LOCUS       NM_145768               3933 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus MAM domain containing 4 (Mamdc4), mRNA.
ACCESSION   NM_145768
VERSION     NM_145768.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3933)
  AUTHORS   McCarter,S.D., Johnson,D.L., Kitt,K.N., Donohue,C., Adams,A. and
            Wilson,J.M.
  TITLE     Regulation of tight junction assembly and epithelial polarity by a
            resident protein of apical endosomes
  JOURNAL   Traffic 11 (6), 856-866 (2010)
   PUBMED   20214753
  REMARK    GeneRIF: endotubin regulates trafficking of polarity proteins and
            tight junction components out of the endosomal compartment
REFERENCE   2  (bases 1 to 3933)
  AUTHORS   Speelman,B.A., Allen,K., Grounds,T.L., Neutra,M.R., Kirchhausen,T.
            and Wilson,J.M.
  TITLE     Molecular characterization of an apical early endosomal
            glycoprotein from developing rat intestinal epithelial cells
  JOURNAL   J Biol Chem 270 (4), 1583-1588 (1995)
   PUBMED   7829488
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 22, 2020 this sequence version replaced NM_145768.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L37380.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               JAXUCZ010000003.1  28789033-28789139   c
            108-218             JAXUCZ010000003.1  28787539-28787649   c
            219-392             JAXUCZ010000003.1  28787294-28787467   c
            393-518             JAXUCZ010000003.1  28787081-28787206   c
            519-649             JAXUCZ010000003.1  28786788-28786918   c
            650-734             JAXUCZ010000003.1  28786619-28786703   c
            735-860             JAXUCZ010000003.1  28786376-28786501   c
            861-998             JAXUCZ010000003.1  28786053-28786190   c
            999-1087            JAXUCZ010000003.1  28785879-28785967   c
            1088-1261           JAXUCZ010000003.1  28785615-28785788   c
            1262-1346           JAXUCZ010000003.1  28785111-28785195   c
            1347-1526           JAXUCZ010000003.1  28784847-28785026   c
            1527-1655           JAXUCZ010000003.1  28784613-28784741   c
            1656-1787           JAXUCZ010000003.1  28784393-28784524   c
            1788-1912           JAXUCZ010000003.1  28784163-28784287   c
            1913-2024           JAXUCZ010000003.1  28783971-28784082   c
            2025-2141           JAXUCZ010000003.1  28783731-28783847   c
            2142-2276           JAXUCZ010000003.1  28783523-28783657   c
            2277-2413           JAXUCZ010000003.1  28783277-28783413   c
            2414-2633           JAXUCZ010000003.1  28782984-28783203   c
            2634-2771           JAXUCZ010000003.1  28782757-28782894   c
            2772-2890           JAXUCZ010000003.1  28782555-28782673   c
            2891-2981           JAXUCZ010000003.1  28782371-28782461   c
            2982-3128           JAXUCZ010000003.1  28782105-28782251   c
            3129-3263           JAXUCZ010000003.1  28781865-28781999   c
            3264-3391           JAXUCZ010000003.1  28781642-28781769   c
            3392-3500           JAXUCZ010000003.1  28781458-28781566   c
            3501-3667           JAXUCZ010000003.1  28780917-28781083   c
            3668-3933           JAXUCZ010000003.1  28780523-28780788   c
FEATURES             Location/Qualifiers
     source          1..3933
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     gene            1..3933
                     /gene="Mamdc4"
                     /gene_synonym="Aegp"
                     /note="MAM domain containing 4"
                     /db_xref="GeneID:252882"
                     /db_xref="RGD:708583"
     exon            1..107
                     /gene="Mamdc4"
                     /gene_synonym="Aegp"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..3709
                     /gene="Mamdc4"
                     /gene_synonym="Aegp"
                     /note="apical endosomal glycoprotein; MAM
                     domain-containing protein 4; apical early endosomal
                     glycoprotein"
                     /codon_start=1
                     /product="apical endosomal glycoprotein precursor"
                     /protein_id="NP_665711.2"
                     /db_xref="GeneID:252882"
                     /db_xref="RGD:708583"
                     /translation="MCLPSCLLSIWVLFMAAQSLGKTWVPDHCRSPTEATCNFVCDCG
                     DCSDEAQCGFHGASTTPNTPFTCNFEQDPCGWQDISTSGYRWLRDRAGAGLDSSGPHS
                     DHTRGTDLGWYMAVGTHSGKEPSTATLRSPVMREAAPTCELRLWYHTDSRDVAELRLD
                     LTHGMETLTLWQSSGPWGPGWQELAVNTGRIQGDFKVTFSATRNATHRGAVALDDMEF
                     WDCGLPIPQARCPLGHHHCQNKACVEPHQLCDGEDNCGDSSDEDPLICSHHMATDFET
                     GLGPWTQLEGWTRNFSAGSMVSPAWPHRDHSRNSAYGFFLVSVAKPGTTAVLYSPEFQ
                     GSVSYNCSFTFYYYLHGSEANQFQLFVQAQGLNTTQPPVLLRSRHGELGTAWVRDRVN
                     IQSAHPFRILLAGETGPGGFVGLDDLIMSNHCILVPGMSTLQSSLSGPVPLALYPQTS
                     IKRTCEPGHLSCDELCVPPEQLCDFQQHCAEGEDEEKCGTTDFESASAGGWEDISIGK
                     LQWQRAEAQESGKPARDTNRNAPGHFLSLRKAWGQLRSEARALTPALGPSGPHCELHM
                     TYYFHSHPQGFLALAVVENGFRELLWQAPSSSSGGWTLQKILLGARRRPFQLEFVSLV
                     DLDGPGQQGAGVDNVTLRDCNPMVTTESDQEVSCNFERDSCSWHTGHLTDAHWHRVKS
                     HGSQYDHTTGQGFFMFLDPMDPPARGQGALLLTRPQVPVVPKECLSFWYHLHGPQIGT
                     LCLAMRREGEEDTLLWSRSGTHGNRWHQAWVTLHHQLQPSTKYQLLFEGLRDGYHGTM
                     GLDDMAVRPGPCWAAKRCSFEDSDCGFSPGGWGLWTRQNNASGLGPWGPWIDHTTGTA
                     QGHYMVVDTSPNLLPKGHVASLTSEEHPPLSRPACLTFWYHLSFHNPGTLRVFVEEST
                     RRQELSISGHGGFAWRLGSVNVQAEQAWKVVFEAMASGVEHSYMALDDISLQDGPCAQ
                     PGSCDFESGLCGWSHLPWPGLGGYSWDWSSGATPSRYPRPSVDHTVGTEAGHFAFFET
                     SVLGPGGQAAWLRSEPLPATAVSCLHFWYYMGFPAHFYKGELRVLLSSTQGQLAVWHR
                     GGHLRDQWLQVQIEVSSSEEFQIVFEATLGGQPALGPIALDDVEYLAGQHCKQPTPSQ
                     GGVAAPVSVPVAVGGALLLFLLLLGLGGWHWLQKQHLPCQSTDAAASGFDNILFNADQ
                     VTLPESITSNP"
     exon            108..218
                     /gene="Mamdc4"
                     /gene_synonym="Aegp"
                     /inference="alignment:Splign:2.1.0"
     exon            219..392
                     /gene="Mamdc4"
                     /gene_synonym="Aegp"
                     /inference="alignment:Splign:2.1.0"
     exon            393..518
                     /gene="Mamdc4"
                     /gene_synonym="Aegp"
                     /inference="alignment:Splign:2.1.0"
     exon            519..649
                     /gene="Mamdc4"
                     /gene_synonym="Aegp"
                     /inference="alignment:Splign:2.1.0"
     exon            650..734
                     /gene="Mamdc4"
                     /gene_synonym="Aegp"
                     /inference="alignment:Splign:2.1.0"
     exon            735..860
                     /gene="Mamdc4"
                     /gene_synonym="Aegp"
                     /inference="alignment:Splign:2.1.0"
     exon            861..998
                     /gene="Mamdc4"
                     /gene_synonym="Aegp"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1087
                     /gene="Mamdc4"
                     /gene_synonym="Aegp"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1261
                     /gene="Mamdc4"
                     /gene_synonym="Aegp"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1346
                     /gene="Mamdc4"
                     /gene_synonym="Aegp"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1526
                     /gene="Mamdc4"
                     /gene_synonym="Aegp"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1655
                     /gene="Mamdc4"
                     /gene_synonym="Aegp"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1787
                     /gene="Mamdc4"
                     /gene_synonym="Aegp"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1912
                     /gene="Mamdc4"
                     /gene_synonym="Aegp"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2024
                     /gene="Mamdc4"
                     /gene_synonym="Aegp"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2141
                     /gene="Mamdc4"
                     /gene_synonym="Aegp"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..2276
                     /gene="Mamdc4"
                     /gene_synonym="Aegp"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..2413
                     /gene="Mamdc4"
                     /gene_synonym="Aegp"
                     /inference="alignment:Splign:2.1.0"
     exon            2414..2633
                     /gene="Mamdc4"
                     /gene_synonym="Aegp"
                     /inference="alignment:Splign:2.1.0"
     exon            2634..2771
                     /gene="Mamdc4"
                     /gene_synonym="Aegp"
                     /inference="alignment:Splign:2.1.0"
     exon            2772..2890
                     /gene="Mamdc4"
                     /gene_synonym="Aegp"
                     /inference="alignment:Splign:2.1.0"
     exon            2891..2981
                     /gene="Mamdc4"
                     /gene_synonym="Aegp"
                     /inference="alignment:Splign:2.1.0"
     exon            2982..3128
                     /gene="Mamdc4"
                     /gene_synonym="Aegp"
                     /inference="alignment:Splign:2.1.0"
     exon            3129..3263
                     /gene="Mamdc4"
                     /gene_synonym="Aegp"
                     /inference="alignment:Splign:2.1.0"
     exon            3264..3391
                     /gene="Mamdc4"
                     /gene_synonym="Aegp"
                     /inference="alignment:Splign:2.1.0"
     exon            3392..3500
                     /gene="Mamdc4"
                     /gene_synonym="Aegp"
                     /inference="alignment:Splign:2.1.0"
     exon            3501..3667
                     /gene="Mamdc4"
                     /gene_synonym="Aegp"
                     /inference="alignment:Splign:2.1.0"
     exon            3668..3933
                     /gene="Mamdc4"
                     /gene_synonym="Aegp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaactgagaa gtctctagac tgcacagctt cgcttgcact gggacaccct ctagcctggc
       61 catgtgcctg cctagctgcc tcctctcaat ctgggtccta tttatggctg cacagtctct
      121 aggcaagacc tgggtccctg accactgcag aagccccacc gaagctacgt gcaactttgt
      181 gtgtgactgt ggagactgtt cagatgaggc tcagtgtggt ttccacggtg cctcaactac
      241 cccaaacacc cccttcacct gcaactttga gcaggatccc tgtggctggc aggacatcag
      301 cacctcgggc tatcgatggc ttcgagaccg ggcaggggca gggctggata gttctgggcc
      361 ccattctgac catacacgtg gcactgactt gggctggtac atggctgtgg gaacccatag
      421 tgggaaggag ccatctactg cgactttgcg ctctcctgtc atgcgtgagg cagcccccac
      481 ctgtgaactg aggctctggt accacactga ctctagagat gtcgctgagc tgcggctgga
      541 tctgacccat ggtatggaga cactgactct atggcagagc tcgggacctt ggggtcctgg
      601 ctggcaggaa ctagcagtga acactggccg aatccagggt gacttcaaag tgacattttc
      661 tgccactcga aatgctacac acaggggcgc tgtggccttg gatgacatgg agttctggga
      721 ctgtggtctg cccatccctc aggccaggtg tcccctgggg caccaccact gccagaacaa
      781 agcttgtgtg gagccccacc agctctgtga cggtgaagac aactgtggag acagttctga
      841 tgaagacccg ctcatctgca gccaccacat ggccaccgac tttgagacag gcctaggacc
      901 atggacccaa ttagagggct ggacacggaa cttcagtgct ggcagcatgg tgagccctgc
      961 ctggccccac cgagatcaca gccggaatag tgcatatggc ttctttctcg tctctgtggc
     1021 caagcctggc accactgctg tcctctacag ccctgagttc caaggctcag tctcctacaa
     1081 ctgctcgttc accttctatt actacctgca tgggtctgag gccaaccaat tccagctctt
     1141 tgtgcaggca caggggctca acaccaccca gcctcctgtc ctactccgaa gccgccatgg
     1201 agagttgggg acagcctggg tcagagaccg ggttaacatt caaagtgccc atccatttcg
     1261 gatccttctt gctggggaga ctggtccagg aggcttcgtg ggcctagacg accttatcat
     1321 gtccaaccac tgcatacttg ttccaggtat gtccaccctg cagtcatcac tttctggacc
     1381 tgtgccattg gccctctatc cccagacatc catcaagcga acctgtgagc caggacatct
     1441 ctcctgtgac gagctgtgtg tgcccccgga gcagctgtgt gatttccagc agcactgtgc
     1501 cgaaggcgag gatgaagaga agtgtggcac cacggacttt gagtctgcct ctgctggggg
     1561 ctgggaggac atcagtatag gaaagctaca gtggcaacgg gctgaagccc aggagagcgg
     1621 gaagcctgcc agggatacca accggaatgc gcctgggcac ttcctatctc tgcggaaggc
     1681 ctgggggcag ctacgatctg aggcccgggc tctcacacct gctctgggcc cctctggccc
     1741 tcactgtgaa ctccacatga cttactattt tcacagtcat ccccaaggct tcttggcact
     1801 ggctgtggtg gagaatggct tccgggagct gctgtggcag gctccaagca gcagcagtgg
     1861 gggctggaca ctacagaaga ttcttcttgg ggcacggcgc cggccattcc agctggagtt
     1921 cgtcagtctg gtggacttgg atggccctgg ccaacagggg gctggggtgg ataatgtgac
     1981 cctgagagac tgcaacccca tggtgaccac tgagagtgac caagaggtct cctgtaactt
     2041 tgaacgggac tcctgcagct ggcacacagg ccacctcaca gatgcccact ggcaccgtgt
     2101 aaaaagccac ggctctcagt atgaccacac caccggccaa ggttttttca tgttcctgga
     2161 tcccatggac ccacctgctc gaggccaagg tgccctgttg ctcacaagac cccaggtgcc
     2221 agttgtcccc aaggaatgtc tcagcttctg gtaccatctg catgggcccc agattgggac
     2281 actgtgcttg gccatgagga gggaggggga ggaagacaca ctactgtggt cccggtcagg
     2341 cacccacggc aaccgctggc accaggcttg ggtcactctt caccaccagc tgcagcccag
     2401 caccaagtac cagttgctgt ttgaaggcct ccgggatggg taccatggca caatgggcct
     2461 ggatgacatg gctgtgcggc ctggcccctg ctgggccgcc aagagatgtt cctttgaaga
     2521 ctctgactgt ggcttctccc cagggggctg ggggctgtgg acacgccaga ataatgcctc
     2581 aggccttggt ccttggggtc cttggataga ccataccaca gggacagccc aggggcacta
     2641 catggtggtg gacaccagcc caaatttact gcccaaaggt catgtggcct ctctgacttc
     2701 agaggagcac ccgcccctgt cccggcctgc ctgcctgacc ttctggtacc acctgagctt
     2761 ccacaatcca ggcaccttga gggtcttcgt ggaagagagc acaaggcgcc aagagctcag
     2821 catcagtggc catggtggat ttgcgtggcg cctaggcagc gtgaatgtac aggctgagca
     2881 ggcctggaag gtagtgtttg aggctatggc ttctggcgtg gaacattcct acatggctct
     2941 ggatgacatt tccctccaag atgggccctg tgctcagcca gggtcctgtg actttgaatc
     3001 tggcctgtgt gggtggagcc acctgccttg gcctggtctg ggtgggtaca gctgggactg
     3061 gagcagtgga gccactccat cccggtaccc ccggccttca gtggaccaca ctgtgggcac
     3121 agaagcaggc cacttcgctt tctttgaaac cagcgtgcta ggtcctgggg gccaggcagc
     3181 ctggctgcgc agtgagccac tgccagcaac tgcagtctcc tgcctccact tctggtacta
     3241 catgggcttt cctgcgcatt tctacaaggg tgagttgaga gtgctcctga gcagtaccca
     3301 aggacagcta gctgtgtggc accggggtgg gcacttgcgg gaccagtggc tacaagtcca
     3361 gattgaagtg tccagctctg aggagttcca gattgttttt gaagccactc tgggtggcca
     3421 gccggctcta gggcccattg cccttgatga tgtggagtac ttggctggac aacactgcaa
     3481 gcaacctaca cctagccagg gtggagtggc agcacccgtg tctgtgccgg ttgcagtcgg
     3541 aggagccctc ctcctcttcc tgttgctcct gggccttgga ggttggcact ggctgcagaa
     3601 gcagcacctc ccctgccaaa gtacagatgc agcagcctct ggctttgaca atatcctctt
     3661 caatgcggat caagttaccc tcccagaatc aatcaccagt aacccataga gcactccaga
     3721 caaggcctgg cctgacatgg caactctcac agcattcaaa cctcacaggc actggcctgc
     3781 ccacctgcct gtgggcctgg atgtagggac cgagtcatga ttacctcacc aggtcttcct
     3841 ctatctggtg tctttgccct ctggtgtgat ggagaagggt agaggagtct ttgtactgtg
     3901 aataaatgct ctacatagtg agggcaaccc aga
//
