LOCUS       NM_012798               2272 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus mal, T-cell differentiation protein (Mal), mRNA.
ACCESSION   NM_012798
VERSION     NM_012798.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2272)
  AUTHORS   Rumah,K.R., Ma,Y., Linden,J.R., Oo,M.L., Anrather,J.,
            Schaeren-Wiemers,N., Alonso,M.A., Fischetti,V.A., McClain,M.S. and
            Vartanian,T.
  TITLE     The Myelin and Lymphocyte Protein MAL Is Required for Binding and
            Activity of Clostridium perfringens epsilon-Toxin
  JOURNAL   PLoS Pathog 11 (5), e1004896 (2015)
   PUBMED   25993478
  REMARK    GeneRIF: Data suggest that expression of MAL in cells confers both
            ETX (Clostridium perfringens epsilon-toxin) binding and
            susceptibility to ETX-mediated cell death; cells expressing rat MAL
            are 100 times more sensitive to ETX than cells expressing human
            MAL.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2272)
  AUTHORS   Huang,Y., Xu,Y., Cheng,Q., Yu,S., Gao,Y., Shu,Q., Yang,C., Sun,Y.,
            Wang,J., Xu,F. and Liang,X.
  TITLE     The expression changes of myelin and lymphocyte protein (MAL)
            following optic nerve crush in adult rats retinal ganglion cells
  JOURNAL   J Mol Neurosci 54 (4), 614-621 (2014)
   PUBMED   24878628
  REMARK    GeneRIF: Significant upregulation of MAL in the retinal ganglion
            cells after optic nerve crush was found.
REFERENCE   3  (bases 1 to 2272)
  AUTHORS   Zhang,J., Cui,Z., Shen,A., Li,W., Xu,G., Bao,G., Sun,Y., Wang,L.,
            Gu,H., Zhou,Y. and Cui,Z.
  TITLE     Upregulation of myelin and lymphocyte protein (MAL) after traumatic
            spinal cord injury in rats
  JOURNAL   J Mol Histol 44 (2), 125-134 (2013)
   PUBMED   23196718
  REMARK    GeneRIF: this is the first description of MAL expression changes in
            gray matter after spinal cord injury. Our results prompted that MAL
            might participate in CNS pathophysiology after SCI.
REFERENCE   4  (bases 1 to 2272)
  AUTHORS   Aranda,J.F., Reglero-Real,N., Marcos-Ramiro,B., Ruiz-Saenz,A.,
            Fernandez-Martin,L., Bernabe-Rubio,M., Kremer,L., Ridley,A.J.,
            Correas,I., Alonso,M.A. and Millan,J.
  TITLE     MYADM controls endothelial barrier function through ERM-dependent
            regulation of ICAM-1 expression
  JOURNAL   Mol Biol Cell 24 (4), 483-494 (2013)
   PUBMED   23264465
REFERENCE   5  (bases 1 to 2272)
  AUTHORS   Zhou,G., Liang,F.X., Romih,R., Wang,Z., Liao,Y., Ghiso,J.,
            Luque-Garcia,J.L., Neubert,T.A., Kreibich,G., Alonso,M.A.,
            Schaeren-Wiemers,N. and Sun,T.T.
  TITLE     MAL facilitates the incorporation of exocytic uroplakin-delivering
            vesicles into the apical membrane of urothelial umbrella cells
  JOURNAL   Mol Biol Cell 23 (7), 1354-1366 (2012)
   PUBMED   22323295
REFERENCE   6  (bases 1 to 2272)
  AUTHORS   Frank,M., Atanasoski,S., Sancho,S., Magyar,J.P., Rulicke,T.,
            Schwab,M.E. and Suter,U.
  TITLE     Progressive segregation of unmyelinated axons in peripheral nerves,
            myelin alterations in the CNS, and cyst formation in the kidneys of
            myelin and lymphocyte protein-overexpressing mice
  JOURNAL   J Neurochem 75 (5), 1927-1939 (2000)
   PUBMED   11032882
REFERENCE   7  (bases 1 to 2272)
  AUTHORS   Frank,M., van der Haar,M.E., Schaeren-Wiemers,N. and Schwab,M.E.
  TITLE     rMAL is a glycosphingolipid-associated protein of myelin and apical
            membranes of epithelial cells in kidney and stomach
  JOURNAL   J Neurosci 18 (13), 4901-4913 (1998)
   PUBMED   9634556
REFERENCE   8  (bases 1 to 2272)
  AUTHORS   Kim,T., Fiedler,K., Madison,D.L., Krueger,W.H. and Pfeiffer,S.E.
  TITLE     Cloning and characterization of MVP17: a developmentally regulated
            myelin protein in oligodendrocytes
  JOURNAL   J Neurosci Res 42 (3), 413-422 (1995)
   PUBMED   8583510
REFERENCE   9  (bases 1 to 2272)
  AUTHORS   Schaeren-Wiemers,N., Valenzuela,D.M., Frank,M. and Schwab,M.E.
  TITLE     Characterization of a rat gene, rMAL, encoding a protein with four
            hydrophobic domains in central and peripheral myelin
  JOURNAL   J Neurosci 15 (8), 5753-5764 (1995)
   PUBMED   7643216
REFERENCE   10 (bases 1 to 2272)
  AUTHORS   Rancano,C., Rubio,T., Correas,I. and Alonso,M.A.
  TITLE     Genomic structure and subcellular localization of MAL, a human
            T-cell-specific proteolipid protein
  JOURNAL   J Biol Chem 269 (11), 8159-8164 (1994)
   PUBMED   8132541
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 26, 2020 this sequence version replaced NM_012798.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U31367.1, SRR26643429.13385.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN16676807,
                                           SAMN16676809 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-170               JAXUCZ010000003.1  135341254-135341423 c
            171-338             JAXUCZ010000003.1  135324968-135325135 c
            339-464             JAXUCZ010000003.1  135323371-135323496 c
            465-2272            JAXUCZ010000003.1  135317664-135319471 c
FEATURES             Location/Qualifiers
     source          1..2272
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..2272
                     /gene="Mal"
                     /gene_synonym="MALGENE"
                     /note="mal, T-cell differentiation protein"
                     /db_xref="GeneID:25263"
                     /db_xref="RGD:3037"
     exon            1..170
                     /gene="Mal"
                     /gene_synonym="MALGENE"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..539
                     /gene="Mal"
                     /gene_synonym="MALGENE"
                     /note="NS 3; MVP17; 17 kDa myelin vesicular protein;
                     T-lymphocyte maturation-associated protein; myelin and
                     lymphocyte protein, T-cell differentiation protein"
                     /codon_start=1
                     /product="myelin and lymphocyte protein"
                     /protein_id="NP_036930.1"
                     /db_xref="GeneID:25263"
                     /db_xref="RGD:3037"
                     /translation="MAPAAASGGSTLPSGFSVFVTFPDLLFIFEFIFGGLVWILIASS
                     LVPMPLVQGWVMFVSVFCFLATTSLMVMYIIGTHGGETSWITLDAAYHCVAALFYLSA
                     SVLEALATITMFDGFTYRHYHENIAAVVFAYVATLLYVIHAVFSLIRWKSS"
     exon            171..338
                     /gene="Mal"
                     /gene_synonym="MALGENE"
                     /inference="alignment:Splign:2.1.0"
     exon            339..464
                     /gene="Mal"
                     /gene_synonym="MALGENE"
                     /inference="alignment:Splign:2.1.0"
     exon            465..2272
                     /gene="Mal"
                     /gene_synonym="MALGENE"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgggctct cgagcaagcg agaggtcagt gcggagccgg aggcgagctt gtccagttcc
       61 aacgccagct cgcaggcatg gccccggcag cagcttcggg tggcagcacc ctgcccagtg
      121 gcttctccgt cttcgtcacc ttccctgact tgctcttcat ctttgagttt atctttggag
      181 gcctggtgtg gatcctgatc gcctcctccc tggtacccat gcccctggtc cagggctggg
      241 tgatgtttgt gtctgtgttc tgcttcctgg ccaccacttc cctgatggtc atgtacataa
      301 ttggtactca tggtggggag acttcctgga tcacactgga tgcagcctac cactgtgtgg
      361 ctgccctgtt ttacctcagt gcctcagtcc tggaagccct ggccaccatc acaatgttcg
      421 atggctttac ctacaggcat taccatgaga acatcgctgc agtggtgttc gcctatgtgg
      481 ctactctgct ctacgtgatc catgctgtgt tttccttaat caggtggaag tcttcatagg
      541 acagcagatt gggagctgaa acccagatgc aattaactgg tcagcctgtc ttccccatta
      601 acttcctgga acagactgaa tggtggagaa aagaaaacaa gccaaaagaa aacaaaacag
      661 acacaaaaac aaaaggaaac catgttcgag tctcttgggt gttacgttta ccttctgtta
      721 gggtttaggg cttgctgaat ttaacttcca gccaaaggag gaaagagttg tcttggcggg
      781 ggccctttct gcccttgacc aggacagtgg gtgggagctt ggaaccttga tctgaagaaa
      841 tgacaatttc cccttgaccc ttggagcagg tcctaacaat tgcctttcgg aattttccac
      901 aagctctttg caccactcat cccctggcat atcttagatt ttgtggatag tctaggtgtc
      961 acaggcactg aaattcaccc aacagaggtc tctagataga tgttcatggt ggaagatgaa
     1021 cccctttgaa atacttcatt aaataccttt atgtctcatg cttcgggtgg ggaactggga
     1081 tgtttttcat tctcaggaat cagggactga cacctttcta ctcaactttc ttcctgccag
     1141 agtcctttga tgtaacctga acctcaaggg acaattcaga tgtgtgtgct gggccagtct
     1201 ttcccacaat gactcactga ggatgccacc ctcacaacag tgtccaccag gacagtgtct
     1261 cccttgtagg tgcatcccag ggagctcaag gaacaacagt ttgctaaatt agaatctttt
     1321 caagctcaga aaactaggtg tgggcattcc ttctcttctt agggctgatc taaaatgctc
     1381 tagtctgtgt ttgggcatgt tctcagatca tttctttcgg ggagaagagg gacctgactc
     1441 cagagcaaag ggagagacaa tggctatttc tggctgccac attccaggtg agggacatct
     1501 gacctgaaag aagaaagtat aattaggaag gacatggaga gcctgcaaag tcagacatct
     1561 gctaggagat ctcacctgga ccccacagtt taaaggattg acaaactaga gttggaaccc
     1621 cagatgcagg gacgtcctgc cagccaccag gactgccagg attctagcct cggtcagctt
     1681 ccactagctg atgttttatt ctccaacaaa gtgggagatt gagacctaca accaaattag
     1741 atttggggag ttttctacct tggttctgag gatggaaccc agggggtaca catgctgggt
     1801 aagcactctt ctcctggatc ccatcttcag ccccaaattg agtcccagtg gcacatccag
     1861 gaggcctttg gttatcccag ccatactggt acccaaatct gccatttgcc ccacttaaca
     1921 cagtcaaaat ttcatactaa aacgcaagca aaagattagg gggatttatt tttaaaaatt
     1981 aaaatataaa ctaagagatt atatgaagtt cattataatg gttaacaaag tctgtaactg
     2041 aacgctgact ggggtcgtct tatattttca acaaaactga accataacat tacactaacc
     2101 agcagctcaa catgagcgag ggttggtttt tttgtttttg tttttttttt ttgataagaa
     2161 gaaaagagag atgaaggaag gaagaaagga acaaaggaag ggtgactaag atgaattttc
     2221 caagggtttc tcaatgtttc agatttttaa tcattaaaag aaactttcat ac
//
