LOCUS       NM_001100536             669 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus mago homolog, exon junction complex subunit
            (Magoh), mRNA.
ACCESSION   NM_001100536 XM_001066689 XM_216485
VERSION     NM_001100536.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 669)
  AUTHORS   Singh,K.K., Wachsmuth,L., Kulozik,A.E. and Gehring,N.H.
  TITLE     Two mammalian MAGOH genes contribute to exon junction complex
            composition and nonsense-mediated decay
  JOURNAL   RNA Biol 10 (8), 1291-1298 (2013)
   PUBMED   23917022
REFERENCE   2  (bases 1 to 669)
  AUTHORS   Todd,M.A. and Picketts,D.J.
  TITLE     PHF6 interacts with the nucleosome remodeling and deacetylation
            (NuRD) complex
  JOURNAL   J Proteome Res 11 (8), 4326-4337 (2012)
   PUBMED   22720776
REFERENCE   3  (bases 1 to 669)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 669)
  AUTHORS   Michelle,L., Cloutier,A., Toutant,J., Shkreta,L., Thibault,P.,
            Durand,M., Garneau,D., Gendron,D., Lapointe,E., Couture,S., Le
            Hir,H., Klinck,R., Elela,S.A., Prinos,P. and Chabot,B.
  TITLE     Proteins associated with the exon junction complex also control the
            alternative splicing of apoptotic regulators
  JOURNAL   Mol Cell Biol 32 (5), 954-967 (2012)
   PUBMED   22203037
REFERENCE   5  (bases 1 to 669)
  AUTHORS   Gehring,N.H., Lamprinaki,S., Kulozik,A.E. and Hentze,M.W.
  TITLE     Disassembly of exon junction complexes by PYM
  JOURNAL   Cell 137 (3), 536-548 (2009)
   PUBMED   19410547
REFERENCE   6  (bases 1 to 669)
  AUTHORS   Diem,M.D., Chan,C.C., Younis,I. and Dreyfuss,G.
  TITLE     PYM binds the cytoplasmic exon-junction complex and ribosomes to
            enhance translation of spliced mRNAs
  JOURNAL   Nat Struct Mol Biol 14 (12), 1173-1179 (2007)
   PUBMED   18026120
REFERENCE   7  (bases 1 to 669)
  AUTHORS   Kunz,J.B., Neu-Yilik,G., Hentze,M.W., Kulozik,A.E. and Gehring,N.H.
  TITLE     Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and
            translation
  JOURNAL   RNA 12 (6), 1015-1022 (2006)
   PUBMED   16601204
REFERENCE   8  (bases 1 to 669)
  AUTHORS   Glanzer,J., Miyashiro,K.Y., Sul,J.Y., Barrett,L., Belt,B.,
            Haydon,P. and Eberwine,J.
  TITLE     RNA splicing capability of live neuronal dendrites
  JOURNAL   Proc Natl Acad Sci U S A 102 (46), 16859-16864 (2005)
   PUBMED   16275927
REFERENCE   9  (bases 1 to 669)
  AUTHORS   Gehring,N.H., Kunz,J.B., Neu-Yilik,G., Breit,S., Viegas,M.H.,
            Hentze,M.W. and Kulozik,A.E.
  TITLE     Exon-junction complex components specify distinct routes of
            nonsense-mediated mRNA decay with differential cofactor
            requirements
  JOURNAL   Mol Cell 20 (1), 65-75 (2005)
   PUBMED   16209946
REFERENCE   10 (bases 1 to 669)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK845348.1, DQ359101.1 and BQ196337.1.
            
            On or before Nov 22, 2008 this sequence version replaced
            XM_001066689.1, XM_216485.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF114860.1, FM087836.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                CK845348.1         566-636             c
            72-499              DQ359101.1         1-428
            500-532             BQ196337.1         139-171             c
            533-669             BQ196337.1         1-137               c
FEATURES             Location/Qualifiers
     source          1..669
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q34"
     gene            1..669
                     /gene="Magoh"
                     /note="mago homolog, exon junction complex subunit"
                     /db_xref="GeneID:298385"
                     /db_xref="RGD:1305174"
     exon            1..159
                     /gene="Magoh"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..512
                     /gene="Magoh"
                     /note="mago-nashi-like proliferation-associated protein;
                     mago-nashi homolog, proliferation-associated; mago
                     homolog, exon junction complex core component"
                     /codon_start=1
                     /product="protein mago nashi homolog"
                     /protein_id="NP_001094006.1"
                     /db_xref="GeneID:298385"
                     /db_xref="RGD:1305174"
                     /translation="MESDFYLRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDV
                     MIRKEAYVHKSVMEELKRIIDDSEITKEDDALWPPPDRVGRQELEIVIGDEHISFTTS
                     KIGSLIDVNQSKDPEGLRVFYYLVQDLKCLVFSLIGLHFKIKPI"
     exon            160..218
                     /gene="Magoh"
                     /inference="alignment:Splign:2.1.0"
     exon            219..329
                     /gene="Magoh"
                     /inference="alignment:Splign:2.1.0"
     exon            330..412
                     /gene="Magoh"
                     /inference="alignment:Splign:2.1.0"
     exon            413..654
                     /gene="Magoh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggactcaga ccgcagacag tgctagtgtc atctgttcct aaagttcggt cttgcttgtc
       61 ccttgcgaag catggagagt gacttttacc tacgttacta cgtgggtcac aaaggcaagt
      121 ttggtcatga gttcctggag tttgaattcc gacctgacgg taaattgcga tatgccaaca
      181 acagcaatta caaaaatgat gtcatgatca ggaaagaggc ttatgtacat aagagtgtga
      241 tggaagaatt aaagaggatt attgacgaca gtgagatcac caaagaagat gacgctctgt
      301 ggccccctcc tgatcgagtg ggccggcagg aactcgaaat tgtcattgga gatgagcaca
      361 tttcttttac aacatcaaaa attggttccc ttattgatgt caaccagtcc aaggatccag
      421 aaggcttgcg agtgttttat tatcttgtcc aggacctgaa gtgtttagtc ttcagcctta
      481 ttggattaca cttcaagatc aagccaatct agattggata ttgtggacac aaggcgggtg
      541 ggagttttta gttaccggaa ttaggaattt tctgtatatt ggggcaattt ttataaacaa
      601 taaatgatgg tctttaataa atgtggtaac atcttttttt gtcatttttc taaaaaaaaa
      661 aaaaaaaaa
//
