LOCUS       NM_053585               5243 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus MAP-kinase activating death domain (Madd), mRNA.
ACCESSION   NM_053585
VERSION     NM_053585.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5243)
  AUTHORS   Imai,A., Ishida,M., Fukuda,M., Nashida,T. and Shimomura,H.
  TITLE     MADD/DENN/Rab3GEP functions as a guanine nucleotide exchange factor
            for Rab27 during granule exocytosis of rat parotid acinar cells
  JOURNAL   Arch Biochem Biophys 536 (1), 31-37 (2013)
   PUBMED   23702376
  REMARK    GeneRIF: These findings indicated that Madd functions as a guanine
            nucleotide exchange factor for Rab27 in parotid acinar cells and
            regulates isoproterenol-stimulated amylase release.
REFERENCE   2  (bases 1 to 5243)
  AUTHORS   Yoshimura,S., Gerondopoulos,A., Linford,A., Rigden,D.J. and
            Barr,F.A.
  TITLE     Family-wide characterization of the DENN domain Rab GDP-GTP
            exchange factors
  JOURNAL   J Cell Biol 191 (2), 367-381 (2010)
   PUBMED   20937701
REFERENCE   3  (bases 1 to 5243)
  AUTHORS   Niwa,S., Tanaka,Y. and Hirokawa,N.
  TITLE     KIF1Bbeta- and KIF1A-mediated axonal transport of presynaptic
            regulator Rab3 occurs in a GTP-dependent manner through DENN/MADD
  JOURNAL   Nat Cell Biol 10 (11), 1269-1279 (2008)
   PUBMED   18849981
REFERENCE   4  (bases 1 to 5243)
  AUTHORS   Sakisaka,T. and Takai,Y.
  TITLE     Purification and properties of Rab3 GEP (DENN/MADD)
  JOURNAL   Methods Enzymol 403, 254-261 (2005)
   PUBMED   16473592
REFERENCE   5  (bases 1 to 5243)
  AUTHORS   Del Villar,K. and Miller,C.A.
  TITLE     Down-regulation of DENN/MADD, a TNF receptor binding protein,
            correlates with neuronal cell death in Alzheimer's disease brain
            and hippocampal neurons
  JOURNAL   Proc Natl Acad Sci U S A 101 (12), 4210-4215 (2004)
   PUBMED   15007167
REFERENCE   6  (bases 1 to 5243)
  AUTHORS   Oishi,H., Sasaki,T., Nagano,F., Ikeda,W., Ohya,T., Wada,M., Ide,N.,
            Nakanishi,H. and Takai,Y.
  TITLE     Localization of the Rab3 small G protein regulators in nerve
            terminals and their involvement in Ca2+-dependent exocytosis
  JOURNAL   J Biol Chem 273 (51), 34580-34585 (1998)
   PUBMED   9852129
REFERENCE   7  (bases 1 to 5243)
  AUTHORS   Schievella,A.R., Chen,J.H., Graham,J.R. and Lin,L.L.
  TITLE     MADD, a novel death domain protein that interacts with the type 1
            tumor necrosis factor receptor and activates mitogen-activated
            protein kinase
  JOURNAL   J Biol Chem 272 (18), 12069-12075 (1997)
   PUBMED   9115275
REFERENCE   8  (bases 1 to 5243)
  AUTHORS   Jin-no,Y., Shirataki,H., Senbonmatsu,T., Yamamoto,T., Fujita,Y.,
            Nakanishi,H. and Takai,Y.
  TITLE     A novel function of the C-terminal lipid moieties of Rab3A small G
            protein implicated in Ca2+-dependent exocytosis--inhibition of
            interaction with GTP and reduction of this inhibition by
            phospholipid
  JOURNAL   Genes Cells 2 (4), 273-288 (1997)
   PUBMED   9224661
REFERENCE   9  (bases 1 to 5243)
  AUTHORS   Wada,M., Nakanishi,H., Satoh,A., Hirano,H., Obaishi,H., Matsuura,Y.
            and Takai,Y.
  TITLE     Isolation and characterization of a GDP/GTP exchange protein
            specific for the Rab3 subfamily small G proteins
  JOURNAL   J Biol Chem 272 (7), 3875-3878 (1997)
   PUBMED   9020086
REFERENCE   10 (bases 1 to 5243)
  AUTHORS   Chow,V.T. and Lee,S.S.
  TITLE     DENN, a novel human gene differentially expressed in normal and
            neoplastic cells
  JOURNAL   DNA Seq 6 (5), 263-273 (1996)
   PUBMED   8988362
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_053585.3.
            
            On Dec 8, 2020 this sequence version replaced NM_053585.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U72995.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                JAXUCZ010000003.1  97613417-97613509   c
            94-236              JAXUCZ010000003.1  97610101-97610243   c
            237-833             JAXUCZ010000003.1  97608988-97609584   c
            834-1137            JAXUCZ010000003.1  97608097-97608400   c
            1138-1269           JAXUCZ010000003.1  97607352-97607483   c
            1270-1383           JAXUCZ010000003.1  97606850-97606963   c
            1384-1464           JAXUCZ010000003.1  97605680-97605760   c
            1465-1643           JAXUCZ010000003.1  97602876-97603054   c
            1644-1879           JAXUCZ010000003.1  97602303-97602538   c
            1880-2036           JAXUCZ010000003.1  97602001-97602157   c
            2037-2140           JAXUCZ010000003.1  97600062-97600165   c
            2141-2331           JAXUCZ010000003.1  97599779-97599969   c
            2332-2585           JAXUCZ010000003.1  97599151-97599404   c
            2586-2725           JAXUCZ010000003.1  97598790-97598929   c
            2726-2827           JAXUCZ010000003.1  97597756-97597857   c
            2828-2930           JAXUCZ010000003.1  97595912-97596014   c
            2931-3117           JAXUCZ010000003.1  97595110-97595296   c
            3118-3268           JAXUCZ010000003.1  97594864-97595014   c
            3269-3475           JAXUCZ010000003.1  97594407-97594613   c
            3476-3576           JAXUCZ010000003.1  97591651-97591751   c
            3577-3648           JAXUCZ010000003.1  97590829-97590900   c
            3649-3807           JAXUCZ010000003.1  97590394-97590552   c
            3808-3910           JAXUCZ010000003.1  97588190-97588292   c
            3911-3973           JAXUCZ010000003.1  97587072-97587134   c
            3974-4094           JAXUCZ010000003.1  97586705-97586825   c
            4095-4200           JAXUCZ010000003.1  97586495-97586600   c
            4201-4311           JAXUCZ010000003.1  97584653-97584763   c
            4312-4419           JAXUCZ010000003.1  97579021-97579128   c
            4420-4584           JAXUCZ010000003.1  97576050-97576214   c
            4585-4657           JAXUCZ010000003.1  97575730-97575802   c
            4658-4764           JAXUCZ010000003.1  97575512-97575618   c
            4765-4834           JAXUCZ010000003.1  97573295-97573364   c
            4835-4881           JAXUCZ010000003.1  97571452-97571498   c
            4882-5243           JAXUCZ010000003.1  97570787-97571148   c
FEATURES             Location/Qualifiers
     source          1..5243
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..5243
                     /gene="Madd"
                     /gene_synonym="RabGEF; RabGEP"
                     /note="MAP-kinase activating death domain"
                     /db_xref="GeneID:94193"
                     /db_xref="RGD:619922"
     exon            1..93
                     /gene="Madd"
                     /gene_synonym="RabGEF; RabGEP"
                     /inference="alignment:Splign:2.1.0"
     exon            94..236
                     /gene="Madd"
                     /gene_synonym="RabGEF; RabGEP"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..4986
                     /gene="Madd"
                     /gene_synonym="RabGEF; RabGEP"
                     /note="rab3 GDP/GTP exchange factor; Rab3 GDP/GTP exchange
                     protein"
                     /codon_start=1
                     /product="MAP kinase-activating death domain protein"
                     /protein_id="NP_446037.1"
                     /db_xref="GeneID:94193"
                     /db_xref="RGD:619922"
                     /translation="MVQKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHPE
                     FPLPPDVVFFCQPEGCLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQK
                     RMPKEKAEGGAGPRGKEGAHAPCASEEAATESSESGSTLQPPSADSTPDVNQSPRGKR
                     RAKAGNRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKPGIPRGVQ
                     RDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQEVQ
                     QALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMS
                     VMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDD
                     VWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQALASMSLNTQPILNLEKFHEG
                     QETPLLLGRFSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMH
                     TRTLRLFPRPVVAFQAGSFLASRPRQTPFAEKLARTQAVEYFGEWILNPSNYAFQRIH
                     NNTFDPALIGDKPKWYAHQLQPIHYRVYDSNSQLAEALSVPPERDSESDPTDDSGSDS
                     MDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPLTHAALGDASEVEIDELQPQKEGE
                     EPGPDSENSQENLPLRSSSSTTASSSPSTIVHGAHSEPADSTEVGDKAATGISKPLPP
                     VPPSICKSTVDRRQTETGEGSVCQRTYDHPYFEPQYGSPAEEDDDEQGESYTPRFSQH
                     ASGSRAQKLLRPNSLKLASDSDAESDSRASSPNSTVSNNSTEGFGGIMSFASSLYRNH
                     STSFSLSNLTLPTKGAREKTTPFPSLKGNRRALVDQKSSVIKHSPTVKREPPSPQGRS
                     SNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLSRAVQSEDDA
                     RQDVIQDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSK
                     EPDKRKRSPTENVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATGRGPKELDTR
                     SLKEENFVASVGPEVIKPVFDLGETEEKKSQISADSGVSLASASQRTDQDSVIGVSPA
                     VMIRSSSQDSEVSNSSGETLGADSDLSSNAGDGPGGEGSAHLASSRATLSDSEIETNS
                     ATSTIFGKAHSLKPKEKPASSPVRSSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMET
                     FSISKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLED
                     DEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHVGLVYSQQINEVLDQLTNL
                     NGRDLSIRSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYE
                     KLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPG
                     PELGGEFPVQDMKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEF
                     VPEIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVRSSEEDLRTPPRPVSS"
     exon            237..833
                     /gene="Madd"
                     /gene_synonym="RabGEF; RabGEP"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1137
                     /gene="Madd"
                     /gene_synonym="RabGEF; RabGEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1269
                     /gene="Madd"
                     /gene_synonym="RabGEF; RabGEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1383
                     /gene="Madd"
                     /gene_synonym="RabGEF; RabGEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1464
                     /gene="Madd"
                     /gene_synonym="RabGEF; RabGEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1643
                     /gene="Madd"
                     /gene_synonym="RabGEF; RabGEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1879
                     /gene="Madd"
                     /gene_synonym="RabGEF; RabGEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..2036
                     /gene="Madd"
                     /gene_synonym="RabGEF; RabGEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2140
                     /gene="Madd"
                     /gene_synonym="RabGEF; RabGEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2331
                     /gene="Madd"
                     /gene_synonym="RabGEF; RabGEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2585
                     /gene="Madd"
                     /gene_synonym="RabGEF; RabGEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2586..2725
                     /gene="Madd"
                     /gene_synonym="RabGEF; RabGEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2726..2827
                     /gene="Madd"
                     /gene_synonym="RabGEF; RabGEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2828..2930
                     /gene="Madd"
                     /gene_synonym="RabGEF; RabGEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2931..3117
                     /gene="Madd"
                     /gene_synonym="RabGEF; RabGEP"
                     /inference="alignment:Splign:2.1.0"
     exon            3118..3268
                     /gene="Madd"
                     /gene_synonym="RabGEF; RabGEP"
                     /inference="alignment:Splign:2.1.0"
     exon            3269..3475
                     /gene="Madd"
                     /gene_synonym="RabGEF; RabGEP"
                     /inference="alignment:Splign:2.1.0"
     exon            3476..3576
                     /gene="Madd"
                     /gene_synonym="RabGEF; RabGEP"
                     /inference="alignment:Splign:2.1.0"
     exon            3577..3648
                     /gene="Madd"
                     /gene_synonym="RabGEF; RabGEP"
                     /inference="alignment:Splign:2.1.0"
     exon            3649..3807
                     /gene="Madd"
                     /gene_synonym="RabGEF; RabGEP"
                     /inference="alignment:Splign:2.1.0"
     exon            3808..3910
                     /gene="Madd"
                     /gene_synonym="RabGEF; RabGEP"
                     /inference="alignment:Splign:2.1.0"
     exon            3911..3973
                     /gene="Madd"
                     /gene_synonym="RabGEF; RabGEP"
                     /inference="alignment:Splign:2.1.0"
     exon            3974..4094
                     /gene="Madd"
                     /gene_synonym="RabGEF; RabGEP"
                     /inference="alignment:Splign:2.1.0"
     exon            4095..4200
                     /gene="Madd"
                     /gene_synonym="RabGEF; RabGEP"
                     /inference="alignment:Splign:2.1.0"
     exon            4201..4311
                     /gene="Madd"
                     /gene_synonym="RabGEF; RabGEP"
                     /inference="alignment:Splign:2.1.0"
     exon            4312..4419
                     /gene="Madd"
                     /gene_synonym="RabGEF; RabGEP"
                     /inference="alignment:Splign:2.1.0"
     exon            4420..4584
                     /gene="Madd"
                     /gene_synonym="RabGEF; RabGEP"
                     /inference="alignment:Splign:2.1.0"
     exon            4585..4657
                     /gene="Madd"
                     /gene_synonym="RabGEF; RabGEP"
                     /inference="alignment:Splign:2.1.0"
     exon            4658..4764
                     /gene="Madd"
                     /gene_synonym="RabGEF; RabGEP"
                     /inference="alignment:Splign:2.1.0"
     exon            4765..4834
                     /gene="Madd"
                     /gene_synonym="RabGEF; RabGEP"
                     /inference="alignment:Splign:2.1.0"
     exon            4835..4881
                     /gene="Madd"
                     /gene_synonym="RabGEF; RabGEP"
                     /inference="alignment:Splign:2.1.0"
     exon            4882..5243
                     /gene="Madd"
                     /gene_synonym="RabGEF; RabGEP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgccggct cgccgcggcg ctgggctagg aagcgacggg cgcttcgcgg ttcggagacg
       61 tccggcgggc ctggcaggtt cctcggagag tagattttat caagattcct ccctggaacg
      121 ctggctcctt gctcagtgcc ctgaagtctc tctgcgatga actgatacat tggaaccatg
      181 gtgcaaaaga agttctgccc tcggttactt gactatctag tgatcgtagg ggccaggcat
      241 ccaagcagtg acagtgtggc tcagactcct gaacttctgc ggaggtaccc actagaggac
      301 cacccggagt ttcccctgcc cccagatgtg gtgttcttct gccagccaga gggatgtctg
      361 agcgtgcggc aacggcgcat gagcctccga gatgatacct cttttgtctt caccctaacc
      421 gataaggaca ctggagtcac ccgttatggc atctgtgtca acttctaccg ttcctttcaa
      481 aagcgaatgc caaaggaaaa ggcggaaggc ggagcaggac cccgtgggaa ggaaggagct
      541 catgccccct gtgcctcaga agaggccgcc accgagagct cagagagtgg ctcaaccttg
      601 cagcctccta gtgctgactc cactcctgac gtaaaccagt ctcctcgggg caaacgtagg
      661 gcaaaagcag gcaaccgctc ccgaaacagt accctgacat ccctgtgtgt gcttagccac
      721 taccctttct tctctacctt cagagagtgt ctgtatactc tcaaacgtct ggtagactgc
      781 tgtagtgaac ggctcctagg caagaaaccg ggcatccctc gaggtgtaca aagggacacc
      841 atgtggcgaa tctttactgg atcactgcta gtggaggaga agtccagtgc ccttctgcat
      901 gaccttcgag agatcgaggc ctggatctat cggttgctac gctccccggt gcctgtctct
      961 gggcagaagc gagtggacat tgaggtccta ccccaggaag tgcagcaggc cctgacattt
     1021 gctcttccag atccatcccg gttcacccta gtagatttcc ctcttcacct tcccttggaa
     1081 cttctgggtg tagatgcttg tcttcaggtg ctaacctgca tcctgttgga gcacaaggtg
     1141 gtgctacagt ctcgagacta caacgcactc tccatgtctg tgatggcgtt tgtggcaatg
     1201 atctaccccc tggagtacat gttccctgtc atcccgctgc ttcccacctg catggcttcg
     1261 gcagagcagc tactcttggc tccaacccca tatatcattg gagtccctgc cagcttcttc
     1321 ctctataagc tagacttcaa aatgcctgat gacgtgtggc tggtggatct ggacagcaac
     1381 agggtgattg cccccaccaa tgcagaagtg ctacccatcc tgccagaacc ggaatcatta
     1441 gagctgaaaa aacacttaaa gcaggctcta gccagcatga gtctcaacac ccagcccatt
     1501 cttaatctgg agaaattcca tgagggccag gagacaccac ttctcttggg aaggttttct
     1561 aatgaccttc agtctacacc ttccactgaa ttcaacccac tcatttatgg caatgatgta
     1621 gattcagtcg atgttgcaac gagagtggcc atggttcgtt tcttcaactc tgctaacgtg
     1681 ctgcagggct ttcagatgca cacacgtacc ctgcgactct tcccccggcc cgtggttgcc
     1741 ttccaagctg gctcctttct ggcctcacgc ccccggcaga ccccctttgc tgagaaactg
     1801 gccaggactc aagccgtgga gtactttgga gaatggatcc tgaacccttc taactatgcc
     1861 ttccagcgga ttcacaacaa tacgtttgat ccagccctca ttggtgacaa gcctaagtgg
     1921 tacgctcacc agctgcagcc cattcactat cgagtctatg acagcaattc tcagctggct
     1981 gaggccctga gtgtgccacc ggagcgtgat tctgagtctg accccactga tgacagcggc
     2041 agtgacagca tggactatga tgactcaagc tcttcttact cctccctggg ggacttcgtc
     2101 agtgaaatga tgaagtgtga catcaatggc gacactccca atgtggatcc tctgacgcat
     2161 gcggccctgg gagacgccag tgaagtggag attgatgagc tgcagcccca gaaggaggga
     2221 gaggagcctg gcccagacag tgagaactct caggagaacc ttcccctgcg ctccagctcc
     2281 agcaccactg ccagcagtag ccctagcacc atcgtccacg gcgcccactc tgaacctgct
     2341 gattctacag aggtgggaga taaggcagca acaggcatct ccaagcccct ccctcctgtg
     2401 cctcccagca tttgcaaatc tactgtggac aggagacaga cagagactgg agaggggtca
     2461 gtgtgccagc gaacctacga ccatccatat tttgagcccc aatatggctc ccccgctgag
     2521 gaagatgatg acgagcaggg agagagctac acgccccggt tcagccaaca tgccagtggc
     2581 agtcgggctc aaaagctgct gcggcccaac agcttgaagc tggccagtga ctcagacgca
     2641 gagtcagact cccgagcaag ctctcccaac tccaccgtct ctaacaacag caccgagggc
     2701 ttcgggggca tcatgtcttt tgctagcagc ctgtatcgga accatagtac aagcttcagc
     2761 ctttcaaacc tcacactgcc caccaaaggt gcccgagaga agactacacc attccccagc
     2821 ctgaaaggaa acaggagggc cttagtggac cagaaatcat ctgtcattaa acacagccca
     2881 actgtgaaaa gagaacctcc atcaccgcag ggccggtcca gcaattctag cgagaaccaa
     2941 cagttcctga aggaggtggt ccacagtgtg ctggatggcc agggagtcgg ctggctcaac
     3001 atgaaaaagg tgcgccggct gctggagagt gagcagctcc gagtctttgt actgagcaag
     3061 ctgagtcgtg cagtgcagtc agaggatgat gcccgacagg atgtcatcca ggatgtggag
     3121 atcagtcgga aggtgtacaa gggaatgcta gacctcctca agtgcacagt cctcagcctc
     3181 gagcagtcct atgcccatgc tggtctgggt ggcatggcca gcatctttgg gcttttggag
     3241 attgcccaga cccattacta tagtaaagaa ccagacaaac gcaagagaag tccaacagag
     3301 aatgtaaata ccccagttgg caaggatcct ggtctggctg ggcgggggga cccaaaggca
     3361 atggctcagc taagggtccc tcagctgggt cctcgggcac caagtgctac aggaaggggt
     3421 cctaaagaac tggacaccag aagtttaaag gaagagaatt ttgtagcgtc tgtgggacca
     3481 gaggtcatca agcctgtctt tgacctgggt gagactgagg agaaaaagtc ccagatcagc
     3541 gcagacagtg gtgtgagcct ggcatctgct tcccagagga ctgatcaaga ctctgtcatc
     3601 ggtgtgagtc cagctgttat gatccgaagc tcaagtcagg attctgaagt gagtaacagt
     3661 tcaggagaga ccctcggagc agacagtgac ctgagcagca atgcaggtga tgggccagga
     3721 ggcgaaggca gtgcccactt ggcaagttct cgggctactc tgtctgacag tgaaattgaa
     3781 accaattctg ctacaagcac catctttggt aaagcccata gcttgaagcc aaaggagaag
     3841 ccggctagta gtccagttcg ctcttccgaa gatgtaagcc agcgagtcta tctctatgag
     3901 ggactactag gaagggacaa aggatccatg tgggaccagt tagaggatgc tgctatggag
     3961 accttttcta taagcaaaga gcggtctact ttatgggacc aaatgcagtt ctgggaagat
     4021 gcgttcctag atgctgtgat gttggaaaga gaaggaatgg gtatggacca gggccctcag
     4081 gaaatgatcg acaggtacct gtccctagga gagcatgacc ggaagcgcct ggaggatgat
     4141 gaagatcgct tactggccac actcttacac aacctcatat cctatatgct cctgatgaag
     4201 gtgaacaaga acgacatcag gaagaaagta cggcgcctaa tgggaaaatc ccacgttggg
     4261 ctggtgtaca gtcaacaaat caatgaggtg ctcgatcagc tgaccaacct gaatgggcgt
     4321 gatctctcca tccgatccag tggcagcagg cacatgaaga agcagacgtt cgttgtgcac
     4381 gcagggacgg acacaaatgg agatatcttt ttcatggaag tgtgtgacga ctgtgtggtc
     4441 ttacgtagta acatcgggac agtgtacgag cgctggtggt atgagaagct tatcaacatg
     4501 acctactgtc ccaagaccaa ggtcctgtgc ttatggcgta gaaatggctc tgagacgcag
     4561 ctcaacaagt tctataccaa gaagtgtcgg gagctgtact actgtgtgaa ggacagcatg
     4621 gagcgtgcgg ctgcccggca acaaagcatc aaacccgggc ctgaactagg tggtgagttc
     4681 cctgtgcagg acatgaagac tggagagggc ggcttgcttc aggtcaccct ggaagggatc
     4741 aatctcaagt tcatgcataa ccaggttttc atagagctga atcacattaa aaagtgcaat
     4801 acagttcgag gcgtctttgt cctggaagaa tttgttcctg aaattaaaga agtggtgagc
     4861 cacaagtaca agactccaat ggcccacgag atctgctatt ctgtgttgtg tctcttctcg
     4921 tatgtggccg cagttcgtag cagtgaagaa gacctccgaa ccccacctcg gcctgtctct
     4981 agctgataga gaggggttac acagctgggc cagcccaggg gtcacccctc acctcttgct
     5041 gctcctaagc gctgaagctg cctcgactga gacagagact ctgtgtgtgt gtgtgtgtgt
     5101 gtgtgtgtgt tctctgcaag gtgttctctg caagctcctt cctgcggttg agctggtttc
     5161 gttttatgtc tgagtgtgtc cttgtgttca tctgtcatgg ggctaagcta gtctcattac
     5221 cttctcttcc tacaatagca gac
//
