LOCUS       NM_012979               6959 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus mannosidase, alpha, class 2A, member 1 (Man2a1),
            mRNA.
ACCESSION   NM_012979 XM_343636
VERSION     NM_012979.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6959)
  AUTHORS   Lu,H., Ma,F., Wang,H., Geng,P.S., Wang,S.S., Wang,J.G., Wu,C.C. and
            Zhao,B.Y.
  TITLE     The effects of swainsonine on the activity and expression of
            alpha-mannosidase in BRL-3A cells
  JOURNAL   Toxicon 99, 44-50 (2015)
   PUBMED   25797317
  REMARK    GeneRIF: Data suggest that hepatocyte expression of Man2a1 (Golgi
            apparatus alpha-mannosidase) and Man2b1 (lysosome
            alpha-mannosidase) is down-regulated by biological toxin
            swainsonine as part of locoweed/Oxytropis kansuensis hepatotoxic
            damage.
REFERENCE   2  (bases 1 to 6959)
  AUTHORS   Lu,H., Wang,S.S., Wang,W.L., Zhang,L. and Zhao,B.Y.
  TITLE     Effect of swainsonine in Oxytropis kansuensis on Golgi
            alpha-mannosidase II expression in the brain tissues of
            Sprague-Dawley rats
  JOURNAL   J Agric Food Chem 62 (30), 7407-7412 (2014)
   PUBMED   24741992
  REMARK    GeneRIF: swainsonine from Oxytropis kansuensis could reduce the
            expression of MAN2A1 in brain tissues
REFERENCE   3  (bases 1 to 6959)
  AUTHORS   Elkis,Y., Bel,S., Lerer-Goldstein,T., Nyska,A., Creasy,D.M.,
            Shpungin,S. and Nir,U.
  TITLE     Testosterone deficiency accompanied by testicular and epididymal
            abnormalities in TMF(-/-) mice
  JOURNAL   Mol Cell Endocrinol 365 (1), 52-63 (2013)
   PUBMED   23000399
REFERENCE   4  (bases 1 to 6959)
  AUTHORS   Tamaki,H., Sanda,M., Katsumata,O., Hara,Y., Fukaya,M. and
            Sakagami,H.
  TITLE     Pilt is a coiled-coil domain-containing protein that localizes at
            the trans-Golgi complex and regulates its structure
  JOURNAL   FEBS Lett 586 (19), 3064-3070 (2012)
   PUBMED   22841714
REFERENCE   5  (bases 1 to 6959)
  AUTHORS   Scrivens,P.J., Noueihed,B., Shahrzad,N., Hul,S., Brunet,S. and
            Sacher,M.
  TITLE     C4orf41 and TTC-15 are mammalian TRAPP components with a role at an
            early stage in ER-to-Golgi trafficking
  JOURNAL   Mol Biol Cell 22 (12), 2083-2093 (2011)
   PUBMED   21525244
REFERENCE   6  (bases 1 to 6959)
  AUTHORS   Cao,H., Weller,S., Orth,J.D., Chen,J., Huang,B., Chen,J.L.,
            Stamnes,M. and McNiven,M.A.
  TITLE     Actin and Arf1-dependent recruitment of a cortactin-dynamin complex
            to the Golgi regulates post-Golgi transport
  JOURNAL   Nat Cell Biol 7 (5), 483-492 (2005)
   PUBMED   15821732
REFERENCE   7  (bases 1 to 6959)
  AUTHORS   Bell,A.W., Ward,M.A., Blackstock,W.P., Freeman,H.N.,
            Choudhary,J.S., Lewis,A.P., Chotai,D., Fazel,A., Gushue,J.N.,
            Paiement,J., Palcy,S., Chevet,E., Lafreniere-Roula,M., Solari,R.,
            Thomas,D.Y., Rowley,A. and Bergeron,J.J.
  TITLE     Proteomics characterization of abundant Golgi membrane proteins
  JOURNAL   J Biol Chem 276 (7), 5152-5165 (2001)
   PUBMED   11042173
REFERENCE   8  (bases 1 to 6959)
  AUTHORS   Moremen,K.W., Touster,O. and Robbins,P.W.
  TITLE     Novel purification of the catalytic domain of Golgi
            alpha-mannosidase II. Characterization and comparison with the
            intact enzyme
  JOURNAL   J Biol Chem 266 (25), 16876-16885 (1991)
   PUBMED   1885615
REFERENCE   9  (bases 1 to 6959)
  AUTHORS   Baron,M.D. and Garoff,H.
  TITLE     Mannosidase II and the 135-kDa Golgi-specific antigen recognized
            monoclonal antibody 53FC3 are the same dimeric protein
  JOURNAL   J Biol Chem 265 (32), 19928-19931 (1990)
   PUBMED   2246269
REFERENCE   10 (bases 1 to 6959)
  AUTHORS   Moremen,K.W.
  TITLE     Isolation of a rat liver Golgi mannosidase II clone by mixed
            oligonucleotide-primed amplification of cDNA
  JOURNAL   Proc Natl Acad Sci U S A 86 (14), 5276-5280 (1989)
   PUBMED   2748583
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Jun 4, 2008 this sequence version replaced NM_012979.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.32564.1,
                                           SRR26643284.12682.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1119              JAXUCZ010000009.1  111698913-111700031
            1120-1371           JAXUCZ010000009.1  111722341-111722592
            1372-1516           JAXUCZ010000009.1  111723156-111723300
            1517-1688           JAXUCZ010000009.1  111733122-111733293
            1689-1816           JAXUCZ010000009.1  111747109-111747236
            1817-1990           JAXUCZ010000009.1  111757881-111758054
            1991-2177           JAXUCZ010000009.1  111764813-111764999
            2178-2355           JAXUCZ010000009.1  111767668-111767845
            2356-2558           JAXUCZ010000009.1  111771777-111771979
            2559-2741           JAXUCZ010000009.1  111775077-111775259
            2742-2856           JAXUCZ010000009.1  111779266-111779380
            2857-2927           JAXUCZ010000009.1  111781780-111781850
            2928-3093           JAXUCZ010000009.1  111810294-111810459
            3094-3315           JAXUCZ010000009.1  111811839-111812060
            3316-3438           JAXUCZ010000009.1  111813118-111813240
            3439-3553           JAXUCZ010000009.1  111815633-111815747
            3554-3687           JAXUCZ010000009.1  111830192-111830325
            3688-3829           JAXUCZ010000009.1  111833263-111833404
            3830-3963           JAXUCZ010000009.1  111834426-111834559
            3964-4167           JAXUCZ010000009.1  111840220-111840423
            4168-4278           JAXUCZ010000009.1  111850966-111851076
            4279-6959           JAXUCZ010000009.1  111852577-111855257
FEATURES             Location/Qualifiers
     source          1..6959
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q37"
     gene            1..6959
                     /gene="Man2a1"
                     /gene_synonym="Mana2; Manno"
                     /note="mannosidase, alpha, class 2A, member 1"
                     /db_xref="GeneID:25478"
                     /db_xref="RGD:3038"
     exon            1..1119
                     /gene="Man2a1"
                     /gene_synonym="Mana2; Manno"
                     /inference="alignment:Splign:2.1.0"
     CDS             985..4431
                     /gene="Man2a1"
                     /gene_synonym="Mana2; Manno"
                     /EC_number="3.2.1.114"
                     /note="mannosidase alpha 2; MAN II; alpha-mannosidase II;
                     golgi alpha-mannosidase II; mannosyl-oligosaccharide
                     1,3-1,6-alpha-mannosidase; AMan II; mannosidase 2, alpha
                     1"
                     /codon_start=1
                     /product="alpha-mannosidase 2"
                     /protein_id="NP_037111.2"
                     /db_xref="GeneID:25478"
                     /db_xref="RGD:3038"
                     /translation="MKLSRQFTVFGSAIFCVVIFSLYLMLDRGHLDYPRGPRQEGSFP
                     QGQLSILQEKIDHLERLLAENNEIISNIRDSVINLSESVEDGPRGPAGNASQGSAHLH
                     SAQLALQADPKDCLFASQSGNQHRDVQMLDVYDLIPFDNPDGGVWKQGFDIKYEADEW
                     DREPLQVFVVPHSHNDPGWLKTFNDYFRDKTQYIFNNMVLKLKEDSSRKFIWSEISYL
                     AKWWDIIDNPKKEAVKSLLQNGQLEIVTGGWVMADEATTHYFALIDQLIEGHQWLEKN
                     LGVKPRSGWAIDPFGHSPTMTYLLKRAGFSHMLIQRVHYSVKKHFSLQKTLEFFWRQN
                     WDLGSTTDILCHMMPFYSYDIPHTCGPDPKICCQFDFKRLPGGRYGCPWGVPPEAISP
                     GNVQSRAQMLLDQYRKKSKLFRTKVLLAPLGDDFRFSEYTEWDLQYRNYEQLFSYMNS
                     QPHLKVKIQFGTLSDYFDALEKSVAAEKKGGQSVFPALSGDFFTYADRDDHYWSGYFT
                     SRPFYKRMDRIMESRLRTAEILYHLALKQAQKYKINKFLSSPHYTTLTEARRNLGLFQ
                     HHDAITGTAKDWVVVDYGTRLFQSLNSLEKIIGDSAFLLILKDKKLYQSDPSKAFLEM
                     DTKQSSQDSLPKKNIIQLSAQEPRYLVVYNPFEQERHSVVSVRVNSATVKVLSDLGKA
                     VEVQVSAVWKDMRTTSQAAYEVAFLAHLPPLGLKVYKILESQSSSSHLADYFLYNNDG
                     QAESGIFHMKNMVDSGDAITIENSFLTLGFDRSGLMEKVRRKEDNKQQELKVQFLWYG
                     TTNKRDKSGAYLFLPDGQGQPYVSLRTPFVRVTRGRIYSDVTCFLEHVTHKVRLYHIQ
                     GIEGQSMEVSNIVDIRSVHNREIVMRISSKINNQNRYYTDLNGYQIQPRRTMAKLPLQ
                     ANVYPMSTMAYIQDAAHRLTLLSAQSLGASSMASGQIEVFMDRRLMQDDNRGLGQGVH
                     DNKITANLFRILLEKRNGMNMEEDKKSPVSYPSLLSHMTSAFLNHPFLPMVLSGQLPS
                     PAIELLSEFRLLQSSLPCDIHLVNLRTIQSKVGKGYSDEAALILHRKVFDCQLSSRAM
                     GLPCSTTQGKMSIPKLFNNFAVESFIPSSLSLMHSPPDAQNTSEVSLSPMEISTSRIR
                     LR"
     exon            1120..1371
                     /gene="Man2a1"
                     /gene_synonym="Mana2; Manno"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1516
                     /gene="Man2a1"
                     /gene_synonym="Mana2; Manno"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1688
                     /gene="Man2a1"
                     /gene_synonym="Mana2; Manno"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1816
                     /gene="Man2a1"
                     /gene_synonym="Mana2; Manno"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1990
                     /gene="Man2a1"
                     /gene_synonym="Mana2; Manno"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2177
                     /gene="Man2a1"
                     /gene_synonym="Mana2; Manno"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..2355
                     /gene="Man2a1"
                     /gene_synonym="Mana2; Manno"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..2558
                     /gene="Man2a1"
                     /gene_synonym="Mana2; Manno"
                     /inference="alignment:Splign:2.1.0"
     exon            2559..2741
                     /gene="Man2a1"
                     /gene_synonym="Mana2; Manno"
                     /inference="alignment:Splign:2.1.0"
     exon            2742..2856
                     /gene="Man2a1"
                     /gene_synonym="Mana2; Manno"
                     /inference="alignment:Splign:2.1.0"
     exon            2857..2927
                     /gene="Man2a1"
                     /gene_synonym="Mana2; Manno"
                     /inference="alignment:Splign:2.1.0"
     exon            2928..3093
                     /gene="Man2a1"
                     /gene_synonym="Mana2; Manno"
                     /inference="alignment:Splign:2.1.0"
     exon            3094..3315
                     /gene="Man2a1"
                     /gene_synonym="Mana2; Manno"
                     /inference="alignment:Splign:2.1.0"
     exon            3316..3438
                     /gene="Man2a1"
                     /gene_synonym="Mana2; Manno"
                     /inference="alignment:Splign:2.1.0"
     exon            3439..3553
                     /gene="Man2a1"
                     /gene_synonym="Mana2; Manno"
                     /inference="alignment:Splign:2.1.0"
     exon            3554..3687
                     /gene="Man2a1"
                     /gene_synonym="Mana2; Manno"
                     /inference="alignment:Splign:2.1.0"
     exon            3688..3829
                     /gene="Man2a1"
                     /gene_synonym="Mana2; Manno"
                     /inference="alignment:Splign:2.1.0"
     exon            3830..3963
                     /gene="Man2a1"
                     /gene_synonym="Mana2; Manno"
                     /inference="alignment:Splign:2.1.0"
     exon            3964..4167
                     /gene="Man2a1"
                     /gene_synonym="Mana2; Manno"
                     /inference="alignment:Splign:2.1.0"
     exon            4168..4278
                     /gene="Man2a1"
                     /gene_synonym="Mana2; Manno"
                     /inference="alignment:Splign:2.1.0"
     exon            4279..6959
                     /gene="Man2a1"
                     /gene_synonym="Mana2; Manno"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgggcgcct attgacccat cggccgccgc gccgccgccg ccgtctcctc cggctcgtgg
       61 cgggcggtac tggagcgccg agtagcgctg gggaaccggc tcttcctctc gcggctgccg
      121 ccgccatctc cgcgttctcg gggcgggaag gagggggtgc tccacggctg cagctggagc
      181 gggctcctct cgggagacgg tcctctcctc ctcgctctgc tcgcctcctc ccggcgccgc
      241 ccgccccctg cgccctccgc gtgcagcccg ggcccgcgag ggggaaggta ggggcggcgg
      301 gggccgggag aggccgggga tcggacgcac gccctgagga aagtctcgga tctcagcgcc
      361 ccagcgcgca gggtgcaccc tagccggccc ccgcagtagc ctcggcagga aggggctccg
      421 gcggggacgc gggggcggcg ttacgggggt gggcctgggt gtcccagcgc taagttgtgg
      481 ggcacggcgc ctccaggtcc agttccttct gcgcgctcct cgctcccagc gccgcacgct
      541 cggccccgga gccgcggaac ccgcgcgttc tctgggcgcg gaggacacgc ctgcccttgt
      601 cgagaaaact tttcctgccg actcagtcgt ggcggctgtg gcaggaagtc gggcagagac
      661 ctctcctctg actgctccgc ccgccctacg gggtgtcgct accctgcagg agagcaagtt
      721 tgtggggacc cttgccttgc tccccaggag tccgccttgc agggacggcc agctccgggg
      781 agggcagcgg gccagggcgt aggccgaggg cgcgtggtgg ctccggagac gaggtgcgga
      841 gcgcagcccg gacccgcgcc gtagcgcgcg aagggtgtgc agcccggagc agggagccct
      901 cggcggtcgc cggctggagt cctcagtctt cctcctcctc ctccgggtga ggaccgcgtc
      961 ctgggcccga gtccatcgag gaaaatgaag ttaagccgcc agttcaccgt gttcggcagc
     1021 gcgatcttct gcgtcgtaat cttctcactc tacctgatgc tggacagggg tcacttggac
     1081 taccctcggg gcccgcgcca ggagggctcc ttcccgcagg gccagctttc aatattgcaa
     1141 gaaaagatcg accatttgga gcgtttgcta gcggagaaca acgagatcat ctcgaatatc
     1201 agagactcgg tcatcaacct gagtgagtct gtggaagatg gcccacgagg tccagcaggc
     1261 aacgccagcc aaggctctgc gcacctccac tctgcacagt tggccctaca ggctgacccc
     1321 aaagactgct tgtttgcctc gcagagcgga aaccagcacc gggatgtgca gatgttggat
     1381 gtttacgatc tgattccttt tgataatcca gatggtggag tttggaagca agggtttgac
     1441 attaagtacg aagctgatga gtgggaccgt gagcccctgc aagtgtttgt ggtgcctcac
     1501 tcccataatg acccaggttg gttgaagact ttcaatgact actttagaga caagactcag
     1561 tatattttta ataacatggt cctaaagctg aaagaagact caagcaggaa gtttatatgg
     1621 tctgagatct cttaccttgc aaaatggtgg gatattatag ataatccgaa gaaggaagct
     1681 gttaaaagtt tactacagaa tggtcagctt gagattgtga ccggtggctg ggtgatggcc
     1741 gatgaagcca ctacacatta ttttgcctta attgaccaac tgattgaagg gcatcaatgg
     1801 ctggaaaaaa atctaggagt gaaacctcga tcgggctggg ccatagatcc ctttggacat
     1861 tcacccacaa tgacttacct tctaaaacgt gctggatttt cacacatgct catccagaga
     1921 gtccattatt cggtgaaaaa acacttctct ttgcaaaaaa cgctggaatt tttctggaga
     1981 cagaattggg atcttggatc caccacagac attttgtgcc acatgatgcc cttctatagc
     2041 tatgacatcc cccacacctg tggacccgat cccaaaatat gctgccagtt tgattttaag
     2101 cggcttcctg gaggcagata cggttgtccc tggggagttc ccccagaagc aatatctcct
     2161 ggaaatgtcc aaagcagggc tcagatgcta ctggatcagt accggaaaaa gtcaaaactt
     2221 ttccgcacca aagttctcct ggctccgctc ggagacgatt ttcggttcag tgaatacaca
     2281 gagtgggacc tgcagtacag gaactatgag cagttattca gttacatgaa ctctcagccc
     2341 catcttaaag tgaagatcca gtttggaact ttgtcagatt atttcgatgc attggagaag
     2401 tctgtggcag ctgagaagaa gggtggccag tctgtgttcc ccgccctgag tggagacttc
     2461 ttcacctacg ctgaccgaga cgaccattac tggagtggct acttcacatc cagacctttc
     2521 tacaaacgaa tggacaggat aatggaatct cgtttaagga ctgctgaaat tctttaccat
     2581 ttggccttga aacaagctca gaaatacaag ataaataaat ttctttcatc acctcattat
     2641 acaacactga cagaagccag aaggaacttg ggactgtttc agcatcatga tgccatcacg
     2701 ggaaccgcga aagactgggt ggtcgtggac tatggtacca gactctttca gtcattaaat
     2761 tctctggaga agataatcgg agattctgca tttcttctca ttttaaagga caaaaagctg
     2821 taccagtcag atccttccaa agccttctta gagatggaca cgaagcaaag ttcacaagat
     2881 tctctgccca aaaaaaatat aatacaactg agtgcacagg agccgaggta cctcgtggtc
     2941 tacaatccct tcgaacaaga acggcactcg gtggtgtccg tccgtgtgaa ctcagccacg
     3001 gtgaaagtgc tgtctgatct ggggaaagcc gtggaggttc aagtcagcgc agtctggaag
     3061 gatatgagaa cgacttcaca agcagcctat gaggtcgctt ttctagctca tctgccaccg
     3121 ctgggactga aagtgtacaa gatcttagaa tcccagagtt caagttcaca tctggctgat
     3181 tatttcctat ataacaatga cgggcaagca gaaagtggaa tattccacat gaagaacatg
     3241 gtagattcag gagatgccat caccatagag aattccttcc tcacacttgg gtttgaccga
     3301 tctgggctga tggagaaagt gagaaggaaa gaagacaata aacagcagga actgaaggtg
     3361 cagttcctgt ggtacggaac caccaacaaa agggacaaga gcggtgccta cctcttcctg
     3421 cctgatgggc agggccagcc ctatgtttcc ctgagaacac cctttgtcag agtgacacgt
     3481 ggaaggatct actcagacgt gacctgcttc cttgaacacg ttactcacaa ggtccggctg
     3541 taccacatac agggaataga aggccagtcc atggaggttt ctaatatcgt ggacatcagg
     3601 agtgtgcata accgtgagat tgtaatgaga atttcctcca aaataaacaa ccaaaataga
     3661 tattataccg acctaaatgg atatcagatt caacctagaa ggacaatggc caaactgcct
     3721 cttcaggcca atgtgtaccc gatgagcaca atggcctaca tccaggatgc tgcacatcgg
     3781 ctcacactgc tttccgctca gtctttaggc gcttccagta tggcctctgg tcaaattgaa
     3841 gtcttcatgg accgaagact catgcaggac gataaccgtg gccttgggca aggtgtacac
     3901 gataataaga ttacagccaa tttgtttcga atcctgctag agaagagaaa tggcatgaac
     3961 atggaagagg acaagaagag ccctgtcagc tacccttccc tcctcagcca tatgacctcg
     4021 gccttcctca accatccctt cctccccatg gtactaagtg gccagctccc ctcccctgcc
     4081 attgagctgc tgagtgaatt tcgtctgctg cagtcctctc tcccttgtga tatccatctg
     4141 gttaatctac ggacaataca gtcaaaggtg ggcaaaggtt actcagatga ggcagccttg
     4201 atcctccaca ggaaggtgtt tgattgccag ttgtccagca gagccatggg gctgccctgt
     4261 tccacgactc agggaaagat gtcaattcca aaacttttca acaactttgc tgtggagagt
     4321 ttcatccctt cctcgctgtc cttgatgcac tcgcctccgg acgcccagaa cacgagtgaa
     4381 gtcagcctga gtcccatgga gattagcacg tcccgaatcc gcttgaggtg aacctggcct
     4441 tcaggttgag tggagaaact ccggtttgct taccttcctt ggtttttaac gtgcaataac
     4501 taagcacatt actttagctt ctggctactg tgagaacata aattctgtga ttcttttttt
     4561 tttttaaaaa ccaatctagt aagaaaagaa gaaaaaaaag ccatgcttta caaacagttt
     4621 ctttctctga gttcgtccca cagctgccct tatcagtgtg aaccgatgta acaaaaatga
     4681 agaaacgttg aaagacaagc cctcgacaga ctgaatctca ggttaaatgc taactacgta
     4741 ggtttgcatt gagggctgca aagagaattc tctagaagta ttcctatctc tgatcatgtt
     4801 ttattaaaaa aaaaattacc tatttgacct aaagagaaag caaaatcaga agttggtata
     4861 gataacagct taatggccaa aatagttgta atcattaatc attggtacaa attgaatatt
     4921 tttttgtgtt aaaatatgtg gaaacgtgca atccctccgt ccttccgcta aatgtagttg
     4981 gttgtcatgc tctccccggt gaacctctcg actactcttt cctacccaca cgtttaaaaa
     5041 ctaagtgatt attttagccg ctcaccagta gaaaaagagg tgtattttca ttacttgaca
     5101 acgtgggatg ggtgcaattt attcccttgt cactaaagca gaagaagcaa ttccatttta
     5161 ggtaccacaa ggtgtctttc tatacagctc atttgaatac aggtgttccg aggtggggtt
     5221 ttctattttt aaattaccat atcaaaaata aatgtgcctt atttttttat aagtctcgtt
     5281 aaatcttatt actgtccata ttactgtttg aaaaggtggg gagtcgggag gttggggtag
     5341 ggggtaggta ctttctatga cataaattat gtaattttct ttgctggata atgctggcca
     5401 cattctgatc tgtgtcatta aatttgtgac ggtgttactc gaaacatttt gactatttga
     5461 atgtactgag atgtcagaaa acaaaacaag gaagagaaat attgttaatt aaaatatgct
     5521 gctgccaagg aagctgcaag tcgaagcaag gactctgtaa cccacgagat ccaaatgctg
     5581 cttgcatttc acagtagtta accatgttaa agagagaatg ctttaaaaat agactgtttt
     5641 aaagcccgcc gtgcgcagct catcttgatg ttactaaaga ctgtgttcca aacgtctgcg
     5701 tgcggtaaac ccggcgtgct atcctagcct atacgtcatc acaggacttt taagttcatt
     5761 ccagatcatc gtatctttaa tagaataata gtatttaatt tcagtacaga aaattctctg
     5821 gctgtacact tcagaaaaat tctcctcagt gtcttaacct tatttagtat tatttgactc
     5881 taaacttccg tttacctctt gccattccaa cacgttacag agaaagtcat ctctgccact
     5941 gtttatcctg ggggtcatct gggttcctcc tcaagacgca gctcctgcat tcactgttgt
     6001 gtttggttca taaagtcctt tgcctataat cattaaggga acaccagagt gaacaggaat
     6061 gttgcaaggg tgtaatctca tgcaaagagt atgcatcgtg cattcccttc ctccctgcgg
     6121 aaaatacggc agaaccactt ccttctgtag acctctgccc acgacagcta ggattgccaa
     6181 gcgcaaatgc caggaatatg agctgtactc ctgctgtatc ctaagtgcgt acctccctgt
     6241 ggatgttcac tgtgctctgt ggttaagtgg ctctgcttaa tcaccacaga agtcctgatg
     6301 aagccaaagg aaaccagagg ctgacagaaa tgaaaaagga aaacagcaga cacagcggac
     6361 ctaccctgtg tccttgccac cagctactta ctcacaggtg aagcagaaat tctatttaac
     6421 cagcaagttt ctgcttttta aagttacttt cacattacca acatcaggga aatgaagaga
     6481 gggtgtgttt tgctttgggt tatggtcacg aactaactaa acaattgagt gtctgtggac
     6541 actcgtggac agccagccac acttcagaca tgacatcagg ggtctgtttg gttaggcctg
     6601 tcacatctgt tttcacaggc gttcagtgga ccatgattgt ctcactaccc tctccccact
     6661 tcctgaaatt ttaatttgga ggcccatggt tcaaatatca gcattctaaa atcatcgatt
     6721 taaacaaaag gctgtatggt gttctgagac attgtgatca ccttcgtgtg tcttttgctg
     6781 tacttgtgct gaaatgtttt cacagtcctt tgtctagaag aaaatgttta ctttcattct
     6841 gattattttg ctcattgaaa tcaacaggtt ttgatatttt tctcttggaa gatttttata
     6901 actttttggg aatatgtaat ataagatctc taataaaata taatcttatc ctgtgcgtt
//
