LOCUS       NM_001033656            3857 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus mannosidase, alpha, class 1A, member 1 (Man1a1),
            mRNA.
ACCESSION   NM_001033656 XM_228157
VERSION     NM_001033656.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3857)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   2  (bases 1 to 3857)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   3  (bases 1 to 3857)
  AUTHORS   Sawitzki,B., Bushell,A., Steger,U., Jones,N., Risch,K., Siepert,A.,
            Lehmann,M., Schmitt-Knosalla,I., Vogt,K., Gebuhr,I., Wood,K. and
            Volk,H.D.
  TITLE     Identification of gene markers for the prediction of allograft
            rejection or permanent acceptance
  JOURNAL   Am J Transplant 7 (5), 1091-1102 (2007)
   PUBMED   17456197
  REMARK    GeneRIF: Downregulation of TOAG-1 and alpha-1,2-mannosidase
            expression occurred in graft infiltrating cells and expression of
            both genes was also downregulated after T-cell activation in vitro.
REFERENCE   4  (bases 1 to 3857)
  AUTHORS   Breuza,L., Halbeisen,R., Jeno,P., Otte,S., Barlowe,C., Hong,W. and
            Hauri,H.P.
  TITLE     Proteomics of endoplasmic reticulum-Golgi intermediate compartment
            (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies
            ERGIC-32, a new cycling protein that interacts with human Erv46
  JOURNAL   J Biol Chem 279 (45), 47242-47253 (2004)
   PUBMED   15308636
REFERENCE   5  (bases 1 to 3857)
  AUTHORS   Bell,A.W., Ward,M.A., Blackstock,W.P., Freeman,H.N.,
            Choudhary,J.S., Lewis,A.P., Chotai,D., Fazel,A., Gushue,J.N.,
            Paiement,J., Palcy,S., Chevet,E., Lafreniere-Roula,M., Solari,R.,
            Thomas,D.Y., Rowley,A. and Bergeron,J.J.
  TITLE     Proteomics characterization of abundant Golgi membrane proteins
  JOURNAL   J Biol Chem 276 (7), 5152-5165 (2001)
   PUBMED   11042173
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Sep 20, 2005 this sequence version replaced XM_228157.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643286.47159.1,
                                           SRR26643294.61567.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-270               JAXUCZ010000020.1  33927232-33927501   c
            271-1125            JAXUCZ010000020.1  33926120-33926974   c
            1126-1222           JAXUCZ010000020.1  33883970-33884066   c
            1223-1338           JAXUCZ010000020.1  33879115-33879230   c
            1339-1419           JAXUCZ010000020.1  33865218-33865298   c
            1420-1514           JAXUCZ010000020.1  33817608-33817702   c
            1515-1638           JAXUCZ010000020.1  33775926-33776049   c
            1639-1732           JAXUCZ010000020.1  33774745-33774838   c
            1733-1848           JAXUCZ010000020.1  33766572-33766687   c
            1849-2068           JAXUCZ010000020.1  33761177-33761396   c
            2069-2241           JAXUCZ010000020.1  33760273-33760445   c
            2242-2357           JAXUCZ010000020.1  33748250-33748365   c
            2358-3857           JAXUCZ010000020.1  33746420-33747919   c
FEATURES             Location/Qualifiers
     source          1..3857
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     gene            1..3857
                     /gene="Man1a1"
                     /gene_synonym="Aa2-166; Man1a"
                     /note="mannosidase, alpha, class 1A, member 1"
                     /db_xref="GeneID:294410"
                     /db_xref="RGD:1310891"
     exon            1..270
                     /gene="Man1a1"
                     /gene_synonym="Aa2-166; Man1a"
                     /inference="alignment:Splign:2.1.0"
     exon            271..1125
                     /gene="Man1a1"
                     /gene_synonym="Aa2-166; Man1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             517..2484
                     /gene="Man1a1"
                     /gene_synonym="Aa2-166; Man1a"
                     /EC_number="3.2.1.113"
                     /note="mannosyl-oligosaccharide alpha-1,2-mannosidase;
                     mannosidase 1, alpha"
                     /codon_start=1
                     /product="mannosyl-oligosaccharide 1,2-alpha-mannosidase
                     IA"
                     /protein_id="NP_001028828.1"
                     /db_xref="GeneID:294410"
                     /db_xref="RGD:1310891"
                     /translation="MPVGGLLPLFSSPGGGGLGGGLGGGLGGGRKGSGPAAFRLTEKF
                     VLLLVFSAFITLCFGAIFFLPDSSKLLSGVLFHSNPALQPPAEHKPGLGARAEDAAEG
                     RVRHREEGVPGDPGAGLEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKEKVA
                     QDQLRDKDLFGGLPKVDFLPPIGVENREPADATIREKRSKIKEMMAHAWNNYKRYAWG
                     LNELKPISKEGHSSSLFGNIKGATIVDALDTLFIMGMKTEFQEAKSWIKKYLDFNVNA
                     EVSVFEVNIRFVGGLLSAYYLSGEEIFRKKAVELGVKLLPAFHSPSGIPWALLNMKSG
                     IGRNWPWASGGSSILAEFGTLHLEFMHLAHLSGNPVFAEKVMNIRTVLNKLDKPEGLY
                     PNYLNPSSGQWGQHHVSVGGLGDSFYEYLLKAWLMSDKTDLEAKKMYFDAVQAIETHL
                     IRKSSGGLTYIAEWKGGLLEHKMGHLTCFAGGMFALGADGAPEARAQHYLELGAEIAR
                     TCHESYNRTYVKLGPEAFRFDGGVEAIATRQNEKYYILRPEVIETYMYMWRLTHDPKY
                     RTWAWEAVEALESHCRVNGGYSGLRDVYIAHESYDDVQQSFFLAETLKYLYLIFSDDD
                     LLPLEHWIFNTEAHPFPILRDQKKEVDVQEK"
     exon            1126..1222
                     /gene="Man1a1"
                     /gene_synonym="Aa2-166; Man1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1338
                     /gene="Man1a1"
                     /gene_synonym="Aa2-166; Man1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1419
                     /gene="Man1a1"
                     /gene_synonym="Aa2-166; Man1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1514
                     /gene="Man1a1"
                     /gene_synonym="Aa2-166; Man1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1638
                     /gene="Man1a1"
                     /gene_synonym="Aa2-166; Man1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1732
                     /gene="Man1a1"
                     /gene_synonym="Aa2-166; Man1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1848
                     /gene="Man1a1"
                     /gene_synonym="Aa2-166; Man1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..2068
                     /gene="Man1a1"
                     /gene_synonym="Aa2-166; Man1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2241
                     /gene="Man1a1"
                     /gene_synonym="Aa2-166; Man1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2357
                     /gene="Man1a1"
                     /gene_synonym="Aa2-166; Man1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2358..3857
                     /gene="Man1a1"
                     /gene_synonym="Aa2-166; Man1a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actctccgga cgcgtcaccg ccctcgtttc cgaccgccgg gagaccggca gtgctattag
       61 tgcacggcgg ggccgcggcg gagggcagca cgttgcctgg tttgttggca cacgccggca
      121 ggtcggcgcg ctcgctcacc tgagtcgtgt cccggggccg cagagccacc gggctgtacg
      181 agcgccaccg cccgccgtga cgcgctcgga gatgggcagc tggagaagtt gacgagcccc
      241 ctacgcacgc ggcgcccttg ctgcccagag gggctgcagc cagcggtttg ccgcgcgtgc
      301 ctgtttgcca aaggagccgc cccggcaagg atcgccggag gggagccgct tccagcgggg
      361 agacccgcag cccagacacg cgctctgggc ggcctggatg cgcaagagcc ggccccgcag
      421 cagctgaccg ccggcggcag cgaagtttgg ctgctgagcg gctcggcgcc ggacgcttgg
      481 acagactgtc agcctgcggc tgcaatctcc ggagccatgc ccgtgggggg cctgttgcca
      541 ctcttcagta gccctggggg cggaggcctg ggcggtggcc tgggcggggg tcttggcggc
      601 gggaggaagg ggtctggccc cgccgccttc cgcctcactg agaagttcgt gctgctgctg
      661 gtgttcagcg ccttcatcac gctctgcttc ggggcaatct tcttcctgcc tgactcctcc
      721 aagctgctga gcggggtcct gttccactcc aaccctgcct tgcagccacc ggcggagcac
      781 aagcccgggc tcggggcgcg tgccgaggat gccgccgaag ggagagtccg gcaccgcgag
      841 gaaggcgtgc ctggggaccc tggagctgga ctggaggata acttagccag aatccgtgaa
      901 aaccacgaga gggctctcag ggaagccaag gaaaccctgc agaagctgcc agaggagatc
      961 caaagagaca ttctgctgga gaaggagaag gtggcccagg accagctgcg tgacaaggat
     1021 ctgtttgggg gcttgcccaa ggtggacttc ctgcccccca tcggggtaga gaaccgagag
     1081 cctgctgacg ccaccatccg tgagaagagg tcaaagatca aagagatgat ggcccatgct
     1141 tggaataatt ataaacgcta tgcgtggggc ttgaacgaac tgaaaccgat atcaaaagaa
     1201 ggccattcaa gcagtttgtt tggcaacatc aaaggagcta caatagtaga tgccctagat
     1261 acccttttca ttatgggtat gaagactgaa tttcaagaag ctaaatcatg gattaaaaaa
     1321 tacttagatt ttaatgtgaa tgctgaagtt tctgtttttg aagtaaacat acgtttcgtt
     1381 ggtggattgc tgtcagccta ctatttgtcc ggagaggaga tatttcgaaa gaaagcagtg
     1441 gaacttgggg taaaattgct acctgcattt catagtccct ctggaatacc ttgggcattg
     1501 ctgaatatga aaagtgggat tggacgtaac tggccctggg cctctggagg cagcagtatt
     1561 ctggcagaat ttggaactct ccatttggag ttcatgcact tggcccactt atcaggaaat
     1621 cccgtctttg ccgaaaaggt aatgaatatt cgaacagtgc tgaacaagct ggacaaacca
     1681 gaaggccttt atcctaacta cctgaacccc agtagtggac agtggggtca acatcatgtg
     1741 tcagttggag gacttggaga cagcttttat gaatatttgc tcaaggcatg gttaatgtct
     1801 gacaagaccg atctcgaagc caagaagatg tattttgatg ctgtccaggc catcgagact
     1861 cacttgatcc gcaagtcaag tgggggacta acgtacatcg cagagtggaa agggggcctc
     1921 ctggagcaca agatgggcca cctgacgtgc tttgcagggg ggatgtttgc acttggggcc
     1981 gacggagctc cagaagctcg ggcccaacac taccttgaac tcggagctga gatcgcccgc
     2041 acctgtcacg agtcttacaa ccgcacatat gtgaagttgg ggccagaagc gtttcgattt
     2101 gatggcggcg tggaagccat tgccacgagg caaaatgaga agtattacat tctacggcca
     2161 gaggttatcg agacatacat gtacatgtgg cgtctgaccc atgatcccaa gtacaggacc
     2221 tgggcctggg aagccgtaga ggccctagaa agccactgta gagtgaacgg aggctactca
     2281 ggcctacggg atgtttacat tgcccatgag agttatgacg acgtccagca aagcttcttc
     2341 ctggcagaga cactgaagta tctgtacttg atattttccg acgatgacct tcttccactg
     2401 gaacactgga tcttcaacac cgaggctcat cctttcccta tactccgtga ccagaagaaa
     2461 gaagttgatg tccaggagaa atgaaagaca tttcctattt tactctgctt cgttccctca
     2521 ctgcatacct taataattcc tttcctggta atatgatgaa ctcttattga ttggcagaag
     2581 tctatcattc tcctaagttc taaaattgtt ttgcagtctt ttatgtttag tatcatgagc
     2641 ctaagtggac atcagttcct tgtttcatta ttcagctagt agatctgcag attctgcctg
     2701 tctttttctt tttcttaaag aatctattgt ttctaaaaat tcatgaagtc acggcatcat
     2761 tttcataata gaaccgtcta ccagtgacct cttgattatg atttgatttg actgcaaaac
     2821 ttcttcctcc tctatgagga gatgctgtct gcttcgagct gtaatgtttt gccatgttgc
     2881 aaaaagccat aataataaat taagtattaa aaaaagcttt ttttttcctt ttcaagttca
     2941 cgttattctg gtttgtctat tcaccagaga caggtcttac aactgtgaca gcctcttagc
     3001 aggtctatca ttatttgata gaatgtcttc taaagtcctc cactctcatt gtgactcaga
     3061 tgagaaagtt gtcccagaag agccagcgac actggcctca tctcttgtct ttttattggg
     3121 tgattatgtt catgtttcct cacttttgat tttgtcctct acgttttctc taaatgccct
     3181 gtgtcatctc tgtaccgtgc actgcttacc ttctcccatg gcccacgaca cagcaagggg
     3241 agctcctgag ttgtgctgaa cgcctggtta cccaattaca ggtttgaaag ggaaaagact
     3301 taacttctaa cgtgccaggc tttcctttta attgaatcca ttccaaaatc tggtctctaa
     3361 gaagagaagg agaattccat atgactggtt catggacctg cattccctcc tgggttctct
     3421 tcaagcaaag gatgcatttg tacttggttc agatcggaaa aagggcccgt cccaggtaca
     3481 gctcgtcaat gtacttcagt ttgtgaaagt gagcttttac ctagtgaaag aagcatttct
     3541 gatttatcta ctcctgttca gctaagggag acaaaaagtg gtctaattag cttctaaaga
     3601 gtattaaatg tgcttgttca gcataaatat cttaacttac aaataattta tagggatgga
     3661 cccactccct cagaatttga tctgcagcag gtcaaaacgg ttatatgatt cttctaaacc
     3721 ttattttgaa tttcccaagg acaaactttg tgatagcttg tgttaccaca cctgttcttt
     3781 atatgaaaga tcaaatatga tccgtatgca ccaaaagaca aagacaataa gcacctcagt
     3841 ttcaacctat gatcaat
//
