LOCUS       NM_139084               5862 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus membrane associated guanylate kinase, WW and PDZ
            domain containing 3 (Magi3), mRNA.
ACCESSION   NM_139084 XM_001068223
VERSION     NM_139084.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5862)
  AUTHORS   Xu,M. and Yu,T.
  TITLE     MiR-20b-5p contributes to the dysfunction of vascular smooth muscle
            cells by targeting MAGI3 in hypertension
  JOURNAL   J Mol Histol 53 (2), 187-197 (2022)
   PUBMED   34985721
  REMARK    GeneRIF: MiR-20b-5p contributes to the dysfunction of vascular
            smooth muscle cells by targeting MAGI3 in hypertension.
REFERENCE   2  (bases 1 to 5862)
  AUTHORS   He,J., Bellini,M., Inuzuka,H., Xu,J., Xiong,Y., Yang,X.,
            Castleberry,A.M. and Hall,R.A.
  TITLE     Proteomic analysis of beta1-adrenergic receptor interactions with
            PDZ scaffold proteins
  JOURNAL   J Biol Chem 281 (5), 2820-2827 (2006)
   PUBMED   16316992
REFERENCE   3  (bases 1 to 5862)
  AUTHORS   Valiente,M., Andres-Pons,A., Gomar,B., Torres,J., Gil,A.,
            Tapparel,C., Antonarakis,S.E. and Pulido,R.
  TITLE     Binding of PTEN to specific PDZ domains contributes to PTEN protein
            stability and phosphorylation by microtubule-associated
            serine/threonine kinases
  JOURNAL   J Biol Chem 280 (32), 28936-28943 (2005)
   PUBMED   15951562
REFERENCE   4  (bases 1 to 5862)
  AUTHORS   Hinojos,C.A., Boerwinkle,E., Fornage,M. and Doris,P.A.
  TITLE     Combined genealogical, mapping, and expression approaches to
            identify spontaneously hypertensive rat hypertension candidate
            genes
  JOURNAL   Hypertension 45 (4), 698-704 (2005)
   PUBMED   15710778
REFERENCE   5  (bases 1 to 5862)
  AUTHORS   Meyer,G., Varoqueaux,F., Neeb,A., Oschlies,M. and Brose,N.
  TITLE     The complexity of PDZ domain-mediated interactions at glutamatergic
            synapses: a case study on neuroligin
  JOURNAL   Neuropharmacology 47 (5), 724-733 (2004)
   PUBMED   15458844
REFERENCE   6  (bases 1 to 5862)
  AUTHORS   Yao,R., Natsume,Y. and Noda,T.
  TITLE     MAGI-3 is involved in the regulation of the JNK signaling pathway
            as a scaffold protein for frizzled and Ltap
  JOURNAL   Oncogene 23 (36), 6023-6030 (2004)
   PUBMED   15195140
REFERENCE   7  (bases 1 to 5862)
  AUTHORS   Adamsky,K., Arnold,K., Sabanay,H. and Peles,E.
  TITLE     Junctional protein MAGI-3 interacts with receptor tyrosine
            phosphatase beta (RPTP beta) and tyrosine-phosphorylated proteins
  JOURNAL   J Cell Sci 116 (Pt 7), 1279-1289 (2003)
   PUBMED   12615970
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 27, 2020 this sequence version replaced NM_139084.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF255614.1, SRR26643288.11040.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-449               JAXUCZ010000002.1  194404699-194405147 c
            450-566             JAXUCZ010000002.1  194297838-194297954 c
            567-686             JAXUCZ010000002.1  194281493-194281612 c
            687-896             JAXUCZ010000002.1  194276689-194276898 c
            897-1074            JAXUCZ010000002.1  194273083-194273260 c
            1075-1154           JAXUCZ010000002.1  194269137-194269216 c
            1155-1212           JAXUCZ010000002.1  194255641-194255698 c
            1213-1307           JAXUCZ010000002.1  194248504-194248598 c
            1308-1496           JAXUCZ010000002.1  194246292-194246480 c
            1497-2102           JAXUCZ010000002.1  194243225-194243830 c
            2103-2134           JAXUCZ010000002.1  194241574-194241605 c
            2135-2291           JAXUCZ010000002.1  194239146-194239302 c
            2292-2383           JAXUCZ010000002.1  194236636-194236727 c
            2384-2576           JAXUCZ010000002.1  194234322-194234514 c
            2577-2759           JAXUCZ010000002.1  194231515-194231697 c
            2760-2945           JAXUCZ010000002.1  194225406-194225591 c
            2946-3048           JAXUCZ010000002.1  194217972-194218074 c
            3049-3175           JAXUCZ010000002.1  194217126-194217252 c
            3176-3319           JAXUCZ010000002.1  194216470-194216613 c
            3320-3458           JAXUCZ010000002.1  194210736-194210874 c
            3459-5862           JAXUCZ010000002.1  194206938-194209341 c
FEATURES             Location/Qualifiers
     source          1..5862
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..5862
                     /gene="Magi3"
                     /gene_synonym="Slipr"
                     /note="membrane associated guanylate kinase, WW and PDZ
                     domain containing 3"
                     /db_xref="GeneID:245903"
                     /db_xref="RGD:621362"
     exon            1..449
                     /gene="Magi3"
                     /gene_synonym="Slipr"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..4540
                     /gene="Magi3"
                     /gene_synonym="Slipr"
                     /note="MAGI-3; scaffolding-like protein;
                     membrane-associated guanylate kinase inverted 3;
                     scaffolding protein SLIPR; membrane-associated guanylate
                     kinase-related (MAGI-3)"
                     /codon_start=1
                     /product="membrane-associated guanylate kinase, WW and PDZ
                     domain-containing protein 3"
                     /protein_id="NP_620784.3"
                     /db_xref="GeneID:245903"
                     /db_xref="RGD:621362"
                     /translation="MSKTLKKKKHWLSKVQECAVSWAGPPGDLGAEIRGGAERGEFPY
                     LGRLRDEPGGGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRL
                     KTVKPGKVINKDLRHYLSLQFQKGSIDHKLQQVIRDNLYLRTIPCTTRAPRDGEVPGV
                     DYNFISVEQFKALEESGALLESGTYDGNFYGTPKPPAEPSPFQPDPVDQVLFDNEFDT
                     ESQRKRTTSVSKMERMDSSLPEEEEDEDKEAVNGSGSMETREMHSESSDCWMKTVPSY
                     NQTNRSMDFRNYMMRDENLEPLPKNWEMAYTDTGTIYFIDHNTKTTTWLDPRLCKKAK
                     APEDCEDGELPYGWEKIEDPQYGTYYVDHLNQKTQFENPVEEAKRKKQIGQAETHSAK
                     TDVERAHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQ
                     DGKMAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYALPDDSEDPVV
                     DIVAATPVINGQSLAKGEACMSTQDFKLGAMVLDQNGKSGKLLSSDHLNGPSDSNEQR
                     ASLASSGSSQPELVTIPLVKGPKGFGFAIADSPTGQKVKMILDSQWCQGLQKGDIIKE
                     IYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPCSPTKTAKMKTDTKETSGSLET
                     INEPTPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFG
                     FRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTT
                     AARNGHVLLTVRRKIFYGEKQPEDESPQAFSQSGSPRLNRTELPTRSAPQESYDVILQ
                     RKENEGFGFVILTSKSKPPPGVIPHKIGRVIDGSPADRCGRLKVGDHISAVNGQSIVD
                     LSHDNIVQLIKDAGVTVTLTVVAEEEHHGPPSGTNSARQSPALQHRPMGQAQATHIPG
                     DRTALEGEVGKDVCSSYRHSWSDHKHLAQPDTAVISVVGSRHSQSLGCYPVELERGPR
                     GFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIEL
                     IQAGGNKVLLLLRPGTGLIPDHGDWDIYSPSSSNVIYDEQPPPLPSSHSAATFEESHV
                     PVTEDSLIRVQTCEKAEELKDTVQEKKSTLNGSQPEMKYQSVQKNVSKKDPSRSHGHG
                     DKNLPKGENGVTRRGRSASPKKSVNRHSEEHLEKIPRPLRSDPKGKSRDRSLSPRKGE
                     NKGQVTIKAGSGQDPCRKDRGRSSSPRKQQKIGGNSLSNTEGKLSEAGSRRAAGLSSD
                     SPEQLPEGKEKSGVSRKDLKLSQLGKNRTRSPEKRSSKVDEASLPSKKTSDTASRVVS
                     EKEKGRKPGTGERSRDKTGESVQTSAKPLTQEAGEKMALSKASEVTDRGKERAGGAPE
                     SSSPVKKAPITPGPWRVPRANKVTGTAGMADKQL"
     exon            450..566
                     /gene="Magi3"
                     /gene_synonym="Slipr"
                     /inference="alignment:Splign:2.1.0"
     exon            567..686
                     /gene="Magi3"
                     /gene_synonym="Slipr"
                     /inference="alignment:Splign:2.1.0"
     exon            687..896
                     /gene="Magi3"
                     /gene_synonym="Slipr"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1074
                     /gene="Magi3"
                     /gene_synonym="Slipr"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1154
                     /gene="Magi3"
                     /gene_synonym="Slipr"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1212
                     /gene="Magi3"
                     /gene_synonym="Slipr"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1307
                     /gene="Magi3"
                     /gene_synonym="Slipr"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1496
                     /gene="Magi3"
                     /gene_synonym="Slipr"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..2102
                     /gene="Magi3"
                     /gene_synonym="Slipr"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..2134
                     /gene="Magi3"
                     /gene_synonym="Slipr"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2291
                     /gene="Magi3"
                     /gene_synonym="Slipr"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2383
                     /gene="Magi3"
                     /gene_synonym="Slipr"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2576
                     /gene="Magi3"
                     /gene_synonym="Slipr"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..2759
                     /gene="Magi3"
                     /gene_synonym="Slipr"
                     /inference="alignment:Splign:2.1.0"
     exon            2760..2945
                     /gene="Magi3"
                     /gene_synonym="Slipr"
                     /inference="alignment:Splign:2.1.0"
     exon            2946..3048
                     /gene="Magi3"
                     /gene_synonym="Slipr"
                     /inference="alignment:Splign:2.1.0"
     exon            3049..3175
                     /gene="Magi3"
                     /gene_synonym="Slipr"
                     /inference="alignment:Splign:2.1.0"
     exon            3176..3319
                     /gene="Magi3"
                     /gene_synonym="Slipr"
                     /inference="alignment:Splign:2.1.0"
     exon            3320..3458
                     /gene="Magi3"
                     /gene_synonym="Slipr"
                     /inference="alignment:Splign:2.1.0"
     exon            3459..5862
                     /gene="Magi3"
                     /gene_synonym="Slipr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgcgcggc tagcgggctg aggcgggagg tcggcggcgg cgcccctctg gccgggctgt
       61 gcgcggggcc cggagcggca ccgcggccgc ccgcgcgggg gctccccatg gtgcagcgga
      121 ggtcgggatg tcgaagacgt tgaagaagaa gaagcattgg ctcagcaagg tgcaggagtg
      181 tgcggtgtcc tgggccgggc ccccgggcga cttgggcgct gagatccgcg gcggcgcgga
      241 gcgcggcgag ttcccttacc tggggcggct ccgtgacgag cctggcggcg gcggaggcac
      301 ctgctgcgtg gtctcgggca aggcgcccag tcctggcgat gtgctgttgg aggtgaacgg
      361 gacgcccgtc agtgggctca ccaaccggga caccctggct gtcatccgcc acttccgcga
      421 gccaatccgt ctgaagaccg tgaagccagg caaagtcata aataaagatt tgcgacatta
      481 cctgagtctg cagtttcaga aaggatcgat tgaccacaaa ctacagcagg tcatcagaga
      541 taacctctac ttgagaacca tcccatgcac tacaagggct cccagggatg gggaagttcc
      601 aggggtggac tataatttca tttctgttga acaattcaag gcactggaag aaagcggagc
      661 attgttagaa agtggaacgt atgatggaaa tttctatggc acgcccaagc ctccagcaga
      721 gcctagtcct ttccagcccg atccagttga tcaggtcctc tttgacaatg agtttgacac
      781 agaatcccaa agaaaacgaa ctacatctgt cagcaagatg gaaaggatgg acagctctct
      841 ccctgaggaa gaggaagatg aggacaaaga agctgtcaat ggcagcggaa gcatggaaac
      901 tagagagatg cattctgagt cgtctgactg ctggatgaag actgttccaa gttataacca
      961 aacaaatcgc tccatggact ttagaaatta tatgatgaga gacgagaatc tggagccgct
     1021 gcccaaaaac tgggaaatgg cctacactga cacaggaacg atctacttca ttgatcacaa
     1081 tacgaagaca accacctggc tggatcctcg tctctgcaag aaagccaaag cccctgaaga
     1141 ctgtgaggat ggagagcttc catatggctg ggagaaaata gaggaccctc agtatggaac
     1201 atactatgtt gatcacctca accagaaaac tcagtttgaa aatccagtgg aggaagcgaa
     1261 aaggaaaaag cagataggac aggctgaaac tcattccgca aaaacagatg tggaaagagc
     1321 acactttacc cgggacccat cccaacttaa aggtgtcctt gttcgagcat cactgaaaaa
     1381 aagcacaatg ggctttggtt tcaccattat aggtggagat cggcctgatg aatttctaca
     1441 agtaaaaaat gtgctcaaag acggtcccgc tgctcaggat gggaaaatgg caccaggtga
     1501 tgttattgta gacatcaatg gcaactgtgt ccttggtcac acccatgcag atgttgtcca
     1561 gatgtttcaa ttggtacctg tcaaccagta tgtcaacctt actttatgcc gtggttatgc
     1621 acttcctgac gacagtgaag accctgttgt ggacattgtt gctgctaccc ctgttatcaa
     1681 tggacaatca ttagcaaagg gagaggcgtg catgagtact caggatttta aactgggagc
     1741 aatggttttg gatcagaatg gaaaatcagg aaaacttttg tccagtgatc atctcaatgg
     1801 cccatcagat tcaaatgagc aaagagcatc cctggcttca tcaggcagct cccagcctga
     1861 actagtgact atcccgctgg ttaagggtcc caaaggcttc gggtttgcaa ttgccgatag
     1921 cccaactggg cagaaggtga aaatgatact ggatagccag tggtgtcaag gccttcaaaa
     1981 aggggatatc atcaaagaaa tttaccatca gaatgtgcag aatttaacac atctccaagt
     2041 cgtagaagta ctgaaacagt tcccagtagg tgcagatgtc ccgttgctta tcttaagagg
     2101 aggtccttgt tcaccaacta aaactgccaa aatgaaaaca gatacaaaag aaacttcagg
     2161 aagtttggag actataaatg agcctactcc ccagcctatg ccttttccac ccagcataat
     2221 cagatcagga tccccgaaat tggatccttc tgaagtctac ctgaaatcta agactttata
     2281 tgaagataaa ccacccaaca ccaaagacct agatgtcttt cttcggaaac aagaatcggg
     2341 gtttggcttc agggtgctgg gaggagatgg acctgaccag tctatatata ttggggccat
     2401 cattcccctg ggagcagcgg aaaaggatgg taggctccgt gctgctgatg aattgatgtg
     2461 tattgatggg attcctgtta aagggaaatc acataagcaa gtcttggact taatgaccac
     2521 tgctgctcga aatggccacg tgttactcac tgtgaggagg aagatcttct atggagagaa
     2581 acaacccgag gatgaaagcc ctcaagcctt ctcacagagt ggatctcctc gcctaaatcg
     2641 gacagagctt ccaaccaggt ctgccccaca ggagtcctat gatgttatct tacagaggaa
     2701 agaaaatgaa gggtttggtt ttgtcatcct cacctctaaa agcaagccgc ccccaggagt
     2761 tattcctcat aaaattggcc gggtcataga tggaagtcca gctgatcgtt gtggaagact
     2821 gaaagttgga gaccacatct ctgcggtgaa tgggcagtcc attgttgacc tgtcccatga
     2881 taatattgtt cagctcatca aagatgctgg ggtcaccgtc acgctgacag tggttgctga
     2941 agaagagcat catggtccac catcaggaac aaactcagcc aggcagagcc cagcactgca
     3001 gcacagaccc atgggacagg cgcaggccac ccacatacct ggggacagaa ctgccctaga
     3061 aggtgaagtt gggaaagatg tctgcagctc ttacagacac tcctggtctg accacaagca
     3121 ccttgcacag ccggacaccg cggtgatttc cgtggtgggc agtcggcaca gtcagagcct
     3181 tgggtgttac cctgtggagc tggagagagg ccctcgaggc tttgggttca gcctccgagg
     3241 agggaaggag tacaacatgg ggctgttcat ccttcgcctt gctgaggacg ggcctgccat
     3301 caaagacggc agaattcacg ttggtgacca gatcgtggaa atcaatgggg aacctacgca
     3361 aggcatcaca cacacgcgag ccattgagct cattcaggct ggcgggaata aagtcctcct
     3421 ccttctgagg ccaggaactg gcttgatacc tgatcatggt gattgggata tttatagtcc
     3481 ttcatcttcc aatgtcattt atgatgaaca gccaccacct ctcccctctt cacattctgc
     3541 tgccacattt gaagagtctc atgtgccagt aactgaagac tctctgatta gagttcagac
     3601 atgtgaaaag gcagaagaat taaaggacac tgtacaagaa aagaaaagca ctttaaatgg
     3661 aagccagcct gagatgaagt atcagtctgt ccagaaaaat gtgagtaaga aggatccatc
     3721 cagaagtcat gggcatggtg acaagaatct acctaaagga gaaaatggtg ttacacggag
     3781 aggtagatct gctagtccca aaaagtcagt taatcgacat tcagaggaac atctggaaaa
     3841 gattcccagg ccccttagaa gtgaccccaa aggaaaatct agagaccggt cactcagccc
     3901 taggaaagga gaaaataaag gtcaggtcac cattaaggcg ggctctggac aagatccctg
     3961 tagaaaagac agaggacggt cttctagccc caggaagcag caaaagattg gaggcaacag
     4021 cctgtcaaac actgaaggca aattatcaga ggctgggagc cgaagagcag caggcctctc
     4081 tagtgacagc cctgaacagc tcccagaggg gaaagaaaag tcaggggtca gcaggaaaga
     4141 tctgaagctc agtcagctgg ggaaaaacag aacaaggtct ccagagaaaa ggagcagcaa
     4201 agttgatgaa gcgtctctcc catccaaaaa gactagtgac actgctagta gggtagtgtc
     4261 tgaaaaggag aaaggaagga agccaggcac aggagaaaga agtagagaca aaacaggaga
     4321 aagcgtccag acctcagcaa agccgctcac gcaggaagcg ggagagaaga tggcattaag
     4381 caaagcatca gaggtcactg acagaggcaa ggagcgtgca gggggcgcac ctgagagtag
     4441 ctctccagtc aagaaagcac ccatcactcc aggaccctgg agggtgccac gtgcaaataa
     4501 agtcacaggc actgctggca tggctgacaa acagctgtga cctttcgtat aaaacaaaga
     4561 aaagtaagtt gtaatcttga ctaacacaga attctttgaa ggtggagagt tgtggttttc
     4621 ccccagaaat tcttcaatac caggtagcca ggctgcatga agggcttctg agattgccaa
     4681 gacccacctg gccctggctg gctgcccttc ctcatgctca ggaaggagct gcatccaagg
     4741 gctcacctgc catgccctgc acaggccgct cgctcagcag tgacatgatc ttaacagtgt
     4801 ggtcacaact cactttgtgt ttgtgccaag ttatctactg tatcatgtct gttttatcct
     4861 tcccattctg atcaaacagt tcagtttggc ttgaagatgt tttcagtagc atgttgcatg
     4921 tttacagacg ggaatatgtg agtccttgca gaggaagaaa ttgttagctc atcattaaag
     4981 tgggcacttg cctcttctca cagcttctga ccatcctagt ttaaaaatgc aattcacaaa
     5041 catcacatta caggaaaggt caaatattag aaatgctttt tttacggcta agtaaggtgt
     5101 ttaaagtaac tgttaaagat actccttaca gttgaatgct caaacgagaa cgtactgtaa
     5161 gcaacagaat taacaacctc ctgccatgtt agccatcgcc tatgtagtga cagtgtctca
     5221 gatcagcggt agccttgggg gaagtacaag agcatgtaga agcactgctt gtttctcttt
     5281 aaagaaaagc tctactacat ctggagattt tgaatattaa tcactagtct ttaatatatt
     5341 gttgaagacc caaaatatca tagatttagt gagggacttg atcacgagac cagttctaca
     5401 gtccacggcc agaaaaagca ccagcccttg ccacgtagga gtcaggaggg gcaggcatgc
     5461 gagcgtcagc atttagaagc agagcctgtc ttgggcttcc tccacaagtc aggactaata
     5521 tggtatagac tgtgtgtatt gaaactttaa tttttagcta attatttaaa aacaaagttt
     5581 tcagagttct ttttaaagtc taataaaaat gtttgctgaa agttggagac agttcttaaa
     5641 ctcatacaat agatccagac atcagctccc tgacgcagca ttcagaaaca tctataaata
     5701 cagacatttc tcagaactgt ctatctgtgg agtatttaaa cactaaacac tcattctgtt
     5761 accttgtgag tctgacaaat tccactgtga caactgtact ggccccttat gacacatgct
     5821 tccatccaga actgtgttga acccatctca aaactacttg aa
//
