atccggttcc attttttaaa ggaacctaag
     4141 catattcagc cgtttttacc tgtgcaccct aaagccagtt ccacacaaat accaacggag
     4201 tgctatattc ccaacattgc tagtgactgt tagaggatgc cttcagagcc tctttcctga
     4261 gtgtccttta cctctgctgt ctgactggaa acacagctag aattacaatg atcacaagta
     4321 aatctcaaca aatgatccca ttcttttgta aatctgaaat gttagaatcc agtaaactta
     4381 aagatgtata atatgtgtaa tgcatgaatt agaatcagat ttttataagg gttttgattt
     4441 tttggattaa tccatcgaat tgtttagaat gtagaaaaga acaatatcct tatttcttct
     4501 tttaatactt aattgtaaaa tctgaccctt ttaatgttta cttgagtttt atattaactt
     4561 gcttatttat gtgtgtaaat tgggaaatgg tttattttat tatatgatgt taattttatc
     4621 taataaaagc ataaatgaaa gtaaa
//
