LOCUS       NM_001109196            3694 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus mannosidase, alpha, class 1B, member 1 (Man1b1),
            mRNA.
ACCESSION   NM_001109196 XM_001077558 XM_575086
VERSION     NM_001109196.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3694)
  AUTHORS   Chiasserini,D., van Weering,J.R., Piersma,S.R., Pham,T.V.,
            Malekzadeh,A., Teunissen,C.E., de Wit,H. and Jimenez,C.R.
  TITLE     Proteomic analysis of cerebrospinal fluid extracellular vesicles: a
            comprehensive dataset
  JOURNAL   J Proteomics 106, 191-204 (2014)
   PUBMED   24769233
REFERENCE   2  (bases 1 to 3694)
  AUTHORS   Aikawa,J., Matsuo,I. and Ito,Y.
  TITLE     In vitro mannose trimming property of human ER alpha-1,2
            mannosidase I
  JOURNAL   Glycoconj J 29 (1), 35-45 (2012)
   PUBMED   22160784
REFERENCE   3  (bases 1 to 3694)
  AUTHORS   Groisman,B., Shenkman,M., Ron,E. and Lederkremer,G.Z.
  TITLE     Mannose trimming is required for delivery of a glycoprotein from
            EDEM1 to XTP3-B and to late endoplasmic reticulum-associated
            degradation steps
  JOURNAL   J Biol Chem 286 (2), 1292-1300 (2011)
   PUBMED   21062743
REFERENCE   4  (bases 1 to 3694)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 3694)
  AUTHORS   Avezov,E., Frenkel,Z., Ehrlich,M., Herscovics,A. and
            Lederkremer,G.Z.
  TITLE     Endoplasmic reticulum (ER) mannosidase I is compartmentalized and
            required for N-glycan trimming to Man5-6GlcNAc2 in glycoprotein
            ER-associated degradation
  JOURNAL   Mol Biol Cell 19 (1), 216-225 (2008)
   PUBMED   18003979
REFERENCE   6  (bases 1 to 3694)
  AUTHORS   Sevilla,L.M., Comstock,S.S., Swier,K. and Miller,J.
  TITLE     Endoplasmic reticulum-associated degradation-induced dissociation
            of class II invariant chain complexes containing a
            glycosylation-deficient form of p41
  JOURNAL   J Immunol 173 (4), 2586-2593 (2004)
   PUBMED   15294975
REFERENCE   7  (bases 1 to 3694)
  AUTHORS   Herscovics,A., Romero,P.A. and Tremblay,L.O.
  TITLE     The specificity of the yeast and human class I ER alpha
            1,2-mannosidases involved in ER quality control is not as strict
            previously reported
  JOURNAL   Glycobiology 12 (4), 14G-15G (2002)
   PUBMED   12090241
REFERENCE   8  (bases 1 to 3694)
  AUTHORS   Tremblay,L.O. and Herscovics,A.
  TITLE     Cloning and expression of a specific human alpha 1,2-mannosidase
            that trims Man9GlcNAc2 to Man8GlcNAc2 isomer B during N-glycan
            biosynthesis
  JOURNAL   Glycobiology 9 (10), 1073-1078 (1999)
   PUBMED   10521544
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC166449.1.
            
            On or before Sep 1, 2012 this sequence version replaced
            XM_575086.4, XM_001077558.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166449.1, SRR8487231.88117.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3694              BC166449.1         1-3694
FEATURES             Location/Qualifiers
     source          1..3694
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     gene            1..3694
                     /gene="Man1b1"
                     /gene_synonym="ERMan1; RGD1563595"
                     /note="mannosidase, alpha, class 1B, member 1"
                     /db_xref="GeneID:499751"
                     /db_xref="RGD:1563595"
     exon            1..173
                     /gene="Man1b1"
                     /gene_synonym="ERMan1; RGD1563595"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..2033
                     /gene="Man1b1"
                     /gene_synonym="ERMan1; RGD1563595"
                     /EC_number="3.2.1.113"
                     /note="ER mannosidase 1; ER alpha-1,2-mannosidase"
                     /codon_start=1
                     /product="endoplasmic reticulum mannosyl-oligosaccharide
                     1,2-alpha-mannosidase"
                     /protein_id="NP_001102666.1"
                     /db_xref="GeneID:499751"
                     /db_xref="RGD:1563595"
                     /translation="MYPPPPAPAPHRDFISVTLSLGESYDNSKSRRRRSCWRKWKQLS
                     RLQRNVILFVLGFLILCGFLYSLQVSDQWKALSGSRAEVEKMKLEVLPVLPAPQKESA
                     EPEGFADILSQKRQRHLRRGPPHLQIRPPNTVSKDGMQDDAKEREAALGKAQQEENTQ
                     RTVISWRGAVIEPEQATEPPSKRAEASIKPLFLASRIWKEPAPPNERQKGVIEAFLHA
                     WKGYQKFAWGHDELKPVSKTFSEWFGLGLTLIDALDTMWILGLKQEFKEARKWVSENL
                     DFQKNVDVNLFESTIRILGGLLSAYHLSGDSLFLSKAEDFGNRLMPAFTTPSKIPYSD
                     VNIGTGFAHSPQWTSDSTVAEVTSIQLEFRELSRLTGIKKFQEAVEEVTKHIHSLSGK
                     KDGLVPMFINTNSGLFTHPGVFTLGARADSYYEYLLKQWIQGGKKETQLLEDYVRAIE
                     GIKAHLLRQSQPRKLTFVGELAHGRFSAKMDHLVCFLPGTLALGVHHGLPADHMDLAR
                     ALMETCYQMNQQMETGLSPEIAHFNMYPRADHKDVEVKPADRHNLLRPETVESLFYLY
                     RVTKDRKYQDWGWEILQSFNKYTRVPSGGYSSINNVQNSHKPEPRDKMESFFVGETLK
                     YLYLLFSDDLELLGLDTCVFNTEAHPLPIWSPA"
     exon            174..282
                     /gene="Man1b1"
                     /gene_synonym="ERMan1; RGD1563595"
                     /inference="alignment:Splign:2.1.0"
     exon            283..398
                     /gene="Man1b1"
                     /gene_synonym="ERMan1; RGD1563595"
                     /inference="alignment:Splign:2.1.0"
     exon            399..553
                     /gene="Man1b1"
                     /gene_synonym="ERMan1; RGD1563595"
                     /inference="alignment:Splign:2.1.0"
     exon            554..663
                     /gene="Man1b1"
                     /gene_synonym="ERMan1; RGD1563595"
                     /inference="alignment:Splign:2.1.0"
     exon            664..849
                     /gene="Man1b1"
                     /gene_synonym="ERMan1; RGD1563595"
                     /inference="alignment:Splign:2.1.0"
     exon            850..998
                     /gene="Man1b1"
                     /gene_synonym="ERMan1; RGD1563595"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1187
                     /gene="Man1b1"
                     /gene_synonym="ERMan1; RGD1563595"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1378
                     /gene="Man1b1"
                     /gene_synonym="ERMan1; RGD1563595"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1499
                     /gene="Man1b1"
                     /gene_synonym="ERMan1; RGD1563595"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1697
                     /gene="Man1b1"
                     /gene_synonym="ERMan1; RGD1563595"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1829
                     /gene="Man1b1"
                     /gene_synonym="ERMan1; RGD1563595"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..3678
                     /gene="Man1b1"
                     /gene_synonym="ERMan1; RGD1563595"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagtcttggg cttcctgaca cctccagcaa gcgaggtctc ttgggccagc ttcgcagtta
       61 tgtacccgcc gccgccggcg ccggcgcctc accgggactt catctcggtg acgctgagcc
      121 tgggagagag ctacgacaac agcaagagcc ggcggcggcg ctcatgctgg aggaaatgga
      181 agcagctttc gaggttacag cggaatgtga ttctcttcgt cctgggcttt ctgattctct
      241 gtggatttct gtattctctt caggtgtctg accagtggaa agctctgagt ggcagccgtg
      301 cagaagtaga gaagatgaag ctagaagtcc tgcctgtctt accagctcct cagaaggaaa
      361 gtgctgaacc agaagggttt gcagacatac tctctcagaa gcggcaaagg catttgcggc
      421 ggggccctcc gcacctgcag atcagacccc ccaacaccgt ctccaaagat gggatgcagg
      481 atgatgctaa ggagagggaa gcagccctgg ggaaggctca gcaggaagaa aacacccaga
      541 gaaccgtcat cagctggcgg ggagcagtaa ttgagcctga acaggccact gaacctcctt
      601 ccaaaagagc tgaagcctcc atcaagcctc tgtttttggc gtccaggata tggaaagagc
      661 cagctccccc aaatgagcgc cagaagggag tgattgaggc ctttctccat gcttggaaag
      721 gttaccaaaa gttcgcttgg ggccatgatg aactgaagcc tgtgtccaaa accttcagtg
      781 agtggtttgg cctgggcctc accctgatcg atgccttgga taccatgtgg attttgggtc
      841 tgaagcaaga atttaaggaa gccaggaagt gggtgtcgga gaacttagac tttcagaaga
      901 atgtcgatgt caacctgttt gagagtacta tccgaatctt agggggcctg ctgagtgcct
      961 accacctgtc tggggacagc ctcttcctga gcaaggccga ggattttgga aaccggttaa
     1021 tgcctgcctt caccacaccc tccaagattc catactctga tgtgaacatt ggcactgggt
     1081 ttgcccactc gccccagtgg acttcagaca gcacggtggc agaagtgacg agcattcagt
     1141 tggagttccg agagctctcc cgtcttaccg ggattaagaa attccaggag gccgtggagg
     1201 aagtgacaaa gcacatccac tccctgtctg ggaagaaaga cgggctggtg cctatgttca
     1261 tcaacacgaa cagcggcctc ttcacccacc cgggagtgtt caccttgggt gccagggctg
     1321 acagctacta cgaatacctg ctgaaacagt ggatccaggg tggcaagaag gagacacagt
     1381 tgctggaaga ctatgttaga gccatcgagg ggatcaaagc tcatctgctt cgacagtctc
     1441 agcccagaaa gctcaccttc gtgggagagc ttgcccatgg ccgcttcagt gccaagatgg
     1501 accacttggt gtgcttcctg ccagggacgc tggccttggg cgtccaccat ggcctaccgg
     1561 ctgaccacat ggatctggct cgggcactca tggagacctg ctaccagatg aaccaacaga
     1621 tggagacagg tctgagccct gagattgcac atttcaacat gtaccctcga gcagatcata
     1681 aagacgtgga ggtcaagccg gctgataggc acaacctgct gcggccggag accgtggaaa
     1741 gcctgttcta tctgtaccgc gtcacaaaag accgcaagta ccaagactgg ggctgggaaa
     1801 tcctgcagag cttcaataag tacacacggg ttccctcggg tggctattct tctatcaaca
     1861 acgtccagaa ttcccacaag cctgagccca gggacaagat ggagagcttc tttgtgggag
     1921 aaacactgaa gtacctctac ctgctgtttt ctgatgacct ggagctgctc ggcctggaca
     1981 cctgtgtgtt taacacagaa gctcatcccc tgcccatctg gtctcctgcc taggaggaga
     2041 gcacctggcc tgggcactaa tggagaccaa ggtggtcctg ttggtctgtg accttcacag
     2101 ggcagcttca caagctggca ggatgctcct gcccagttgt aggtctctcc tgattcagct
     2161 tttcatgaag gtggtgggag gggcaggagt cagatcagca ggtatgggtt ctgggattta
     2221 ggctggtgag tctaccaaac ctttgacttc ctcaaaacct catatcatgg ctcacgattc
     2281 ccatgcctga atgaccctgt tggctggctg ccggcagccc catggtagta ccaagacttc
     2341 ttatcacctc ctgggaccac ccaggacccc agtgcctgta ttgagttcag agtgatagcc
     2401 caagccagtg aggtgctggg cttggcccat tggcctataa aagccctgat tccgctggcc
     2461 cagtgtgacc ttgagggtcc ttgtggctct agtgtttacg ggttggactc agggatccac
     2521 ctggctaccc tagtgggctg gcaggggcta gaacagcaaa tttgtcttat tcccaggata
     2581 accctggtac aatgtgattt ctcatccgag aagaaagtgg acttggtccc actgtaatga
     2641 gtcttgggga gaggaggaaa ggggtggtgt ctgtttagac tgaccttaag gggacagcaa
     2701 gttctcttga taacatctca gtaactaccc ctaaaatcag agttcctgcc cacttcaggt
     2761 aggaagacca agctgggaaa agcaggcttt gggaccatta tacaaacagg ccaggatgct
     2821 cggctgtgct atctcagagt ggtctgtgaa gagcgtctgc tgctgctggc cgacagctgc
     2881 atggtagttt gcaccttgac gtccgaaccc atggagtagg cctggcctat ctttgacgag
     2941 tcgttactag agcgtccgtc cctgggcctt ggctaggatt ccttatccaa gcagcacagc
     3001 ctaggacaga gcagacaacc taaggacctt aaggctctgg gcctgtgttc cctgtgctcc
     3061 gagatctgga gatttgacgt gggaactcct tgcctgcagc tcaaagcgtc tcagtggcag
     3121 cctgcgcctc tgaggtacag tagttgctct gggagtttcc tgtcaaacac ttgtacccca
     3181 agccagtcgt aacaccagaa gtctacaaag aaggacctgg ctggtaacat gtccttagtc
     3241 tcgaattcat gggcagaagc tctccccctt ctccccccaa atcagttgta gtccctccca
     3301 ctgatgttag cttctcccta cgctgtcctg tgccaggagc cccataggct tgtgaatgga
     3361 caggctctgg ctgtggtgaa ggctgaagca gttgagaagt atattctcca tccccagcct
     3421 tctcccagat gtattctgga agatgtggtt ggtatcaaag ggatagcaac tgccctgtgg
     3481 ccctctgaag aatttctgtg gatcagagta actgggtaga ggcccacaaa gctgggagcc
     3541 acattaaagc agacaacatt ggaatggtcc tgggagggga agccagtgcc caggaggggc
     3601 agatttcccc ccatccctcc tctgaagcgg gaaacctaag ctggagtctc tgctcaatta
     3661 aatgtctaac tggtctcaaa aaaaaaaaaa aaaa
//
