LOCUS       NM_001014085            1649 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus MAF1 homolog, negative regulator of RNA
            polymerase III (Maf1), mRNA.
ACCESSION   NM_001014085 XM_235448
VERSION     NM_001014085.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1649)
  AUTHORS   Andreev,D.E., O'Connor,P.B., Zhdanov,A.V., Dmitriev,R.I.,
            Shatsky,I.N., Papkovsky,D.B. and Baranov,P.V.
  TITLE     Oxygen and glucose deprivation induces widespread alterations in
            mRNA translation within 20 minutes
  JOURNAL   Genome Biol 16 (1), 90 (2015)
   PUBMED   25943107
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1649)
  AUTHORS   Moir,R.D. and Willis,I.M.
  TITLE     Regulation of pol III transcription by nutrient and stress
            signaling pathways
  JOURNAL   Biochim Biophys Acta 1829 (3-4), 361-375 (2013)
   PUBMED   23165150
  REMARK    Review article
REFERENCE   3  (bases 1 to 1649)
  AUTHORS   Vannini,A.
  TITLE     A structural perspective on RNA polymerase I and RNA polymerase III
            transcription machineries
  JOURNAL   Biochim Biophys Acta 1829 (3-4), 258-264 (2013)
   PUBMED   23031840
  REMARK    Review article
REFERENCE   4  (bases 1 to 1649)
  AUTHORS   Smith,K.R., Oliver,P.L., Lumb,M.J., Arancibia-Carcamo,I.L.,
            Revilla-Sanchez,R., Brandon,N.J., Moss,S.J. and Kittler,J.T.
  TITLE     Identification and characterisation of a Maf1/Macoco protein
            complex that interacts with GABAA receptors in neurons
  JOURNAL   Mol Cell Neurosci 44 (4), 330-341 (2010)
   PUBMED   20417281
  REMARK    GeneRIF: We report the characterisation of the proteins Maf1 and
            Macoco in the brain, which we identify as novel GABAAR beta-subunit
            interacting proteins.
REFERENCE   5  (bases 1 to 1649)
  AUTHORS   Kantidakis,T., Ramsbottom,B.A., Birch,J.L., Dowding,S.N. and
            White,R.J.
  TITLE     mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes,
            and targets their repressor Maf1
  JOURNAL   Proc Natl Acad Sci U S A 107 (26), 11823-11828 (2010)
   PUBMED   20543138
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11465]
REFERENCE   6  (bases 1 to 1649)
  AUTHORS   Shor,B., Wu,J., Shakey,Q., Toral-Barza,L., Shi,C., Follettie,M. and
            Yu,K.
  TITLE     Requirement of the mTOR kinase for the regulation of Maf1
            phosphorylation and control of RNA polymerase III-dependent
            transcription in cancer cells
  JOURNAL   J Biol Chem 285 (20), 15380-15392 (2010)
   PUBMED   20233713
REFERENCE   7  (bases 1 to 1649)
  AUTHORS   Goodfellow,S.J., Graham,E.L., Kantidakis,T., Marshall,L.,
            Coppins,B.A., Oficjalska-Pham,D., Gerard,M., Lefebvre,O. and
            White,R.J.
  TITLE     Regulation of RNA polymerase III transcription by Maf1 in mammalian
            cells
  JOURNAL   J Mol Biol 378 (3), 481-491 (2008)
   PUBMED   18377933
  REMARK    Erratum:[J Mol Biol. 2013 Mar 25;425(6):1099]
REFERENCE   8  (bases 1 to 1649)
  AUTHORS   Johnson,S.S., Zhang,C., Fromm,J., Willis,I.M. and Johnson,D.L.
  TITLE     Mammalian Maf1 is a negative regulator of transcription by all
            three nuclear RNA polymerases
  JOURNAL   Mol Cell 26 (3), 367-379 (2007)
   PUBMED   17499043
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083712.1.
            
            On Apr 20, 2005 this sequence version replaced XM_235448.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083712.1, SRR8487231.127098.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1649
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1649
                     /gene="Maf1"
                     /note="MAF1 homolog, negative regulator of RNA polymerase
                     III"
                     /db_xref="GeneID:315093"
                     /db_xref="RGD:1359315"
     exon            1..305
                     /gene="Maf1"
                     /inference="alignment:Splign:2.1.0"
     exon            306..438
                     /gene="Maf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             356..1138
                     /gene="Maf1"
                     /note="MAF1 negative regulator of RNA polymerase III"
                     /codon_start=1
                     /product="repressor of RNA polymerase III transcription
                     MAF1 homolog"
                     /protein_id="NP_001014107.1"
                     /db_xref="GeneID:315093"
                     /db_xref="RGD:1359315"
                     /translation="MKLLENSSFEAINSQLTVETGDAHIIGRIESYSCKMAGDDKHMF
                     KQFCQEGQPHVLEALSPPQTSGLSPSRLSKSQGGEDESPLSDKCSRKTLFYLIATLNE
                     SFRPDYDFSTARSHEFSREPSLRWVVNAVNCSLFSAVREDFKALKPQLWNAVDEEICL
                     AECDIYSYNPDLDSDPFGEDGSLWSFNYFFYNKRLKRIVFFSCRSISGSTYTPSEAGN
                     ALDLELGAEEVDEESGGGGGGGEGRAEETSTMEEDRVPVICM"
     exon            439..567
                     /gene="Maf1"
                     /inference="alignment:Splign:2.1.0"
     exon            568..733
                     /gene="Maf1"
                     /inference="alignment:Splign:2.1.0"
     exon            734..855
                     /gene="Maf1"
                     /inference="alignment:Splign:2.1.0"
     exon            856..975
                     /gene="Maf1"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1116
                     /gene="Maf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1625
                     /gene="Maf1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtcgctgtt tcgttctctg gctggtgcga tctcggcggt ccgcggcagg tcggtcgcga
       61 aagcggacgc tgcagggggg cgaggctatg tcgcggctgc agcccgtatg ggccggcagg
      121 gcctggagta acgggacgtc gccgcgaagc ttcttccccc ggatacagtg cggccctagt
      181 ggaggccgcg gcgccgccct ccagtcctga agaacccgcg ctgcgcagag cccgcgccgc
      241 cgtcacctcg gcaccgacac taagcaaccc agctagcttg gcttgatcta gcccattttt
      301 ggcaggtagc gctgcactag tcccactggc acaagaagct cccttcccaa aggacatgaa
      361 gctattggag aactccagct ttgaggccat caactcacag ttgacagtgg agactggaga
      421 tgcccatatt attggcagga tcgaaagcta ttcctgtaag atggcaggcg acgataagca
      481 tatgtttaag cagttctgcc aggagggcca gccccatgtg ctggaggcac tgtccccgcc
      541 ccagacctca ggcctcagtc ccagcagact gagcaagagc cagggtggtg aggatgaaag
      601 tcctctaagt gacaagtgca gtcgtaagac cctcttctat ctgattgcca ccctcaacga
      661 gtccttccgg ccagactatg acttcagcac agccagaagt cacgaattca gccgggagcc
      721 aagcctccgc tgggtggtaa atgcggtcaa ctgcagcctg ttttcagctg ttcgggaaga
      781 cttcaaggcc ctgaagccac agctgtggaa tgcagtggac gaggaaatct gcttggctga
      841 atgtgacatc tacagctata acccagatct agactccgac ccctttgggg aagatggaag
      901 cctctggtca ttcaactact tcttctacaa caagcgactt aaacgaattg tcttctttag
      961 ctgccgctcc atcagtggct ccacctacac accctcagag gcaggcaacg ccctggactt
     1021 ggaactgggg gcagaagagg ttgatgaaga gagtggaggt ggaggtggag gtggtgaggg
     1081 cagggcggag gagaccagca ccatggagga agacagggtt ccagtgatat gtatgtgatg
     1141 agaagaagcg gagggcccag ctttccagct tcgaccagtg cctggacctg tctacccgag
     1201 gagctccaga gactccccag atgccggcta cgccttggca ctgcctaagg ctatacctgc
     1261 ctagcccttt ggtttcagcc tgtggatgtc cactcacccc tgcaggctcc tactgcccat
     1321 gctgtggctg gatcaagcag cacggggtct gatagaaaaa gtgactgctc tgcaccaacg
     1381 gtctgtcaca gacaggacag ctggaccaca gagtttattt ttgtatttct tattgggcct
     1441 gtacactcca gctctaaggg ccagtagttt gaaggcccta taagtggtgc ccagtgttta
     1501 tggggtctgg tctttgacca acccctggtg cccacttttg ccccccactt caccaggtgg
     1561 gacacatgca ctgagtgtca ctttgctgca gctcatttgt ttccaataaa agtttctgtg
     1621 acttaaaaaa aaaaaaaaaa aaaaaaaaa
//
