LOCUS       NM_139256               3239 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus mannosidase, alpha, class 2C, member 1 (Man2c1),
            mRNA.
ACCESSION   NM_139256
VERSION     NM_139256.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3239)
  AUTHORS   Bischoff,J., Moremen,K. and Lodish,H.F.
  TITLE     Isolation, characterization, and expression of cDNA encoding a rat
            liver endoplasmic reticulum alpha-mannosidase
  JOURNAL   J Biol Chem 265 (28), 17110-17117 (1990)
   PUBMED   2211613
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 24, 2020 this sequence version replaced NM_139256.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M57547.1, BC086989.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               JAXUCZ010000008.1  66434523-66434658
            137-259             JAXUCZ010000008.1  66434938-66435060
            260-383             JAXUCZ010000008.1  66435360-66435483
            384-454             JAXUCZ010000008.1  66437057-66437127
            455-632             JAXUCZ010000008.1  66438503-66438680
            633-822             JAXUCZ010000008.1  66438925-66439114
            823-929             JAXUCZ010000008.1  66440065-66440171
            930-1040            JAXUCZ010000008.1  66440331-66440441
            1041-1133           JAXUCZ010000008.1  66440646-66440738
            1134-1250           JAXUCZ010000008.1  66440854-66440970
            1251-1346           JAXUCZ010000008.1  66441184-66441279
            1347-1492           JAXUCZ010000008.1  66441360-66441505
            1493-1616           JAXUCZ010000008.1  66441812-66441935
            1617-1738           JAXUCZ010000008.1  66442248-66442369
            1739-1824           JAXUCZ010000008.1  66442462-66442547
            1825-1980           JAXUCZ010000008.1  66442633-66442788
            1981-2078           JAXUCZ010000008.1  66442993-66443090
            2079-2173           JAXUCZ010000008.1  66443241-66443335
            2174-2278           JAXUCZ010000008.1  66443570-66443674
            2279-2435           JAXUCZ010000008.1  66443863-66444019
            2436-2579           JAXUCZ010000008.1  66444109-66444252
            2580-2689           JAXUCZ010000008.1  66444561-66444670
            2690-2769           JAXUCZ010000008.1  66444775-66444854
            2770-2918           JAXUCZ010000008.1  66445013-66445161
            2919-3028           JAXUCZ010000008.1  66445248-66445357
            3029-3239           JAXUCZ010000008.1  66445438-66445648
FEATURES             Location/Qualifiers
     source          1..3239
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..3239
                     /gene="Man2c1"
                     /gene_synonym="AMAN"
                     /note="mannosidase, alpha, class 2C, member 1"
                     /db_xref="GeneID:246136"
                     /db_xref="RGD:628787"
     exon            1..136
                     /gene="Man2c1"
                     /gene_synonym="AMAN"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..3155
                     /gene="Man2c1"
                     /gene_synonym="AMAN"
                     /EC_number="3.2.1.24"
                     /note="alpha-D-mannoside mannohydrolase"
                     /codon_start=1
                     /product="alpha-mannosidase 2C1"
                     /protein_id="NP_640349.2"
                     /db_xref="GeneID:246136"
                     /db_xref="RGD:628787"
                     /translation="MAAAPFLKHWRTTFERVEKFVSPIYFTDCNLRGRLFGDSCPVTL
                     SSFLTPERLPYEKAVQQNFSPAQVGDSFGPTWWTCWFRVELVIPEVWVGKEVHLCWES
                     DGESLVWRDGEPVQGLTKEGEKTSYVLSERLHAADPRSLTLYVEVACNGLLGAGKGSM
                     IAAPDPEKMFQLSQAKLAVFHRDVHNLLVDLELLLGVAKGLGEDNQRSFQALYTANQM
                     VNICDPAQPETYPAAEALASKFFGQRGGESQHTIHATGHCHIDTAWLWPFKETVRKCA
                     RSWSTAVKLMERNTEFTFACSQAQQLEWVKNQYPGLYAQLQEFACRGQFVPVGGTWVE
                     MDGNLPSGEAMVRQFLQGQNFFLQEFGKMCSEFWLPDTFGYSAQLPQIMQGCGIKRFL
                     TQKLSWNLVNSFPHHTFFWEGLDGSQVLVHFPPGDSYGMQGSVEEVLKTVTNNRDKGR
                     TNHSGFLFGFGDGGGGPTQTMLDRLKRLGNTDGLPRVQLSSPGQLFTALERDSGQLCT
                     WVGELFLELHNGTYTTHAQLKKGNRECEQILHDVELLSSLALARSAQFLYPAVQLQRL
                     WRLLLLNQFHDVVTGSCIQLVAEDAMNYYEDIRSHGNTLLSAAAAALCAGEPGPKGLL
                     IINTLPWKRTEVLALPKPCGAHSLALVTVPSIGYAPAPTPTSLQPLLPQQPVFVMQET
                     DGSVTLDNGIIRVRLDPTGCLTSLVLVASGREAIAEGALGNQFVLFDDVPLYWDAWDV
                     MDYHLETRKPVRGQAGTLAVGAEGGLRGSAWFLLQISPNSRLSQEVVLDVGCPYVRFH
                     TEVHWHETHKFLKVEFPARVRSPQATYEIQFGHLQRPTHNNTSWDWARYEVWAHRWID
                     LSECDFGLALLNNCKYGTSVRGNVLSLSLLRAPKAPDVTADMGRHEFTYALMPHKGSF
                     QEAGVIQAAYNLNFPLLALPAPGPAPDTTWSAFSVSSPAVVLETIKQAEKSHQHRTLV
                     LRLYEAHGSHVDCWLHTSLPVQEATLCDLLEQRDPTGHLSLQDNRLKLTFSPFQVRSL
                     LLVLQPPAN"
     exon            137..259
                     /gene="Man2c1"
                     /gene_synonym="AMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            260..383
                     /gene="Man2c1"
                     /gene_synonym="AMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            384..454
                     /gene="Man2c1"
                     /gene_synonym="AMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            455..632
                     /gene="Man2c1"
                     /gene_synonym="AMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            633..822
                     /gene="Man2c1"
                     /gene_synonym="AMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            823..929
                     /gene="Man2c1"
                     /gene_synonym="AMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1040
                     /gene="Man2c1"
                     /gene_synonym="AMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1133
                     /gene="Man2c1"
                     /gene_synonym="AMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1250
                     /gene="Man2c1"
                     /gene_synonym="AMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1346
                     /gene="Man2c1"
                     /gene_synonym="AMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1492
                     /gene="Man2c1"
                     /gene_synonym="AMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1616
                     /gene="Man2c1"
                     /gene_synonym="AMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1738
                     /gene="Man2c1"
                     /gene_synonym="AMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1824
                     /gene="Man2c1"
                     /gene_synonym="AMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1980
                     /gene="Man2c1"
                     /gene_synonym="AMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2078
                     /gene="Man2c1"
                     /gene_synonym="AMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2173
                     /gene="Man2c1"
                     /gene_synonym="AMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2278
                     /gene="Man2c1"
                     /gene_synonym="AMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2435
                     /gene="Man2c1"
                     /gene_synonym="AMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..2579
                     /gene="Man2c1"
                     /gene_synonym="AMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            2580..2689
                     /gene="Man2c1"
                     /gene_synonym="AMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            2690..2769
                     /gene="Man2c1"
                     /gene_synonym="AMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            2770..2918
                     /gene="Man2c1"
                     /gene_synonym="AMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            2919..3028
                     /gene="Man2c1"
                     /gene_synonym="AMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            3029..3239
                     /gene="Man2c1"
                     /gene_synonym="AMAN"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accaaggatc ttccgggaag ggaaggtgca tcgtcatggc ggcagcgccg ttcttgaagc
       61 actggcgcac cacttttgag cgggtggaga agttcgtgtc cccgatctac ttcaccgact
      121 gtaaccttcg cggcaggctc ttcggggaca gctgcccggt gacactctcc agcttcctga
      181 cgccggaaag gcttccctat gagaaggcag tgcagcagaa cttcagccct gcgcaggtcg
      241 gcgacagctt cggacccaca tggtggacct gctggtttcg ggtagaactg gtcatccctg
      301 aagtttgggt gggcaaggaa gttcatcttt gctgggaaag tgatggagaa agccttgtct
      361 ggcgtgatgg ggaacctgtc cagggtttga ccaaggaggg tgaaaagact agttatgtcc
      421 tgagtgagag gctgcacgca gcagatcctc ggagcttgac tctctatgtg gaagtagcct
      481 gcaatgggct tctgggagcc gggaagggaa gcatgatcgc agcccctgac cctgagaaga
      541 tgttccagct gagccaggct aagctggctg tgttccaccg ggatgtccac aatctcctgg
      601 tggacctgga gctgttgctg ggtgtggcca agggcctcgg ggaggacaac cagcgcagct
      661 tccaggccct gtacacagcc aaccagatgg tgaacatatg tgaccctgcg cagcctgaga
      721 cttacccagc agccgaggcc ctggcctcca agttctttgg ccaacgtgga ggtgaaagcc
      781 agcataccat ccatgcaaca ggacactgtc acattgatac agcctggctt tggcccttca
      841 aggagactgt gaggaaatgt gcccggagct ggtcaacagc tgtgaagctc atggagcgga
      901 acactgagtt cacctttgcc tgctctcagg cacaacagct cgagtgggta aagaaccaat
      961 accctggtct gtatgcccag ctccaggagt ttgcctgccg aggacagttt gtgcctgtgg
     1021 ggggcacctg ggtagaaatg gatgggaacc ttcccagtgg agaggccatg gtgaggcagt
     1081 tcctacaggg ccagaacttc tttctgcaag agtttggaaa gatgtgctct gagttctggc
     1141 tgccagatac atttggctac tcagcacagc tcccccagat catgcaaggc tgtggcatca
     1201 aacgcttcct gacacagaaa ctgagctgga acttggtcaa ctccttccca caccatacct
     1261 tcttctggga ggggctggat ggctcccaag tgctggtaca cttcccccct ggagactcat
     1321 atggaatgca gggcagtgtg gaagaggtgc tgaagactgt gaccaacaac cgggacaagg
     1381 gacggaccaa ccacagtggc ttcctctttg gcttcgggga tgggggtggt ggccccacac
     1441 agaccatgtt ggaccgattg aagcggctgg gcaacactga tgggctgccc agggtgcagc
     1501 tgtcttctcc tggacagctc ttcacagcac tggagagaga ctcagggcag ctgtgcacat
     1561 gggttgggga actcttcttg gagctgcaca atggcaccta tactacccat gcccagctca
     1621 agaaggggaa ccgagaatgt gagcagattc ttcatgacgt ggagctgctc agcagccttg
     1681 ccctagcccg aagtgcccag ttcctgtacc cggcagtcca gctgcagcgc ctctggaggc
     1741 tcctactcct caaccagttc catgatgtgg tgactggaag ctgcattcag ctggtggcag
     1801 aagatgccat gaactactat gaagacatcc gttctcatgg caatacgctg ctcagtgctg
     1861 cagccgcagc cttgtgtgct ggggagccag gtcccaaggg cctcctcatt atcaacacac
     1921 tgccctggaa gcgcacagaa gtgttggcac tacccaagcc ttgtggggct cacagcctag
     1981 ccctggtgac agtgcccagt attggctatg ctcctgctcc cacccctact tcactgcagc
     2041 ccctcctacc ccagcagccc gtgtttgtga tgcaggagac tgacggttcc gtgacgctgg
     2101 acaatggcat catccgggtg agactggatc caactggctg tcttacttcc ctggtcctgg
     2161 tggcttctgg cagggaagcc attgctgagg gtgccctggg gaaccagttt gtgctgtttg
     2221 atgatgtgcc actgtactgg gatgcatggg acgtcatgga ctaccatcta gagacacgga
     2281 agcctgtgcg gggccaggca ggtaccctgg cagtaggcgc tgaaggtggc cttcggggta
     2341 gtgcctggtt cctgctacag atcagcccca acagtcggct cagccaggaa gtcgtgctgg
     2401 atgttggttg cccctatgtc cgcttccaca cggaggtgca ctggcacgag acccacaagt
     2461 tcctgaaggt ggagttcccc gctcgagtac ggagccccca ggctacctat gagatccagt
     2521 ttgggcacct tcagaggccg acccacaaca acacctcctg ggactgggct cgctatgagg
     2581 tgtgggctca tcgctggata gatctgtccg agtgtgactt tgggctggcc ctgctcaaca
     2641 actgcaagta tggaacgtca gtacgaggca acgtcctcag cctctcactg ctgcgtgcac
     2701 ccaaggctcc agatgttact gctgacatgg ggcgccatga attcacttat gccttgatgc
     2761 cacacaaggg ttctttccaa gaagctggtg ttatccaggc tgcctacaac ctcaactttc
     2821 ccctcttggc actgccagct ccaggcccag cccctgatac cacctggagc gccttttccg
     2881 tgtcttcacc agcagtcgtg ttggagacca tcaagcaggc cgagaagagc catcagcacc
     2941 gcacactggt tctaaggctg tatgaggctc atggcagcca tgtggactgc tggctacaca
     3001 catcattgcc tgttcaggag gccacccttt gtgacctcct ggagcagcga gaccctaccg
     3061 gtcacctgtc ccttcaggac aaccgcctga agctcacctt ttctcccttt caagtgaggt
     3121 ccttattgct cgtgcttcag cctccagcaa actgagtctc ggctgtggaa agctttgggg
     3181 gctcctcgtc tccacctccc aagtctgaag catcttgtgc aataaatgct tagatcagc
//
