LOCUS       NM_022386               4936 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus MAF bZIP transcription factor G (Mafg), mRNA.
ACCESSION   NM_022386
VERSION     NM_022386.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4936)
  AUTHORS   Hayes,J.D. and Dinkova-Kostova,A.T.
  TITLE     The Nrf2 regulatory network provides an interface between redox and
            intermediary metabolism
  JOURNAL   Trends Biochem Sci 39 (4), 199-218 (2014)
   PUBMED   24647116
  REMARK    Review article
REFERENCE   2  (bases 1 to 4936)
  AUTHORS   Berg,D.T., Gupta,A., Richardson,M.A., O'Brien,L.A., Calnek,D. and
            Grinnell,B.W.
  TITLE     Negative regulation of inducible nitric-oxide synthase expression
            mediated through transforming growth factor-beta-dependent
            modulation of transcription factor TCF11
  JOURNAL   J Biol Chem 282 (51), 36837-36844 (2007)
   PUBMED   17928287
  REMARK    GeneRIF: the up-regulation of TCF11/MafG binding could be
            suppressed by overexpression of the TGF-beta inhibitor Smad7, and a
            small interfering RNA to TCF11 blocked the suppression of iNOS by
            TGF-beta.
REFERENCE   3  (bases 1 to 4936)
  AUTHORS   Shimokawa,N., Kumaki,I., Qiu,C.H., Ohmiya,Y., Takayama,K. and
            Koibuchi,N.
  TITLE     Extracellular acidification enhances DNA binding activity of
            MafG-FosB heterodimer
  JOURNAL   J Cell Physiol 205 (1), 77-85 (2005)
   PUBMED   15828020
  REMARK    GeneRIF: MafG-FBJ osteosarcoma oncogene B complexes are involved in
            transcriptional regulation in response to extracellular
            acidification
REFERENCE   4  (bases 1 to 4936)
  AUTHORS   Katsuoka,F., Motohashi,H., Engel,J.D. and Yamamoto,M.
  TITLE     Nrf2 transcriptionally activates the mafG gene through an
            antioxidant response element
  JOURNAL   J Biol Chem 280 (6), 4483-4490 (2005)
   PUBMED   15574414
REFERENCE   5  (bases 1 to 4936)
  AUTHORS   Motohashi,H., Katsuoka,F., Engel,J.D. and Yamamoto,M.
  TITLE     Small Maf proteins serve as transcriptional cofactors for
            keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway
  JOURNAL   Proc Natl Acad Sci U S A 101 (17), 6379-6384 (2004)
   PUBMED   15087497
REFERENCE   6  (bases 1 to 4936)
  AUTHORS   Cullinan,S.B., Zhang,D., Hannink,M., Arvisais,E., Kaufman,R.J. and
            Diehl,J.A.
  TITLE     Nrf2 is a direct PERK substrate and effector of PERK-dependent cell
            survival
  JOURNAL   Mol Cell Biol 23 (20), 7198-7209 (2003)
   PUBMED   14517290
REFERENCE   7  (bases 1 to 4936)
  AUTHORS   Gong,P., Stewart,D., Hu,B., Vinson,C. and Alam,J.
  TITLE     Multiple basic-leucine zipper proteins regulate induction of the
            mouse heme oxygenase-1 gene by arsenite
  JOURNAL   Arch Biochem Biophys 405 (2), 265-274 (2002)
   PUBMED   12220541
REFERENCE   8  (bases 1 to 4936)
  AUTHORS   Shimokawa,N., Kumaki,I. and Takayama,K.
  TITLE     MafG-2 is a novel Maf protein that is expressed by stimulation of
            extracellular H(+)
  JOURNAL   Cell Signal 13 (11), 835-839 (2001)
   PUBMED   11583919
REFERENCE   9  (bases 1 to 4936)
  AUTHORS   Shimokawa,N., Okada,J. and Miura,M.
  TITLE     Cloning of MafG homologue from the rat brain by differential
            display and its expression after hypercapnic stimulation
  JOURNAL   Mol Cell Biochem 203 (1-2), 135-141 (2000)
   PUBMED   10724342
REFERENCE   10 (bases 1 to 4936)
  AUTHORS   Shavit,J.A., Motohashi,H., Onodera,K., Akasaka,J., Yamamoto,M. and
            Engel,J.D.
  TITLE     Impaired megakaryopoiesis and behavioral defects in mafG-null
            mutant mice
  JOURNAL   Genes Dev 12 (14), 2164-2174 (1998)
   PUBMED   9679061
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000220.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_022386.4.
            
            On Jan 12, 2022 this sequence version replaced NM_022386.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078828.1, CK472072.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               JACYVU010000220.1  62736453-62736666   c
            215-278             JACYVU010000220.1  62732904-62732967   c
            279-4936            JACYVU010000220.1  62728165-62732822   c
FEATURES             Location/Qualifiers
     source          1..4936
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.3"
     gene            1..4936
                     /gene="Mafg"
                     /note="MAF bZIP transcription factor G"
                     /db_xref="GeneID:64188"
                     /db_xref="RGD:619953"
     exon            1..214
                     /gene="Mafg"
                     /inference="alignment:Splign:2.1.0"
     exon            215..278
                     /gene="Mafg"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..731
                     /gene="Mafg"
                     /note="v-maf avian musculoaponeurotic fibrosarcoma
                     oncogene homolog G; v-maf musculoaponeurotic fibrosarcoma
                     oncogene family, protein G"
                     /codon_start=1
                     /product="transcription factor MafG"
                     /protein_id="NP_071781.1"
                     /db_xref="GeneID:64188"
                     /db_xref="RGD:619953"
                     /translation="MTTPNKGNKALKVKREPGENGTSLTDEELVTMSVRELNQHLRGL
                     SKEEIIQLKQRRRTLKNRGYAASCRVKRVTQKEELEKQKAELQQEVEKLASENASMKL
                     ELDALRSKYEALQNFARTVARSPVAPARGPLAAGLGPLVPGKVAATSVITIVKSKTDA
                     RS"
     exon            279..4936
                     /gene="Mafg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtgacgtc tgaggagcgg cggcggcggt ggcggattct gagcccggtc cggcccggcc
       61 ttcctagcgc gcttggcccg gcccgcgcaa gcggccagta ctcctaagcc cccggcccgg
      121 acccttcgcg cccgacccag ccccgcgcag ccccggagcg cgcgcgcgcg gccccgcccc
      181 agccccgcct tggcccgccc gggcccgcag tgtgagtgcc tgctcactgt gtcccccggg
      241 ttatgacgac ccccaataaa ggaaacaagg ccttaaaggt gaagcgggag ccaggcgaga
      301 atggcaccag cttgactgat gaggagctgg tgaccatgtc ggtgcgagag ttgaaccagc
      361 acctgcgagg cctatccaag gaagagatta tccagctgaa gcagcgccgg cgcacactca
      421 agaaccgagg ctacgcagcc agctgtcgag tgaagcgggt gacacagaag gaggagctgg
      481 aaaagcagaa ggcggagcta cagcaggagg tggagaagct ggcctctgag aatgccagca
      541 tgaagctgga gctcgatgcg ctgcgctcca agtatgaggc cctgcagaac tttgccagga
      601 ccgtggcccg cagccctgtg gccccggctc ggggtcccct tgctgctggc ctggggcccc
      661 tggtccctgg caaggtggct gccaccagcg tcatcacaat agtaaagtcc aagacagatg
      721 ctcggtcata gggacacgtg cagttgccag gcaggtcttt gaggggccac taggtgcgtg
      781 gcaaagttgg cagccccgtc cctcttcctt tcttttccct tcctttctac tttcccttcc
      841 ctctttcctt ccctgcaaag cacaacctgc acccaggggc accgggctga gccccttgat
      901 atcatctttg ttgtcacgcc tgtgttttgt acgttgggat cggtcagttc aacagtgatg
      961 ttgggttgcc cctaacccct ttgtaccaag gccatgcagg ctaggagtcc ggagtgggca
     1021 ctgtgggaat ggacgagagt gcaagtgggc aagtgtactg ggcttgggtc tgcccttcct
     1081 ggtggtctgc agggggactt gaaagctttc ttttcagatt tccagtgggc ctcagtttga
     1141 tccagaagga ggagatgggc tctgccctga aacgtggtta tatcttgaag cccctggatg
     1201 gataggccac cagcctgggc attggggcag gaaccatggt gctggagcct ggcacagtgc
     1261 accggataag accaaatcgc cggttatgag tgtgggtgga aggtgtgtca gtgtgtcctg
     1321 cgatgggtcc ggtgtcactg tttacatgac ctatttgtgt ggttatatag ccctttattt
     1381 aaaagagaag ttccttttac ggagttatta aattatatgt ttaagagcta aaaagaaaaa
     1441 aaagctgcag agtatttata aaattgtctt aaaaaacaaa aacagaaaac aacatttgac
     1501 cgtataaatg gataagggaa gaaagtatag tagaaacttt gctagttgaa aaaaaaaaat
     1561 ccctttcttg taaacctggg gacagctctg tggctgttgg agtttagttt ttatacacag
     1621 agttatcaga cattacttat aaaacttagt ttaaaaaaag aaaaagaaaa aaaagaaaaa
     1681 aaaaaaaaaa aggccaggct gcgagcctac cagaggctgt cctctttgat atctcttttg
     1741 caactgtacc gaaagtgact tactccttcg cccttcctgc ttccgtcttg ccggtgccgt
     1801 ggtgttgtcc gtgcctggtg aggttttgtg cagccgtaaa gtgctggtgc ttctggtgac
     1861 ctttgacctg tggctgtccc tgtgtttttg tgtgtgtgtg cgtgtgtgta tgtgtgtttg
     1921 tcttttggat ttttgttgtg gttttgcttc tgctggcttg ctggacccag gcagaacata
     1981 ctctgccgct ggagtacagg agattgcctg ctggctcaca ttcttctgca cttgtccatt
     2041 cctctgccac ttggtccctc tgagccttgg cttggcattg tgggtctagg gcttggctta
     2101 aggcagtggc agagtaagtg aaattgggag ctatcgggcc cccatgctgc ttccacatcc
     2161 accacctctg gccctgggtg gtgacattgc agggaccaag gtgtcactgt gggtgcccac
     2221 agggctgtgc cctacctgtc ctcggccgtc ttccttctgg cctcagctta gttcctagag
     2281 tcttcattgg ggcctcagct aggccgcccc aggggcctac cttgtggatt gggagtcctg
     2341 tcactcgtgt atttctgaaa ccccgttctg tggggtgttg tttcccaggc agattggtta
     2401 ggggccccac ttggggcaac ccattcttcc ctgtctcact gtgagagcct ggaggcctcc
     2461 accatggcca gacaaaggct ttggccctcg ggcccagtct gttcttccca gtgtctgcag
     2521 ctcttggctc tgggccctat tctgcctcct tcaggatctg cgtcttccag ggatccgctg
     2581 ttcgacttgg aggtgcttct ctgcaggtcc caagcctgcc tcctcacccc agctttccag
     2641 tggaggctgc ccccttccag gcttggctca ggaagctcct cataggcgga tgcccaccca
     2701 taagaggcta catccctttg tggtcacatg gcctgtagcc tcttgctgac attgctggtg
     2761 tcttctctgg ggccctggat ccctgacaag cacagaaatg tgatctggta aaaggaaaga
     2821 ctgtggcctg ataggccttt acctcgtagg cagcaggatt ttcactcagt ttgacacagc
     2881 atgcagtgct ctgggagcag gacctctgcc accctggcat ttttggtagg ctggtttggc
     2941 tcaaggtgct cagacactcc cattgatgcc tgagtcggat atgggtggaa atctggactg
     3001 ttgattataa gttaccaggt gacctcattc cctccctttg tctcttaact ggtatccagt
     3061 gagttgctga tgccgactgg caagcagagc tggcccatgc ctagaggagg agagggacag
     3121 gctttctgag tgctttgatt ctggctgggc tgtagtgtat agctgagaat ggcctcctgc
     3181 atgggtccag ccttttggga ggatgaggaa gaggaggctg aggctagatg tgtgttaaac
     3241 aggagtagca gatctttgct tctgaaccgg atagagccgt gctcaaggct ttcaggtttg
     3301 cagtatcttc ttattgagtc tggggaacgt tccctattga gccagccctg cagctccact
     3361 ccctgcccca ttcccctgat ttcttgacag taaatcctgt gtccagttgt gactgttggc
     3421 tgttttcctg atcattgtta attccgtttt cctactgtga gggtgttgtg tttgactttc
     3481 tgacacagcg aatggagagc ttgggctgag gccaggtctc ccaaacttct ccgctaagta
     3541 aaccgtaatg tgtgacttcc ctcctatctt gactgcccga ctccttcctt ccacatggac
     3601 actcagattt caaagaaaac ccgcaggagg tgggtcagtt tcctctgtag aatatggtcc
     3661 cagagagtcc tcccctctgt tgtgtctagc tgctagtctg ggtgttgtac catcagtgca
     3721 gggagtccac ggcaacactg agttatacag ggaccactac catcgccagg cttcctagca
     3781 ggctgttctc agttcatctt tcaggtccgt gtgtactctg tgctagcagc agccttggtg
     3841 ttcaaggcca ggatttgcag ttttgataag ctacagccca cttggagatg gtgaggccac
     3901 ttccctgcta cctccctctc tggtgtggcc acttggccaa agctcccatc cacagctggg
     3961 gtgtctgagc cacagcctgc tacactgttt ccgctctggg atcttctgag ttactctttt
     4021 aggctgtggt ttggtgaaag gaaccaacac attaacgatc cccccccccc cccaaagcca
     4081 ctgagtaatt cttggcatgt tttctaagtg ctgttggctg cctggtttgg gagcagttgt
     4141 ggagaggaca gacttagtac cacacagagg catgggtgtg cgagctgctc acagcttcct
     4201 tgtttctggc atgtgtcctg ggtgcgtgct atacctcccg ggccagctgc acacctatgt
     4261 actctgcccc tgagaggtag agtgttcagg aagtgtccct gatagattcc ctgttctctg
     4321 tggccccagt tgggcttttg gctcctccag caacttcatg ccccaaccct acctttcctc
     4381 ccatttcttt ctgtctgcta gtccctgaag cctttaacca aatgggaatg ggtacagaaa
     4441 gccttctcct ggcaacttag ggcaacagga caagggctat tgtgtgtcca gctctgttgg
     4501 tctcctggtg ctgagaggtg tgtccaagca gagttgatca gcccctgcct gccctgcagg
     4561 gctgaagcca gggggaggtt agtagagagt accctaaatg gggtgagggt ccttaaacat
     4621 ccaagtgagg aggggctgtt gtgtggctgc aaggtgagac cctgtctcca gcacctgggt
     4681 agggccatcg gggatctggc tgcaaggtga ggtctggact tggcatcagt gcagagcgat
     4741 caagtcacct ggcctcagca ggcagcagcc ttggtgccca cccgtgccct gcgcagtatt
     4801 tattgctaaa ttattgtcca ggaggggcgg cactgggcct ggccccccgg gtatttattg
     4861 ctgtacatag tgtatgtttg tgatatataa ggttttcttt attttgtata tgatcaataa
     4921 acgcctttta aagaga
//
