LOCUS       NM_053409               2695 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus MAGE family member D1 (Maged1), mRNA.
ACCESSION   NM_053409
VERSION     NM_053409.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2695)
  AUTHORS   Li,M., Yu,X., Luo,Y., Yuan,H., Zhang,Y., Wen,X. and Zhou,Z.
  TITLE     Dynamic expression of Mage-D1 in rat dental germs and potential
            role in mineralization of ectomesenchymal stem cells
  JOURNAL   Sci Rep 12 (1), 22615 (2022)
   PUBMED   36585447
  REMARK    GeneRIF: Dynamic expression of Mage-D1 in rat dental germs and
            potential role in mineralization of ectomesenchymal stem cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2695)
  AUTHORS   Luo,Y., Yang,Z., Li,M., Zhao,M., Wen,X. and Zhou,Z.
  TITLE     [Mage-D1 binding to activated p75NTR positively regulates
            mineralization of rat ectomesenchymal stem cells in vitro]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 41 (10), 1547-1553 (2021)
   PUBMED   34755671
  REMARK    GeneRIF: [Mage-D1 binding to activated p75NTR positively regulates
            mineralization of rat ectomesenchymal stem cells in vitro].
REFERENCE   3  (bases 1 to 2695)
  AUTHORS   Teuber,J., Mueller,B., Fukabori,R., Lang,D., Albrecht,A. and
            Stork,O.
  TITLE     The ubiquitin ligase Praja1 reduces NRAGE expression and inhibits
            neuronal differentiation of PC12 cells
  JOURNAL   PLoS One 8 (5), e63067 (2013)
   PUBMED   23717400
  REMARK    GeneRIF: Praja1, through ubiquitination and degradation of NRAGE,
            inhibits neuronal differentiation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2695)
  AUTHORS   Reddy,E.M., Chettiar,S.T., Kaur,N., Shepal,V. and Shiras,A.
  TITLE     Dlxin-1, a MAGE family protein, induces accelerated neurite
            outgrowth and cell survival by enhanced and early activation of MEK
            and Akt signalling pathways in PC12 cells
  JOURNAL   Exp Cell Res 316 (14), 2220-2236 (2010)
   PUBMED   20595047
  REMARK    GeneRIF: effects on neuritogenesis are promoted through
            interactions of Dlxin-1 with the neurotrophin receptor TrkA
REFERENCE   5  (bases 1 to 2695)
  AUTHORS   Wang,X., Tang,J., Xing,L., Shi,G., Ruan,H., Gu,X., Liu,Z., Wu,X.,
            Gao,X. and Xu,Y.
  TITLE     Interaction of MAGED1 with nuclear receptors affects circadian
            clock function
  JOURNAL   EMBO J 29 (8), 1389-1400 (2010)
   PUBMED   20300063
REFERENCE   6  (bases 1 to 2695)
  AUTHORS   Williams,M.E., Strickland,P., Watanabe,K. and Hinck,L.
  TITLE     UNC5H1 induces apoptosis via its juxtamembrane region through an
            interaction with NRAGE
  JOURNAL   J Biol Chem 278 (19), 17483-17490 (2003)
   PUBMED   12598531
REFERENCE   7  (bases 1 to 2695)
  AUTHORS   Salehi,A.H., Xanthoudakis,S. and Barker,P.A.
  TITLE     NRAGE, a p75 neurotrophin receptor-interacting protein, induces
            caspase activation and cell death through a JNK-dependent
            mitochondrial pathway
  JOURNAL   J Biol Chem 277 (50), 48043-48050 (2002)
   PUBMED   12376548
  REMARK    GeneRIF: identification of NRAGE as a p75NTR interactor capable of
            inducing caspase activation and cell death through a JNK-dependent
            mitochondrial apoptotic pathway
REFERENCE   8  (bases 1 to 2695)
  AUTHORS   Masuda,Y., Sasaki,A., Shibuya,H., Ueno,N., Ikeda,K. and Watanabe,K.
  TITLE     Dlxin-1, a novel protein that binds Dlx5 and regulates its
            transcriptional function
  JOURNAL   J Biol Chem 276 (7), 5331-5338 (2001)
   PUBMED   11084035
REFERENCE   9  (bases 1 to 2695)
  AUTHORS   Hennuy,B., Reiter,E., Cornet,A., Bruyninx,M., Daukandt,M.,
            Houssa,P., N'Guyen,V.H., Closset,J. and Hennen,G.
  TITLE     A novel messenger ribonucleic acid homologous to human MAGE-D is
            strongly expressed in rat Sertoli cells and weakly in Leydig cells
            and is regulated by follitropin, lutropin, and prolactin
  JOURNAL   Endocrinology 141 (10), 3821-3831 (2000)
   PUBMED   11014239
REFERENCE   10 (bases 1 to 2695)
  AUTHORS   Salehi,A.H., Roux,P.P., Kubu,C.J., Zeindler,C., Bhakar,A.,
            Tannis,L.L., Verdi,J.M. and Barker,P.A.
  TITLE     NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin
            receptor and facilitates nerve growth factor-dependent apoptosis
  JOURNAL   Neuron 27 (2), 279-288 (2000)
   PUBMED   10985348
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081756.1.
            
            On Jun 10, 2007 this sequence version replaced NM_053409.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081756.1, AF217964.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2695
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..2695
                     /gene="Maged1"
                     /gene_synonym="Nrage"
                     /note="MAGE family member D1"
                     /db_xref="GeneID:84469"
                     /db_xref="RGD:70898"
     exon            1..101
                     /gene="Maged1"
                     /gene_synonym="Nrage"
                     /inference="alignment:Splign:2.1.0"
     exon            102..175
                     /gene="Maged1"
                     /gene_synonym="Nrage"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..2458
                     /gene="Maged1"
                     /gene_synonym="Nrage"
                     /note="SNERG-1; MAGE-D1 antigen; sertoli cell
                     necdin-related gene protein 1; neurotrophin
                     receptor-interacting MAGE homolog; melanoma antigen,
                     family D, 1"
                     /codon_start=1
                     /product="melanoma-associated antigen D1"
                     /protein_id="NP_445861.1"
                     /db_xref="GeneID:84469"
                     /db_xref="RGD:70898"
                     /translation="MAQKPDGGAGLRGFQAEASVEDSALLVQTLMEAIQISEAPPTSQ
                     ATAAASGPNASPQSSQPPTANEKADTEVSAAAARPKTGFKAQNTTTKGPNDYSQARNA
                     KEMPKNQPKVAFKSQNATSKGPHAASDFSHAASTGKSAAKKSEMAFKGQNTTTKAGPS
                     ATYNFTQSPSANEMTNNQPKTAKAWNDTTKIPGADAQTQNVNQAKMADVGTSAGISET
                     DGAAAQTSADGSQAQNVESRTIIRGKRTRKINNLNVEENSNGDQRRASLASGNWRSAP
                     VPVTTQNPPGAPPNVLWQTPLAWQNPSGWQNQTARQTPPARQSPPARQTPSAWQNPVA
                     WQNPVIWPNPVIWQNPVIWPNPIVWPGPIVWPNPMAWQSTPGWQSPPSWQAPPSWQSP
                     QDWQGPPDWQLPPDWSMPPDWSFPSDWPFPPDWIPADWPIPPDWQNLRPSPNLRSSPN
                     SRASQNQGPPQPRDVALLQERANKLVKYLMLKDYTKVPIKRSEMLRDIIREYTDVYPE
                     IIERACFVLEKKFGIQLKEIDKEEHLYILISTPESLAGILGTTKDTPKLGLLLVILGI
                     IFMNGNRATEAVLWEALRKMGLRPGVRHPLLGDLRKLLTYEFVKQKYLDYRRVPNSNP
                     PEYEFLWGLRSYHETSKMKVLRFIAEVQKRDPRDWTAQFMEAADEALDALDAAAAEAE
                     ARAEARNRMGIGDEAVSGPWSWDDIEFELLTWDEEGDFGDPWSRIPFTFWARYHQNAR
                     SRFPQAFTGPIIGPSGTATANFAANFGAIGFFWVE"
     exon            176..874
                     /gene="Maged1"
                     /gene_synonym="Nrage"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1543
                     /gene="Maged1"
                     /gene_synonym="Nrage"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1607
                     /gene="Maged1"
                     /gene_synonym="Nrage"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1687
                     /gene="Maged1"
                     /gene_synonym="Nrage"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1779
                     /gene="Maged1"
                     /gene_synonym="Nrage"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1859
                     /gene="Maged1"
                     /gene_synonym="Nrage"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..1902
                     /gene="Maged1"
                     /gene_synonym="Nrage"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..1965
                     /gene="Maged1"
                     /gene_synonym="Nrage"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2080
                     /gene="Maged1"
                     /gene_synonym="Nrage"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2466
                     /gene="Maged1"
                     /gene_synonym="Nrage"
                     /inference="alignment:Splign:2.1.0"
     exon            2467..2671
                     /gene="Maged1"
                     /gene_synonym="Nrage"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagagagtg cgggtgcaga gagcggagca gagcagtccc gatcctctga gtcgtgaaga
       61 aggaagcaac gaagggggtt ggggttgggg cctgaggcaa ggctctgctc ttgccagaga
      121 gacaagagct atggctcaga aaccggacgg cggtgcaggc ctccgcggct tccaggcaga
      181 ggcctctgta gaagacagcg ccttgcttgt gcagaccttg atggaagcca tccagatctc
      241 cgaggctccg cccaccagcc aggccacagc agctgccagt gggccgaatg ctagtcccca
      301 gagttcacag cccccaactg ccaatgagaa ggctgatact gaggtttcag cagctgctgc
      361 caggcctaag acaggcttta aggcccagaa taccaccaca aaggggccaa atgattactc
      421 tcaggcacgt aatgccaagg agatgcccaa gaatcagcct aaggtggcct ttaagtcaca
      481 gaatgccacc tctaaaggtc cacatgctgc ctctgatttt tcccatgcag catccacagg
      541 caaatcagca gctaaaaagt ctgaaatggc ctttaagggt cagaatacca ctactaaggc
      601 tggccccagt gccacctaca atttcactca gtctcccagt gccaatgaga tgaccaacaa
      661 ccagcctaag acagctaagg cttggaatga caccactaag atccctggag ctgatgccca
      721 gacccagaat gtaaaccagg ccaaaatggc tgacgtaggg accagtgcag gtatctctga
      781 aactgacggt gcagcagccc agacctcagc agatggctcc caggctcaga atgtggagtc
      841 ccggactata attcggggca agaggacccg caagattaat aacttgaatg tggaagagaa
      901 cagcaatggg gaccaaaggc gtgcctcgct ggcttccggg aactggaggt ctgctccggt
      961 tccagtaacc actcagaacc cacctggcgc accccctaat gtgctgtggc agacaccact
     1021 ggcttggcag aacccatcag gctggcaaaa ccagacagcc aggcagaccc caccagcacg
     1081 tcagagtccc ccagctaggc agacaccatc agcttggcag aaccccgttg catggcagaa
     1141 tccagtgatc tggcctaacc cagtgatctg gcagaatcca gtgatctggc caaaccccat
     1201 tgtctggcct ggcccaattg tctggccaaa cccaatggcc tggcagagta cacctggatg
     1261 gcagagccca cccagttggc aggctccacc tagttggcag agccctcaag attggcaagg
     1321 ccctccagat tggcagttac cacctgactg gtcaatgcct cctgactggt cctttccctc
     1381 tgactggcct tttccacctg actggatccc tgccgactgg ccaattccac ccgactggca
     1441 gaacttacga ccctcaccta atctgagatc ctcccccaac tctcgtgcct cacagaacca
     1501 gggtcctcca cagccccgag atgtggccct tcttcaggaa agagcaaata agctggtcaa
     1561 gtacttgatg cttaaagact acacgaaggt gcccatcaag cgctcagaaa tgctgagaga
     1621 tatcatccga gaatacactg atgtttatcc agaaatcatt gaacgcgcat gctttgtcct
     1681 ggagaagaaa tttggaatcc agctcaagga aatcgacaaa gaagagcatc tgtatatcct
     1741 catcagtacc cctgaatccc tggctggcat actgggaacg accaaagaca caccgaagct
     1801 aggcctcctc ttagtgattc tgggcattat cttcatgaat ggcaaccgtg ccactgaggc
     1861 cgtcctctgg gaagcactgc gcaagatggg actacgtcct ggggtcagac atcccctcct
     1921 tggcgatctg aggaaacttc ttacttacga gtttgtaaag cagaaatacc tggactacag
     1981 acgagtgccc aacagcaacc ctcctgagta tgagttcctc tggggcctcc gctcctacca
     2041 tgagactagc aagatgaaag tgctgagatt cattgcagag gttcagaaga gagaccctcg
     2101 tgactggact gcacagttca tggaagctgc agatgaagcc ttggatgctc tggatgctgc
     2161 tgcagctgag gcagaggccc gggccgaagc aagaaaccgc atggggattg gagacgaggc
     2221 tgtgtctggg ccctggagct gggatgacat tgagtttgag ctgctgacct gggatgagga
     2281 aggagatttt ggagatcctt ggtccaggat cccctttacc ttctgggcca gataccacca
     2341 gaatgcccgc tccaggtttc cccaggcctt taccggcccc atcattggcc ccagcggcac
     2401 tgccaccgcc aacttcgccg ccaacttcgg tgccattggc ttcttctggg ttgagtaaag
     2461 tgtcagatac tgctcatcat ttgcaatagt tttccctgag tgaggctgaa gcctcagatt
     2521 ccttcaaaac acagctatct agagagccac atcctgttga ctgagagtgg catgcaagat
     2581 aaatttattt gctattctgt ctattacttt tttttccttg tgtgttgtca agttttggta
     2641 tcagaaataa atgttgaaat tgcaaagtga aaaaaaaaaa aaaaaaaaaa aaaaa
//
