LOCUS       NM_001419765            5154 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Rattus norvegicus MALT1 paracaspase (Malt1), transcript variant 1,
            mRNA.
ACCESSION   NM_001419765 XM_003751798
VERSION     NM_001419765.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5154)
  AUTHORS   Ruan,Z., Li,Y. and Chen,Y.
  TITLE     HECTD3 promotes NLRP3 inflammasome and pyroptosis to exacerbate
            diabetes-related cognitive impairment by stabilising MALT1 to
            regulate JNK pathway
  JOURNAL   Arch Physiol Biochem 130 (4), 373-384 (2024)
   PUBMED   35913790
  REMARK    GeneRIF: HECTD3 promotes NLRP3 inflammasome and pyroptosis to
            exacerbate diabetes-related cognitive impairment by stabilising
            MALT1 to regulate JNK pathway.
REFERENCE   2  (bases 1 to 5154)
  AUTHORS   Jiang,Y.Q., Yang,X.Y., Duan,D.Q., Zhang,Y.Y., Li,N.S., Tang,L.J.,
            Peng,J. and Luo,X.J.
  TITLE     Inhibition of MALT1 reduces ferroptosis in rat hearts following
            ischemia/reperfusion via enhancing the Nrf2/SLC7A11 pathway
  JOURNAL   Eur J Pharmacol 950, 175774 (2023)
   PUBMED   37146710
  REMARK    GeneRIF: Inhibition of MALT1 reduces ferroptosis in rat hearts
            following ischemia/reperfusion via enhancing the Nrf2/SLC7A11
            pathway.
REFERENCE   3  (bases 1 to 5154)
  AUTHORS   Zhang,Q., Zhang,S., Chen,H., Chen,G., Cui,C., Zhang,J., Wang,W.,
            Zhang,Q. and Guo,S.
  TITLE     Targeting of MALT1 May Improve Functional Recovery and Attenuate
            Microglia M1 Polarization-Mediated Neuroinflammation During Spinal
            Cord Injury
  JOURNAL   Mol Neurobiol 60 (5), 2632-2643 (2023)
   PUBMED   36692707
  REMARK    GeneRIF: Targeting of MALT1 May Improve Functional Recovery and
            Attenuate Microglia M1 Polarization-Mediated Neuroinflammation
            During Spinal Cord Injury.
REFERENCE   4  (bases 1 to 5154)
  AUTHORS   Zhang,Y.Y., Yang,X.Y., Liu,H.Q., Zhang,Z., Hu,C.P., Peng,J. and
            Luo,X.J.
  TITLE     The Weakened Interaction Between HECTD4 and GluN2B in Ischemic
            Stroke Promotes Calcium Overload and Brain Injury Through a
            Mechanism Involving the Decrease of GluN2B and MALT1 Ubiquitination
  JOURNAL   Mol Neurobiol 60 (3), 1563-1579 (2023)
   PUBMED   36527595
  REMARK    GeneRIF: The Weakened Interaction Between HECTD4 and GluN2B in
            Ischemic Stroke Promotes Calcium Overload and Brain Injury Through
            a Mechanism Involving the Decrease of GluN2B and MALT1
            Ubiquitination.
REFERENCE   5  (bases 1 to 5154)
  AUTHORS   Peng,Z.M., Zhang,Y.Y., Wei,D., Zhang,X.J., Liu,B., Peng,J. and
            Luo,X.J.
  TITLE     MALT1 promotes necroptosis in stroke rat brain via targeting the
            A20/RIPK3 pathway
  JOURNAL   Arch Biochem Biophys 735, 109502 (2023)
   PUBMED   36603698
  REMARK    GeneRIF: MALT1 promotes necroptosis in stroke rat brain via
            targeting the A20/RIPK3 pathway.
REFERENCE   6  (bases 1 to 5154)
  AUTHORS   Hulpiau,P., Driege,Y., Staal,J. and Beyaert,R.
  TITLE     MALT1 is not alone after all: identification of novel paracaspases
  JOURNAL   Cell Mol Life Sci 73 (5), 1103-1116 (2016)
   PUBMED   26377317
REFERENCE   7  (bases 1 to 5154)
  AUTHORS   Sanchez-Izquierdo,D., Buchonnet,G., Siebert,R., Gascoyne,R.D.,
            Climent,J., Karran,L., Marin,M., Blesa,D., Horsman,D.,
            Rosenwald,A., Staudt,L.M., Albertson,D.G., Du,M.Q., Ye,H.,
            Marynen,P., Garcia-Conde,J., Pinkel,D., Dyer,M.J. and
            Martinez-Climent,J.A.
  TITLE     MALT1 is deregulated by both chromosomal translocation and
            amplification in B-cell non-Hodgkin lymphoma
  JOURNAL   Blood 101 (11), 4539-4546 (2003)
   PUBMED   12560219
REFERENCE   8  (bases 1 to 5154)
  AUTHORS   Reed,J.C., Doctor,K., Rojas,A., Zapata,J.M., Stehlik,C.,
            Fiorentino,L., Damiano,J., Roth,W., Matsuzawa,S., Newman,R.,
            Takayama,S., Marusawa,H., Xu,F., Salvesen,G. and Godzik,A.
  CONSRTM   RIKEN GER Group; GSL Members
  TITLE     Comparative analysis of apoptosis and inflammation genes of mice
            and humans
  JOURNAL   Genome Res 13 (6B), 1376-1388 (2003)
   PUBMED   12819136
REFERENCE   9  (bases 1 to 5154)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   10 (bases 1 to 5154)
  AUTHORS   Akagi,T., Motegi,M., Tamura,A., Suzuki,R., Hosokawa,Y., Suzuki,H.,
            Ota,H., Nakamura,S., Morishima,Y., Taniwaki,M. and Seto,M.
  TITLE     A novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21)
            found in low-grade B-cell lymphoma of mucosa-associated lymphoid
            tissue
  JOURNAL   Oncogene 18 (42), 5785-5794 (1999)
   PUBMED   10523859
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 18, 2023 this sequence version replaced XM_003751798.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.19809.1,
                                           SRR26643294.57947.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-366               JAXUCZ010000018.1  61212368-61212733
            367-533             JAXUCZ010000018.1  61219116-61219282
            534-655             JAXUCZ010000018.1  61224999-61225120
            656-815             JAXUCZ010000018.1  61230633-61230792
            816-994             JAXUCZ010000018.1  61231395-61231573
            995-1091            JAXUCZ010000018.1  61231966-61232062
            1092-1124           JAXUCZ010000018.1  61232646-61232678
            1125-1151           JAXUCZ010000018.1  61235381-61235407
            1152-1181           JAXUCZ010000018.1  61237370-61237399
            1182-1385           JAXUCZ010000018.1  61242632-61242835
            1386-1563           JAXUCZ010000018.1  61246895-61247072
            1564-1638           JAXUCZ010000018.1  61248095-61248169
            1639-1766           JAXUCZ010000018.1  61248731-61248858
            1767-1916           JAXUCZ010000018.1  61257314-61257463
            1917-2074           JAXUCZ010000018.1  61260250-61260407
            2075-2200           JAXUCZ010000018.1  61262444-61262569
            2201-5154           JAXUCZ010000018.1  61263319-61266272
FEATURES             Location/Qualifiers
     source          1..5154
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..5154
                     /gene="Malt1"
                     /gene_synonym="Pcasp1"
                     /note="MALT1 paracaspase"
                     /db_xref="GeneID:307366"
                     /db_xref="RGD:1309195"
     exon            1..366
                     /gene="Malt1"
                     /gene_synonym="Pcasp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..2638
                     /gene="Malt1"
                     /gene_synonym="Pcasp1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mucosa associated lymphoid tissue lymphoma translocation
                     gene 1; paracaspase-1; mucosa-associated lymphoid tissue
                     lymphoma translocation protein 1"
                     /codon_start=1
                     /product="mucosa-associated lymphoid tissue lymphoma
                     translocation protein 1 isoform 1"
                     /protein_id="NP_001406694.1"
                     /db_xref="GeneID:307366"
                     /db_xref="RGD:1309195"
                     /translation="MSLWGQPLQASPPPAVQQPLTASSGPSTAPPAGSTLNRLPEPLL
                     RRLSESLDRAPEGRGWRQLAELAGSRGRLRLSCLDLEQCSLKVLEPEGSPSLCLLKLM
                     GEKGCTVPELSDFLQALEHTEVLQLLNPPGLKITVNPESKAVLAGQFVKLCCRATGHP
                     FVQYQWFKMNKEIPYGNSSELIFNTVHVKDAGFYVCRVNNNSTFEFSQWSQLDVCDVT
                     EVSDSFQGSLDGVSESKLRICVEPQSQKLAPGSALLLQCVAIGSPVPHYQWFKDESPL
                     AHETKKHYTVPYVDLEHEGTYWCHVYNDRDSQDSKKVEIIIGRTDGAVECTEDELNNL
                     GRPDNKEQTGQPLAKDKVALLIGNMNYWEHPKLKAPLVDVYELTNLLRQLDFKVVSLL
                     DLTEYEMCNAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAPNPYRSENCLCV
                     QNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIVFGYATCQGAEAFE
                     IQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGRQALEIRSSLSEKR
                     ALTDPIQGAPCSAEALVRNLQWAKAHELPESMCLKFQCGVHIQLGFAAEFSNVMIIYT
                     SIVHKPPEIIMCDAYVTDFPLDLDIDPKHANKGTPEETGSYLVSKELPKHCLYTRLSS
                     LQKLKEHLIFTVCLSYQYSGLEDTVEEKQEVSVGKPLIAKLDMHRGLGRKTCLQACPM
                     PDETCHSSTSTSAGAGHFHSSQDSFHDVYHSQLGNSDSAMPPDRCHCSRTPHAFISNY
                     PPHHYCQFGRSNVPVETTDEMPFSFSDRLMISEN"
     exon            367..533
                     /gene="Malt1"
                     /gene_synonym="Pcasp1"
                     /inference="alignment:Splign:2.1.0"
     exon            534..655
                     /gene="Malt1"
                     /gene_synonym="Pcasp1"
                     /inference="alignment:Splign:2.1.0"
     exon            656..815
                     /gene="Malt1"
                     /gene_synonym="Pcasp1"
                     /inference="alignment:Splign:2.1.0"
     exon            816..994
                     /gene="Malt1"
                     /gene_synonym="Pcasp1"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1091
                     /gene="Malt1"
                     /gene_synonym="Pcasp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1124
                     /gene="Malt1"
                     /gene_synonym="Pcasp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1151
                     /gene="Malt1"
                     /gene_synonym="Pcasp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1181
                     /gene="Malt1"
                     /gene_synonym="Pcasp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1385
                     /gene="Malt1"
                     /gene_synonym="Pcasp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1563
                     /gene="Malt1"
                     /gene_synonym="Pcasp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1638
                     /gene="Malt1"
                     /gene_synonym="Pcasp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1766
                     /gene="Malt1"
                     /gene_synonym="Pcasp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1916
                     /gene="Malt1"
                     /gene_synonym="Pcasp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2074
                     /gene="Malt1"
                     /gene_synonym="Pcasp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2200
                     /gene="Malt1"
                     /gene_synonym="Pcasp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..5154
                     /gene="Malt1"
                     /gene_synonym="Pcasp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttcttcct gtgagggcct cgctgtgcgg ctgacttctc cttccgctcc tgcgactccc
       61 aggactgcga gaggcaagcg gaaggtgcgc ggacgccgga gcccgaggga actgggcagt
      121 cggggccacc ggcgtaacca tgtcgctgtg ggggcagccg ctgcaggcct cgccgcctcc
      181 ggcggtgcag cagcccctga ccgcgtcttc gggaccttcg accgcccctc cagccggctc
      241 aactctcaac cgcctgcccg agccgctgct gcggaggctc agcgagagct tggaccgcgc
      301 gccggagggc cggggctggc ggcagctggc cgagctggcg ggcagtcggg gacgccttcg
      361 gctcagttgc ctggacttgg aacagtgttc tcttaaagta ttggagccag agggaagccc
      421 aagtttgtgt ttactgaaac tgatgggtga gaaaggatgt acagtcccag aactgagcga
      481 cttcctccag gctttggagc acaccgaggt tctgcagctt ctcaaccccc caggattaaa
      541 gatcaccgta aacccagaat ccaaggcagt tttggctgga cagtttgtaa aactgtgctg
      601 ccgggcaact ggacatcctt ttgtacaata ccaatggttc aagatgaata aagagatccc
      661 atatggaaat tcatcagaac ttatttttaa cacagtccat gtaaaagacg caggctttta
      721 tgtctgccga gttaacaaca actccacctt tgaatttagc cagtggtcgc agctggatgt
      781 gtgtgatgtg acagaagtat cagacagctt ccagggaagt ctggatggcg tctcagaatc
      841 caagttgcga atctgtgttg aaccacagtc ccaaaagctg gcgccaggca gtgcgttgct
      901 gttacagtgc gttgccattg gaagccctgt gccccactac cagtggttta aagacgaatc
      961 accattagca catgagacaa aaaagcatta cacagtccca tatgtggatc tagagcatga
     1021 aggaacctac tggtgtcatg tatataatga ccgggacagt caagatagta agaaggtaga
     1081 aatcatcata ggaagaacag atggggcagt ggagtgcact gaagatgaat taaataattt
     1141 ggggcgtcct gataataaag aacaaactgg ccagcctttg gcaaaggaca aagttgctct
     1201 tttgatagga aatatgaatt actgggagca ccccaagctt aaagctccat tggtggatgt
     1261 gtatgaattg accaacttat taaggcaact agatttcaaa gttgtttcat tgttggatct
     1321 tactgaatac gagatgtgta atgctgtgga tgaattctta ctacttttag acaaaggagt
     1381 atatggcttg ttatattatg ccgggcatgg ttatgaaaac tttgggaaca gttttatggt
     1441 ccctgttgat gctccaaatc cgtataggtc tgaaaattgc ctctgtgtac aaaacatact
     1501 gaaattaatg caagaaaagg agactggact gaatgtgttc ctgttggata tgtgtcggaa
     1561 aagaaatgac tacgatgata ccattccaat cttggacgca ctgaaagtca ctgccaatat
     1621 cgtgtttgga tatgccacgt gccaaggagc agaagccttt gaaatccagc attctggatt
     1681 ggcaaatggg atttttatga aatttttgaa agatagatta ttagaagaca agaaaattac
     1741 tgtgttactg gatgaagttg cagaagatat gggtaaatgc caccttacca aaggcagaca
     1801 agctctagag attcgcagca gcttatctga aaagagagca ctgactgatc caatccaggg
     1861 agctccttgc tctgcagagg ctctggtacg caatctgcag tgggccaagg ctcacgaact
     1921 gccagagagt atgtgcctta agtttcagtg tggtgttcat attcagttag gatttgctgc
     1981 cgagttctcc aacgtcatga taatctacac aagtatagtc cacaagccac ctgagataat
     2041 aatgtgcgac gcctatgtta ctgacttccc tcttgaccta gatattgatc caaaacatgc
     2101 caataagggg actccagaag aaactggcag ctacttagtg tccaaagagc tccccaagca
     2161 ctgcctctat actagactca gctcactaca aaaactaaag gaacatctga tcttcacagt
     2221 ctgtttatcc taccagtatt caggactaga agacactgtg gaagagaagc aggaagtgag
     2281 tgtcgggaaa cctcttatcg ccaagttaga catgcatcga ggactgggca ggaagacttg
     2341 cctccaagcc tgtcccatgc ctgatgagac ttgccacagc tccacatcta cctcagcggg
     2401 agcagggcac ttccattcct cccaagactc cttccacgat gtgtaccatt ctcagctcgg
     2461 caactcagac agtgctatgc caccagacag gtgccattgc agccggactc cacatgcgtt
     2521 catttccaac tatccccccc accactactg ccagtttggt agaagtaatg tgcctgtaga
     2581 gacgactgat gaaatgccgt tcagtttttc tgacaggctt atgatttctg aaaactgacc
     2641 ttcatgtttt tgaaaattag aatagttaga gtaaactcac ataatttaac acttataaat
     2701 aaggtgtggt gaaaaggcaa atgcgtacgt atggagagaa aactagcaac tgtttttata
     2761 gcaagttctc aggaatatga aactttagaa ttacattatt taagctgggc agtggtggta
     2821 cacatcttta atctcagcac tcagaaggca gaggaagggg cagatctctg agttcgagac
     2881 cagcctggta tacatagtga gttccagggc agccagagat acagagaaat cctgcctaac
     2941 aaaaacaaaa gcaaaaaaaa gattacatta tttaaccaga ctctcttgct tttgtcctgt
     3001 tttaaggctt tgtgaattaa tttgttctgt aaaaatgggg ggctggggat ttagctcagt
     3061 ggtagagcgc ttacctagga agcgcaaggc cctgggttca gtccccagct ccgaaaaaaa
     3121 gaaccaaaaa aaaaaaaaaa aaaatgaagt atggggcctg taaatagtgc tcaatggtgc
     3181 agtgctcagc taacgtgtgg aaggccctgg acctgctcat cgttactgga ggggaaaatg
     3241 tgttattaga gtaaatgtgt atgtgtatca gatggtttca ttttgaccac tcagaagagc
     3301 cgtgaaatgg cgttattata gattgagtta tgttgctaac accaaaagag aaccctttct
     3361 ctttttcaga gttattttat ttatgtgtat atgtgggagt ctcagtgtgt atgtgtacta
     3421 atggagacca gaagagggca tcaggtcctg gaactggaat tacaggcagg tgtaagccac
     3481 tcagtgtgag tgttaggagc tgaacctatt tcccctccaa gtgctcttaa catctctcat
     3541 ccccagagag aacctttcag tcattgggct taataacttc attttatcaa ggggaaaacc
     3601 agctagaggc tagctgtctt actggagcac aactgaagtc tcagttctag tctcaagttt
     3661 ttcttccagt gctttctgct ctacaagtgg ttttgccaga ctgtgatggt gcatgccttt
     3721 aatcccagca ctcaggaaac agaggcaagt agacctctgt gagttcgagg ccatcctggt
     3781 ctacaaagaa agtccaggac agccagggct acactaagaa acctgtctca aaaaaaacaa
     3841 aaacaaaaac aaaacagtct tagagctagg gtaatggctc aattaataga gtgccaaggg
     3901 tgaagaccag agattggatc cccagcatct gcataaaagg ttgagggtgt agacaggcaa
     3961 ttccctgagc tgttcggcta gccaaatcaa ggctgtctaa acaaggtagg aagcagctga
     4021 ggaagacagc cactgtcaac ttcagtgtcc agttgtgtgt atgcatatgc actcacacaa
     4081 catacataca tacacacaaa ggtcttggga gaatgctagc acagaaagta ggcatttgga
     4141 ctgtcgtggg gtttctgtta ctatggtaaa cactatgacc aaacacaagt ggggaagaaa
     4201 agatttattt cagcttacaa ttcaggtgat actccatcac taaggaaagt cactgatgga
     4261 gaggccatgg acgagtgctg cttattggct tgctctccag ggcttgctca gcctgcttcc
     4321 ttacagcatg taggactaac aacccacagt gtgattgatt actcatcaat caaggaaatg
     4381 caccacagac cctacaagcc aacctgatga aggcattttc tcagttgagg ttcctcttcc
     4441 aaaaggacta gtttgtgtca aactaacaga aaaaggccag catatggacc ttccctcaac
     4501 ctctttaaag tgtgtgacct ttcaagtctc tggcttgagc ataaaagcca ggtaaccttg
     4561 tcagtaagtc acaaatcctt gtcaaatccc atagccagag cttaggtccg tgccgtgtac
     4621 atgaggacag gtttaacatg actgttgttt tactttcgtg ggttctctta acaaacagcc
     4681 tggtatttgt gtattgtctc ctgttatctg agacaatcca tagataagtt acggaggctg
     4741 gagagatagc tcagaggtta cgagcactgg ctgctcttcc agaggtcctg agaaccacat
     4801 ggtggctcac aagtgtctat aatgatgtct ggtgcccttt tctggcctgc aggcatatat
     4861 gcaggcagga cactgtatac ataataaatc tttaaaagaa aaagataagt taaaagtgaa
     4921 ttgtattcac tccagaatta ctttgtaaaa acaaaaatgc atatttaaca tgaccagttt
     4981 ttaatgtaca aaatattctg tgtagcaacc cagaacagca taacagttta tctgcattgg
     5041 gattatattc ttgtttgctt agctgtgttt tcctaattgt atatactgaa caactgttgt
     5101 gtaacttaaa atacagatgt atgcaactat tataaagatg cccagttttg ataa
//
