LOCUS       NM_001106452            3482 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus mannosidase, alpha, class 1A, member 2 (Man1a2),
            mRNA.
ACCESSION   NM_001106452 XM_001062587 XM_227543
VERSION     NM_001106452.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3482)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   2  (bases 1 to 3482)
  AUTHORS   Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE and
            Yates JR.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   3  (bases 1 to 3482)
  AUTHORS   Tremblay LO, Nagy Kovacs E, Daniels E, Wong NK, Sutton-Smith M,
            Morris HR, Dell A, Marcinkiewicz E, Seidah NG, McKerlie C and
            Herscovics A.
  TITLE     Respiratory distress and neonatal lethality in mice lacking Golgi
            alpha1,2-mannosidase IB involved in N-glycan maturation
  JOURNAL   J Biol Chem 282 (4), 2558-2566 (2007)
   PUBMED   17121831
REFERENCE   4  (bases 1 to 3482)
  AUTHORS   Bell AW, Ward MA, Blackstock WP, Freeman HN, Choudhary JS, Lewis
            AP, Chotai D, Fazel A, Gushue JN, Paiement J, Palcy S, Chevet E,
            Lafreniere-Roula M, Solari R, Thomas DY, Rowley A and Bergeron JJ.
  TITLE     Proteomics characterization of abundant Golgi membrane proteins
  JOURNAL   J Biol Chem 276 (7), 5152-5165 (2001)
   PUBMED   11042173
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474015.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001062587.1, XM_227543.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3482
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..3482
                     /gene="Man1a2"
                     /gene_synonym="Man1b"
                     /note="mannosidase, alpha, class 1A, member 2"
                     /db_xref="GeneID:295319"
                     /db_xref="RGD:1309767"
     exon            1..665
                     /gene="Man1a2"
                     /gene_synonym="Man1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             364..2289
                     /gene="Man1a2"
                     /gene_synonym="Man1b"
                     /EC_number="3.2.1.113"
                     /note="mannosidase 1, beta"
                     /codon_start=1
                     /product="mannosyl-oligosaccharide 1,2-alpha-mannosidase
                     IB"
                     /protein_id="NP_001099922.1"
                     /db_xref="GeneID:295319"
                     /db_xref="RGD:1309767"
                     /translation="MTTPALLPLSGRRIPPLNLGPPSFPHHRATLRLSEKFILLLILS
                     AFITLCFGAFFFLPDSSKHKRFDLGLEDVLIPHVDAGKGAKDPGVFLIHGPDEHRHRE
                     EEERLRNKIRADHEKALEEAKEKLRKSREEIRAEIQTEKNKVAQAMKTKETRVLPPVP
                     VPQRVGVSGGDPEDAEIRKKRDKIKEMMKHAWDNYRTYGWGHNELRPIARKGHSTNIF
                     GSSQMGATIVDALDTLYIMGLHDEFMDGQRWIEDNLDFSVNSEVSVFEVNIRFIGGLL
                     AAYYLSGEEIFKTKAVQLAEKLLPAFNTPTGIPWAMVNLKSGVGRNWGWASAGSSILA
                     EFGTLHMEFVHLSYLTGDLTYYNKVMHIRKLLQKMERPNGLYPNYLNPRTGRWGQYHT
                     SVGGLGDSFYEYLLKAWLMSDKTDHEARRMYDDAVEAIEKHLIKKSRGGLVFIGEWKN
                     GHLERKMGHLACFAGGMFALGADGSRKDKAGHYLELGAEIARTCHESYDRTALKLGPE
                     SFKFDGAVEAVAVRQAEKYYILRPEVIETYWYLWRFTHDPRYRQWGWEAALAIEKSCR
                     VSGGFSGVKDVYSPTPAHDDVQQSFFLAETLKYLYLLFSGDDLLPLDHWVFNTEAHPL
                     PVLRLANTTLSGNPAVR"
     exon            666..921
                     /gene="Man1a2"
                     /gene_synonym="Man1b"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1018
                     /gene="Man1a2"
                     /gene_synonym="Man1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1137
                     /gene="Man1a2"
                     /gene_synonym="Man1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1218
                     /gene="Man1a2"
                     /gene_synonym="Man1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1313
                     /gene="Man1a2"
                     /gene_synonym="Man1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1437
                     /gene="Man1a2"
                     /gene_synonym="Man1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1531
                     /gene="Man1a2"
                     /gene_synonym="Man1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1647
                     /gene="Man1a2"
                     /gene_synonym="Man1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1867
                     /gene="Man1a2"
                     /gene_synonym="Man1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..2040
                     /gene="Man1a2"
                     /gene_synonym="Man1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..2156
                     /gene="Man1a2"
                     /gene_synonym="Man1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..3482
                     /gene="Man1a2"
                     /gene_synonym="Man1b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catggcagaa cccaccttgc agcttctctg cagtgtgttt cgcccggtcc gctctcggga
       61 atgaagagga gactcgcgat cacccggtga ggaactgaga gccaaatggc gagaagatct
      121 taccggacag aaatcagcga tcgcttggga ggtcacccgg gcttctggat gtaatcggag
      181 accatgaaag aggtggcctc gtaaataatc atcatcataa taaaaaagca caacaatcct
      241 ttgagaggcg ggaagttgag tttattcatt ttttttgtcg aggttttgag aaacggttcg
      301 atgtgttgta catttgatat aagatgagaa ctttataaag tattccgtcc aagagcctaa
      361 acgatgacta ccccagcgct gctgcccctg tctggtcgta ggataccacc tctgaacctg
      421 gggccgccct ccttcccaca tcacagggct accttgagac tctccgagaa gtttatcctt
      481 ctcctcatcc ttagtgcctt catcaccctg tgttttgggg cattcttctt ccttccagac
      541 tcttcaaaac acaaacgctt tgatctgggc ttagaagatg tgttaattcc tcacgtagat
      601 gcgggcaaag gggctaaaga ccccggagtc ttcctgattc atggacccga cgaacacaga
      661 cacagggaag aagaagagcg tctgagaaat aagattagag ctgatcatga gaaagccctg
      721 gaagaagcaa aagaaaaatt aagaaagtca agagaggaaa tccgtgcaga aattcagaca
      781 gagaaaaata aagtagccca agcaatgaag acaaaagaga ccagggtact gccacctgtc
      841 cctgtcccac agcgtgtagg ggtcagtggt ggggacccag aagacgcgga gatcaggaag
      901 aaaagagaca aaattaaaga gatgatgaaa catgcctggg ataattacag aacatacgga
      961 tggggccata atgagctcag acctattgca aggaaagggc attccactaa catattcgga
     1021 agctcacaga tgggggccac catagtggat gctttggata ccctttatat catggggctt
     1081 catgatgaat tcatggatgg gcaaagatgg attgaagaca accttgattt cagtgtgaac
     1141 tcggaagtgt ctgtgtttga agttaacatt cgctttattg gagggctcct tgcagcatat
     1201 tacctgtcag gagaggaaat tttcaagact aaagcagtgc agttggctga gaagctcctt
     1261 cctgccttta acactcctac tgggattcct tgggcaatgg tgaacctgaa aagtggagta
     1321 ggtcggaact ggggctgggc atctgcaggc agcagcatcc tggctgaatt tggcaccctg
     1381 cacatggagt tcgtgcacct cagctacttg actggtgacc tgacttacta taataaggtc
     1441 atgcacatcc ggaaactact acagaaaatg gaacgcccaa atggtcttta tccaaattat
     1501 ttaaacccga ggacagggcg ctggggtcag tatcacacat cagttggtgg cctaggtgac
     1561 agtttttatg aatacttact aaaagcatgg ctgatgtcag ataaaacaga ccacgaggca
     1621 agaaggatgt acgacgacgc tgttgaggct atagagaaac atcttattaa gaagtcccga
     1681 ggaggtctag tctttattgg agaatggaaa aatggacact tggaaaggaa gatgggtcat
     1741 ttggcctgct ttgctggggg aatgtttgca cttggagcgg atggttccag aaaggataaa
     1801 gctggccact atttagaact aggggcagaa attgcacgaa catgccatga gtcatatgac
     1861 agaactgcat taaaactagg tcctgagtca ttcaagtttg atggtgcagt ggaagcagtg
     1921 gctgtgcggc aagctgagaa gtattacatc cttcgtccgg aagtgatcga aacctattgg
     1981 tatctatggc gattcaccca cgacccaaga tacaggcagt ggggctggga agccgcattg
     2041 gctattgaga agtcctgccg agtcagtggt gggttttctg gtgtcaagga tgtctactcc
     2101 ccgactcctg cgcacgacga cgtgcagcag agcttttttc ttgccgagac gttaaaatac
     2161 ttgtacctgc tgttctctgg cgatgacctc ctacctttag accactgggt gtttaataca
     2221 gaggctcatc ctctgccggt gttgcgttta gccaacacca ctctttcagg taaccctgct
     2281 gttcgatgag cacagctgca gaaggaccat tcttacctgt gttttgttta catggaccac
     2341 tacagaaatt gtctggagag gcggcttttg aaaacctgga cctttacatc aatatgccgg
     2401 atggaactct tccctgcaag acttttcact tgtagatata tcaactttga aattattcca
     2461 ttttatacct gaccaaaaca tgttctggta cacgtaggac agagacctga tgtgttttga
     2521 ttcttaatga gatggccaca tgagaaacaa tgtcttattc tatactgtca gtgcaaatca
     2581 agaacataga gcaccttaca ggagttagag atggcttttg aaccaattat acatttgttt
     2641 cctcccacag tggagcagct ttcaaataaa atataacata ttgtgtagcc cctttcctcc
     2701 attttaataa tggaacaaac ggaatgacca ggaacagagg aacagtgtaa ctacattgta
     2761 gcaagaagac ttgggaaagc aacagatact gtccctgtct gaattttcaa gctcctcatt
     2821 ggatttttac cagactggca accattttat tcccaaccta gtcattgaaa tctgtttaga
     2881 tttagttttt ctctgagggg catgatctca tgaagaatac ttttcaagtc tttgtctccg
     2941 tatgatatgc tgaacctggt atttatcata actgctgctt atgagcccaa gtgtgggagt
     3001 gtgcatgtag ctcacgctag cgttgggagc atggcggaag gtggggaagt gccagattgt
     3061 tgcctgaaac ctatttgaga gaaatccttg atttgttggt aggaaattat cttctgaacc
     3121 aacaactgaa tcaagcaaac attttctgct ttaatctcac aacacagtta atagagtcat
     3181 ttaccttcca cgtcatgtgg cttggcaaaa tcgactacac tgtcaagcag ctctgtattt
     3241 gctagaacaa gcctgatcgc ttacaacttc ctaaagcaaa ggcaaaagtc tgcagtgtcc
     3301 ctcgagcagg gtcaggcgct ctacttgtta cctcacaggt gtgagctgct cacaaagagt
     3361 ccatgttttt aagtttctcc aagatattat acatccaaag aattactaga atagcttcaa
     3421 agtaatcttc agaggcaaat gtgtgatgta agaatcatac tcactaaaac tgacataaac
     3481 ct
//
