LOCUS       NM_145673               2670 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus MAF bZIP transcription factor K (Mafk), mRNA.
ACCESSION   NM_145673
VERSION     NM_145673.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2670)
  AUTHORS   Hayes JD and Dinkova-Kostova AT.
  TITLE     The Nrf2 regulatory network provides an interface between redox and
            intermediary metabolism
  JOURNAL   Trends Biochem Sci 39 (4), 199-218 (2014)
   PUBMED   24647116
  REMARK    Review article
REFERENCE   2  (bases 1 to 2670)
  AUTHORS   Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P,
            Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM,
            Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E,
            Kivioja T and Taipale J.
  TITLE     DNA-binding specificities of human transcription factors
  JOURNAL   Cell 152 (1-2), 327-339 (2013)
   PUBMED   23332764
REFERENCE   3  (bases 1 to 2670)
  AUTHORS   Ohta K, Ohigashi M, Naganawa A, Ikeda H, Sakai M, Nishikawa J,
            Imagawa M, Osada S and Nishihara T.
  TITLE     Histone acetyltransferase MOZ acts as a co-activator of Nrf2-MafK
            and induces tumour marker gene expression during
            hepatocarcinogenesis
  JOURNAL   Biochem J 402 (3), 559-566 (2007)
   PUBMED   17083329
  REMARK    GeneRIF: during early hepatocarcinogenesis, aberrantly expressed
            MYST histone acetyltransferase 3 may induce glutathione
            S-transferase placental form expression through the Nrf2-mediated
            pathway
REFERENCE   4  (bases 1 to 2670)
  AUTHORS   Nioi P, Nguyen T, Sherratt PJ and Pickett CB.
  TITLE     The carboxy-terminal Neh3 domain of Nrf2 is required for
            transcriptional activation
  JOURNAL   Mol Cell Biol 25 (24), 10895-10906 (2005)
   PUBMED   16314513
REFERENCE   5  (bases 1 to 2670)
  AUTHORS   Torocsik B, Angelastro JM and Greene LA.
  TITLE     The basic region and leucine zipper transcription factor MafK is a
            new nerve growth factor-responsive immediate early gene that
            regulates neurite outgrowth
  JOURNAL   J Neurosci 22 (20), 8971-8980 (2002)
   PUBMED   12388604
REFERENCE   6  (bases 1 to 2670)
  AUTHORS   Gong P, Stewart D, Hu B, Vinson C and Alam J.
  TITLE     Multiple basic-leucine zipper proteins regulate induction of the
            mouse heme oxygenase-1 gene by arsenite
  JOURNAL   Arch Biochem Biophys 405 (2), 265-274 (2002)
   PUBMED   12220541
REFERENCE   7  (bases 1 to 2670)
  AUTHORS   Itoh K, Chiba T, Takahashi S, Ishii T, Igarashi K, Katoh Y, Oyake
            T, Hayashi N, Satoh K, Hatayama I, Yamamoto M and Nabeshima Y.
  TITLE     An Nrf2/small Maf heterodimer mediates the induction of phase II
            detoxifying enzyme genes through antioxidant response elements
  JOURNAL   Biochem Biophys Res Commun 236 (2), 313-322 (1997)
   PUBMED   9240432
REFERENCE   8  (bases 1 to 2670)
  AUTHORS   Toki T, Itoh J, Kitazawa J, Arai K, Hatakeyama K, Akasaka J,
            Igarashi K, Nomura N, Yokoyama M, Yamamoto M and Ito E.
  TITLE     Human small Maf proteins form heterodimers with CNC family
            transcription factors and recognize the NF-E2 motif
  JOURNAL   Oncogene 14 (16), 1901-1910 (1997)
   PUBMED   9150357
REFERENCE   9  (bases 1 to 2670)
  AUTHORS   Oyake T, Itoh K, Motohashi H, Hayashi N, Hoshino H, Nishizawa M,
            Yamamoto M and Igarashi K.
  TITLE     Bach proteins belong to a novel family of BTB-basic leucine zipper
            transcription factors that interact with MafK and regulate
            transcription through the NF-E2 site
  JOURNAL   Mol Cell Biol 16 (11), 6083-6095 (1996)
   PUBMED   8887638
REFERENCE   10 (bases 1 to 2670)
  AUTHORS   Kotkow KJ and Orkin SH.
  TITLE     Complexity of the erythroid transcription factor NF-E2 as revealed
            by gene targeting of the mouse p18 NF-E2 locus
  JOURNAL   Proc Natl Acad Sci U S A 93 (8), 3514-3518 (1996)
   PUBMED   8622968
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC070906.1.
            
            On May 24, 2004 this sequence version replaced NM_145673.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070906.1, CK355288.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN06680447
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2670
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q11"
     gene            1..2670
                     /gene="Mafk"
                     /note="MAF bZIP transcription factor K"
                     /db_xref="GeneID:246760"
                     /db_xref="RGD:628633"
     exon            1..148
                     /gene="Mafk"
                     /inference="alignment:Splign:2.1.0"
     exon            149..228
                     /gene="Mafk"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..663
                     /gene="Mafk"
                     /note="v-maf musculoaponeurotic fibrosarcoma oncogene
                     family, protein K; v-maf musculoaponeurotic fibrosarcoma
                     oncogene homolog K; v-maf avian musculoaponeurotic
                     fibrosarcoma oncogene homolog K"
                     /codon_start=1
                     /product="transcription factor MafK"
                     /protein_id="NP_663706.2"
                     /db_xref="GeneID:246760"
                     /db_xref="RGD:628633"
                     /translation="MTTNPKPNKTLKVKKEAGENAPVLSDDELVSMSVRELNQHLRGL
                     TKEEVTRLKQRRRTLKNRGYAASCRIKRVTQKEELERQRVELQQEVEKLARENSSMRL
                     ELDALRSKYEALQTFARTVARGPVTPTKVATTSVITIVKSAELSSTSVPFSAAS"
     exon            229..2646
                     /gene="Mafk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgggacttg ttgttctttg ccgagtcgga acgagtagtc cgaagcgcgc aggcggagac
       61 ggcgactgag gggagcgcga gagcagaagc gcgcgtgaag agtgcgtgtc tacaggagcc
      121 gccgcgcccg gccccgcgcg cgacccggct acgatttcct ggtggttccg tcctggtgac
      181 agggcccggg ttatgacgac taatcccaag cccaacaaga cattgaaggt caagaaggag
      241 gcgggcgaga acgcccctgt tcttagcgac gatgagctgg tgtccatgtc ggtgcgggag
      301 ctgaaccagc acctgcgggg gctcaccaag gaggaggtaa ctcggctgaa gcagcggcgg
      361 cgcacactca agaaccgagg ctacgccgcc agctgtcgca tcaagcgcgt gacacagaag
      421 gaggagctgg agcggcagcg ggtggagctg cagcaggagg tagagaagct ggctcgtgag
      481 aacagcagca tgcgtctgga gctggatgcc ctgcgctcca agtacgaggc cctgcagacc
      541 ttcgcacgca ccgtggcccg agggcctgtc acacccacca aggtggccac caccagtgtc
      601 atcaccatcg tcaaatccgc agagctctcc tccacctctg tgcccttctc agcggcctcc
      661 tagtgtctgc tggggccggg cagggtgcgg gcagtggcac agccctcatg cctatcccag
      721 gctccctggt acagattcct catgtctacc tgcccactgt ggaccctgca gggctgaggg
      781 cagggacggc agggacaggc agatgcagga taaaagggaa gctctcatga gccagtgcca
      841 caagcaaccc ccactcacat ctctccttcc cctgggggta cgtctctagg agctgacagg
      901 aaccacacgg gcaaccgcga tgaacaactc taggcctctg tggcagagtg tgaggactca
      961 gtcttccact tctccggtgc ctgcttatca gcgtcatcgg tgccgtcccc tctaagggcc
     1021 tccagctggg ttggacacca tctgtctgtc acttctgggc tctggccttc ctgtccttac
     1081 taaagggcgc tacaacctgc tttagccctt aggtagagcc aggcccatgt cctgggaaac
     1141 agttcctgat atagccactt gcaggggcta atgtatgtgt tcctgtgtgt acacaggcta
     1201 ccatcacagc ctgtgaagac cggaaactgc tggccaagtg ggagagcctg gccggtatgt
     1261 gtgctgaggg ttacacaagt gtcatggagt gtccctggaa gtctggtagg ctgcacccca
     1321 ttgtggtgca ggggccacct gtccacagag ccagcaaaca gccaggctcg ggttctctgg
     1381 gccttagcag aggggagagg ctggagagga gcaggggaag cctgagagat gctaaggggt
     1441 atgtcggtgg cgtgtgtgtg ttgttgcgga aagaacagga atgaagtaga cagggatagt
     1501 gtggaagccg aggtccaggg gatgtggaag aggccgagag gaatactgtg gagggacaga
     1561 gacgacttct ggagggcctt atgcacatag ccattgtggg caggtcggca aggaccccag
     1621 gcagactata ggtcacaaat actctgcaac tttggtgtcc aattgttacc tgccttttcc
     1681 tccttcatag cactctgggg ccactggcca tcttggtttt ttttaactga aggaattgtg
     1741 tcctccagat cctggggaat atggtggaca gggagtcagg ggcaggctga actacagcca
     1801 ggcacttaga aagcactgtt ggaaccatag ccttggtagg taatccatat tggatatcaa
     1861 taaggaccat ggatatttaa agagagaaga tatatatata tatataatta tacacacatt
     1921 ttatcgtaca gatttttcat aacaattttc tttcccagtt tgatactgta gatctttatt
     1981 aatgcagagt aggttggaca gtggggtggg gaacggaggc ccagggtgcc aacagcctcc
     2041 ctcagtcttt ctgtggtggt gctggcaggc cgggtcactg gatgagtggt ctccagggta
     2101 ggcaggtgac cactgactgg cttgctgccc gctcctggcc tctggtggtc ctcctgggtg
     2161 gaggccccat actcttggcg gccaggggag acagggctgt cagtaccact ggagcacctg
     2221 cagaggacac ctgccaggag ggggctggga agggtgtgag catgccccat ggcttcgtgt
     2281 cactgaaatt tcattgtcac aacttaataa tatatggatg tttttattta aagataaaag
     2341 tgagttttct gtcttgttcc tctgacttct taaagcaagc tttaactatt tcaaaaggtg
     2401 tcagggacac atgccgatca tgccgaggcc tggcatcctc agccgcctgc cacttggcaa
     2461 tttcatttca atatttattt tttttttgtg ctttttttcc cccatgttat aaattattga
     2521 gaagagatca agatcacaga ctgttggccc cgtctgcacc ctgcctcatg gccaccacct
     2581 aatttattgc tgtacatgtc gccgtgactg cttttgtatc tttgcaataa agaatttcct
     2641 gtttgaaaaa aaaaaaaaaa aaaaaaaaaa
//
