LOCUS       NM_001008319            2178 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus macrophage erythroblast attacher, E3 ubiquitin
            ligase (Maea), mRNA.
ACCESSION   NM_001008319 XM_216694
VERSION     NM_001008319.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2178)
  AUTHORS   Lampert,F., Stafa,D., Goga,A., Soste,M.V., Gilberto,S., Olieric,N.,
            Picotti,P., Stoffel,M. and Peter,M.
  TITLE     The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell
            proliferation and targets the transcription factor Hbp1 for
            degradation
  JOURNAL   Elife 7, e35528 (2018)
   PUBMED   29911972
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2178)
  AUTHORS   Francis,O., Han,F. and Adams,J.C.
  TITLE     Molecular phylogeny of a RING E3 ubiquitin ligase, conserved in
            eukaryotic cells and dominated by homologous components, the
            muskelin/RanBPM/CTLH complex
  JOURNAL   PLoS One 8 (10), e75217 (2013)
   PUBMED   24143168
  REMARK    Erratum:[PLoS One. 2013 Nov 8;8(11). doi:
            10.1371/annotation/1e464689-3c86-4399-b229-1e00d65593a5.. PMID:
            29161723]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2178)
  AUTHORS   Kobayashi,N., Yang,J., Ueda,A., Suzuki,T., Tomaru,K., Takeno,M.,
            Okuda,K. and Ishigatsubo,Y.
  TITLE     RanBPM, Muskelin, p48EMLP, p44CTLH, and the armadillo-repeat
            proteins ARMC8alpha and ARMC8beta are components of the CTLH
            complex
  JOURNAL   Gene 396 (2), 236-247 (2007)
   PUBMED   17467196
REFERENCE   4  (bases 1 to 2178)
  AUTHORS   Soni,S., Bala,S., Gwynn,B., Sahr,K.E., Peters,L.L. and Hanspal,M.
  TITLE     Absence of erythroblast macrophage protein (Emp) leads to failure
            of erythroblast nuclear extrusion
  JOURNAL   J Biol Chem 281 (29), 20181-20189 (2006)
   PUBMED   16707498
REFERENCE   5  (bases 1 to 2178)
  AUTHORS   Bala,S., Kumar,A., Soni,S., Sinha,S. and Hanspal,M.
  TITLE     Emp is a component of the nuclear matrix of mammalian cells and
            undergoes dynamic rearrangements during cell division
  JOURNAL   Biochem Biophys Res Commun 342 (4), 1040-1048 (2006)
   PUBMED   16510120
REFERENCE   6  (bases 1 to 2178)
  AUTHORS   Hanspal,M., Smockova,Y. and Uong,Q.
  TITLE     Molecular identification and functional characterization of a novel
            protein that mediates the attachment of erythroblasts to
            macrophages
  JOURNAL   Blood 92 (8), 2940-2950 (1998)
   PUBMED   9763581
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CV109439.1 and BC085770.1.
            
            On Sep 30, 2011 this sequence version replaced NM_001008319.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085770.1, SRR8487226.189215.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                CV109439.1         1-29
            30-2178             BC085770.1         1-2149
FEATURES             Location/Qualifiers
     source          1..2178
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..2178
                     /gene="Maea"
                     /note="macrophage erythroblast attacher, E3 ubiquitin
                     ligase"
                     /db_xref="GeneID:298982"
                     /db_xref="RGD:1309877"
     exon            1..102
                     /gene="Maea"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1224
                     /gene="Maea"
                     /EC_number="2.3.2.27"
                     /codon_start=1
                     /product="E3 ubiquitin-protein transferase MAEA"
                     /protein_id="NP_001008320.2"
                     /db_xref="GeneID:298982"
                     /db_xref="RGD:1309877"
                     /translation="MAVQESAAQLSMTLKVQEYPTLKVPYETLNKRFRAAQKNIDRET
                     SHVTMVVAELEKTLSSCPAVDSVVSLLDGVVEKLSVLKRKAVESIQAEDESAKLCKRR
                     IEHLKEHSSDQPAAASMWKRKRMDRMMVEHLLRCGYYNTAVKLARQSGIEDLVNIEMF
                     LTAKEVEESLERRETATCLAWCHDNKSRLRKMKSCLEFSLRIQEFIELVRQNKRLDAV
                     RHARKHFSQAEGSQLDEVRQVMGMLAFPPDTHISPYKDLLDPARWRMLIQQFRYDNYR
                     LHQLGNSSVFTLTLQAGLSAIKTPQCYKEDGSSKSPDCPVCSRSLNKLAQPLPMAHCA
                     NSRLVCKISGDVMNENNPPMMLPNGYVYGYNSLLSIRQDDKVVCPRTKEVFHFSQAEK
                     VYIM"
     exon            103..285
                     /gene="Maea"
                     /inference="alignment:Splign:2.1.0"
     exon            286..489
                     /gene="Maea"
                     /inference="alignment:Splign:2.1.0"
     exon            490..612
                     /gene="Maea"
                     /inference="alignment:Splign:2.1.0"
     exon            613..689
                     /gene="Maea"
                     /inference="alignment:Splign:2.1.0"
     exon            690..798
                     /gene="Maea"
                     /inference="alignment:Splign:2.1.0"
     exon            799..932
                     /gene="Maea"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1128
                     /gene="Maea"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..2151
                     /gene="Maea"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgtacccgc ctcctccgct cggccggccc aagatggcgg tgcaggagtc ggcggcccag
       61 ctgtccatga ccctgaaggt gcaggagtac ccgaccctca aggtgcccta tgagacactg
      121 aataaacgct tccgagctgc tcagaaaaac attgatcggg agaccagcca cgtcaccatg
      181 gtggtagctg agcttgagaa gaccttgagt agctgcccag ctgtggactc tgtggtcagc
      241 ctactggatg gagtggtgga gaagctgagt gtcctcaaga ggaaggcagt agagtccatc
      301 caggccgagg atgagagcgc caagctctgc aaacgtagga tcgagcacct caaggagcac
      361 agcagtgacc agccagcggc ggccagcatg tggaagcgga agcgcatgga ccgaatgatg
      421 gtggagcacc tgctgcgctg tggctactac aacacagctg tgaagctggc tcgccagagt
      481 ggcattgagg accttgtgaa tatcgagatg ttcctgacag ccaaagaagt ggaggagtcc
      541 ttggagaggc gtgagacagc cacctgcctt gcctggtgcc atgataacaa gtcccgactc
      601 cggaagatga agagctgctt agagttcagc ctcaggattc aggagttcat cgaacttgtc
      661 cggcagaaca agcgcctgga tgctgtgaga catgcaagaa agcacttcag tcaggctgaa
      721 gggagccaac tggatgaggt ccgccaggtc atgggcatgc tggccttccc accagacaca
      781 catatctctc catacaagga cctcctggac ccagcccggt ggcgaatgct gatccagcag
      841 tttcgatatg acaactaccg gctgcaccag ctgggaaaca gctccgtctt caccctcacc
      901 ctgcaggctg ggctctcagc aataaagaca ccacagtgct acaaggagga tggcagctcc
      961 aagagccccg actgccctgt gtgcagccgc tctctgaaca aactggcaca gcccctaccc
     1021 atggctcact gtgccaactc ccgcctggtc tgcaagatct ctggtgacgt gatgaacgag
     1081 aacaacccac ccatgatgct gcctaatggc tatgtctatg gctacaattc tctgctttct
     1141 attcgtcaag atgataaagt tgtttgccca agaaccaaag aagtcttcca cttctcccaa
     1201 gctgagaaag tgtacatcat gtaggcctgc gttgccatgt gcacgccctt ggccagaggc
     1261 tgtggtgggt gggagccatg ccctcctgcc ctgacccttg acccctgacc ccagcctgcc
     1321 tcggcatttg tttcttgcga ccaaagatca gtgagcaacg acaaatactc ttagaaaaag
     1381 aggaagtgag atttactaag tctgtgcttg agaacagcgt ttggttggta ggattttgta
     1441 acataagtcg actgatgcct ctgcaggttc ttgcacctct caaaggaaac tctctctaca
     1501 gtgtggcctg agcaccagga aatccagagc atctcagaag taggaattgg gtcatcgatt
     1561 atttccctgt gtctctccgt ttccttcctt ttgctagtga tgggactcag gggagcttga
     1621 ggagcaggct ggtcctttgc caactcttgt tggtcatagc ctgggcaagg tgctggccgt
     1681 accaggttgg ctgcagtgac ttgtgacgtg gtgccgaggc ctttcctgac ttcactgtct
     1741 agctgctgcc aaagcaccat ccaccacatg cacctgggct gctactcgag cctctgccct
     1801 tgtggccagg gtgtctgggg ctgtgtctgt gcacaggttc agcgtctcac cttccagcac
     1861 cgccttatct cctgctttga gaatgtattc acgggaaagc cactggactg agtttctgca
     1921 gaggccttgc caggtggttc cgtagtccta gagtgtacat gcttttcatt acggaaactg
     1981 atagttcagc taaagtaagt actgacgggt tttccagaca tgaaccattg taattcacac
     2041 aaaaccatat tgtagaggtt tgtatctagc gcttattttt gcatgttgat gttgattagc
     2101 taatgaactg taaatgtaaa gcgtgttaat aaaatagctt tctatttctc aaaaaaaaaa
     2161 aaaaaaaaaa aaaaaaaa
//
