LOCUS       NM_001134971            3225 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus mannosidase, alpha, class 2B, member 2 (Man2b2),
            mRNA.
ACCESSION   NM_001134971
VERSION     NM_001134971.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3225)
  AUTHORS   Abonnenc M, Nabeebaccus AA, Mayr U, Barallobre-Barreiro J, Dong X,
            Cuello F, Sur S, Drozdov I, Langley SR, Lu R, Stathopoulou K,
            Didangelos A, Yin X, Zimmermann WH, Shah AM, Zampetaki A and Mayr
            M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   2  (bases 1 to 3225)
  AUTHORS   Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M,
            Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail
            S, Li P and Sutton G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   3  (bases 1 to 3225)
  AUTHORS   Haeuw JF, Grard T, Alonso C, Strecker G and Michalski JC.
  TITLE     The core-specific lysosomal alpha(1-6)-mannosidase activity depends
            on aspartamidohydrolase activity
  JOURNAL   Biochem J 297 (Pt 3) (Pt 3), 463-466 (1994)
   PUBMED   8110182
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000254.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001134971.4.
            
            On Nov 27, 2020 this sequence version replaced NM_001134971.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168692.1, SRR8487231.72913.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               JACYVU010000254.1  27670417-27670556
            141-287             JACYVU010000254.1  27671221-27671367
            288-393             JACYVU010000254.1  27673019-27673124
            394-566             JACYVU010000254.1  27676573-27676745
            567-682             JACYVU010000254.1  27678502-27678617
            683-860             JACYVU010000254.1  27680238-27680415
            861-1059            JACYVU010000254.1  27681198-27681396
            1060-1250           JACYVU010000254.1  27683549-27683739
            1251-1392           JACYVU010000254.1  27684515-27684656
            1393-1526           JACYVU010000254.1  27685999-27686132
            1527-1801           JACYVU010000254.1  27686609-27686883
            1802-1993           JACYVU010000254.1  27687595-27687786
            1994-2246           JACYVU010000254.1  27688160-27688412
            2247-2357           JACYVU010000254.1  27688676-27688786
            2358-2574           JACYVU010000254.1  27688871-27689087
            2575-2691           JACYVU010000254.1  27691733-27691849
            2692-2804           JACYVU010000254.1  27693027-27693139
            2805-2922           JACYVU010000254.1  27694451-27694568
            2923-3225           JACYVU010000254.1  27695125-27695427
FEATURES             Location/Qualifiers
     source          1..3225
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..3225
                     /gene="Man2b2"
                     /gene_synonym="Ab2-450"
                     /note="mannosidase, alpha, class 2B, member 2"
                     /db_xref="GeneID:360955"
                     /db_xref="RGD:1308840"
     exon            1..140
                     /gene="Man2b2"
                     /gene_synonym="Ab2-450"
                     /inference="alignment:Splign:2.1.0"
     CDS             3..3017
                     /gene="Man2b2"
                     /gene_synonym="Ab2-450"
                     /EC_number="3.2.1.24"
                     /note="mannosidase 2, alpha B2; epididymis-specific
                     alpha-mannosidase"
                     /codon_start=1
                     /product="epididymis-specific alpha-mannosidase precursor"
                     /protein_id="NP_001128443.2"
                     /db_xref="GeneID:360955"
                     /db_xref="RGD:1308840"
                     /translation="MGLLRWLPLLGQLLLLWPLAARPASPIRAFVVPHSHMDVGWVYT
                     VQESMRAYAANVYTTVVEELVRGRQRRFIAVEQEFFRLWWDGVASEQQKQQVRQLLDE
                     GRLEFVLGGQVMHDEAVTHLDDQILQLTEGHGFLYETFGIRPQFSWHVDPFGASATTP
                     TLFALAGFNAHLISRIDYDLKDAMQEAQGLQFVWHGSPSLSEQQEIYTHVMDLYSYCT
                     PSHIPFSNRSGFYWNGVAVFPEPPPDGVYPNMSEPVTVDNIHLYAEALVANVKQRAAW
                     FRTPHVLWPWGCDKQFFNASVQFDNMDPLLEYINNRSAQFGISVQYATLNDYFQALHD
                     FNVTWDIRDHHDFLPYSSEPQQAWTGFFTSRSTLKGLARQASALLYAGESMFTRYMWP
                     HPRGTLDPTWALQQLQQLRWAVSEVQHHDAITGTESPKVKNMYMEHLSMGMRGVHKLM
                     ASIALDRPPGSGTDTRPVGYSASVYNPLAWKITTIITLTVAFPSVSVTDELGRPVSAQ
                     IQNSTKDPSAYDLLILTTIPGLSYRHYKVRRTRGDQAGTRELVTPRANTLKFSRKLRN
                     QTSQEGKLLVPVMNDCYTLLFDQDTNMLHSIQDRQSNRTVHMTQEFLEYRANGDVKQG
                     PISDNYLFASNDTAEPSWEAVGMEMVVGTLATDVRQYFYRNITDQGYIYSIHTRLAHV
                     HPSLAGELLCRRIEQQYQVGPLDLNREAILRTSSDLNSQQVLYSDNNGYQMQRRPYKA
                     FKSNPIPRNYYPMVQSAFIEDDKSRLVLLAERPHGVSSQENGQVEVMLHRRLWNNLVW
                     DLNYNLTLNDTSVVHPVLWLLLGPKSTTTALRPRSGVALQHRPVVLLKELTDEEETAI
                     HRPHHPWPVTLPPSLHLQVLSLPGWQYSRNHAQHLKNLQRGHPEKPQVNLQRVLLRLH
                     HLYEAGEDPVLSRPATVDLKIALRGLGSVVAVEERSLTGTWDVQTLQRWHWRTKIGQL
                     KGHPTSPPRSPGGSIITVYPKEIRTFFIYLQQ"
     exon            141..287
                     /gene="Man2b2"
                     /gene_synonym="Ab2-450"
                     /inference="alignment:Splign:2.1.0"
     exon            288..393
                     /gene="Man2b2"
                     /gene_synonym="Ab2-450"
                     /inference="alignment:Splign:2.1.0"
     exon            394..566
                     /gene="Man2b2"
                     /gene_synonym="Ab2-450"
                     /inference="alignment:Splign:2.1.0"
     exon            567..682
                     /gene="Man2b2"
                     /gene_synonym="Ab2-450"
                     /inference="alignment:Splign:2.1.0"
     exon            683..860
                     /gene="Man2b2"
                     /gene_synonym="Ab2-450"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1059
                     /gene="Man2b2"
                     /gene_synonym="Ab2-450"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1250
                     /gene="Man2b2"
                     /gene_synonym="Ab2-450"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1392
                     /gene="Man2b2"
                     /gene_synonym="Ab2-450"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1526
                     /gene="Man2b2"
                     /gene_synonym="Ab2-450"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1801
                     /gene="Man2b2"
                     /gene_synonym="Ab2-450"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..1993
                     /gene="Man2b2"
                     /gene_synonym="Ab2-450"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2246
                     /gene="Man2b2"
                     /gene_synonym="Ab2-450"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2357
                     /gene="Man2b2"
                     /gene_synonym="Ab2-450"
                     /inference="alignment:Splign:2.1.0"
     exon            2358..2574
                     /gene="Man2b2"
                     /gene_synonym="Ab2-450"
                     /inference="alignment:Splign:2.1.0"
     exon            2575..2691
                     /gene="Man2b2"
                     /gene_synonym="Ab2-450"
                     /inference="alignment:Splign:2.1.0"
     exon            2692..2804
                     /gene="Man2b2"
                     /gene_synonym="Ab2-450"
                     /inference="alignment:Splign:2.1.0"
     exon            2805..2922
                     /gene="Man2b2"
                     /gene_synonym="Ab2-450"
                     /inference="alignment:Splign:2.1.0"
     exon            2923..3225
                     /gene="Man2b2"
                     /gene_synonym="Ab2-450"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caatggggct gctgcgctgg ctgccgctgc tcggccagct attgctgctg tggccgctgg
       61 cggcccggcc cgccagcccc atccgggcct ttgtggtgcc ccacagtcac atggacgtgg
      121 gctgggtcta cacggtccag gaaagcatgc gggcctatgc agccaatgtc tacaccaccg
      181 tggtggagga actggtccga ggcaggcagc gccgcttcat cgctgtggag caggagttct
      241 tccggctgtg gtgggatggt gtagcctctg agcagcagaa acagcaggtc cgccagctcc
      301 tggatgaagg acgcctggag ttcgttcttg gaggccaggt catgcatgac gaggctgtga
      361 cccacctgga tgaccagatc ctacagctca cagaaggaca tggctttctc tacgaaacgt
      421 ttggaatccg gccacagttc tcctggcacg tggacccctt tggtgcatca gcgacgaccc
      481 ctaccctatt tgccctggcc ggcttcaatg cccacctcat ctcccggatt gactacgacc
      541 tcaaggatgc catgcaggaa gctcaggggc tgcagttcgt gtggcacggg tccccatctc
      601 tgtcagagca gcaggagatc tacacccacg tcatggacct ttatagctac tgcaccccct
      661 cacacatccc tttctctaac aggtctggat tttactggaa tggtgtggcc gtcttcccag
      721 agccaccccc agatggcgtg tatcctaaca tgagtgaacc tgtcaccgta gacaacatcc
      781 acctctacgc tgaggctctg gtggccaacg ttaaacagag ggccgcatgg ttccggactc
      841 cccacgtcct ctggccctgg ggatgtgaca agcagttctt caacgcctcg gtgcagtttg
      901 acaacatgga ccccctgctg gagtacatta acaaccgctc tgcccagttt ggcatctcag
      961 tgcagtacgc cacactgaat gattacttcc aggccctgca cgacttcaac gtgacctggg
     1021 acatccgaga tcaccatgac ttcctaccct attcttcaga gccacagcag gcctggaccg
     1081 gcttcttcac atcccggagc actctcaagg gtctagcgag acaagccagt gccttgctat
     1141 atgctgggga gtccatgttc acacgctata tgtggccaca cccccgtgga actctggacc
     1201 ctacctgggc cctgcagcag ctccaacagc ttcgctgggc tgtgtctgag gtccagcacc
     1261 atgatgccat cacaggcact gaatccccca aggtgaaaaa catgtacatg gaacatctca
     1321 gcatggggat gcgaggtgta cataagctga tggcctccat tgccctggac aggcccccag
     1381 ggtctggcac agacacgagg cctgtgggat actctgcctc tgtgtacaac ccgctagcct
     1441 ggaagatcac taccattatc accctgactg tcgctttccc cagtgtcagc gtcacagatg
     1501 agttgggccg tccagtgtca gcacagattc agaactcgac aaaggaccct tctgcgtatg
     1561 acctgctcat cctgaccacc atcccaggcc tcagctaccg gcactacaaa gtcaggcgca
     1621 cacgcgggga ccaggcaggc accagagagc tggtcacccc cagggccaac accctcaagt
     1681 ttagtcgcaa actgaggaac cagaccagcc aggaaggcaa gctcctggtg cctgtaatga
     1741 atgactgcta cactttgctg ttcgaccagg acaccaacat gttacatagc attcaggaca
     1801 gacagagtaa ccgcacagtg cacatgaccc aagagttcct ggagtatcga gccaacgggg
     1861 acgtgaagca gggccccatt tctgacaact acctctttgc atccaacgat accgctgagc
     1921 cttcctggga agcggtgggg atggagatgg tggtgggcac gctggccacg gacgtaaggc
     1981 agtatttcta caggaacata acagaccagg gttacatcta ttcgatccac actcgtctgg
     2041 cccatgtgca tccgagcctt gctggggaac tgctctgccg acggatagag cagcagtacc
     2101 aagtgggccc cctggaccta aaccgtgagg ccatcctgag gaccagcagt gacctaaaca
     2161 gccaacaagt cctctactct gacaacaatg gctaccagat gcagcggagg ccctacaagg
     2221 ctttcaagag caatcccatc ccccggaatt actaccccat ggtacagtcg gccttcatcg
     2281 aggatgacaa gagcaggctg gtgctgctgg cagagcgacc gcatggtgtc tccagccaag
     2341 agaatgggca ggtggaggta atgctccatc ggcggctgtg gaacaacctg gtctgggacc
     2401 tgaactacaa cctcacactg aatgacacct ctgtcgtcca cccagtgctc tggcttctgc
     2461 tggggcccaa gtccaccaca actgccctgc gcccgaggag tggggtggcc ctccagcaca
     2521 ggcctgtcgt gttgttaaaa gagctaactg atgaagaaga gacagccatt cacagacccc
     2581 atcacccctg gcctgtgaca ttgcccccaa gcctgcacct gcaggtcctc agcttacctg
     2641 gctggcagta cagcaggaac catgcccagc acctgaagaa ccttcagaga ggccacccag
     2701 agaaaccaca ggtcaaccta caacgtgtgc tgctgcgcct gcaccacctg tatgaagcag
     2761 gggaggaccc ggtactgtct cggcctgcta cagtggatct caagattgca cttcgaggac
     2821 tagggtctgt agtggccgtg gaggaacgct cactcacagg gacctgggat gtgcagacgc
     2881 tgcagcgctg gcactggagg acaaagattg gccagctaaa agggcaccct acctctccac
     2941 caaggtcacc aggaggctcc atcatcactg tgtaccccaa ggaaatccgg accttcttca
     3001 tttacctcca gcagtgacat cagtgcactt ggccccaggg acatggaact ggaaccactc
     3061 cccccccccc ccccccccgc gcaaaaaaaa aaaaaaaaaa aaaacaacga agctggcccc
     3121 agagggagga gcaagctgct catctgacag ctctccatct gacagaagtg gccatgtggg
     3181 gagaggaata gctctgattt tttttaataa aaaattaaca tctgg
//
