LOCUS       NM_001031655            3665 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus mannosidase beta (Manba), mRNA.
ACCESSION   NM_001031655 XM_227701
VERSION     NM_001031655.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3665)
  AUTHORS   Gytz,H., Liang,J., Liang,Y., Gorelik,A., Illes,K. and Nagar,B.
  TITLE     The structure of mammalian beta-mannosidase provides insight into
            beta-mannosidosis and nystagmus
  JOURNAL   FEBS J 286 (7), 1319-1331 (2019)
   PUBMED   30552791
REFERENCE   2  (bases 1 to 3665)
  AUTHORS   Boonen,M., Vogel,P., Platt,K.A., Dahms,N. and Kornfeld,S.
  TITLE     Mice lacking mannose 6-phosphate uncovering enzyme activity have a
            milder phenotype than mice deficient for
            N-acetylglucosamine-1-phosphotransferase activity
  JOURNAL   Mol Biol Cell 20 (20), 4381-4389 (2009)
   PUBMED   19710420
REFERENCE   3  (bases 1 to 3665)
  AUTHORS   Zhu,M., Lovell,K.L., Patterson,J.S., Saunders,T.L., Hughes,E.D. and
            Friderici,K.H.
  TITLE     Beta-mannosidosis mice: a model for the human lysosomal storage
            disease
  JOURNAL   Hum Mol Genet 15 (3), 493-500 (2006)
   PUBMED   16377659
REFERENCE   4  (bases 1 to 3665)
  AUTHORS   Sleat,D.E., Sohar,I., Lackland,H., Majercak,J. and Lobel,P.
  TITLE     Rat brain contains high levels of mannose-6-phosphorylated
            glycoproteins including lysosomal enzymes and palmitoyl-protein
            thioesterase, an enzyme implicated in infantile neuronal
            lipofuscinosis
  JOURNAL   J Biol Chem 271 (32), 19191-19198 (1996)
   PUBMED   8702598
REFERENCE   5  (bases 1 to 3665)
  AUTHORS   Lundin,L.G.
  TITLE     A gene (Bmn) controlling beta-mannosidase activity in the mouse is
            located in the distal part of chromosome 3
  JOURNAL   Biochem Genet 25 (7-8), 603-610 (1987)
   PUBMED   3447593
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001031655.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099094.1, SRR26360172.2372624.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               JAXUCZ010000002.1  226583968-226584159
            193-287             JAXUCZ010000002.1  226601997-226602091
            288-393             JAXUCZ010000002.1  226604755-226604860
            394-564             JAXUCZ010000002.1  226605586-226605756
            565-688             JAXUCZ010000002.1  226611978-226612101
            689-864             JAXUCZ010000002.1  226616243-226616418
            865-975             JAXUCZ010000002.1  226617855-226617965
            976-1127            JAXUCZ010000002.1  226640765-226640916
            1128-1245           JAXUCZ010000002.1  226644337-226644454
            1246-1332           JAXUCZ010000002.1  226645920-226646006
            1333-1500           JAXUCZ010000002.1  226646886-226647053
            1501-1719           JAXUCZ010000002.1  226648395-226648613
            1720-1884           JAXUCZ010000002.1  226653059-226653223
            1885-2029           JAXUCZ010000002.1  226668286-226668430
            2030-2172           JAXUCZ010000002.1  226671470-226671612
            2173-2430           JAXUCZ010000002.1  226672440-226672697
            2431-3665           JAXUCZ010000002.1  226675286-226676520
FEATURES             Location/Qualifiers
     source          1..3665
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q43"
     gene            1..3665
                     /gene="Manba"
                     /note="mannosidase beta"
                     /db_xref="GeneID:310864"
                     /db_xref="RGD:1305785"
     exon            1..192
                     /gene="Manba"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..2661
                     /gene="Manba"
                     /EC_number="3.2.1.25"
                     /note="beta-mannosidase; mannase; mannanase; lysosomal
                     beta A mannosidase; mannosidase, beta A, lysosomal;
                     mannosidase beta A"
                     /codon_start=1
                     /product="beta-mannosidase precursor"
                     /protein_id="NP_001026825.1"
                     /db_xref="GeneID:310864"
                     /db_xref="RGD:1305785"
                     /translation="MHLHLLFLLALCGAGCMAAGPSYSLRGSWRVSNGNSSLELPATV
                     PGYVHSALQQHGLIQDPYYRFNDLNYRWISLDNWTYSTEFKIPFNRSEWQKVKLIFDG
                     VDTVAEILFNNVTIGKTDNMFTRYSFDVTNVVKDVNSLKLRFQSAVQYAECQSKAHTQ
                     YRVPPECPPVEQKGECHVNFIRKEQCSFSWDWGPSFPSQGIWKDVRIEAYNIAHLDHL
                     TFLPLYDNTSQAWTIEIEASFDVVSTKPVGGQVTIAIPELKTQQANHIELQHGQRIVK
                     LLVKIRKDVTVETWWPHGHGNQTGYNTTILFALDGGLKIEKAAKVYFRTVQLIEEPIT
                     GSPGLSFYFKINGLPIFLKGSNWIPADSFQDKVTSELLQLLLQSAVDANMNTLRVWGG
                     GIYEQDEFYALCDELGIMVWQDFMFASALYPTEPGFLESVRKEVTYQVRRLKSHPSVI
                     IWSGNNENEVALRVNWFHVNPRDLGTYINDYVTLYVKTIREIVLSEDRSRPFIASSPT
                     NGVKTMTEGWISKDPYSTQYGDMHFYDYFSDCWDWKVFPKARLVSEYGYQSWPSFSTL
                     QKVSRQEDWSYSSRFSLHRQHHGNGNNEMLHQVQLHFQLPQRRDPVRAFKDTIYLTQV
                     MQAQCIKTETEFYLRSRSEIVNGEGHTMGALYWQLNDIWQAPSWASLEYGGKWKMLHY
                     FAQRFFAPLLPVGFEDEGVFYVYGVSDLHKDYPTKLTVRLHRWSSQKPLCTFVSLSAV
                     IKAGEAMVLFQMPVSKLLKRCKECTRDTCVVSFYLSTDNELFSPTNYHFLSSLKDAKG
                     MVKANITVSISQKGDLFVFDLKSSTSAITPFVWLDVGSIPGRFSDNGFLMIKKELSVL
                     FYPWKPTSKSELQQAFSVTSLTDLY"
     exon            193..287
                     /gene="Manba"
                     /inference="alignment:Splign:2.1.0"
     exon            288..393
                     /gene="Manba"
                     /inference="alignment:Splign:2.1.0"
     exon            394..564
                     /gene="Manba"
                     /inference="alignment:Splign:2.1.0"
     exon            565..688
                     /gene="Manba"
                     /inference="alignment:Splign:2.1.0"
     exon            689..864
                     /gene="Manba"
                     /inference="alignment:Splign:2.1.0"
     exon            865..975
                     /gene="Manba"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1127
                     /gene="Manba"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1245
                     /gene="Manba"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1332
                     /gene="Manba"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1500
                     /gene="Manba"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1719
                     /gene="Manba"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1884
                     /gene="Manba"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..2029
                     /gene="Manba"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2172
                     /gene="Manba"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2430
                     /gene="Manba"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..3665
                     /gene="Manba"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgcgagcgg tcagcatgca tctccacctg ctctttctgt tggcgctgtg cggggcaggc
       61 tgtatggccg caggtcccag ctacagcctg agagggagct ggcgggtgag caacgggaat
      121 agttccctgg agctgccggc tactgtccct ggctatgtgc acagcgccct gcagcagcac
      181 gggctgatcc aggatcctta ctacagattt aatgacctga actacagatg gatttcctta
      241 gataactgga cctacagcac agaatttaaa atccccttta atcgcagtga atggcagaag
      301 gtaaagttga tttttgacgg agtcgataca gttgcagaaa tcctgttcaa taatgtcact
      361 attgggaaga cagacaacat gttcaccaga tatagctttg acgtcaccaa tgtggtcaaa
      421 gacgtgaact ccctaaagct gcggttccag tcagcagtgc agtatgctga gtgtcagagc
      481 aaagctcaca ctcaataccg ggtgccccca gagtgccccc cagtggaaca gaagggtgaa
      541 tgccacgtca acttcatccg aaaggagcag tgctccttca gctgggactg ggggccttcc
      601 tttccctctc aaggaatctg gaaagacgtt agaatcgaag cctataacat cgctcatctg
      661 gatcacctga catttttgcc attgtatgat aacacttctc aggcgtggac tattgaaata
      721 gaggcttctt ttgatgttgt cagcacaaag ccagttggtg gtcaggtgac tatagccatc
      781 cccgaactga aaacacagca ggcaaaccac attgaacttc aacatgggca aaggattgtt
      841 aaactccttg tcaaaattag gaaggacgtc accgtggaga cctggtggcc tcatggacat
      901 gggaaccaga ctgggtacaa cacgacaatt ctctttgcgc tggatggagg cttaaaaatt
      961 gaaaaagcag ccaaggttta tttcagaaca gtgcaactta tagaagaacc tataacaggg
     1021 tctcctggtc tgagtttcta cttcaaaatt aatgggcttc ctatatttct gaaaggctca
     1081 aactggatcc cagctgactc attccaagac aaagtcactt ctgaactgct gcagctcctt
     1141 ctccagtccg ccgtggatgc taacatgaac actctgcgcg tgtggggggg tggcatctac
     1201 gagcaggatg aattctatgc actgtgtgac gaacttggaa taatggtgtg gcaggacttc
     1261 atgtttgcca gtgccctcta tccaactgag ccaggcttcc tagagtcagt gagaaaagaa
     1321 gtcacttacc aggtcaggag actgaagtct cacccctccg tcatcatctg gagtggtaat
     1381 aatgagaatg aagtggctct cagggtgaac tggttccatg taaaccccag ggacctgggg
     1441 acttacatca acgactatgt gaccctctac gtgaaaacca tcagggagat tgtcttatcg
     1501 gaagatagga gtcgtccgtt cattgcatcc agcccaacca atggggtcaa aaccatgacg
     1561 gaaggctgga tctctaagga cccttatagc acccagtatg gcgacatgca tttttacgac
     1621 tatttcagtg actgctggga ctggaaggtc tttccaaaag ctcgattagt gtctgaatat
     1681 ggctaccagt cctggccttc cttcagcaca ctacaaaagg tctctcgtca agaggactgg
     1741 tcttacagca gccgcttctc ccttcatcgg cagcatcatg gaaatggcaa caatgaaatg
     1801 cttcaccagg tacagcttca tttccaactc ccccaaagga gagacccagt gcgtgcattt
     1861 aaagatacca tctacctcac tcaggtgatg caggcccagt gtatcaaaac agaaaccgag
     1921 ttctacctgc gcagccgcag cgagatagtg aatggagaag gccacaccat gggggcactg
     1981 tactggcagc tgaatgatat ctggcaggct ccttcctggg cctctcttga gtacggaggg
     2041 aaatggaaaa tgcttcatta cttcgctcag cgtttcttcg ctccgctgct gccagtcggt
     2101 tttgaagatg aaggcgtttt ttatgtctac ggtgtgtcag atcttcacaa ggactacccc
     2161 acaaagctca ccgtgaggct ccaccgctgg agctcccaga agcctttgtg caccttcgtg
     2221 agtttgagtg ctgtgattaa ggcaggggag gcgatggttc tgttccagat gccagtgtct
     2281 aagctgctga agaggtgtaa agaatgcaca agggacacct gtgtggtttc cttttacctc
     2341 tcaactgaca atgaactctt cagtccaacc aactaccatt tcctgtcctc cctgaaggat
     2401 gccaaaggga tggtcaaggc caacatcact gtcagcatct ctcagaaggg tgatctattt
     2461 gtttttgatc tgaaatcgtc aacatcagcc atcactccct ttgtttggtt ggatgtagga
     2521 agcatcccgg ggagatttag tgacaacggc ttcctcatga ttaagaagga gctctcggta
     2581 ctgttttacc catggaagcc caccagcaag agtgagctgc agcaggcctt cagtgtcacc
     2641 tccctgacag atctgtactg aagggacgtg agttgtattt tggtggacac tggggacgaa
     2701 ggctttctag agcacggttg gaggagaggc agcctgaggt aaagccaagg acatatccat
     2761 gcctgggatc tttgacttcc aactctccag tctgaacagt gactactact aatccaggtg
     2821 acatccttag acaaggtctt gcctgggttt tcttgaatct tgcaggattg tggtttttga
     2881 gaactttgtt ccacagctaa aacacatcca gaagagttat aacacctgat gaccttttgg
     2941 ggaaccacta gattgtgaca tgatgataca tgtccaacca aatgtggggg ttctgaagta
     3001 atgtaggcct ttcatagcac cacgaattct acccactgaa ggtgaagtgc gtgcctacga
     3061 ttgccagagg agatgggaac tcagatacta caacagatat tgcttgatgg cagccatatt
     3121 gattatgggt agacagagga ggggcctgaa tgttgtattt gattaccatc tccatgaagg
     3181 attccctttt tcatatggtt tgtcaataac tctttttatt taaagaccaa gaaagtgatc
     3241 tttctttaaa aagcagtcta ggttgattgt gctggtacct tcctatagtt ccggcactct
     3301 gggggcagag gcaggaggat cacaagttca aagttggccc tgactacact gtagaatttt
     3361 tcacctctct tggttctgag tgttctcgtg agctttaggc ttaacactga ttctaatgaa
     3421 ctctctaatc caaaggtaac gagctacatt taaattcatt ggctctgctg gggaagtggc
     3481 aaaaaaaatg ttaataagta gctattttgg gtactggttt gtgggctttt gggtacaact
     3541 tttatacttt tctatatatt ttaaattata tgaaaaaacc ataaggttat gtaaattgca
     3601 ttgacaactt gaaagtttat ttgcactcta tttaaccatt taataaacac ttcattgcat
     3661 acaaa
//
