LOCUS       NM_001399773            2793 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus MAF bZIP transcription factor A (Mafa), mRNA.
ACCESSION   NM_001399773 XM_006241903
VERSION     NM_001399773.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2793)
  AUTHORS   Navik,U., Rawat,K. and Tikoo,K.
  TITLE     L-Methionine prevents beta-cell damage by modulating the expression
            of Arx, MafA and regulation of FOXO1 in type 1 diabetic rats
  JOURNAL   Acta Histochem 124 (1), 151820 (2022)
   PUBMED   34871948
  REMARK    GeneRIF: L-Methionine prevents beta-cell damage by modulating the
            expression of Arx, MafA and regulation of FOXO1 in type 1 diabetic
            rats.
REFERENCE   2  (bases 1 to 2793)
  AUTHORS   Lu,J., Lin,L., Dong,H., Meng,X., Fang,F., Wang,Q., Huang,L. and
            Tan,J.
  TITLE     Protein therapy using MafA fused to a polyarginine transduction
            domain attenuates glucose levels of streptozotocin-induced diabetic
            mice
  JOURNAL   Mol Med Rep 15 (6), 4041-4048 (2017)
   PUBMED   28487936
REFERENCE   3  (bases 1 to 2793)
  AUTHORS   Mahadevan,J., Parazzoli,S., Oseid,E., Hertzel,A.V., Bernlohr,D.A.,
            Vallerie,S.N., Liu,C.Q., Lopez,M., Harmon,J.S. and Robertson,R.P.
  TITLE     Ebselen treatment prevents islet apoptosis, maintains intranuclear
            Pdx-1 and MafA levels, and preserves beta-cell mass and function in
            ZDF rats
  JOURNAL   Diabetes 62 (10), 3582-3588 (2013)
   PUBMED   23801580
REFERENCE   4  (bases 1 to 2793)
  AUTHORS   Bonnavion,R., Jaafar,R., Kerr-Conte,J., Assade,F., van Stralen,E.,
            Leteurtre,E., Pouponnot,C., Gargani,S., Pattou,F., Bertolino,P.,
            Cordier-Bussat,M., Lu,J. and Zhang,C.X.
  TITLE     Both PAX4 and MAFA are expressed in a substantial proportion of
            normal human pancreatic alpha cells and deregulated in patients
            with type 2 diabetes
  JOURNAL   PLoS One 8 (8), e72194 (2013)
   PUBMED   24013263
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2793)
  AUTHORS   Cao,M., Long,Y., Tong,Y., Wan,J. and Tong,N.
  TITLE     Activation of PPARdelta up-regulates the expression of insulin gene
            transcription factor MafA and ameliorates glucose-induced insulin
            secretion impaired by palmitate
  JOURNAL   Mol Cell Biochem 366 (1-2), 183-189 (2012)
   PUBMED   22466807
  REMARK    GeneRIF: PPAR-gamma may regulate the expression of MafA
REFERENCE   6  (bases 1 to 2793)
  AUTHORS   Wang,S., Zhang,J., Zhao,A., Hipkens,S., Magnuson,M.A. and Gu,G.
  TITLE     Loss of Myt1 function partially compromises endocrine islet cell
            differentiation and pancreatic physiological function in the mouse
  JOURNAL   Mech Dev 124 (11-12), 898-910 (2007)
   PUBMED   17928203
REFERENCE   7  (bases 1 to 2793)
  AUTHORS   Muniappan,L. and Ozcan,S.
  TITLE     Induction of insulin secretion in engineered liver cells by nitric
            oxide
  JOURNAL   BMC Physiol 7, 11 (2007)
   PUBMED   17941991
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2793)
  AUTHORS   Kato,T., Shimano,H., Yamamoto,T., Yokoo,T., Endo,Y., Ishikawa,M.,
            Matsuzaka,T., Nakagawa,Y., Kumadaki,S., Yahagi,N., Takahashi,A.,
            Sone,H., Suzuki,H., Toyoshima,H., Hasty,A.H., Takahashi,S.,
            Gomi,H., Izumi,T. and Yamada,N.
  TITLE     Granuphilin is activated by SREBP-1c and involved in impaired
            insulin secretion in diabetic mice
  JOURNAL   Cell Metab 4 (2), 143-154 (2006)
   PUBMED   16890542
REFERENCE   9  (bases 1 to 2793)
  AUTHORS   Matsuoka,T.A., Zhao,L., Artner,I., Jarrett,H.W., Friedman,D.,
            Means,A. and Stein,R.
  TITLE     Members of the large Maf transcription family regulate insulin gene
            transcription in islet beta cells
  JOURNAL   Mol Cell Biol 23 (17), 6049-6062 (2003)
   PUBMED   12917329
REFERENCE   10 (bases 1 to 2793)
  AUTHORS   Kataoka,K., Han,S.I., Shioda,S., Hirai,M., Nishizawa,M. and
            Handa,H.
  TITLE     MafA is a glucose-regulated and pancreatic beta-cell-specific
            transcriptional activator for the insulin gene
  JOURNAL   J Biol Chem 277 (51), 49903-49910 (2002)
   PUBMED   12368292
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000007.1.
            
            On Jan 14, 2022 this sequence version replaced XM_006241903.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR22582424.300095.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2793              JAXUCZ010000007.1  109313021-109315813 c
FEATURES             Location/Qualifiers
     source          1..2793
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2793
                     /gene="Mafa"
                     /gene_synonym="RGD1562627"
                     /note="MAF bZIP transcription factor A"
                     /db_xref="GeneID:366949"
                     /db_xref="RGD:1562627"
     exon            1..2793
                     /gene="Mafa"
                     /gene_synonym="RGD1562627"
                     /inference="alignment:Splign:2.1.0"
     CDS             395..1480
                     /gene="Mafa"
                     /gene_synonym="RGD1562627"
                     /note="v-maf musculoaponeurotic fibrosarcoma oncogene
                     family, protein A; v-maf musculoaponeurotic fibrosarcoma
                     oncogene homolog A; v-maf avian musculoaponeurotic
                     fibrosarcoma oncogene A; v-maf avian musculoaponeurotic
                     fibrosarcoma oncogene homolog A; pancreatic
                     beta-cell-specific transcriptional activator"
                     /codon_start=1
                     /product="transcription factor MafA"
                     /protein_id="NP_001386702.1"
                     /db_xref="GeneID:366949"
                     /db_xref="RGD:1562627"
                     /translation="MAAELAMGAELPSSPLAIEYVNDFDLMKFEVKKEPPEAERFCHR
                     LPPGSLSSTPLSTPCSSVPSSPSFCAPSPGTGSSAGGGGSAAQAGGAPGPPSGGPGTV
                     GGASGKAVLEDLYWMSGYQHHLNPEALNLTPEDAVEALIGSGHHSAHHGAHHPAAAAA
                     YEAFRGQSFAGGGGGGADDMGAGHHHGAHHTAHHHHSAHHHHHHHHHHGGSGHHGGGA
                     GHGGGGAGHHVRLEERFSDDQLVSMSVRELNRQLRGFSKEEVIRLKQKRRTLKNRGYA
                     QSCRFKRVQQRHILESEKCQLQSQVEQLKLEVGRLAKERDLYKEKYEKLAGRGGPGGA
                     GGAGFPREPSPAQAGPGAAKGAPDFFL"
ORIGIN      
        1 gagggaggcg gggccggccg gcagcgcggg tggggcacgg ggcggggccg agcgggagag
       61 ccccgagcgc ggcagagccc ggggcgcggc ctctgcaccc tccaggccag gacagccgag
      121 gagcaggagg aggagcgcaa gatcggggcc ctgcgcccgc ccgcagcggg ccggggggcc
      181 gcccgagagg cctggcccgc ggcgtcccct gagcgcagcg cagagttgac agcacgaaac
      241 ttttgctgcg cccttcggcg gcgcgaccag agcctgcacc caccgcggcc cggggggagc
      301 tagggggaga gaagcccgcg gctcccccca cgctcccccg ccgcccgtcg gggcgcggcc
      361 cggcgcggca gcggcggggc tggggccccg ggcgatggcc gcggagctgg cgatgggcgc
      421 agagctgcct agcagcccac tggccatcga gtacgtcaac gacttcgacc tgatgaagtt
      481 cgaggtgaag aaggagccgc ccgaggccga gcgcttctgc caccgcctgc cacccggctc
      541 gctatcctcg acgcccctca gcacgccctg ctcctcggtg ccctcttcgc ccagcttctg
      601 cgcacccagc cccggcaccg gcagcagcgc gggcggcggg ggtagcgcgg ctcaggccgg
      661 gggcgccccg gggccgccga gtggaggccc cggcactgtc gggggcgcct caggaaaagc
      721 ggtgctggag gatctgtact ggatgagcgg gtatcagcac cacctgaacc ccgaggcgct
      781 caacctgacg ccggaggacg cggtggaggc gctcatcggc agcggccacc acagcgcgca
      841 ccacggcgcg catcacccag cggctgctgc ggcctatgag gccttccggg gccagagctt
      901 cgcgggcggc ggcggcggcg gcgcggacga catgggtgcc ggccaccacc acggcgcaca
      961 ccacactgca caccaccacc actctgccca ccatcaccat catcaccacc accaccacgg
     1021 aggctctggc caccacggtg gaggcgcggg tcacggtgga ggcggcgcgg gccaccacgt
     1081 gcgcttggag gagcgcttct ccgacgacca gctggtgtcc atgtcagtgc gggagctgaa
     1141 ccggcagctc cgcggcttca gcaaggagga ggtcatccga ctgaaacaga agcggcgcac
     1201 gctcaagaac cgcggctacg cgcagtcgtg ccgcttcaag cgggtgcagc agcggcacat
     1261 tctggagagc gagaagtgcc agctccagag ccaggtggag cagctgaagc tggaggtggg
     1321 gcgtttggcc aaggagcggg acctgtacaa ggagaaatac gagaagttgg cgggccgggg
     1381 cgggccgggg ggcgcgggcg gggccggctt ccctcgggag ccctcgccag cgcaggctgg
     1441 ccccggggca gccaaaggcg cacccgactt ctttctgtga gcgcgggacc ctgggcctcg
     1501 tcgccgccgg ggacaagttt gcgcaggccg ccccggcctc ggttcggact ctgaggcccg
     1561 ggacgcgcgc tccggcggtg cagtcgcagc agcccgggtc ctccggtccg ccctgcgcgc
     1621 cccgccgtga agccccagct ccaggtactt accgcggtgc gcctctccca ccgggccccg
     1681 gtccgagcgt cttcagggtc gccgtctaga ctttgccggg gtcccacggc gccccgagaa
     1741 cggtgaatac ttaagggaag cccgagccag atctgacttc cttggcagcc tccacttgta
     1801 cagacgtgga gcgcagttct gcgtcccaac ctcagcccag ccgcagcggg gccgcgccgc
     1861 caccagctcc cggtagcctc cgccggcccg gcgctcctct gtcgtctttc cttctgcctc
     1921 cgttttcttg ccctgttttt actcctactc ctccttttta aagcggtcat attttcgcaa
     1981 cattaatatt tattttgctt ggtaattaga aaacccggag gaactccctg gtccccgtgc
     2041 gccctcggag gtcggcgagt gcccgcatgt gcccccctcc tcgctcattt gctctgaagg
     2101 gtccggccct gcctgccttc caacccgctt gtccccaccc tgttcgctgc tccctgtaga
     2161 ggaagccgag gaacttacct gcgtgttggt cccactgtcc tgctatactc gactggggga
     2221 ggggggtggg gggtggccgt gctcagccga gttggggctg gcccggactc ccgcgctgct
     2281 atttctctat gcaccagatc gtatttatga ctcctgggga aatatatctt attttaacct
     2341 tccagagaag tgaaagaatt taaaaagtaa tgcacagttc tagaagaaaa atttttttaa
     2401 agaggaggct taggcctgaa cctcctggca tgggcgggtg gaaaggtgtt tttatttaat
     2461 ttaaattgtg tttcgtttgt ggaatctttt ttaaagcttg gtcgcttttt tggactagcc
     2521 ggaagagagg cccggtggag ggtgttctga gatgggcgcg tctgcaccgg ctgagctctg
     2581 gcttgatccc gggttctctg aggctccttc gtcctttgct gctcccaggt ggctcctgct
     2641 gagccttctg aacaggacgc tagacaaatc gttggggaaa attttttgtg ttgttggttt
     2701 ttgttgtgtt cttttttttt ccatttgtta caaaactgag gaaaggaaga aattaaaaaa
     2761 aataaatctg tttagatcca aaagtcactg gaa
//
