LOCUS       NM_001107527            4200 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus mannosidase, alpha, class 2A, member 2 (Man2a2),
            mRNA.
ACCESSION   NM_001107527 XM_001066272 XM_218816
VERSION     NM_001107527.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4200)
  AUTHORS   Akama,T.O., Nakagawa,H., Wong,N.K., Sutton-Smith,M., Dell,A.,
            Morris,H.R., Nakayama,J., Nishimura,S., Pai,A., Moremen,K.W.,
            Marth,J.D. and Fukuda,M.N.
  TITLE     Essential and mutually compensatory roles of {alpha}-mannosidase II
            and {alpha}-mannosidase IIx in N-glycan processing in vivo in mice
  JOURNAL   Proc Natl Acad Sci U S A 103 (24), 8983-8988 (2006)
   PUBMED   16754854
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473980.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_218816.4, XM_001066272.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMD00132261, SAMD00132262
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4200
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..4200
                     /gene="Man2a2"
                     /note="mannosidase, alpha, class 2A, member 2"
                     /db_xref="GeneID:308757"
                     /db_xref="RGD:1310238"
     exon            1..84
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            85..286
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            287..437
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     CDS             306..3800
                     /gene="Man2a2"
                     /EC_number="3.2.1.114"
                     /note="mannosidase 2, alpha 2"
                     /codon_start=1
                     /product="alpha-mannosidase 2x"
                     /protein_id="NP_001100997.1"
                     /db_xref="GeneID:308757"
                     /db_xref="RGD:1310238"
                     /translation="MKLKKQVTVCGAAIFCVAVFSLYLMLDRVQHDPARHQNGGNFPR
                     SQISVLQNRIEQLEQLLEENHEIISHIKDSVLELTANAEGPPALLPYHTANGSWAVLP
                     EPRPSFFSVSPEDCQFALGGRGQKPELQMLTVSEDLPFDNVEGGVWRQGFDISYSPND
                     WDAEDLQVFVVPHSHNDPGWIKTFDKYYTEQTQHILNSMVSKLQEDPRRRFLWAEVSF
                     FAKWWDNISAQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALVDQLIEGHQWLER
                     NLGATPRSGWAVDPFGHSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQ
                     TWDSDSSTDIFCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGGRINCPWKVPPRAIT
                     EANVADRAALLLDQYRKKSRLFRSSVLLVPLGDDFRYDKPQEWDAQFFNYQRLFDFLN
                     SKPEFHVQAQFGTLSEYFDALYKRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYY
                     TSRPFYKSLDRVLETHLRGAEVLYSLALAHARRSGLTGQYPLSDYAVLTEARRTLGLF
                     QHHDAITGTAKEAVVVDYGVRLLRSLVSLKQVIINAAHYLVLGDKETYSFDPRAPFLQ
                     MDDSRVSHDALPERTVIRLDSSPRFVVVFNPLEQERLSVVSLLVNSPRVRVLSEEGQP
                     LSVQISVQWSSATNMVPDVYQVSVPVRLPALGLGVLQLQPDLDGPYTLQSSVHVYLNG
                     VKLSVSRQTTFPLRVVDSGTSDFAISNRYMQVWFSGLTGLLKSVRRVDEEQEQQVDMK
                     LFVYGTRTSKDKSGAYLFLPDNEAKPYVPKKPPVLRVTEGPFFSEVAAYYEHFHQVIR
                     LYNLPGVEGLSLDVSFQVDIRDYVNKELALRIHTDIDSQGTFFTDLNGFQVQPRKYLK
                     KLPLQANFYPMPVMAYIQDSQRRLTLHTAQALGVSSLGNGQLEVILDRRLMQDDNRGL
                     GQGLKDNKITCNHFRLLLERRTLMSPEVQQERSTSYPSLLSHMTSMYLNTPPLVLPVA
                     KRESTSPTLHSFHPLASPLPCDFHLLNLRMLPAEVSVPVRANPHHQAEDTLPAADAAL
                     ILHRKGFDCGLEAKNLGFNCTTSQGKLALGSLFHGLDVLFLQPTSLTLLYPLASPSNS
                     TDISLEPMEISTFRLRLG"
     exon            438..695
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            696..840
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            841..1012
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1140
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1314
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1501
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1679
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1882
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..2065
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2180
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2248
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..2414
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2415..2651
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2652..2774
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..2889
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2890..3023
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3024..3165
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3166..3302
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3303..3539
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3540..3647
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3648..4200
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgctggcg gaggtccccg gggatgcgag cagtggcggc ttggcgggcc gggtccggag
       61 cgccgcggag gccggccgcg tacgctccgc cctctgtggc ccggacccaa tctccaggga
      121 ctaaaaatat tgcccggagg ctcctgagcg gaatcagatc gcgttaagta ggacgcaggc
      181 tgaggtgaca gagcttttca gcaccagggc cggaagagca gactccagaa cgcggtcccg
      241 cccacgcgcg ttcaggagct agcgtcctcc ctcctccagc aggcaagagt gtgcctggtg
      301 tcagtatgaa gctgaaaaag caggtgacag tgtgcggggc tgctatcttc tgtgtggccg
      361 tcttttccct gtacctaatg ctggaccgag tgcagcatga tcctgccaga caccagaatg
      421 gtgggaactt ccccaggagc caaatttctg tgctacagaa ccggatcgaa cagctggaac
      481 agctgctgga agaaaaccat gagatcataa gccatatcaa ggactctgtg ctggaactga
      541 cagccaatgc ggagggccca ccagccctgc tgccctacca cacagccaac ggctcctggg
      601 ctgtgctccc cgagccccgg cccagcttct tctctgtatc ccctgaggac tgccagtttg
      661 ctttgggggg ccggggtcag aagccagagc tacagatgtt aactgtgtct gaggatttgc
      721 cgtttgacaa tgtggagggc ggcgtgtgga ggcaaggctt cgacatctcc tacagcccaa
      781 atgactggga tgctgaagac ctgcaggtgt ttgtggtgcc tcactcccac aatgatccag
      841 gctggatcaa gacttttgac aagtactaca cggaacaaac ccaacacatc ctcaacagca
      901 tggtgtccaa gctgcaggaa gatccccgac ggcgctttct ctgggcagaa gtctccttct
      961 tcgccaagtg gtgggacaac atcagtgccc agaaaagggc agcagttcga aggctggtgg
     1021 gaaatgggca gctggaaatt gcaacgggtg gatgggtgat gccagatgag gccaactccc
     1081 attactttgc cctggtcgac cagctcatcg agggacacca gtggctggag agaaacctgg
     1141 gtgcaactcc tcgctcgggc tgggcagtgg acccctttgg acacagctcc accatgcctt
     1201 acctgctgcg ccgtgccaac ctgaccagca tgctaattca gagggtgcat tacgccatca
     1261 agaagcactt tgcggccact cacagcctgg agttcatgtg gaggcagaca tgggattcag
     1321 actccagcac agacatcttc tgccacatga tgcccttcta cagctacgac gtcccacaca
     1381 cctgtggccc tgatcccaag atctgctgcc agtttgattt caaacgtctg ccgggtggga
     1441 gaatcaattg tccttggaag gtgccgccgc gggctatcac agaggccaac gtggcagaca
     1501 gggcagccct gctcctggac cagtaccgga agaagtcccg gctgtttcga agcagtgtcc
     1561 tccttgtgcc gctgggtgat gacttccgat atgacaagcc ccaggaatgg gatgcccagt
     1621 tcttcaacta tcaacggctc tttgacttcc tcaacagcaa gccggagttc cacgtacagg
     1681 cacagtttgg gaccctctct gagtattttg atgccctgta taagaggaca ggagtggagc
     1741 ctggtgcccg gcctccaggg tttcctgtgc tgagtgggga cttcttctcc tatgctgacc
     1801 gggaggacca ctactggaca ggctattaca cttcccggcc tttctataag agcttggacc
     1861 gcgtgctaga aactcacctt cgtggggcag aggttctata cagcctggct ttggcgcatg
     1921 cccgccgttc tggactgact ggccagtatc cgctgtctga ttacgctgtc ctgacggaag
     1981 ctcgtcgtac actgggcctc ttccagcacc acgatgccat caccggaact gccaaggagg
     2041 cagttgtagt agactatggg gtcaggttgc tgcgttccct ggtcagccta aagcaggtca
     2101 tcatcaatgc tgcccactac ctggtgctgg gggacaagga gacctacagc tttgacccta
     2161 gggcaccctt cctccaaatg gatgacagtc gagtaagtca cgatgccctg cctgagcgca
     2221 cggtgatccg tctggactcc tcacccaggt ttgtggtggt ctttaaccca ctggaacagg
     2281 agcggctcag tgtggtgtcc ctgctggtca actcaccccg agtgcgagtg ctttcagagg
     2341 agggtcagcc cttgtctgtg cagatcagtg tgcagtggag ctccgccacc aacatggtcc
     2401 ccgatgtcta ccaggtgtca gtgcctgtcc gcctgccagc cctgggcctg ggtgtgctgc
     2461 agctgcagcc agatctcgat ggaccctaca cactgcagtc ttcggtgcat gtctacctga
     2521 acggcgtgaa actgtctgtc agcaggcaaa caacattccc tctccgtgtt gtggactcgg
     2581 gcaccagtga cttcgccatc agcaatcgat acatgcaggt ctggttctcc ggccttactg
     2641 ggcttctcaa gagcgtccga cgtgtggacg aagagcagga acagcaggtg gacatgaagc
     2701 tcttcgtcta tggaacccgc acatccaagg ataagagtgg tgcctacctc ttcctgcctg
     2761 ataacgaggc taagccctat gtccctaaga aacctcctgt gctgcgtgtc accgaaggcc
     2821 ctttcttctc agaggtggct gcgtattatg agcactttca ccaagtgatt cgactttaca
     2881 acctgccagg ggtagagggg ctgtctctgg acgtgtcgtt ccaggtggac atcagggact
     2941 acgtgaacaa ggagctagcc ctgcgcatcc acacagacat cgacagccag ggcactttct
     3001 tcacagacct caatggcttt caggtacagc cccggaagta tctgaagaag ttgcccctgc
     3061 aggctaattt ctaccctatg ccagtcatgg cctacatcca ggattcccag aggcgcctca
     3121 cgctgcacac tgctcaggct ctgggtgtct ccagcctcgg caatggccag ctggaggtga
     3181 tcttggaccg aaggctaatg caggatgaca accggggact aggccaaggg ctcaaagaca
     3241 acaagatcac ctgcaaccat ttccgcctcc tgttagaacg tcgaaccctg atgagccctg
     3301 aggtccaaca ggagcgctct acaagctacc cgtccctcct cagccacatg acttccatgt
     3361 acctcaacac acctcctctg gtcttaccgg tggccaagag ggagagcacc agccccactc
     3421 tgcactcttt ccaccctctg gcttctccgt tgccctgcga tttccatctg ctcaatctgc
     3481 gcatgctccc cgccgaggtg agtgtcccgg tccgtgccaa tcctcaccat caggctgagg
     3541 acaccttgcc cgcggctgat gctgctctca tcctacaccg caagggtttt gactgtggcc
     3601 ttgaagccaa gaacctgggc ttcaactgta ccacaagcca aggcaagctg gccctgggga
     3661 gcctcttcca tggcctggat gtgctattcc tgcagcccac ctctttgact ttgctatacc
     3721 ctctggcctc gccctccaac agcactgaca tctctctgga gcccatggag atcagcacct
     3781 tccgcctgcg cttgggttag gttagggctt cttgtggcct gaagacgaag ttcatccaca
     3841 aagactgcct cctaacacca agaccgagtt ggaccagcca cactgagtat cacattctgc
     3901 ctcagaactg acagaccatg ctctgccctt acgttgtcta ttgctgcttc tgtgtttggg
     3961 ccagccctta catcagcaga cggcagatac agtgggacag ggagaggagg cccttccctt
     4021 gggttgtaag tagctgccca gctgggcacg gcttaggttc catccttttc ccacaatggg
     4081 atctaggaag agcggggaca aacagaagag gtcagggagg ctgaggggaa caacctcgca
     4141 ccaggtgact ggagttatga ccgtgctctg tggggtgata ggggccccac agtgctggta
//
