LOCUS       NM_053946               2047 bp    mRNA    linear   ROD 08-DEC-2024
DEFINITION  Rattus norvegicus magnesium transporter 1 (Magt1), mRNA.
ACCESSION   NM_053946 XM_346875
VERSION     NM_053946.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2047)
  AUTHORS   Blommaert,E., Peanne,R., Cherepanova,N.A., Rymen,D., Staels,F.,
            Jaeken,J., Race,V., Keldermans,L., Souche,E., Corveleyn,A.,
            Sparkes,R., Bhattacharya,K., Devalck,C., Schrijvers,R.,
            Foulquier,F., Gilmore,R. and Matthijs,G.
  TITLE     Mutations in MAGT1 lead to a glycosylation disorder with a variable
            phenotype
  JOURNAL   Proc Natl Acad Sci U S A 116 (20), 9865-9870 (2019)
   PUBMED   31036665
REFERENCE   2  (bases 1 to 2047)
  AUTHORS   Zheng,J.M., Kong,Y.Y., Li,Y.Y. and Zhang,W.
  TITLE     MagT1 regulated the odontogenic differentiation of BMMSCs induced
            byTGC-CM via ERK signaling pathway
  JOURNAL   Stem Cell Res Ther 10 (1), 48 (2019)
   PUBMED   30704530
  REMARK    GeneRIF: Authors clarified the pivotal role of MagT1 and ERK/MAPK
            pathway in odontogenic differentiation of BMMSCs, and suppression
            of MagT1 inhibited the odontogenic differentiation of BMMSCs by
            decreasing the intracellular Mg(2+) and inactivating ERK/MAPK
            pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2047)
  AUTHORS   Zheng,J., Mao,X., Ling,J., Chen,C. and Zhang,W.
  TITLE     Role of Magnesium Transporter Subtype 1 (MagT1) in the Osteogenic
            Differentiation of Rat Bone Marrow Stem Cells
  JOURNAL   Biol Trace Elem Res 171 (1), 131-137 (2016)
   PUBMED   26358767
  REMARK    GeneRIF: The results indicate that Mg and MagT1 play an important
            role in osteogenic differentiation of rBMSCs and may be involved in
            the bone regeneration.
REFERENCE   4  (bases 1 to 2047)
  AUTHORS   Cherepanova,N.A., Shrimal,S. and Gilmore,R.
  TITLE     Oxidoreductase activity is necessary for N-glycosylation of
            cysteine-proximal acceptor sites in glycoproteins
  JOURNAL   J Cell Biol 206 (4), 525-539 (2014)
   PUBMED   25135935
REFERENCE   5  (bases 1 to 2047)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 2047)
  AUTHORS   Zhou,H. and Clapham,D.E.
  TITLE     Mammalian MagT1 and TUSC3 are required for cellular magnesium
            uptake and vertebrate embryonic development
  JOURNAL   Proc Natl Acad Sci U S A 106 (37), 15750-15755 (2009)
   PUBMED   19717468
REFERENCE   7  (bases 1 to 2047)
  AUTHORS   Molinari,F., Foulquier,F., Tarpey,P.S., Morelle,W., Boissel,S.,
            Teague,J., Edkins,S., Futreal,P.A., Stratton,M.R., Turner,G.,
            Matthijs,G., Gecz,J., Munnich,A. and Colleaux,L.
  TITLE     Oligosaccharyltransferase-subunit mutations in nonsyndromic mental
            retardation
  JOURNAL   Am J Hum Genet 82 (5), 1150-1157 (2008)
   PUBMED   18455129
REFERENCE   8  (bases 1 to 2047)
  AUTHORS   Shibatani,T., David,L.L., McCormack,A.L., Frueh,K. and Skach,W.R.
  TITLE     Proteomic analysis of mammalian oligosaccharyltransferase reveals
            multiple subcomplexes that contain Sec61, TRAP, and two potential
            new subunits
  JOURNAL   Biochemistry 44 (16), 5982-5992 (2005)
   PUBMED   15835887
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Dec 3, 2020 this sequence version replaced NM_053946.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF008554.2, SRR26643288.65277.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760433,
                                           SAMN09345238 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               JAXUCZ010000021.1  75145074-75145212   c
            140-309             JAXUCZ010000021.1  75128948-75129117   c
            310-427             JAXUCZ010000021.1  75124525-75124642   c
            428-568             JAXUCZ010000021.1  75122003-75122143   c
            569-709             JAXUCZ010000021.1  75121584-75121724   c
            710-799             JAXUCZ010000021.1  75116708-75116797   c
            800-863             JAXUCZ010000021.1  75116057-75116120   c
            864-938             JAXUCZ010000021.1  75113629-75113703   c
            939-1029            JAXUCZ010000021.1  75108808-75108898   c
            1030-2047           JAXUCZ010000021.1  75106154-75107171   c
FEATURES             Location/Qualifiers
     source          1..2047
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..2047
                     /gene="Magt1"
                     /gene_synonym="Iag2"
                     /note="magnesium transporter 1"
                     /db_xref="GeneID:116967"
                     /db_xref="RGD:620094"
     exon            1..139
                     /gene="Magt1"
                     /gene_synonym="Iag2"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1045
                     /gene="Magt1"
                     /gene_synonym="Iag2"
                     /note="implantation-associated protein; magnesium
                     transporter protein 1; IAP; oligosaccharyl transferase
                     subunit MAGT1; dolichyl-diphosphooligosaccharide--protein
                     glycosyltransferase subunit MAGT1"
                     /codon_start=1
                     /product="dolichyl-diphosphooligosaccharide--protein
                     glycosyltransferase subunit MAGT1 precursor"
                     /protein_id="NP_446398.2"
                     /db_xref="GeneID:116967"
                     /db_xref="RGD:620094"
                     /translation="MASPRWLWCVCATAAVTLLLVSKVPSASAQRKKEMVLAEKVSQL
                     MEWTNKRPVIRMNGDKFRRLVKAPPRNYSVIVMFTALQLHRQCVVCKQADEEFQILAN
                     SWRYSSAFTNRIFFAMVDFDEGSDVFQMLNMNSAPTFINFPPKGKPKRADTYELQVRG
                     FSAEQIARWIADRTDVNIRVIRPPNYAGPLMLGLLLAVIGGLVYLRRSNMEFLFNKTG
                     WAFAALCFVLAMTSGQMWNHIRGPPYAHKNPHTGHVNYIHGSSQAQFVAETHIVLLFN
                     GGVTLGMVLLCEAAASDMDIGKRRMMCIAGIGLVVLFFSWMLSIFRSKYHGYPYSFLM
                     S"
     exon            140..309
                     /gene="Magt1"
                     /gene_synonym="Iag2"
                     /inference="alignment:Splign:2.1.0"
     exon            310..427
                     /gene="Magt1"
                     /gene_synonym="Iag2"
                     /inference="alignment:Splign:2.1.0"
     exon            428..568
                     /gene="Magt1"
                     /gene_synonym="Iag2"
                     /inference="alignment:Splign:2.1.0"
     exon            569..709
                     /gene="Magt1"
                     /gene_synonym="Iag2"
                     /inference="alignment:Splign:2.1.0"
     exon            710..799
                     /gene="Magt1"
                     /gene_synonym="Iag2"
                     /inference="alignment:Splign:2.1.0"
     exon            800..863
                     /gene="Magt1"
                     /gene_synonym="Iag2"
                     /inference="alignment:Splign:2.1.0"
     exon            864..938
                     /gene="Magt1"
                     /gene_synonym="Iag2"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1029
                     /gene="Magt1"
                     /gene_synonym="Iag2"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..2047
                     /gene="Magt1"
                     /gene_synonym="Iag2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaagtttcg cccggtcgcc gagagagaca agcgaacatg gcctcgccga ggtggctctg
       61 gtgtgtgtgt gcgaccgcag cggtcacact gctgctcgtt tccaaggttc cttcggcctc
      121 tgcccaaaga aagaaggaga tggtgttagc tgagaaggtt agtcagctga tggaatggac
      181 caataaaaga cctgtaataa gaatgaatgg agacaagttc cgtcgccttg ttaaagcacc
      241 accaagaaat tactctgtta ttgtcatgtt tactgctctc caacttcata gacaatgtgt
      301 cgtttgcaag caagctgatg aagaattcca gattctggca aattcttggc gatactccag
      361 tgcatttacc aaccggatat tttttgccat ggtggatttt gatgaaggct ctgatgtatt
      421 tcaaatgcta aacatgaatt cagctccaac tttcatcaac tttcctccaa aaggaaaacc
      481 caaaagggct gatacatatg agttgcaggt gcgagggttt tcagctgaac agattgcccg
      541 gtggatcgca gacagaactg acgtcaacat tagagtaatc agacctccaa attatgctgg
      601 acctctaatg ttggggttgc ttcttgctgt tattggtgga cttgtgtatc tgcgacgaag
      661 taatatggaa ttcctcttta ataaaaccgg atgggctttt gcagcattgt gttttgtact
      721 tgcaatgaca tctggccaaa tgtggaacca tataagagga ccaccatatg ctcataagaa
      781 tccccataca ggacatgtga attatatcca cggaagcagc caagcacagt ttgtagctga
      841 aacccacatt gttcttctct tcaatggtgg ggttacctta ggtatggtgc ttttatgtga
      901 agctgctgcc tctgacatgg atattgggaa gcgaaggatg atgtgtattg ctgggattgg
      961 acttgttgtg ttattcttca gttggatgct gtccatcttt cgatcaaaat accatggcta
     1021 tccatacagc tttctgatga gttaaagagg attccagaga aacattgaca ccggtaatgg
     1081 aaactgaaaa ataaaacctg tttggtgttt gaagaatgca actcatgtat tttatcttac
     1141 ctctttttgt caagtgatcg aactagttaa tcatttaacc aaagatctgt agtgccttaa
     1201 caagcaattg tgagatcatg aagtatttgg aattatgttc ctgttaacct ttccttccca
     1261 atgaacttac gaaacatttg ggttttgtag tattaagtac tttataaaat ttaaaactac
     1321 tacgtcattt tacttagagc aaaactcaaa actactttag ttaacttttg gtcatctgct
     1381 tttatcttac ctaaggttgg atagaaggtt ctgagcagga attttcacct ctgcctattg
     1441 caaacagctg catctggaag cggttacctt tccttctttg tgcagatgtg tgtgctttac
     1501 agacctttcc tcttgggcca aggtatcata tgcactgtag gatctgaaaa tggactgtgt
     1561 agcctttgga aagacacatg ccttgctctg tctttctgac tgaaatcagc tacataggcc
     1621 tccttttaca cattaagaag tacctctaac taaagactat gatttgtgca tgagtgtgct
     1681 ataactacct tgtacatgaa aagatttctc attcattctg tttctagttt tatttaaagt
     1741 ggccctactc taataataat agtttgttgc taaaaatcag tataacttac aagtggtctc
     1801 aaatgtttgt ataagttaca tattgtcatt gatgtcgttt tttacctaac agaaaaataa
     1861 gctgagttgt gttcatggaa aggactctgt tagaatgaga aaacaaaatt gtgaaatatt
     1921 gactcgttgt ataggtatag aagtgaaata gttaggggtt ggagatttag ctcagtggta
     1981 gagctcttgc ctaggaagcg caaggccctg ggttcggtcc ccagctccga aaaaaaaaaa
     2041 aagaacc
//
