LOCUS       NM_019317               1279 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus mucosal vascular addressin cell adhesion molecule
            1 (Madcam1), mRNA.
ACCESSION   NM_019317
VERSION     NM_019317.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1279)
  AUTHORS   Zhang,K., Pan,Y., Qi,J., Yue,J., Zhang,M., Xu,C., Li,G. and Chen,J.
  TITLE     Disruption of disulfide restriction at integrin knees induces
            activation and ligand-independent signaling of alphabeta
  JOURNAL   J Cell Sci 126 (Pt 21), 5030-5041 (2013)
   PUBMED   23986478
REFERENCE   2  (bases 1 to 1279)
  AUTHORS   Miles,A., Liaskou,E., Eksteen,B., Lalor,P.F. and Adams,D.H.
  TITLE     CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of
            lymphocytes to MAdCAM-1 under shear flow
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 294 (5), G1257-G1267 (2008)
   PUBMED   18308860
REFERENCE   3  (bases 1 to 1279)
  AUTHORS   Burke,S.D., Dong,H., Hazan,A.D. and Croy,B.A.
  TITLE     Aberrant endometrial features of pregnancy in diabetic NOD mice
  JOURNAL   Diabetes 56 (12), 2919-2926 (2007)
   PUBMED   17827401
REFERENCE   4  (bases 1 to 1279)
  AUTHORS   Sugito,K., Koshinaga,T., Inoue,M., Ikeda,T., Hagiwara,N. and
            Fukuzawa,M.
  TITLE     Effect of FTY720 in rat small bowel transplantation: expression of
            mucosal addressin cell adhesion molecule-1
  JOURNAL   Transplant Proc 37 (10), 4472-4474 (2005)
   PUBMED   16387148
  REMARK    GeneRIF: During small bowel allograft rejection., FTY720 was found
            to prevent the down-regulation of MAdCAM-1 expression in
            endothelial venules
REFERENCE   5  (bases 1 to 1279)
  AUTHORS   Fernekorn,U., Butcher,E.C., Behrends,J., Hartz,S. and Kruse,A.
  TITLE     Functional involvement of P-selectin and MAdCAM-1 in the
            recruitment of alpha4beta7-integrin-expressing monocyte-like cells
            to the pregnant mouse uterus
  JOURNAL   Eur J Immunol 34 (12), 3423-3433 (2004)
   PUBMED   15484189
REFERENCE   6  (bases 1 to 1279)
  AUTHORS   Fujisaki,S., Park,E., Kimizuka,K., Inoue,M., Tomita,R., Fukuzawa,M.
            and Matsumoto,K.
  TITLE     Immunohistochemical analysis of MAdCAM-1 expression during acute
            rejection on small bowel grafts in rats
  JOURNAL   Transplant Proc 34 (3), 1045-1046 (2002)
   PUBMED   12034298
  REMARK    GeneRIF: Immunohistochemical analysis of MAdCAM-1 expression during
            acute rejection on small bowel grafts in rats
REFERENCE   7  (bases 1 to 1279)
  AUTHORS   Hokari,R., Kato,S., Matsuzaki,K., Iwai,A., Kawaguchi,A., Nagao,S.,
            Miyahara,T., Itoh,K., Sekizuka,E., Nagata,H., Ishii,H., Iizuka,T.,
            Miyasaka,M. and Miura,S.
  TITLE     Involvement of mucosal addressin cell adhesion molecule-1
            (MAdCAM-1) in the pathogenesis of granulomatous colitis in rats
  JOURNAL   Clin Exp Immunol 126 (2), 259-265 (2001)
   PUBMED   11703369
REFERENCE   8  (bases 1 to 1279)
  AUTHORS   Iizuka,T., Tanaka,T., Suematsu,M., Miura,S., Watanabe,T., Koike,R.,
            Ishimura,Y., Ishii,H., Miyasaka,N. and Miyasaka,M.
  TITLE     Stage-specific expression of mucosal addressin cell adhesion
            molecule-1 during embryogenesis in rats
  JOURNAL   J Immunol 164 (5), 2463-2471 (2000)
   PUBMED   10679083
REFERENCE   9  (bases 1 to 1279)
  AUTHORS   Iizuka,T., Koike,R., Miyasaka,N., Miyasaka,M. and Watanabe,T.
  TITLE     Cloning and characterization of the rat MAdCAM-1 cDNA and gene
  JOURNAL   Biochim Biophys Acta 1395 (3), 266-270 (1998)
   PUBMED   9512658
REFERENCE   10 (bases 1 to 1279)
  AUTHORS   Yang,X.D., Sytwu,H.K., McDevitt,H.O. and Michie,S.A.
  TITLE     Involvement of beta 7 integrin and mucosal addressin cell adhesion
            molecule-1 (MAdCAM-1) in the development of diabetes in obese
            diabetic mice
  JOURNAL   Diabetes 46 (10), 1542-1547 (1997)
   PUBMED   9313747
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D87840.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D87840.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760434, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1279
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1279
                     /gene="Madcam1"
                     /note="mucosal vascular addressin cell adhesion molecule
                     1"
                     /db_xref="GeneID:54266"
                     /db_xref="RGD:3029"
     exon            1..68
                     /gene="Madcam1"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1198
                     /gene="Madcam1"
                     /note="mucosal addressin cell adhesion molecule 1;
                     MAdCAM-1; rMAdCAM-1"
                     /codon_start=1
                     /product="mucosal addressin cell adhesion molecule 1
                     precursor"
                     /protein_id="NP_062190.1"
                     /db_xref="GeneID:54266"
                     /db_xref="RGD:3029"
                     /translation="MEPILALLLALGPFQLSRGQSFQVNPPEPEVAVAMGTSLQINCS
                     MSCDKDIARVHWHGLDTNLGNVQTLPGSRVLSVRGMLSDTGTRVCVGSCGSRSFQHSV
                     KILVYAFPDQLEVTPEFLVPGRDQVVSCTAHNIWPAGPDSLSFALLRGEQSLEGAQAL
                     ETEQEEEMQETEGTPLFQVTQRWLLPSLGTPALPALYCQVTMQLPKLVLTHRRKIPVL
                     QSQTSPEPPSTTSAKPYILTSSHTTKAVSTGLSSVALPSTPLSSEGPCYPEIHQNPEA
                     DWELLCEASCGSGVTVHWTLAPGDLAAYHKREAGAQAWLSVLPLGPIPEGWFQCRMDP
                     GGQVTSLYVTGQVIPNPSSMVALWIGSLVLGLLALAFLAYCLWKRYRPGPLPDSSSCT
                     LL"
     exon            69..335
                     /gene="Madcam1"
                     /inference="alignment:Splign:2.1.0"
     exon            336..662
                     /gene="Madcam1"
                     /inference="alignment:Splign:2.1.0"
     exon            663..1067
                     /gene="Madcam1"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1279
                     /gene="Madcam1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacagagaaa ggcatggagc ccatcctggc cctcctgctg gccctgggac ccttccagct
       61 cagcagaggc cagtccttcc aggtgaatcc tcctgagcct gaggtagctg tagccatggg
      121 cacatccctc cagatcaact gcagcatgtc ctgtgacaag gatatagccc gggtgcactg
      181 gcatggcctg gacaccaacc tgggcaatgt gcagaccctc ccaggcagca gggtcctctc
      241 cgtacgaggc atgctgtcag acacgggcac tcgtgtatgc gtgggttcct gtgggagtcg
      301 aagctttcag cactctgtga agatccttgt gtatgccttt ccagaccagc tggaggtaac
      361 cccggagttc cttgtacctg gacgggacca ggtagtgtcc tgcacagccc acaacatctg
      421 gcctgcaggc ccggacagtc tttcctttgc cttgctccga ggagagcaga gcctggaggg
      481 tgctcaggcc ctggaaacag agcaagagga ggagatgcaa gagactgagg gcactccact
      541 cttccaagtg acacaacgct ggttgctgcc ctccctgggg acccccgccc ttcccgccct
      601 ttattgccag gtcaccatgc agctgcccaa actggtgctg acacatagaa ggaagattcc
      661 agtcctacag agccagacct caccagagcc ccccagcacc acctctgcta agccatacat
      721 cctgacctca tcacatacta ctaaggcagt ctccactggg ctcagcagtg tagccctgcc
      781 ttctacgcct ctgagctccg aggggccctg ctaccccgaa atccaccaga acccagaggc
      841 agactgggaa cttctctgcg aagcctcctg tgggtctgga gtgacggtgc attggaccct
      901 ggctcctggt gacctggcag cctaccacaa gagagaagct ggggcccagg catggctaag
      961 cgtgctgccc ctgggcccca ttcctgaggg ctggttccag tgtcgcatgg accctggcgg
     1021 gcaggtgacc agtctgtatg ttactggcca ggtgatccca aacccctcct ccatggtcgc
     1081 cctgtggatt ggcagcttgg tgctggggct gcttgcactc gccttccttg cctactgcct
     1141 gtggaaacgc taccggccgg gtcctctccc agactccagc tcgtgtacgc tcctatgaag
     1201 ttccattatg ccagactaag ggaggcaaag gattaccaga tgtaggtttg gggcatcaag
     1261 atgatagtgt ggccccttt
//
