LOCUS       NM_017190               2475 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus myelin-associated glycoprotein (Mag), mRNA.
ACCESSION   NM_017190
VERSION     NM_017190.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2475)
  AUTHORS   Nikulina,E., Gkioka,V., Siddiq,M.M., Mellado,W., Hilaire,M.,
            Cain,C.R., Hannila,S.S. and Filbin,M.T.
  TITLE     Myelin-associated glycoprotein inhibits neurite outgrowth through
            inactivation of the small GTPase Rap1
  JOURNAL   FEBS Lett 594 (9), 1389-1402 (2020)
   PUBMED   31985825
  REMARK    GeneRIF: Myelin-associated glycoprotein inhibits neurite outgrowth
            through inactivation of the small GTPase Rap1.
REFERENCE   2  (bases 1 to 2475)
  AUTHORS   Pronker,M.F., Lemstra,S., Snijder,J., Heck,A.J., Thies-Weesie,D.M.,
            Pasterkamp,R.J. and Janssen,B.J.
  TITLE     Structural basis of myelin-associated glycoprotein adhesion and
            signalling
  JOURNAL   Nat Commun 7, 13584 (2016)
   PUBMED   27922006
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2475)
  AUTHORS   Hu,B., Arpag,S., Zhang,X., Mobius,W., Werner,H., Sosinsky,G.,
            Ellisman,M., Zhang,Y., Hamilton,A., Chernoff,J. and Li,J.
  TITLE     Tuning PAK Activity to Rescue Abnormal Myelin Permeability in HNPP
  JOURNAL   PLoS Genet 12 (9), e1006290 (2016)
   PUBMED   27583434
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2475)
  AUTHORS   Palandri,A., Salvador,V.R., Wojnacki,J., Vivinetto,A.L.,
            Schnaar,R.L. and Lopez,P.H.
  TITLE     Myelin-associated glycoprotein modulates apoptosis of motoneurons
            during early postnatal development via NgR/p75(NTR)
            receptor-mediated activation of RhoA signaling pathways
  JOURNAL   Cell Death Dis 6 (9), e1876 (2015)
   PUBMED   26335717
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2475)
  AUTHORS   Lossos,A., Elazar,N., Lerer,I., Schueler-Furman,O., Fellig,Y.,
            Glick,B., Zimmerman,B.E., Azulay,H., Dotan,S., Goldberg,S.,
            Gomori,J.M., Ponger,P., Newman,J.P., Marreed,H., Steck,A.J.,
            Schaeren-Wiemers,N., Mor,N., Harel,M., Geiger,T.,
            Eshed-Eisenbach,Y., Meiner,V. and Peles,E.
  TITLE     Myelin-associated glycoprotein gene mutation causes
            Pelizaeus-Merzbacher disease-like disorder
  JOURNAL   Brain 138 (Pt 9), 2521-2536 (2015)
   PUBMED   26179919
REFERENCE   6  (bases 1 to 2475)
  AUTHORS   Pedraza,L., Owens,G.C., Green,L.A. and Salzer,J.L.
  TITLE     The myelin-associated glycoproteins: membrane disposition, evidence
            of a novel disulfide linkage between immunoglobulin-like domains,
            and posttranslational palmitylation
  JOURNAL   J Cell Biol 111 (6 Pt 1), 2651-2661 (1990)
   PUBMED   1703542
REFERENCE   7  (bases 1 to 2475)
  AUTHORS   Owens,G.C., Boyd,C.J., Bunge,R.P. and Salzer,J.L.
  TITLE     Expression of recombinant myelin-associated glycoprotein in primary
            Schwann cells promotes the initial investment of axons by
            myelinating Schwann cells
  JOURNAL   J Cell Biol 111 (3), 1171-1182 (1990)
   PUBMED   1697293
REFERENCE   8  (bases 1 to 2475)
  AUTHORS   Arquint,M., Roder,J., Chia,L.S., Down,J., Wilkinson,D., Bayley,H.,
            Braun,P. and Dunn,R.
  TITLE     Molecular cloning and primary structure of myelin-associated
            glycoprotein
  JOURNAL   Proc Natl Acad Sci U S A 84 (2), 600-604 (1987)
   PUBMED   2432614
REFERENCE   9  (bases 1 to 2475)
  AUTHORS   Johnson,D., Sato,S., Quarles,R.H., Inuzuka,T., Brady,R.O. and
            Tourtellotte,W.W.
  TITLE     Quantitation of the myelin-associated glycoprotein in human nervous
            tissue from controls and multiple sclerosis patients
  JOURNAL   J Neurochem 46 (4), 1086-1093 (1986)
   PUBMED   2419505
REFERENCE   10 (bases 1 to 2475)
  AUTHORS   Sternberger,N.H., Quarles,R.H., Itoyama,Y. and Webster,H.D.
  TITLE     Myelin-associated glycoprotein demonstrated immunocytochemically in
            myelin and myelin-forming cells of developing rat
  JOURNAL   Proc Natl Acad Sci U S A 76 (3), 1510-1514 (1979)
   PUBMED   375239
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M16800.1.
            
            On Oct 11, 2005 this sequence version replaced NM_017190.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M16800.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2475
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2475
                     /gene="Mag"
                     /gene_synonym="1B236"
                     /note="myelin-associated glycoprotein"
                     /db_xref="GeneID:29409"
                     /db_xref="RGD:3035"
     exon            1..19
                     /gene="Mag"
                     /gene_synonym="1B236"
                     /inference="alignment:Splign:2.1.0"
     exon            20..72
                     /gene="Mag"
                     /gene_synonym="1B236"
                     /inference="alignment:Splign:2.1.0"
     exon            73..135
                     /gene="Mag"
                     /gene_synonym="1B236"
                     /inference="alignment:Splign:2.1.0"
     exon            136..208
                     /gene="Mag"
                     /gene_synonym="1B236"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..2043
                     /gene="Mag"
                     /gene_synonym="1B236"
                     /note="S-MAG (C-term.); siglec-4a; brain neuron
                     cytoplasmic protein 3; sialic acid-binding Ig-like lectin
                     4a"
                     /codon_start=1
                     /product="myelin-associated glycoprotein precursor"
                     /protein_id="NP_058886.1"
                     /db_xref="GeneID:29409"
                     /db_xref="RGD:3035"
                     /translation="MIFLTTLPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRF
                     DFPDELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTL
                     LLSTLSPELGGKYYFRGDLGGYNQYTFSEHSVLDIINTPNIVVPPEVVAGTEVEVSCM
                     VPDNCPELRPELSWLGHEGLGEPTVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQ
                     AAFPNTTLQFEGYASLDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRD
                     GMVLREAVAESLYLDLEEVTPAEDGIYACLAENAYGQDNRTVELSVMYAPWKPTVNGT
                     VVAVEGETVSILCSTQSNPDPILTIFKEKQILATVIYESQLQLELPAVTPEDDGEYWC
                     VAENQYGQRATAFNLSVEFAPIILLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRN
                     VTVNETEREFVYSERSGLLLTSILTLRGQAQAPPRVICTSRNLYGTQSLELPFQGAHR
                     LMWAKIGPVGAVVAFAILIAIVCYITQTRRKKNVTESPSFSAGDNPHVLYSPEFRISG
                     APDKYESEKRLGSERRLLGLRGEPPELDLSYSHSDLGKRPTKDSYTLTEELAEYAEIR
                     VK"
     exon            209..577
                     /gene="Mag"
                     /gene_synonym="1B236"
                     /inference="alignment:Splign:2.1.0"
     exon            578..874
                     /gene="Mag"
                     /gene_synonym="1B236"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1132
                     /gene="Mag"
                     /gene_synonym="1B236"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1393
                     /gene="Mag"
                     /gene_synonym="1B236"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1681
                     /gene="Mag"
                     /gene_synonym="1B236"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1778
                     /gene="Mag"
                     /gene_synonym="1B236"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1878
                     /gene="Mag"
                     /gene_synonym="1B236"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2475
                     /gene="Mag"
                     /gene_synonym="1B236"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagaagccag accatccaac cttctgtatc agtgctcctc gtcgcctcac tgtacttcac
       61 ggaagagact tggttgactg gccacttgga gcggaatcag gagacattcc caactcaggg
      121 agactgaggt gagggcccta gctcgcccac ttgctggaca agatgatatt ccttaccacc
      181 ctgcctctgt tttggataat gatttcagct tctcgagggg ggcactgggg tgcctggatg
      241 ccctcgtcca tctcagcctt cgagggcacg tgtgtctcca tcccctgccg tttcgacttc
      301 ccggatgagc tcagaccggc tgtggtacat ggcgtctggt atttcaacag tccctacccc
      361 aagaactacc cgccagtggt cttcaagtcc cgcacacaag tggtccacga gagcttccag
      421 ggccgtagcc gcctgttggg agacctgggc ctacgaaact gcaccctgct tctcagcacg
      481 ctgagccctg agctgggagg gaaatactat ttccgaggtg acctgggcgg ctacaaccag
      541 tacaccttct cggagcacag cgtcctggac atcatcaaca cccccaacat cgtggtgccc
      601 ccagaagtgg tggcaggaac ggaagtagag gtcagctgca tggtgccgga caactgccca
      661 gagctgcgcc ctgagctgag ctggctgggc cacgaggggc taggggagcc cactgttctg
      721 ggtcggctgc gggaggatga aggcacctgg gtgcaggtgt cactgctaca cttcgtgcct
      781 actagagagg ccaacggcca ccgtctgggc tgtcaggctg ccttccccaa caccaccttg
      841 cagttcgagg gttacgccag tctggacgtc aagtaccccc cggtgattgt ggagatgaat
      901 tcctctgtgg aggccattga gggctcccat gtcagcctgc tctgtggggc tgacagcaac
      961 ccgccaccgc tgctgacttg gatgcgggat gggatggtgt tgagggaggc agttgctgag
     1021 agcctgtacc tggatctgga ggaggtgacc ccagcagagg acggcatcta tgcttgcctg
     1081 gcagagaatg cctatggcca ggacaaccgc acggtggagc tgagcgtcat gtatgcacct
     1141 tggaagccca cagtgaatgg gacggtggtg gcggtagagg gggagacagt ctccatcctg
     1201 tgttccacac agagcaaccc ggaccctatt ctcaccatct tcaaggagaa gcagatcctg
     1261 gccacggtca tctatgagag tcagctgcag ctggaactcc ctgcagtgac gcccgaggac
     1321 gatggggagt actggtgtgt agctgagaac cagtatggcc agagagccac cgccttcaac
     1381 ctgtctgtgg agtttgctcc cataatcctt ctggaatcgc actgtgcagc ggccagagac
     1441 accgtgcagt gcctgtgtgt ggtaaaatcc aacccggaac cctccgtggc ctttgagctg
     1501 ccttcccgca acgtgactgt gaacgagaca gagagggagt ttgtgtactc agagcgcagc
     1561 ggcctcctgc tcaccagcat cctcacgctc cggggtcagg cccaagcccc accccgcgtc
     1621 atttgtacct ccaggaacct ctacggcacc cagagcctcg agctgccttt ccagggagca
     1681 caccgactga tgtgggccaa aatcggccct gtgggtgctg tggtcgcctt tgccatcctg
     1741 attgccattg tctgctacat cacccagaca agaagaaaaa agaacgtcac agagagcccc
     1801 agcttctcag cgggagacaa ccctcatgtc ctgtacagcc ccgaattccg aatctctgga
     1861 gcacctgata agtatgagag tgagaagcgc ctggggtccg agaggaggct gctgggcctt
     1921 aggggggaac ccccagaact ggacctcagt tattcccact cagacctggg gaaacgaccc
     1981 accaaggaca gctacaccct gacagaggag ctggctgagt acgcagaaat ccgagtcaag
     2041 tgaggaagct gggggctggc cctgtggctc accccccatc aggaccctcg cttggccccc
     2101 actggccgtg ggctcccttt ctcttgagag tggtaggggt gggggcggga aggggcgggg
     2161 caggaaacag tgaggtctta ggggcccggc ctcccctcct tcccggctgc tcctctctgc
     2221 caacatcctg cacctatgtt acagctccct ctcccctcct tttaacctca gctgttgaga
     2281 ggggtgctct gtctgtccat gttatttatt gttatcctgg tctcctgtcc ccttacccgg
     2341 ccccaggacc tgtacaaaag ggacatgaaa taaatgtcct aatgacaagt gccagtctag
     2401 acccatcctt tggaggaaag gggcatatta gtaatacttt tctcgttgct gtaacaaaat
     2461 actggacaaa aacac
//
