LOCUS       NM_198786               2800 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus mal, T-cell differentiation protein 2 (Mal2),
            mRNA.
ACCESSION   NM_198786 XM_343240
VERSION     NM_198786.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2800)
  AUTHORS   Aranda JF, Reglero-Real N, Marcos-Ramiro B, Ruiz-Saenz A,
            Fernandez-Martin L, Bernabe-Rubio M, Kremer L, Ridley AJ, Correas
            I, Alonso MA and Millan J.
  TITLE     MYADM controls endothelial barrier function through ERM-dependent
            regulation of ICAM-1 expression
  JOURNAL   Mol Biol Cell 24 (4), 483-494 (2013)
   PUBMED   23264465
REFERENCE   2  (bases 1 to 2800)
  AUTHORS   In JG and Tuma PL.
  TITLE     MAL2 selectively regulates polymeric IgA receptor delivery from the
            Golgi to the plasma membrane in WIF-B cells
  JOURNAL   Traffic 11 (8), 1056-1066 (2010)
   PUBMED   20444237
  REMARK    GeneRIF: Data show that in addition to its role in transcytosis,
            MAL2 also regulates polymeric IgA receptor delivery from the Golgi
            to the plasma membrane.
REFERENCE   3  (bases 1 to 2800)
  AUTHORS   Gronborg M, Pavlos NJ, Brunk I, Chua JJ, Munster-Wandowski A,
            Riedel D, Ahnert-Hilger G, Urlaub H and Jahn R.
  TITLE     Quantitative comparison of glutamatergic and GABAergic synaptic
            vesicles unveils selectivity for few proteins including MAL2, a
            novel synaptic vesicle protein
  JOURNAL   J Neurosci 30 (1), 2-12 (2010)
   PUBMED   20053882
  REMARK    GeneRIF: MAL2 is a novel synaptic vesicle protein that is
            preferentially associated with vesicular glutamate
            (VGLUT-1)-containing nerve terminals.
REFERENCE   4  (bases 1 to 2800)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 2800)
  AUTHORS   de Marco MC, Martin-Belmonte F, Kremer L, Albar JP, Correas I,
            Vaerman JP, Marazuela M, Byrne JA and Alonso MA.
  TITLE     MAL2, a novel raft protein of the MAL family, is an essential
            component of the machinery for transcytosis in hepatoma HepG2 cells
  JOURNAL   J Cell Biol 159 (1), 37-44 (2002)
   PUBMED   12370246
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC062388.1.
            
            On Oct 6, 2005 this sequence version replaced NM_198786.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062388.1, CK477819.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2800              BC062388.1         1-2800
FEATURES             Location/Qualifiers
     source          1..2800
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q32"
     gene            1..2800
                     /gene="Mal2"
                     /note="mal, T-cell differentiation protein 2"
                     /db_xref="GeneID:362911"
                     /db_xref="RGD:735066"
     exon            1..290
                     /gene="Mal2"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..689
                     /gene="Mal2"
                     /note="MAL2A; MAL2 proteolipid protein; protein MAL2-like"
                     /codon_start=1
                     /product="protein MAL2"
                     /protein_id="NP_942081.2"
                     /db_xref="GeneID:362911"
                     /db_xref="RGD:735066"
                     /translation="MSAGGAAVPPPPNPAVSFPAPRITLPAGPDILRTYSGAFVCLEI
                     VLGGLVWILVASSNVPLPLLQGWVMFVSVTAFFFSLLFLGLFLSGMVTQIDANWNFLD
                     FAYHFIVFVFYFGAFLLEAAATSLHDLQCNTTMVVKPLLNDNQYNINVAATVFAFMTT
                     ACYGCSLCLALRRWRP"
     exon            291..461
                     /gene="Mal2"
                     /inference="alignment:Splign:2.1.0"
     exon            462..617
                     /gene="Mal2"
                     /inference="alignment:Splign:2.1.0"
     exon            618..2780
                     /gene="Mal2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2760..2765
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mal2"
     polyA_site      2780
                     /gene="Mal2"
ORIGIN      
        1 cgtagccaca ccctttccgc gctcagcacg cctgaacccc gcgaaccgga gcggcggcgg
       61 cggcggcggc ggcggcggcc aagcccggga ggcggaggcg ggacgcggga ggcggtggcg
      121 acggtggcgg cggtgcgcgg agacgtagca gcggcagcat gtcggccggc ggagcggcag
      181 tcccgccgcc cccgaaccct gccgtgtcct tcccggcgcc ccggatcacc ctgccggctg
      241 gccctgacat cctgaggacc tactcgggag ctttcgtctg cctggagatt gtacttgggg
      301 gacttgtctg gattttggtc gcttcttcca atgttcctct acctctgctg caaggatggg
      361 tcatgtttgt atctgtgaca gctttcttct tttcgcttct cttcctgggt ttgttcctct
      421 ctggtatggt gactcagatt gatgccaact ggaactttct ggattttgcc taccatttca
      481 tagtctttgt cttctacttc ggcgcctttt tattggaagc agcggccacc tccctgcatg
      541 acctgcaatg caacactacg atggttgtga agccgctact gaacgataac cagtacaaca
      601 tcaacgtggc tgccacagtt ttcgccttta tgaccacggc ttgttatggt tgcagtttgt
      661 gtctggcttt gcgaagatgg cgaccgtaac actccttgga aaccgacagt tgtgtgctag
      721 tttcatttgt ctgctttaca tgtctgatca cttgggcacc atttgtccca atgtaacatt
      781 ccaaacatca tttgcttagt acagagagaa cctcagtgaa accaagtttg ttacatgggc
      841 gggattttca ttttgttcta atgttagaaa agtatacttt tgttttttca tctcttttct
      901 ttttaaatac atttcccttg tatattctta aaatatacag gcactgttca caaaacaata
      961 gtattccttt ttttttatga ttttggttaa gtcacccaaa ccttaataat agtaaaaact
     1021 aaaacatctc aagcagactt ctcatttaat tctatcttta atgtaaaaca ggaaatgata
     1081 cacttttttt taaccaaaag accaggcagc acctgcatag gctttaataa gccttattat
     1141 agcttctggg gcagttgttc catcctgtgg taacaaaagc agctgcagat aacatgtaaa
     1201 taaatgtcta tcctaataaa gctttattta caaaaaggga tcgaaactgg atggtctgca
     1261 gaccacaact ttatcaacta ctgccataaa aaccttaggt gttttgcatt ctactgaacc
     1321 aatcatgaaa gtttatcaac ctcactagaa aagccacgta acatattttg ttttgttatg
     1381 caacaatcac attgcctttg tgtaatagtc aaatattacc cttggaaggg catatagttt
     1441 ctcaagctaa ccccggcaga gccttggatg tatagcaaaa taaggtagta aataaactcc
     1501 aaactaatga tttcctaaca gctcagcaag gcactcacac gagagtgctt aaaacatgat
     1561 ccccagaggc aattaatcac tactggatct agtatcttgc tactgatgtc taacattggt
     1621 ttatttatgc catagactgt ggttgtttgc cctgtgcatg aacatataaa tatttatgtg
     1681 tgtaaagctt ttccagatag ctctctgaag agttgaactt ttaacttctg attgtttttg
     1741 cattgctatc tgaactaaat ttgagtaaca tcagctataa cataaagcta tagattctta
     1801 catgctttga taatatccca gatatctatg ttgtttttac attgtgtcaa acaggcaaag
     1861 gaaatttagc agaacagcta acacaaaaac gagatctagc tgaataggac acaatcctag
     1921 tccacctata tgtgtcatgg gcttggcaac ataacacgac tggccacagt tcctacagca
     1981 ttctcagaca ggggacgtcc ctattgtttt aacagggctg cctctggaaa tggaggcttg
     2041 acaattgctt tctagctgac tcatcaccta agagtgccat gcatggttgg ggtattggac
     2101 tccctggaac acagtgaaaa acatgaatga ataacataac caatgcccag tgatcaagtg
     2161 ctgtttatct aatactcctc cagaagaaga accaactaga agctcagttt gtaacacagc
     2221 tgaagaagag atatatttct atatgttgcg tgatgaaacc agtcttatgg ccttacactc
     2281 atgtcttatc tcttctaaaa tgcctgactt ccttcatatt tttccagctc cagaccacac
     2341 acctgaaacc tgtattatga atactatgaa gtcacaaatg tgccataaag atacattgta
     2401 cattgtactt ggaatcacta aagtgtagta cactagaatt tagtggaggt tttatttttc
     2461 ccaaggtgta acaggccatg ttcagtgtgg tatcaactaa ttaattcatt cagatgtatt
     2521 ggtgggactt ctataaatgg attgctacta gattagcaag gaccaagccc aaagctgact
     2581 gactgtgaat acttagaact ggagatgaac tacattctac atttgtgagc tgaatgacaa
     2641 agcacttgaa cagagatgat ggcgtttaag attctcgtta tgtatcttag ctataaaaat
     2701 gaaaaagtgt tggttggtct taaaatctga taaatttatt ttataagtgt tacaactcta
     2761 ataaagtatt catttgataa aaaaaaaaaa aaaaaaaaaa
//
