LOCUS       NM_013136               2392 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus male germ cell-associated kinase (Mak), mRNA.
ACCESSION   NM_013136 XM_039095390
VERSION     NM_013136.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2392)
  AUTHORS   Wang,L.Y. and Kung,H.J.
  TITLE     Male germ cell-associated kinase is overexpressed in prostate
            cancer cells and causes mitotic defects via deregulation of
            APC/CCDH1
  JOURNAL   Oncogene 31 (24), 2907-2918 (2012)
   PUBMED   21986944
REFERENCE   2  (bases 1 to 2392)
  AUTHORS   Tucker,B.A., Scheetz,T.E., Mullins,R.F., DeLuca,A.P.,
            Hoffmann,J.M., Johnston,R.M., Jacobson,S.G., Sheffield,V.C. and
            Stone,E.M.
  TITLE     Exome sequencing and analysis of induced pluripotent stem cells
            identify the cilia-related gene male germ cell-associated kinase
            (MAK) as a cause of retinitis pigmentosa
  JOURNAL   Proc Natl Acad Sci U S A 108 (34), E569-E576 (2011)
   PUBMED   21825139
REFERENCE   3  (bases 1 to 2392)
  AUTHORS   Omori,Y., Chaya,T., Katoh,K., Kajimura,N., Sato,S., Muraoka,K.,
            Ueno,S., Koyasu,T., Kondo,M. and Furukawa,T.
  TITLE     Negative regulation of ciliary length by ciliary male germ
            cell-associated kinase (Mak) is required for retinal photoreceptor
            survival
  JOURNAL   Proc Natl Acad Sci U S A 107 (52), 22671-22676 (2010)
   PUBMED   21148103
REFERENCE   4  (bases 1 to 2392)
  AUTHORS   Ma,A.H., Xia,L., Desai,S.J., Boucher,D.L., Guan,Y., Shih,H.M.,
            Shi,X.B., deVere White,R.W., Chen,H.W., Tepper,C.G. and Kung,H.J.
  TITLE     Male germ cell-associated kinase, a male-specific kinase regulated
            by androgen, is a coactivator of androgen receptor in prostate
            cancer cells
  JOURNAL   Cancer Res 66 (17), 8439-8447 (2006)
   PUBMED   16951154
REFERENCE   5  (bases 1 to 2392)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   6  (bases 1 to 2392)
  AUTHORS   Xia,L., Robinson,D., Ma,A.H., Chen,H.C., Wu,F., Qiu,Y. and
            Kung,H.J.
  TITLE     Identification of human male germ cell-associated kinase, a kinase
            transcriptionally activated by androgen in prostate cancer cells
  JOURNAL   J Biol Chem 277 (38), 35422-35433 (2002)
   PUBMED   12084720
REFERENCE   7  (bases 1 to 2392)
  AUTHORS   Matsushime,H., Jinno,A., Takagi,N. and Shibuya,M.
  TITLE     A novel mammalian protein kinase gene (mak) is highly expressed in
            testicular germ cells at and after meiosis
  JOURNAL   Mol Cell Biol 10 (5), 2261-2268 (1990)
   PUBMED   2183027
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On or before Nov 14, 2022 this sequence version replaced
            XM_039095390.1, NM_013136.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2087320.1,
                                           SRR26643293.71587.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                JAXUCZ010000017.1  23889491-23889525
            36-356              JAXUCZ010000017.1  23899616-23899936
            357-411             JAXUCZ010000017.1  23906073-23906127
            412-533             JAXUCZ010000017.1  23906924-23907045
            534-613             JAXUCZ010000017.1  23909242-23909321
            614-746             JAXUCZ010000017.1  23911049-23911181
            747-918             JAXUCZ010000017.1  23913317-23913488
            919-1086            JAXUCZ010000017.1  23913802-23913969
            1087-1398           JAXUCZ010000017.1  23915652-23915963
            1399-1571           JAXUCZ010000017.1  23920699-23920871
            1572-1714           JAXUCZ010000017.1  23922741-23922883
            1715-1846           JAXUCZ010000017.1  23926839-23926970
            1847-1969           JAXUCZ010000017.1  23931892-23932014
            1970-2392           JAXUCZ010000017.1  23935312-23935734
FEATURES             Location/Qualifiers
     source          1..2392
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p12"
     gene            1..2392
                     /gene="Mak"
                     /note="male germ cell-associated kinase"
                     /db_xref="GeneID:25677"
                     /db_xref="RGD:3036"
     exon            1..35
                     /gene="Mak"
                     /inference="alignment:Splign:2.1.0"
     exon            36..356
                     /gene="Mak"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..2124
                     /gene="Mak"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase MAK"
                     /protein_id="NP_037268.2"
                     /db_xref="GeneID:25677"
                     /db_xref="RGD:3036"
                     /translation="MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDE
                     CMNLREVKSLKKLNHANVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVI
                     RNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQPPYTDYV
                     STRWYRAPEVLLRSSVYSSPIDVWAVGSIMAELYTFRPLFPGTSEVDEIFKICQVLGT
                     PKKSDWPEGYQLASSMNFRFPQCIPINLKTLIPNASSEAIQLMTEMLNWDPKKRPTAS
                     QALKHPYFQVGQVLGPSAHHLDAKQTLHKQLQPPEPKPSSSERDPKPLPNILDQPAGQ
                     PQPKQGHQPLQAIQPPQNTVVQPPPKQQGHHKQPQTMFPSIVKTIPTNPVSTVGHKGA
                     RRRWGQTVFKSGDSCDNIEDCDLGASHSKKPSMDAFKEKKKKESPFRFPEAGLPVSNH
                     LKGENRNLHASLKSDTNLSTASTAKQYYLKQSRYLPGVNPKNVSLVAGGKDINSHSWN
                     NQLFPKSLGSMGADLAFKRSNAAGNLGSYSAYSQTGCVPSFLKKEVGSAGQRIHLAPL
                     GASAADYTWSTKTGQGQFSGRTYNPTAKNLNIVNRTQPVPSVHGRTDWVAKYGGHR"
     exon            357..411
                     /gene="Mak"
                     /inference="alignment:Splign:2.1.0"
     exon            412..533
                     /gene="Mak"
                     /inference="alignment:Splign:2.1.0"
     exon            534..613
                     /gene="Mak"
                     /inference="alignment:Splign:2.1.0"
     exon            614..746
                     /gene="Mak"
                     /inference="alignment:Splign:2.1.0"
     exon            747..918
                     /gene="Mak"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1086
                     /gene="Mak"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1398
                     /gene="Mak"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1571
                     /gene="Mak"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1714
                     /gene="Mak"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1846
                     /gene="Mak"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..1969
                     /gene="Mak"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2392
                     /gene="Mak"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acaaggcgct ggagcttcac aagggagcga tcgagggtgt ccttaagaat ggactcagtg
       61 tctctttgcc agattcctta ttgctgtatc ccatgagcct acctgacctt gaggaagagc
      121 cgtgtttaat gatgacaagc ctgtctcccg tgtagtgaca aaaaggagga ggaccacaag
      181 gaaagacgga tttagatttc tactcagcaa ggaagcgagc tctgtcagca acctctctgg
      241 attacccttc ccaagatgaa ccgatataca accatgaggc agctggggga cggcacgtac
      301 gggagtgtgc ttatgggcaa gagcaatgag tctggggagc tggtggcaat caagaggatg
      361 aagagaaagt tctattcttg ggatgagtgt atgaacttgc gagaagttaa gtccctgaag
      421 aaactcaatc atgccaatgt gattaaacta aaagaagtta tcagagaaaa tgaccatctt
      481 tattttatat ttgaatatat gaaagaaaac ctctatcagc taatgaaaga cagaaacaaa
      541 ctgttccctg agtcagtcat cagaaatatt atgtatcaaa tactacaggg gctggcattt
      601 atccacaaac atggcttttt tcacagggac atgaaacctg agaatttgct ttgcatgggt
      661 ccagagctgg tgaagattgc tgattttgga cttgcgagag aattaagatc acagccacca
      721 tatactgact atgtgtctac cagatggtac cgtgctcctg aagttttgct aaggtcttca
      781 gtgtacagct ctcccattga cgtgtgggcc gtgggaagta taatggccga gctatatacg
      841 tttagaccgc ttttcccagg gaccagtgaa gttgatgaga tctttaaaat ttgccaagtg
      901 ttagggactc ccaagaaaag tgactggccg gaggggtacc agctggcatc ctccatgaac
      961 ttccgctttc cccagtgcat tcctataaac ctgaaaactc tcattcccaa tgccagtagt
     1021 gaggctattc agcttatgac agaaatgctt aactgggatc caaagaaacg gccaactgca
     1081 agccaggcac tgaagcaccc atattttcaa gtcggtcagg tattgggccc ttctgcacac
     1141 catctggatg caaaacagac tttgcacaag cagctgcagc ctccagagcc aaagccatct
     1201 tcctctgaac gggatcctaa gcctttgcca aacatccttg atcagcctgc cgggcagccc
     1261 cagccaaaac agggccacca accactgcag gccattcagc caccacagaa cacagtggtt
     1321 cagccacctc caaagcagca gggtcaccat aagcaaccac aaacgatgtt tccaagtatc
     1381 gtcaaaacca taccaacgaa tccagtcagc acagtaggcc ataagggggc ccggagacgg
     1441 tggggtcaga cagtcttcaa gtctggagac agctgtgaca acatcgagga ctgcgacttg
     1501 ggagcctccc actccaagaa gccgagcatg gatgccttca aggaaaaaaa gaagaaggag
     1561 tctccatttc ggtttccaga agcaggactc ccagtctcca accacttgaa gggggaaaat
     1621 agaaatttac atgcatcctt aaaatctgac acaaacttgt caactgcttc aaccgctaag
     1681 cagtactatt tgaaacaatc aagatacctt ccgggtgtga accccaagaa cgtgtctttg
     1741 gtagctggcg gcaaggatat aaattcacac tcttggaata atcagctatt tcctaagtct
     1801 ctgggatcca tgggggcgga cctcgctttc aagaggagta acgcagcagg gaaccttggg
     1861 agctacagcg cttacagcca gacgggatgc gtgccttcct ttctcaagaa agaagtggga
     1921 tcagctggcc agaggatcca cttggcgcct ctgggtgcgt cggctgccga ctatacctgg
     1981 agcacaaaaa ctggccaagg ccagttttca ggacgaactt acaatcccac agccaaaaat
     2041 ctcaatattg tgaaccgcac acagccagtt ccctcggtgc acgggaggac agactgggtg
     2101 gctaagtacg gaggccaccg gtaggagaag tggaagcctg aagcattgct ccgtagagga
     2161 taatcacgcc ccttgatcct gggagacgtc tacagagtct atttctaccg agttccacag
     2221 gacgcacaca accgtgggcg cctcagagac cggaagtcag ctcccgattt cttccttttc
     2281 cggaaatgca atgcattttc ttaacttgtg gccagcagtg ctgatgcagc accgtgctga
     2341 aacttttgag cgggactttt aaagagtatt gaataaatta tttgccaaag ta
//
