LOCUS       NM_053621               6672 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus membrane associated guanylate kinase, WW and PDZ
            domain containing 2 (Magi2), mRNA.
ACCESSION   NM_053621
VERSION     NM_053621.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6672)
  AUTHORS   Bender,J., Engeholm,M., Ederer,M.S., Breu,J., Moller,T.C.,
            Michalakis,S., Rasko,T., Wanker,E.E., Biel,M., Martinez,K.L.,
            Wurst,W. and Deussing,J.M.
  TITLE     Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering
            with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif
  JOURNAL   PLoS One 10 (9), e0136768 (2015)
   PUBMED   26352593
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6672)
  AUTHORS   Woo,J., Kwon,S.K., Nam,J., Choi,S., Takahashi,H., Krueger,D.,
            Park,J., Lee,Y., Bae,J.Y., Lee,D., Ko,J., Kim,H., Kim,M.H.,
            Bae,Y.C., Chang,S., Craig,A.M. and Kim,E.
  TITLE     The adhesion protein IgSF9b is coupled to neuroligin 2 via S-SCAM
            to promote inhibitory synapse development
  JOURNAL   J Cell Biol 201 (6), 929-944 (2013)
   PUBMED   23751499
REFERENCE   3  (bases 1 to 6672)
  AUTHORS   Orlowski,D., Elfving,B., Muller,H.K., Wegener,G. and Bjarkam,C.R.
  TITLE     Wistar rats subjected to chronic restraint stress display increased
            hippocampal spine density paralleled by increased expression levels
            of synaptic scaffolding proteins
  JOURNAL   Stress 15 (5), 514-523 (2012)
   PUBMED   22128856
  REMARK    GeneRIF: Chronic restraint stress influences hippocampal
            neuroplasticity by modulation of dendrite branching pattern and
            spine density paralleled by increased expression levels of synaptic
            scaffolding proteins.
REFERENCE   4  (bases 1 to 6672)
  AUTHORS   Danielson,E., Zhang,N., Metallo,J., Kaleka,K., Shin,S.M., Gerges,N.
            and Lee,S.H.
  TITLE     S-SCAM/MAGI-2 is an essential synaptic scaffolding molecule for the
            GluA2-containing maintenance pool of AMPA receptors
  JOURNAL   J Neurosci 32 (20), 6967-6980 (2012)
   PUBMED   22593065
  REMARK    GeneRIF: these results suggest that S-SCAM is an essential AMPAR
            scaffolding molecule for the GluA2-containing pool of AMPARs, which
            are involved in the constitutive pathway of maintaining synaptic
            strength.
REFERENCE   5  (bases 1 to 6672)
  AUTHORS   Babayeva,S., Zilber,Y. and Torban,E.
  TITLE     Planar cell polarity pathway regulates actin rearrangement, cell
            shape, motility, and nephrin distribution in podocytes
  JOURNAL   Am J Physiol Renal Physiol 300 (2), F549-F560 (2011)
   PUBMED   20534871
REFERENCE   6  (bases 1 to 6672)
  AUTHORS   Hirao,K., Hata,Y., Yao,I., Deguchi,M., Kawabe,H., Mizoguchi,A. and
            Takai,Y.
  TITLE     Three isoforms of synaptic scaffolding molecule and their
            characterization. Multimerization between the isoforms and their
            interaction with N-methyl-D-aspartate receptors and
            SAP90/PSD-95-associated protein
  JOURNAL   J Biol Chem 275 (4), 2966-2972 (2000)
   PUBMED   10644767
REFERENCE   7  (bases 1 to 6672)
  AUTHORS   Ohtsuka,T., Hata,Y., Ide,N., Yasuda,T., Inoue,E., Inoue,T.,
            Mizoguchi,A. and Takai,Y.
  TITLE     nRap GEP: a novel neural GDP/GTP exchange protein for rap1 small G
            protein that interacts with synaptic scaffolding molecule (S-SCAM)
  JOURNAL   Biochem Biophys Res Commun 265 (1), 38-44 (1999)
   PUBMED   10548487
REFERENCE   8  (bases 1 to 6672)
  AUTHORS   Yao,I., Hata,Y., Ide,N., Hirao,K., Deguchi,M., Nishioka,H.,
            Mizoguchi,A. and Takai,Y.
  TITLE     MAGUIN, a novel neuronal membrane-associated guanylate
            kinase-interacting protein
  JOURNAL   J Biol Chem 274 (17), 11889-11896 (1999)
   PUBMED   10207009
REFERENCE   9  (bases 1 to 6672)
  AUTHORS   Ide,N., Hata,Y., Deguchi,M., Hirao,K., Yao,I. and Takai,Y.
  TITLE     Interaction of S-SCAM with neural plakophilin-related
            Armadillo-repeat protein/delta-catenin
  JOURNAL   Biochem Biophys Res Commun 256 (3), 456-461 (1999)
   PUBMED   10080919
REFERENCE   10 (bases 1 to 6672)
  AUTHORS   Hirao,K., Hata,Y., Ide,N., Takeuchi,M., Irie,M., Yao,I.,
            Deguchi,M., Toyoda,A., Sudhof,T.C. and Takai,Y.
  TITLE     A novel multiple PDZ domain-containing molecule interacting with
            N-methyl-D-aspartate receptors and neuronal cell adhesion proteins
  JOURNAL   J Biol Chem 273 (33), 21105-21110 (1998)
   PUBMED   9694864
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Mar 2, 2021 this sequence version replaced NM_053621.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF034863.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-436               JAXUCZ010000004.1  16761700-16762135   c
            437-553             JAXUCZ010000004.1  16299462-16299578   c
            554-673             JAXUCZ010000004.1  15893579-15893698   c
            674-889             JAXUCZ010000004.1  15779757-15779972   c
            890-1100            JAXUCZ010000004.1  15754981-15755191   c
            1101-1180           JAXUCZ010000004.1  15741168-15741247   c
            1181-1238           JAXUCZ010000004.1  15626610-15626667   c
            1239-1360           JAXUCZ010000004.1  15589823-15589944   c
            1361-1543           JAXUCZ010000004.1  15587521-15587703   c
            1544-2182           JAXUCZ010000004.1  15506005-15506643   c
            2183-2214           JAXUCZ010000004.1  15444551-15444582   c
            2215-2404           JAXUCZ010000004.1  15438628-15438817   c
            2405-2446           JAXUCZ010000004.1  15429598-15429639   c
            2447-2538           JAXUCZ010000004.1  15423758-15423849   c
            2539-2731           JAXUCZ010000004.1  15417898-15418090   c
            2732-2980           JAXUCZ010000004.1  15410386-15410634   c
            2981-3166           JAXUCZ010000004.1  15385117-15385302   c
            3167-3344           JAXUCZ010000004.1  15382990-15383167   c
            3345-3540           JAXUCZ010000004.1  15376970-15377165   c
            3541-3684           JAXUCZ010000004.1  15375314-15375457   c
            3685-3823           JAXUCZ010000004.1  15331349-15331487   c
            3824-3912           JAXUCZ010000004.1  15321316-15321404   c
            3913-6672           JAXUCZ010000004.1  15278518-15281277   c
FEATURES             Location/Qualifiers
     source          1..6672
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     gene            1..6672
                     /gene="Magi2"
                     /gene_synonym="Acvrinp1; Acvrip1; AIP-1; S-SCAM"
                     /note="membrane associated guanylate kinase, WW and PDZ
                     domain containing 2"
                     /db_xref="GeneID:113970"
                     /db_xref="RGD:621855"
     exon            1..436
                     /gene="Magi2"
                     /gene_synonym="Acvrinp1; Acvrip1; AIP-1; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..3969
                     /gene="Magi2"
                     /gene_synonym="Acvrinp1; Acvrip1; AIP-1; S-SCAM"
                     /function="assembles NMDA receptors and neuronal cell
                     adhesion proteins"
                     /note="synaptic-scaffolding molecule;
                     atrophin-1-interacting protein 1; membrane-associated
                     guanylate kinase inverted 2; activin receptor interacting
                     protein 1"
                     /codon_start=1
                     /product="membrane-associated guanylate kinase, WW and PDZ
                     domain-containing protein 2"
                     /protein_id="NP_446073.2"
                     /db_xref="GeneID:113970"
                     /db_xref="RGD:621855"
                     /translation="MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYL
                     GEVKPGKVAYESGSKLVSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGG
                     IVDKDLRHYLNLRFQKGSVDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITV
                     EDFMELEKSGALLESGTYEDNYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRN
                     KSVTNMEKASIEPPEEEEEERPVVNGNGVVITPESSEHEDKSAGASGETPSQPYPAPV
                     YSQPEELKDQMDDTKSTKPEENEDSDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPR
                     LAKKAKPAEECKENELPYGWEKIDDPIYGTYYVDHINRRTQFENPVLEAKRKLQQHNM
                     PHTELGTKPLQAPGFREKPLFTRDASQLKGTFLSTTLKKSNMGFGFTIIGGDEPDEFL
                     QVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVPIGQSVNLVLCR
                     GYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISRTSQSVPDITDRPP
                     HSLHSMPADGQLDGTYPPPVHDDNVSVASSGATQAELMTLTIVKGAQGFGFTIADSPT
                     GQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPVGSETSLIIHRG
                     GFFSPWKTPKPMVDRWENQGSPQTSLSAPAVPQSLPFPPALHRSSFPDSTEAFDPRKP
                     DPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKELDVHLRRMESGFGFRILGGDEP
                     GQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNL
                     TVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYANSNHAAPSSNASPPEGFASH
                     SLQTSDVIIHRKENEGFGFVIISSLNRPESGATITVPHKIGRIIDGSPADRCAKLKVG
                     DRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQ
                     HSPLAQQHSPLAQPSPATPNSPVAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQP
                     PFTDYRQPPLDYRQPPGGDYSQPSPLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEK
                     GAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARA
                     IELIKSGGRRVRLLLKRGTGQVPEYGMVPSSLSMCMKSDKHGSPYFYLLGHPKDTTNP
                     TPGALPLPPPQACRK"
     exon            437..553
                     /gene="Magi2"
                     /gene_synonym="Acvrinp1; Acvrip1; AIP-1; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            554..673
                     /gene="Magi2"
                     /gene_synonym="Acvrinp1; Acvrip1; AIP-1; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            674..889
                     /gene="Magi2"
                     /gene_synonym="Acvrinp1; Acvrip1; AIP-1; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1100
                     /gene="Magi2"
                     /gene_synonym="Acvrinp1; Acvrip1; AIP-1; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1180
                     /gene="Magi2"
                     /gene_synonym="Acvrinp1; Acvrip1; AIP-1; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1238
                     /gene="Magi2"
                     /gene_synonym="Acvrinp1; Acvrip1; AIP-1; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1360
                     /gene="Magi2"
                     /gene_synonym="Acvrinp1; Acvrip1; AIP-1; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1543
                     /gene="Magi2"
                     /gene_synonym="Acvrinp1; Acvrip1; AIP-1; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..2182
                     /gene="Magi2"
                     /gene_synonym="Acvrinp1; Acvrip1; AIP-1; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2183..2214
                     /gene="Magi2"
                     /gene_synonym="Acvrinp1; Acvrip1; AIP-1; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2215..2404
                     /gene="Magi2"
                     /gene_synonym="Acvrinp1; Acvrip1; AIP-1; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2405..2446
                     /gene="Magi2"
                     /gene_synonym="Acvrinp1; Acvrip1; AIP-1; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2447..2538
                     /gene="Magi2"
                     /gene_synonym="Acvrinp1; Acvrip1; AIP-1; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..2731
                     /gene="Magi2"
                     /gene_synonym="Acvrinp1; Acvrip1; AIP-1; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2732..2980
                     /gene="Magi2"
                     /gene_synonym="Acvrinp1; Acvrip1; AIP-1; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2981..3166
                     /gene="Magi2"
                     /gene_synonym="Acvrinp1; Acvrip1; AIP-1; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3167..3344
                     /gene="Magi2"
                     /gene_synonym="Acvrinp1; Acvrip1; AIP-1; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3345..3540
                     /gene="Magi2"
                     /gene_synonym="Acvrinp1; Acvrip1; AIP-1; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3541..3684
                     /gene="Magi2"
                     /gene_synonym="Acvrinp1; Acvrip1; AIP-1; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3685..3823
                     /gene="Magi2"
                     /gene_synonym="Acvrinp1; Acvrip1; AIP-1; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3824..3912
                     /gene="Magi2"
                     /gene_synonym="Acvrinp1; Acvrip1; AIP-1; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3913..6672
                     /gene="Magi2"
                     /gene_synonym="Acvrinp1; Acvrip1; AIP-1; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcggagcag agggagagaa aggcaaagtc tgccaccctc ttcccttggc ccccttgctc
       61 ctccatcccg attttgactc ccagaccctc cttcccaacg gaccctcagg aactgaggag
      121 actcacccta ctgccatgtc caaaagcttg aaaaagaaaa gccactggac tagcaaagtc
      181 cacgagagtg tcattggcag aaacccggag ggccagctgg gctttgaact gaaggggggc
      241 gccgaaaacg gacagttccc ctacctgggg gaggtgaagc cgggcaaggt ggcctatgaa
      301 agcggcagca agttggtgtc cgaggagctg ctgctggagg tgaacgagac ccccgtggcg
      361 gggctcacca tcagggatgt tctggccgtg atcaaacact gcaaggaccc cctccggctc
      421 aagtgtgtca agcaaggagg aattgttgat aaggatcttc gtcactacct caacttaaga
      481 tttcagaagg gttctgttga ccacgaacta cagcaaatca tccgtgacaa cctctacctc
      541 cgcacagtgc catgcaccac aaggccacat aaggagggtg aggtccctgg agtggactac
      601 attttcataa ccgttgagga ctttatggaa ttggagaaaa gcggtgctct cctagaaagt
      661 gggacctatg aagacaacta ttacggcact ccaaagcctc cagctgaacc agcaccatta
      721 ttattaaatg taacagacca gatactcccg ggagctactc caagtgctga ggggaagcgg
      781 aaaagaaata agtctgtgac caacatggag aaagcaagta tagagccacc ggaggaggag
      841 gaggaagaaa ggcctgtggt caacggaaat ggcgtcgtca taacaccaga atccagtgaa
      901 catgaagaca aaagtgcagg tgcctcaggg gagaccccct cccagcctta ccctgcacca
      961 gtgtacagtc agcctgaaga gctcaaggac cagatggatg atacaaagtc aacaaagccc
     1021 gaggagaatg aggactccga cccattgcct gataactggg aaatggccta cacagagaag
     1081 ggtgaagtct acttcattga ccataacaca aagacaacat catggctgga tccacgactt
     1141 gccaaaaagg ctaagcctgc agaggagtgc aaggaaaatg agcttccata tggctgggaa
     1201 aaaatcgatg atcctatata tggcacttac tatgtcgacc acataaatag aagaacacag
     1261 tttgaaaacc ctgtcctgga agcaaaaagg aagctacagc aacataacat gccccacaca
     1321 gaacttggaa caaagcccct gcaggcccca ggtttccgag aaaagccact cttcacccgg
     1381 gatgcatccc agttgaaggg aacattcctc agcaccaccc tcaaaaagag caacatgggc
     1441 tttgggttta cgatcatcgg tggagatgag ccggacgagt ttctacaggt gaagagtgtg
     1501 atcccggatg ggcccgccgc acaggatggg aaaatggaga caggtgatgt cattgtctat
     1561 attaatgaag tttgtgtcct tggacacact catgcagatg ttgtcaaact tttccagtct
     1621 gttcctattg gtcagagcgt caacctggtg ttgtgtcgtg gctacccttt gccctttgat
     1681 cctgaagacc ctgccaacag catggtgcca ccccttgcaa taatggagag gccacctccg
     1741 gtgatggtca atggaagaca taactatgaa acatatttgg aatacatttc tcggacctca
     1801 cagtcggtcc cagatattac agaccggcca cctcattctt tgcactccat gccagctgat
     1861 ggccaactag atggcacata tccaccaccc gtccacgatg acaatgtgtc tgtggcttca
     1921 tctggagcca ctcaagctga acttatgacc ttaaccattg tgaaaggtgc ccagggattt
     1981 ggctttacta ttgccgacag tcccacggga cagcgggtga aacaaatact tgacattcag
     2041 ggatgccccg ggctgtgtga aggagacctc attgttgaga tcaaccaaca gaatgtacag
     2101 aacctgagcc atacagaagt ggtggatata cttaaggact gccccgtcgg aagtgagact
     2161 tctctaatca tccatcgagg aggtttcttt tctccatgga aaactccaaa gcctatggtg
     2221 gaccggtggg agaaccaagg cagccctcaa acaagtttat ctgctccggc cgtcccacag
     2281 agcctgccct tcccacctgc ccttcatagg agctcctttc ctgactcaac agaggccttt
     2341 gacccacgga agcctgaccc gtatgagctc tacgagaaat cgagagccat ttatgaaagt
     2401 aggcaacaag tgccacccag gaccagtttt cgaatggatt cctctggtcc agattataag
     2461 gaattggatg ttcaccttcg gaggatggag tctggatttg gcttcagaat ccttggggga
     2521 gacgagcccg gacagcctat tttgatcgga gctgtcattg cgatgggctc agctgacaga
     2581 gacggccgtc tgcacccagg agacgagctt gtctacgtgg atgggatccc ggtggctggc
     2641 aagacccacc gctacgtcat cgacctcatg caccatgcgg cccgcaacgg gcaggttaac
     2701 ctcactgtga gaagaaaggt gctatgtgga ggggagccct gcccagagaa tgggaggagt
     2761 ccaggctctg tatcaacaca ccacagctct ccccgcagtg actatgccac ctacgccaac
     2821 agcaaccacg cggcccccag tagcaatgcc tcaccccctg aaggctttgc ctcgcacagc
     2881 ctgcagacca gtgacgtcat cattcaccga aaggaaaacg aaggcttcgg cttcgtcatc
     2941 atcagctccc tgaacaggcc tgagtctgga gccaccataa ccgtgcccca taaaatcgga
     3001 cgaatcatcg atgggagccc tgcagatcgc tgcgcaaaac tcaaagtggg cgaccggatc
     3061 ttagcagtca acggccagtc tatcatcaac atgcctcacg ctgacatcgt gaagctcatc
     3121 aaggatgcgg gtctcagcgt caccctccgc atcattcctc aggaggagct caacagccca
     3181 acatcagcac ccagttcaga gaagcagagc cccatggccc agcagcacag ccctctggcc
     3241 cagcagcaca gccctctggc ccagccgagc ccagccaccc ccaacagccc agttgcacag
     3301 ccagctcctc ctcaacctct ccagctgcaa ggacatgaaa atagttacag gtcagaagtt
     3361 aaagcaaggc aagatgtgaa gccagacatc cggcagccgc ccttcacaga ctacaggcag
     3421 ccgccactgg actacaggca acccccggga ggggactact cgcagccctc acccttggac
     3481 tacaggcagc actccccaga caccaggcag taccctctgt cagactacag gcagccacag
     3541 gatttcgatt atttcactgt ggacatggag aaaggagcca aaggatttgg attcagcatc
     3601 cgtggaggaa gggaatacaa aatggatcta tacgtgttga gattggcgga ggatgggcca
     3661 gccataagga acggcaggat gagggtggga gatcagatca tcgaaataaa tggggaaagc
     3721 acacgagaca tgacccacgc cagagcaata gaactcatca agtcgggagg aagaagagtg
     3781 cggttgctgc tgaaacgagg cacggggcag gtcccggagt atggaatggt gccttccagc
     3841 ctctccatgt gcatgaaaag tgacaagcat gggtccccat atttctactt actgggccac
     3901 cctaaagaca cgacgaaccc tacgcctgga gcgctgccgc tgccgccgcc ccaggcctgc
     3961 cggaagtagg cgtctccctc gaagacatcc tctctccatt ctctccatca catccagccc
     4021 caccctccga cccttcccac cagataggcc cagacccaac ttgggatatc caaagggaac
     4081 acgacgttag gaaaccaaag gagctttcgg ccggcggcca gaagaagcag cgcctggggg
     4141 agcagaggga gcgctcggcg agcccgcagc gcagtgcaag gcccaggctg gaggaggtgc
     4201 caggcggcca ggggcggccc gaggccggca ggcccgcctc ggaggcggcc gatggaaagg
     4261 aggcgctgcg cggccggcgc gagggccccg gggccgcggg cgcgcgggag gccgaggcca
     4321 aggtgggcgt gcgctcgggg gcccgacccg cagcacggcc cacggggggc ggcctggcgc
     4381 gcaaagcggc ggtggcaccg gggccctgga aggtgccggg ctccgacaag ctgccgggcg
     4441 ccctgcagcc tggcgcctcg gccgcgggca gatgagcccc gaggcggggc ccccgcccgc
     4501 ctccccgcag gccgatcttc ctgggttccg tctgacggcg ttttaattta tttccactgt
     4561 cacacgcata gatctacacg aggcgccgag gcccgggagc accggcgtgc gacgcgcgtg
     4621 ggcggcacgg cacggtgtgc gcgcaggcag acctaaactg atcctaaagc ccccggttcc
     4681 atggtgggag ctttggcagc tatggaagaa ccaaaatcac gcaaacatca cagagagaca
     4741 gtgcagtgta gctttagttt aaaaagagaa aagaaaaaag ttccccccac tgcatgaagg
     4801 atttggatgt catccaaact ttatatcaag aaactggaca agttcagagc aatcacaaac
     4861 tggaatatcg ccttaaaaaa aaaatcaaac tgcacggagc aagcggaaac tgagacaaga
     4921 ttatatcttt taattgatct aaagtgttgt aaataagtcg ttcttgacat atctagacag
     4981 gggttaaagg gtttctttga gacatccaga actgttcgcc catgatactg atacgtttcc
     5041 atggctcccc cttaggcatc caccgacggt attagcagca tcgttccctg cctactgcag
     5101 gatgagttag aaacctagtg aattcattgg tgtggtgcca tttttactgc catttctgtg
     5161 gtcaagtcac atttctgtac attttccgta gtagggaaaa aaaaggttta aaaattgtat
     5221 cctagggaac agtttgccgt aagtcagaat tttgcaggtt agctcgtaga tcttaattgg
     5281 ttttcctcta aaataatgag tttgataatc aaaagaccat aatctgttta atcgagattg
     5341 acagcgctgc aggtccttcc tgaaaaggcc ttcctgccat cccaggcact cggagatacg
     5401 tagctgctct gttagcaatc ttctatttta cctattttat gtcttatttt aaagctcttc
     5461 atttgcactt tgacaaagta tttgtcctat atttctcaaa ttagaatctc taatattgaa
     5521 agcattatga taactaattt attttcatta aagaacatga gtcctttggc attcctttct
     5581 gctttcctta tttgatctcc cttttgtttc catctggtta gctttcgcct tatattcgct
     5641 aatggttttt gtcacactaa tgatctatag atgcgccttt atgttcctgg gttaccatct
     5701 caggtcagtg attgtcccag tagtaaaaac tgtcgaacat ttacttcagt cagctatcca
     5761 ttggtattta ttgtagctgc acatattaaa agacaaaatg tctaaaggca ttttgccatg
     5821 aatatgtttt gtatatgtga ggcttcaacc cttcggatat tctgcccctt acacaagttc
     5881 caaagcaagt aagacccatc cctctcactt gtcaagtgag taaaaggggt ccgtcgagca
     5941 gggtcacagg gaactgctgt ctcaaatgag tctcccccac tctctgggca ctacctagtt
     6001 taatttccat cagacataaa gatagttcca caagccaata tggtcaaaag cctcatgtga
     6061 ggggtattgc agcttgtaaa agtaatttcc aaaatgaaac acattcatca taaacaaaag
     6121 cacaaacaca tgtagcggtt ttagactttt tgtttaatct caattcgtct ttctcccctg
     6181 gactagaaat ccagtctagt ttgccattaa tttattgact ctgggtttgg acaatgcttc
     6241 tgtagtgtaa ctgcacgtcc cagtactgta tcctctgacc tttatttttt cacacgttac
     6301 aaaaggaaaa gagtgaagat tacccttgca taaactctaa tttgcacagt tcacagctac
     6361 tacttgtgca gtagttgctt tatgcggctg taatctataa cccgtgaaga cagcacatca
     6421 tctaaaatct cattccaaat aatatttctg tgtagtgtta gctgtgaatt taccctgtac
     6481 agctgtatct ctataaatat aattccgtgt attaatagtc acagaaagac tgtaagtgag
     6541 caactatttt tatgaaacgc accactatgg ataaattaac ttttacagaa atcttgttta
     6601 ctgtatgata ttctaaaaca ctgtcaaata aaatatatat ccaaaaatct tttccttttt
     6661 cagctatata aa
//
