LOCUS       NM_001401825            7724 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Rattus norvegicus membrane associated guanylate kinase, WW and PDZ
            domain containing 1 (Magi1), transcript variant 1, mRNA.
ACCESSION   NM_001401825 XM_006236928
VERSION     NM_001401825.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7724)
  AUTHORS   Xiang,Y., Sun,M., Wu,Y. and Hu,Y.
  TITLE     MiR-205-5p-Mediated MAGI1 Inhibition Attenuates the Injury Induced
            by Diabetic Nephropathy
  JOURNAL   Pharmacology 109 (2), 98-109 (2024)
   PUBMED   38325349
  REMARK    GeneRIF: MiR-205-5p-Mediated MAGI1 Inhibition Attenuates the Injury
            Induced by Diabetic Nephropathy.
REFERENCE   2  (bases 1 to 7724)
  AUTHORS   Pryce,K.D., Powell,R., Agwa,D., Evely,K.M., Sheehan,G.D., Nip,A.,
            Tomasello,D.L., Gururaj,S. and Bhattacharjee,A.
  TITLE     Magi-1 scaffolds NaV1.8 and Slack KNa channels in dorsal root
            ganglion neurons regulating excitability and pain
  JOURNAL   FASEB J 33 (6), 7315-7330 (2019)
   PUBMED   30860870
  REMARK    GeneRIF: Dorsal root ganglion (DRG)-specific knockdown of Magi-1
            attenuated thermal nociception and acute inflammatory pain and
            NaV1.8 protein expression. Magi-1 bound to Slack potassium
            channels, macrocomplexing with NaV1.8 channels.Magi-1 is an
            essential scaffold for ion transport in DRG neurons and a central
            player in pain.Magi-1 is expressed in small- and medium-sized DRG
            neurons, their axonal tracts, and nodes of Ranvier.
REFERENCE   3  (bases 1 to 7724)
  AUTHORS   Ito,H., Morishita,R., Sudo,K., Nishimura,Y.V., Inaguma,Y.,
            Iwamoto,I. and Nagata,K.
  TITLE     Biochemical and morphological characterization of MAGI-1 in
            neuronal tissue
  JOURNAL   J Neurosci Res 90 (9), 1776-1781 (2012)
   PUBMED   22605569
  REMARK    GeneRIF: MAGI-1 was expressed in Purkinje cells, in hypocampal
            neurons in CA1 region, in the glomerulus region of olfactory bulb,
            and at the dorsal root entry zone in embryonic rat spinal cord
REFERENCE   4  (bases 1 to 7724)
  AUTHORS   Rovelet-Lecrux,A., Legallic,S., Wallon,D., Flaman,J.M.,
            Martinaud,O., Bombois,S., Rollin-Sillaire,A., Michon,A., Le Ber,I.,
            Pariente,J., Puel,M., Paquet,C., Croisile,B., Thomas-Anterion,C.,
            Vercelletto,M., Levy,R., Frebourg,T., Hannequin,D. and Campion,D.
  CONSRTM   Investigators of the GMAJ project
  TITLE     A genome-wide study reveals rare CNVs exclusive to extreme
            phenotypes of Alzheimer disease
  JOURNAL   Eur J Hum Genet 20 (6), 613-617 (2012)
   PUBMED   22166940
REFERENCE   5  (bases 1 to 7724)
  AUTHORS   Zou,S., Pita-Almenar,J.D. and Eskin,A.
  TITLE     Regulation of glutamate transporter GLT-1 by MAGI-1
  JOURNAL   J Neurochem 117 (5), 833-840 (2011)
   PUBMED   21426345
  REMARK    GeneRIF: These data suggest that MAGI-1 regulates surface
            expression of GLT-1 and the level of glutamate in the hippocampus
REFERENCE   6  (bases 1 to 7724)
  AUTHORS   Tanemoto,M., Toyohara,T., Abe,T. and Ito,S.
  TITLE     MAGI-1a functions as a scaffolding protein for the distal renal
            tubular basolateral K+ channels
  JOURNAL   J Biol Chem 283 (18), 12241-12247 (2008)
   PUBMED   18303016
  REMARK    GeneRIF: These results demonstrate that the
            phosphorylation-dependent scaffolding of the basolateral K(+)
            channels by MAGI-1a-long participates in the renal regulation of
            the fluid and electrolyte homeostasis.
REFERENCE   7  (bases 1 to 7724)
  AUTHORS   Kremerskothen,J., Kindler,S., Finger,I., Veltel,S. and Barnekow,A.
  TITLE     Postsynaptic recruitment of Dendrin depends on both dendritic mRNA
            transport and synaptic anchoring
  JOURNAL   J Neurochem 96 (6), 1659-1666 (2006)
   PUBMED   16464232
REFERENCE   8  (bases 1 to 7724)
  AUTHORS   Thomas,G.M., Rumbaugh,G.R., Harrar,D.B. and Huganir,R.L.
  TITLE     Ribosomal S6 kinase 2 interacts with and phosphorylates PDZ
            domain-containing proteins and regulates AMPA receptor transmission
  JOURNAL   Proc Natl Acad Sci U S A 102 (42), 15006-15011 (2005)
   PUBMED   16217014
REFERENCE   9  (bases 1 to 7724)
  AUTHORS   Mizuhara,E., Nakatani,T., Minaki,Y., Sakamoto,Y., Ono,Y. and
            Takai,Y.
  TITLE     MAGI1 recruits Dll1 to cadherin-based adherens junctions and
            stabilizes it on the cell surface
  JOURNAL   J Biol Chem 280 (28), 26499-26507 (2005)
   PUBMED   15908431
REFERENCE   10 (bases 1 to 7724)
  AUTHORS   Dobrosotskaya,I., Guy,R.K. and James,G.L.
  TITLE     MAGI-1, a membrane-associated guanylate kinase with a unique
            arrangement of protein-protein interaction domains
  JOURNAL   J Biol Chem 272 (50), 31589-31597 (1997)
   PUBMED   9395497
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Feb 27, 2022 this sequence version replaced XM_006236928.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760393, SAMEA5760400
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-905               JAXUCZ010000004.1  128367322-128368226 c
            906-1022            JAXUCZ010000004.1  128025955-128026071 c
            1023-1142           JAXUCZ010000004.1  127899452-127899571 c
            1143-1349           JAXUCZ010000004.1  127877557-127877763 c
            1350-1551           JAXUCZ010000004.1  127870284-127870485 c
            1552-1634           JAXUCZ010000004.1  127859032-127859114 c
            1635-1670           JAXUCZ010000004.1  127854972-127855007 c
            1671-1728           JAXUCZ010000004.1  127846602-127846659 c
            1729-1859           JAXUCZ010000004.1  127843255-127843385 c
            1860-1952           JAXUCZ010000004.1  127840978-127841070 c
            1953-2135           JAXUCZ010000004.1  127833223-127833405 c
            2136-2756           JAXUCZ010000004.1  127831474-127832094 c
            2757-2788           JAXUCZ010000004.1  127803824-127803855 c
            2789-3005           JAXUCZ010000004.1  127794794-127795010 c
            3006-3089           JAXUCZ010000004.1  127791177-127791260 c
            3090-3181           JAXUCZ010000004.1  127788267-127788358 c
            3182-3374           JAXUCZ010000004.1  127786540-127786732 c
            3375-3668           JAXUCZ010000004.1  127784088-127784381 c
            3669-3836           JAXUCZ010000004.1  127780848-127781015 c
            3837-3930           JAXUCZ010000004.1  127773886-127773979 c
            3931-3991           JAXUCZ010000004.1  127773684-127773744 c
            3992-4135           JAXUCZ010000004.1  127772629-127772772 c
            4136-4274           JAXUCZ010000004.1  127769986-127770124 c
            4275-7724           JAXUCZ010000004.1  127762590-127766039 c
FEATURES             Location/Qualifiers
     source          1..7724
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..7724
                     /gene="Magi1"
                     /gene_synonym="Baiap1; BAP-1; MAGI-1"
                     /note="membrane associated guanylate kinase, WW and PDZ
                     domain containing 1"
                     /db_xref="GeneID:500261"
                     /db_xref="RGD:1586025"
     exon            1..905
                     /gene="Magi1"
                     /gene_synonym="Baiap1; BAP-1; MAGI-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             593..5029
                     /gene="Magi1"
                     /gene_synonym="Baiap1; BAP-1; MAGI-1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     membrane-associated guanylate kinase, WW and PDZ
                     domain-containing protein 1; BAI1-associated protein 1;
                     membrane-associated guanylate kinase inverted 1"
                     /codon_start=1
                     /product="membrane-associated guanylate kinase, WW and PDZ
                     domain-containing protein 1 isoform 1"
                     /protein_id="NP_001388754.1"
                     /db_xref="GeneID:500261"
                     /db_xref="RGD:1586025"
                     /translation="MSKVIQKKNHWTGRVHECTVKRGPQGELGVTVLGGAEHGEFPYV
                     GAVAAAEAAGLPGGGEGPKLAEGELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAV
                     RQGGRLNKDLRHFLNQRFQKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYS
                     FLTVKEFLDLEQSGTLLEVGTYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQST
                     PKRTKSYNDMQNAGIVHTENEEEEDVPEMNSSFTADSGDQDEPTLQEATLPPVNSSAL
                     AAPITDPSQKFPQYLPLSAEDNLGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCL
                     NKQQKPLEECEDDEGVHTEELDSELELPAGWEKIEDPVYGVYYVDHINRKTQYENPVL
                     EAKRKRQLEQQQQQQQHQQQPQQPQPPQPEEWTEDHASVVPPVAPSHPPSNPEPAREA
                     PLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAAL
                     DGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNT
                     SLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVSNMKDARPSSPADVASNSSHGYP
                     NDTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEG
                     DLIVEVNKRNVQALTHNQVVDMLIECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDS
                     QNSSQHSVSSLRSLHTASPSHSAQVLPEYPPADVPAPDQTDSSGQKKPDPFKIWAQSR
                     SMYENRPMSPSPASGLSKGERDREINSTNFGECQIPDYQEQDIFLWRKETGFGFRILG
                     GNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQG
                     HVNLTVRRKVVFTVPKAENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGS
                     GSTSGIGSGGGGGSGVVSAVLQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGRIIE
                     GSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATL
                     LTNAEKIATITTTHAPSQQGTQETRTTTKPKPDSQFEFKGPQATQEQDFYTVELERGA
                     KGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIE
                     LIKNGGRRVRLFLRRGDGSVPEYDPSSDRNGPSTGAQGVPEVRLGPPDHRSHPALESS
                     YPPDLHKSSQHAEKRAHAKDPKGNREHSGQPNEHHTWNGTSRKPDSGACRPKDRPPDT
                     WREAQPEWTATNGPKRRSPEKRREGTRSADNTLERREKHEKRREMSPERKRERSPTRR
                     KDSSPSRRRRSLERLLDQRRSPERRRGGSPERRAKSTDRRRARSPERRRERSLDKRNR
                     DDKVGHREREEAGLKLEAGRSPRNPPEQRRRPYKECSTDLSI"
     exon            906..1022
                     /gene="Magi1"
                     /gene_synonym="Baiap1; BAP-1; MAGI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1142
                     /gene="Magi1"
                     /gene_synonym="Baiap1; BAP-1; MAGI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1349
                     /gene="Magi1"
                     /gene_synonym="Baiap1; BAP-1; MAGI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1551
                     /gene="Magi1"
                     /gene_synonym="Baiap1; BAP-1; MAGI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1634
                     /gene="Magi1"
                     /gene_synonym="Baiap1; BAP-1; MAGI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1670
                     /gene="Magi1"
                     /gene_synonym="Baiap1; BAP-1; MAGI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1728
                     /gene="Magi1"
                     /gene_synonym="Baiap1; BAP-1; MAGI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1859
                     /gene="Magi1"
                     /gene_synonym="Baiap1; BAP-1; MAGI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..1952
                     /gene="Magi1"
                     /gene_synonym="Baiap1; BAP-1; MAGI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2135
                     /gene="Magi1"
                     /gene_synonym="Baiap1; BAP-1; MAGI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2756
                     /gene="Magi1"
                     /gene_synonym="Baiap1; BAP-1; MAGI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2757..2788
                     /gene="Magi1"
                     /gene_synonym="Baiap1; BAP-1; MAGI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2789..3005
                     /gene="Magi1"
                     /gene_synonym="Baiap1; BAP-1; MAGI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3006..3089
                     /gene="Magi1"
                     /gene_synonym="Baiap1; BAP-1; MAGI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3090..3181
                     /gene="Magi1"
                     /gene_synonym="Baiap1; BAP-1; MAGI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3182..3374
                     /gene="Magi1"
                     /gene_synonym="Baiap1; BAP-1; MAGI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3375..3668
                     /gene="Magi1"
                     /gene_synonym="Baiap1; BAP-1; MAGI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3669..3836
                     /gene="Magi1"
                     /gene_synonym="Baiap1; BAP-1; MAGI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3837..3930
                     /gene="Magi1"
                     /gene_synonym="Baiap1; BAP-1; MAGI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3931..3991
                     /gene="Magi1"
                     /gene_synonym="Baiap1; BAP-1; MAGI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3992..4135
                     /gene="Magi1"
                     /gene_synonym="Baiap1; BAP-1; MAGI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4136..4274
                     /gene="Magi1"
                     /gene_synonym="Baiap1; BAP-1; MAGI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4275..7724
                     /gene="Magi1"
                     /gene_synonym="Baiap1; BAP-1; MAGI-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgcctcct atccagccgg ccgccgcgct ccgccgcgcg gagtagaatg aactgtaaca
       61 aaacaagcag agcctttgta tctgcttaaa ggggccgcgg ccacttccct cgcgtcccct
      121 cacccccgcc ccgcgccgcc gcgtctccag ggctcccggc aactagcttg gaaagggctt
      181 ccctcgcgct gaggagcggc cggcgggcgc ggagcaggcg cggcgcgtgt ggagaaagct
      241 gcggagcaga gagcgggccc gggcggcgtc ggagtggact ctggtcccgg gagcgcgatc
      301 ggcgccggaa cgcggacccg gaggcaccgg aatgcaaaca aagctcgcgg gcgcctgtgc
      361 agggctctca acggagcccg gaaagtttgt tttatgatgg cttgagagcg cgagagagtc
      421 gggcgaggag gctcgagtag ctcgctcccg cgctccgaga gagagatgct tctcccgtga
      481 gcccgccgct ccgggggctc gtgctgtggg ggcacctgtc tctcgtttta gcagttttcc
      541 tttttttttc tttaatttta atttttcttt tgaggagggg ctgtaactca tcatgtcgaa
      601 agtgatccag aagaagaacc actggactgg ccgcgttcac gaatgcaccg tgaagcgggg
      661 accccagggc gagctggggg tgacggtgct ggggggcgcg gagcatgggg agtttccgta
      721 cgtgggggcg gtggcggcgg ccgaggcggc ggggcttccc ggcggtggcg agggaccgaa
      781 gctggctgaa ggtgagctgc tgctggaggt gcagggggtc cgggtgtccg gcttgccccg
      841 ctatgacgtg ctgggagtca tcgacagctg caaggaggcc gtcaccttca aagccgtcag
      901 acaaggagga aggctcaaca aggacctgcg acatttcctc aaccaacggt tccagaaggg
      961 gtctccggat catgaactcc agcagaccat aagggacaac ctctaccgcc atgccgtgcc
     1021 ttgcacaacc cggtctccca gagaaggaga agtgcctggc gtcgattaca gctttctgac
     1081 tgtgaaggag ttcctggacc tcgagcagag tgggaccctg ttggaagtcg gcacctatga
     1141 aggaaactat tatgggacac ccaaacctcc cagccagcca gtcagtggga aagtgatcac
     1201 gacggatgcc ttgcacagcc ttcagtctgg ctccaagcag tcgaccccta agcgaacaaa
     1261 atcctacaat gatatgcaaa atgctggcat agtccacacg gagaatgagg aagaggagga
     1321 tgttcctgaa atgaacagta gcttcacagc cgactctgga gaccaggacg agcccactct
     1381 ccaagaagcg acgctcccgc ctgtgaatag tagcgccctt gctgctccca tcacggaccc
     1441 ttctcagaag ttccctcagt acctacctct ttctgcagag gataatttag gtcctctacc
     1501 tgaaaactgg gagatggcct atactgaaaa tggagaagtc tattttatag accacaacac
     1561 gaaaacaaca tcatggttag accctcggtg cctgaacaaa cagcagaagc ctctggaaga
     1621 atgtgaagat gatgaagggg tacacaccga ggagctggac agtgaactag agctgcctgc
     1681 tggctgggaa aagattgaag accctgtcta cggtgtctac tatgtagacc acatcaacag
     1741 gaagacgcaa tatgaaaacc cagtcctaga agccaaaagg aagagacagc ttgaacaaca
     1801 gcagcagcag cagcagcacc agcagcagcc gcagcagcct cagccaccgc agccagaaga
     1861 gtggacagaa gatcatgcat ctgttgtgcc tcctgttgct ccttcccatc ccccaagcaa
     1921 cccggagcca gccagggaag ctccacttca gggcaaacct ttttttacaa gaaacccttc
     1981 tgagctgaaa ggcaagttca ttcacacaaa gctacggaaa agcagtcgag gctttggctt
     2041 cacggtggtt ggaggggacg aacctgatga gttcctgcag atcaagagcc ttgtcctaga
     2101 tggtcctgct gcactggatg gcaagatgga gacaggagat gtaatcgtca gtgtgaatga
     2161 cacctgtgtt ttgggacaca cacatgctca agttgtgaaa attttccagt ccattcccat
     2221 tggtgccagt gtggaccttg aactctgcag aggttatcca ttgccttttg acccggatga
     2281 ccctaacaca agtttagtga cctcggtggc cattttggac aaagaaccaa taattgtaaa
     2341 cggacaagag acctatgatt caccagcaag ccacagtagt aaaacgggca aagtcagcaa
     2401 catgaaggat gccaggccaa gcagccccgc agacgtggct tccaacagtt ctcatgggta
     2461 tcccaacgac acagtctcct tggcttcctc catagccacc cagccagagc taataaccgt
     2521 tcacatagtc aaagggccaa tgggatttgg ctttacgatc gcagatagtc ccggtggggg
     2581 tggccaaaga gtgaagcaga ttgttgacag tccgcgctgc agaggcctca aagaagggga
     2641 tctgattgtg gaggtgaata agaggaacgt gcaggccctg acgcacaatc aagtcgtgga
     2701 tatgctgatt gagtgtccaa agggaagtga ggtcacactg ttggtgcagc gaggagggct
     2761 accagttccc aagaagagtc caaagtcgca gccactggag aggaaagaca gccagaacag
     2821 ctcccagcac agtgtgtcca gcctccggag cctgcacaca gcttccccga gccacagtgc
     2881 acaggtgctc cctgagtacc cacctgcaga cgtccctgct ccagatcaga ccgacagctc
     2941 tgggcagaaa aagccagatc cctttaaaat ctgggcccag tcgaggagca tgtatgaaaa
     3001 ccgacctatg tcaccttcgc ctgcgtcagg actgagcaag ggtgaaagag acagagagat
     3061 caattccacg aattttggag aatgtcagat tccagattac caggagcagg acatcttcct
     3121 ctggagaaaa gagaccggtt ttggatttag gattctgggt ggaaatgagc caggggaacc
     3181 catttatatc ggtcacatcg taccactggg tgctgctgac acagacggcc gcctgaggtc
     3241 tggagatgaa ttaatctgtg tggatgggac accagtaatt gggaaatcac accagctcgt
     3301 ggtccagctt atgcaacaag ctgccaagca aggccacgtc aatctcacag tgaggcgtaa
     3361 agtggtgttt acggtcccca aagcagagaa cgaggtgccc tcaccagcct catcgcacca
     3421 cagtagcaac cagccagcgt ccctgacgga agagaagcgc acaccgcagg gcagccagaa
     3481 ctcgctgaac accgtgagct caggcagcgg cagcaccagc ggcattggca gtggtggtgg
     3541 cggaggcagc ggcgtggtga gcgctgtgct gcagccatat gatgtggaga ttcggcgtgg
     3601 ggagaacgag ggctttgggt ttgtcatcgt gtcctccgtg agcaggcctg aagcgggcac
     3661 caccttcggt cggattattg aggggagccc tgctgaccgc tgtggcaagc tgaaagtagg
     3721 agaccggatc ttggcggtaa atggatgttc catcaccaac aaatcccatt ctgacattgt
     3781 caacctaatc aaagaagcag gcaacacagt gactctccgc atcatccccg gggatgagtc
     3841 ctccaatgcc acactgctga ctaatgcgga gaagattgcc accatcacca ccactcatgc
     3901 cccctcacaa caggggaccc aggaaacaag gaccaccacc aaaccaaagc cggattctca
     3961 gtttgagttc aaaggaccgc aggctacaca ggagcaagat ttttacactg tggaattgga
     4021 aagaggagcc aagggatttg gctttagtct tcgaggaggg cgagagtata acatggacct
     4081 ttatgttctg cgcttagcag aggatggtcc tgcagaaaga tgcggaaaga tgaggattgg
     4141 cgatgaaatt ctagagatca atggtgagac caccaaaaac atgaaacact ctcgggccat
     4201 agaactgatc aagaatggcg gccgcagagt ccgtctgttt ctgaggcggg gagacggctc
     4261 ggtcccagaa tatgacccca gcagcgacag gaacggcccc tccaccggtg cacaaggtgt
     4321 tccggaagtg aggctggggc caccggacca cagatcacat ccagccttgg agtccagtta
     4381 cccacccgat cttcacaaat catcacaaca tgccgaaaag cgagcacacg cgaaggatcc
     4441 gaaaggcaac agggagcaca gcggacagcc caacgaacat cacacttgga acggaacttc
     4501 tagaaaaccc gacagtgggg catgccggcc caaagaccgg ccacccgaca catggagaga
     4561 ggcgcagccg gaatggacag ccaccaatgg cccaaagagg aggtctccgg agaagcgcag
     4621 ggaaggcacc cgcagtgctg acaacacttt ggaaagaagg gagaagcatg agaagagaag
     4681 agagatgtct cctgagagga agcgagagcg gtcacccacc cggagaaaag acagctcccc
     4741 gagccgccgg cggaggtccc tcgaaagact cctggatcaa agaaggtccc cagagcgcag
     4801 aagagggggc tcgcccgaga ggagagcaaa gtccaccgac aggaggaggg ccaggtcccc
     4861 agagcgcagg cgagagcggt cactggacaa aaggaaccga gacgacaaag ttggccaccg
     4921 agaaagggag gaggctggtc tgaagctgga agccgggaga agccccagaa atcccccaga
     4981 gcagagaagg cggccttaca aagaatgtag caccgacctc agcatctgag actcagagca
     5041 ttgcaacctt taccgtgtca aaggttctaa gaggaaggtc gcaaaatgaa ataatttagt
     5101 ttcttacctg aggaagcatc tgacacctgg tagtcctaag aacagtaaca gacattttat
     5161 gcatctgaaa tcttataagg aaaaaaatat atatgaaaag tcttgtgcct gatgtataat
     5221 attaaagaaa gtatttttaa atgcatactt ttttttttga aaattatttg ccaaaatact
     5281 ggcccaaagg gatatataca ttttgtttct tcacaagcta tagagttgtt ccttctttgg
     5341 ggcaaactct ttctctccta aataaacggg gctgttggtc atgtcctata agtaaatgca
     5401 gttaaattta actcagtata aactgtttcg aagtgacgta gtgctatact gtaagcccct
     5461 gtttttctga aaagcagaac acagaaatat acagactgag gatcttttag gatggattag
     5521 ggtggccatt gagcctaaaa ttcagccaac tatgggacaa gaatactact gcaaatgaag
     5581 gatatttatg actacagtgc atggcactaa gaaaccttat gatcttgagg tataattggt
     5641 atagtcaaag aacggtttgt gctctccctg gcccagaaag gtgcagaaac aagaaggttg
     5701 gctgccatta accaaaccca gccttagctg agacgatcag gttcaccagg ttccaccaca
     5761 gaatacatct cacctgcagc agcgcccatt gcaaagtgtc agcctctggg cagagcagac
     5821 aagctccttc tgggttgtct ggtccagttt gaagctgagt agatggaatg taggacccgt
     5881 acctctggga tgagggagat gtaaatgtct cccacatgca aagagtaccc tccccccact
     5941 atttagcata agcccctgct tgccctctgc ccagtgggag cagaggagtg aactttggtg
     6001 gtggaaacct gtcacgatat tttaaaagta ttggggctgc atattcctgg aatagttgat
     6061 cacacacttt gaaaccataa tccaagtcct aaggattgat tgaaagggaa ggaagaacat
     6121 gatgacgcct gtgggtcttg atctgtctgc tgggaaatga ccctatccct tgtgtttggg
     6181 gacagcgaag gaaaatgtaa tggtttttct tgctgaaata gacccatttt ctgaacctca
     6241 gaaggtgtgg ttgggtcagt tgtagccctg agatgtggtt taaatggatt actgcctagc
     6301 tgagccaaag cgtttgcttg tatctgttgg accactgcag caaaccctgc tgacagagca
     6361 tttgtatttc tgtagtactg ttttgcattt tccattcaga cacagaactg tgcaagtcaa
     6421 tcactgttga ttcccgtggt actgtaataa gggaggggcg aaaaaaaaaa tagaaaagaa
     6481 aaccagccaa tcattgtacg tagagtttaa aattgtaatt aatagagcct ctttggaaga
     6541 aaaaaataaa acaactgttg cctttttttg tataaaagag aatttatgac agaagtctag
     6601 ctgtgaggaa tgtgatacgt gtctatattt ctgaatatga acagattgat tcttggggat
     6661 atactttatt gtaaatcagg tatgtaaagt tgttttaaag tgggacatta tataagtaat
     6721 cgtcacagct ttcatttgtt agggctgttg tttctccgtg gagagactgc tcatttgcac
     6781 tctctgttca cttatttctt gcctcacgct ccctctgtgt tgatgaaaag caatgtgtgg
     6841 gccattcctt ttataaaaca ctatgcacat ataaatgtta cattgttcat agctttattt
     6901 gacttagggt ttatatataa cattacactg agtagttata gagtggacat ttctccaagt
     6961 tctttccttg aatcaaacaa tatacatgct atagctacag ggacaggagg tctgtgactg
     7021 ctacttgtgt tattggagtg ctccctacag atcatacacg gatgattgca ttaatgcgga
     7081 ggaagactga gtccgaaagc cagcttggag gtgttgctct ggagcctgtg tgactagggt
     7141 tttcctcact agttctggca caacctatga tgttaactga tggattcatt ctcttgatca
     7201 tggtctatgg gttttaaaca agttttaaaa aaaaaaaaaa aaggttgatt tttggagtgg
     7261 gtccaaagtt agcatcatga tatctgtctc agtttaaaaa ataaagtcag tgctacccaa
     7321 gtgagcctgg ctcagtatct gaggactttt gctatgacaa gttcacctta aattcagtac
     7381 atcagatttg gtttgcactg tatgggaaac tacgtgtggt aagccgaaat ctagaattct
     7441 cttcaatcta ctgtagacta tattggaaac tgattcttgt gagccttctt ccccaacctt
     7501 tcacttacca taagagtgct gatgagggtt gagtattttg tatggttaaa tcaaacaatt
     7561 taagattccc cagcccccat gacacaacca atgcctgaaa gaatgtttgg ggggtagggg
     7621 gagtcaatag cgtacttgga tttttttaag tttcttttgt gaaagatttt tttaatgcat
     7681 ttttactgta aaaatacatg gaagtgtatg cattccatta ccac
//
