LOCUS       NP_001128443            1004 aa            linear   ROD 03-APR-2024
DEFINITION  epididymis-specific alpha-mannosidase precursor [Rattus
            norvegicus].
ACCESSION   NP_001128443
VERSION     NP_001128443.2
DBSOURCE    REFSEQ: accession NM_001134971.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1004)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   2  (residues 1 to 1004)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   3  (residues 1 to 1004)
  AUTHORS   Haeuw,J.F., Grard,T., Alonso,C., Strecker,G. and Michalski,J.C.
  TITLE     The core-specific lysosomal alpha(1-6)-mannosidase activity depends
            on aspartamidohydrolase activity
  JOURNAL   Biochem J 297 (Pt 3) (Pt 3), 463-466 (1994)
   PUBMED   8110182
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Nov 27, 2020 this sequence version replaced NP_001128443.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168692.1, SRR26643285.38796.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1004
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     Protein         1..1004
                     /product="epididymis-specific alpha-mannosidase precursor"
                     /EC_number="3.2.1.24"
                     /note="mannosidase 2, alpha B2; epididymis-specific
                     alpha-mannosidase"
                     /calculated_mol_wt=112506
     sig_peptide     1..21
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2388
     Region          27..792
                     /region_name="PLN02701"
                     /note="alpha-mannosidase"
                     /db_xref="CDD:178304"
     Region          27..352
                     /region_name="GH38N_AMII_Epman_like"
                     /note="N-terminal catalytic domain of mammalian
                     core-specific lysosomal alpha 1,6-mannosidase and similar
                     proteins; glycoside hydrolase family 38 (GH38); cd10811"
                     /db_xref="CDD:212122"
     Site            order(36,38,41,151,153,175,288..289,291)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:212122"
     CDS             1..1004
                     /gene="Man2b2"
                     /gene_synonym="Ab2-450"
                     /coded_by="NM_001134971.4:3..3017"
                     /db_xref="GeneID:360955"
                     /db_xref="RGD:1308840"
ORIGIN      
        1 mgllrwlpll gqllllwpla arpaspiraf vvphshmdvg wvytvqesmr ayaanvyttv
       61 veelvrgrqr rfiaveqeff rlwwdgvase qqkqqvrqll degrlefvlg gqvmhdeavt
      121 hlddqilqlt eghgflyetf girpqfswhv dpfgasattp tlfalagfna hlisridydl
      181 kdamqeaqgl qfvwhgspsl seqqeiythv mdlysyctps hipfsnrsgf ywngvavfpe
      241 pppdgvypnm sepvtvdnih lyaealvanv kqraawfrtp hvlwpwgcdk qffnasvqfd
      301 nmdplleyin nrsaqfgisv qyatlndyfq alhdfnvtwd irdhhdflpy ssepqqawtg
      361 fftsrstlkg larqasally agesmftrym wphprgtldp twalqqlqql rwavsevqhh
      421 daitgtespk vknmymehls mgmrgvhklm asialdrppg sgtdtrpvgy sasvynplaw
      481 kittiitltv afpsvsvtde lgrpvsaqiq nstkdpsayd llilttipgl syrhykvrrt
      541 rgdqagtrel vtprantlkf srklrnqtsq egkllvpvmn dcytllfdqd tnmlhsiqdr
      601 qsnrtvhmtq efleyrangd vkqgpisdny lfasndtaep sweavgmemv vgtlatdvrq
      661 yfyrnitdqg yiysihtrla hvhpslagel lcrrieqqyq vgpldlnrea ilrtssdlns
      721 qqvlysdnng yqmqrrpyka fksnpiprny ypmvqsafie ddksrlvlla erphgvssqe
      781 ngqvevmlhr rlwnnlvwdl nynltlndts vvhpvlwlll gpkstttalr prsgvalqhr
      841 pvvllkeltd eeetaihrph hpwpvtlpps lhlqvlslpg wqysrnhaqh lknlqrghpe
      901 kpqvnlqrvl lrlhhlyeag edpvlsrpat vdlkialrgl gsvvaveers ltgtwdvqtl
      961 qrwhwrtkig qlkghptspp rspggsiitv ypkeirtffi ylqq
//
