LOCUS       NM_001394241            1226 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus mitotic arrest deficient 2 like 2 (Mad2l2),
            transcript variant 1, mRNA.
ACCESSION   NM_001394241 XM_006239391
VERSION     NM_001394241.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1226)
  AUTHORS   Gupta,R., Somyajit,K., Narita,T., Maskey,E., Stanlie,A., Kremer,M.,
            Typas,D., Lammers,M., Mailand,N., Nussenzweig,A., Lukas,J. and
            Choudhary,C.
  TITLE     DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of
            NHEJ and PARP Inhibitor Sensitivity
  JOURNAL   Cell 173 (4), 972-988 (2018)
   PUBMED   29656893
REFERENCE   2  (bases 1 to 1226)
  AUTHORS   Meng,X., Chu,G., Ye,C., Tang,H., Qiu,P., Hu,Y., Li,M. and Zhang,C.
  TITLE     Involvement of AMPK in regulating the degradation of MAD2B under
            high glucose in neuronal cells
  JOURNAL   J Cell Mol Med 21 (6), 1150-1158 (2017)
   PUBMED   27957796
  REMARK    GeneRIF: this study demonstrates that AMPK acts as a key regulator
            of MAD2B expression, suggesting that activation of AMPK signalling
            might be crucial for the treatment of high glucose-induced neuronal
            injury
REFERENCE   3  (bases 1 to 1226)
  AUTHORS   Tang,H., Fan,D., Lei,C.T., Ye,C., Gao,P., Chen,S., Meng,X.F., Su,H.
            and Zhang,C.
  TITLE     MAD2B promotes tubular epithelial-to-mesenchymal transition and
            renal tubulointerstitial fibrosis via Skp2
  JOURNAL   J Mol Med (Berl) 94 (11), 1297-1307 (2016)
   PUBMED   27488450
  REMARK    GeneRIF: Skp2, a confirmed APC/C-CDH1 substrate and E-cadherin
            destroyer, was increased in TGF-beta1-treated proximal tubular
            epithelial cells, which could be blocked by MAD2B depletion.
REFERENCE   4  (bases 1 to 1226)
  AUTHORS   Su,H., Wan,Q., Tian,X.J., He,F.F., Gao,P., Tang,H., Ye,C., Fan,D.,
            Chen,S., Wang,Y.M., Meng,X.F. and Zhang,C.
  TITLE     MAD2B contributes to podocyte injury of diabetic nephropathy via
            inducing cyclin B1 and Skp2 accumulation
  JOURNAL   Am J Physiol Renal Physiol 308 (7), F728-F736 (2015)
   PUBMED   25651564
  REMARK    GeneRIF: that MAD2B may play an important role in high
            glucose-mediated podocyte injury of diabetic nephropathy via
            modulation of Cdh1, cyclin B1, and Skp2 expression
REFERENCE   5  (bases 1 to 1226)
  AUTHORS   Meng,X., Wang,X., Tian,X., Yang,Z., Li,M. and Zhang,C.
  TITLE     Protection of neurons from high glucose-induced injury by deletion
            of MAD2B
  JOURNAL   J Cell Mol Med 18 (5), 844-851 (2014)
   PUBMED   24444371
  REMARK    GeneRIF: hyperglycaemia induced neuronal apoptosis through inducing
            expression of MAD2B, which represents a novel mechanism of diabetic
            encephalopathy.
REFERENCE   6  (bases 1 to 1226)
  AUTHORS   Li,L., Shi,Y., Wu,H., Wan,B., Li,P., Zhou,L., Shi,H. and Huo,K.
  TITLE     Hepatocellular carcinoma-associated gene 2 interacts with MAD2L2
  JOURNAL   Mol Cell Biochem 304 (1-2), 297-304 (2007)
   PUBMED   17541814
REFERENCE   7  (bases 1 to 1226)
  AUTHORS   Zhang,L., Yang,S.H. and Sharrocks,A.D.
  TITLE     Rev7/MAD2B links c-Jun N-terminal protein kinase pathway signaling
            to activation of the transcription factor Elk-1
  JOURNAL   Mol Cell Biol 27 (8), 2861-2869 (2007)
   PUBMED   17296730
REFERENCE   8  (bases 1 to 1226)
  AUTHORS   Okada,T., Sonoda,E., Yoshimura,M., Kawano,Y., Saya,H., Kohzaki,M.
            and Takeda,S.
  TITLE     Multiple roles of vertebrate REV genes in DNA repair and
            recombination
  JOURNAL   Mol Cell Biol 25 (14), 6103-6111 (2005)
   PUBMED   15988022
REFERENCE   9  (bases 1 to 1226)
  AUTHORS   Chen,J. and Fang,G.
  TITLE     MAD2B is an inhibitor of the anaphase-promoting complex
  JOURNAL   Genes Dev 15 (14), 1765-1770 (2001)
   PUBMED   11459826
REFERENCE   10 (bases 1 to 1226)
  AUTHORS   Pfleger,C.M., Salic,A., Lee,E. and Kirschner,M.W.
  TITLE     Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel
            mechanism for regulating Cdh1
  JOURNAL   Genes Dev 15 (14), 1759-1764 (2001)
   PUBMED   11459825
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 8, 2021 this sequence version replaced XM_006239391.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399481.3033018.1,
                                           SRR26643289.17008.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-324               JAXUCZ010000005.1  163855170-163855493
            325-443             JAXUCZ010000005.1  163855573-163855691
            444-515             JAXUCZ010000005.1  163857151-163857222
            516-616             JAXUCZ010000005.1  163857727-163857827
            617-711             JAXUCZ010000005.1  163858471-163858565
            712-785             JAXUCZ010000005.1  163858872-163858945
            786-878             JAXUCZ010000005.1  163859323-163859415
            879-1226            JAXUCZ010000005.1  163859504-163859851
FEATURES             Location/Qualifiers
     source          1..1226
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1226
                     /gene="Mad2l2"
                     /note="mitotic arrest deficient 2 like 2"
                     /db_xref="GeneID:313702"
                     /db_xref="RGD:1307499"
     exon            1..324
                     /gene="Mad2l2"
                     /inference="alignment:Splign:2.1.0"
     CDS             285..920
                     /gene="Mad2l2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mitotic spindle assembly checkpoint protein MAD2B;
                     MAD2-like protein 2; mitotic arrest deficient 2-like
                     protein 2; MAD2 mitotic arrest deficient-like 2"
                     /codon_start=1
                     /product="mitotic spindle assembly checkpoint protein
                     MAD2B isoform 1"
                     /protein_id="NP_001381170.1"
                     /db_xref="GeneID:313702"
                     /db_xref="RGD:1307499"
                     /translation="MTTLTRQDLNFGQVVADVLSEFLEVAVHLILYVREVYPVGIFQK
                     RKKYNVPVQMSCHPELNQYIQDTLHCVKPLLEKNDVEKVVVVILDKEHRPVEKFVFEI
                     TQPPLLSINSDSLLSHVEQLLRAFILKISVCDAVLDHNPPGCTFTVLVHTREAATRNM
                     EKIQVIKDFPWILADEQDVHMHDPRLIPLKTMTSDILKMQLYVEERAHKNS"
     exon            325..443
                     /gene="Mad2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            444..515
                     /gene="Mad2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            516..616
                     /gene="Mad2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            617..711
                     /gene="Mad2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            712..785
                     /gene="Mad2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            786..878
                     /gene="Mad2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1226
                     /gene="Mad2l2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggaccgccg gagctccgcg gtggttactg aggccaggga attctggaga agtgataggg
       61 ttcccagcgg gtggctcctg tagccgggtc gtagattcga acctgaggtc gaagccggag
      121 ccggcgaatc ggggaggagc gcagagaggg cgggatttcc gccgagaggg atccggccgc
      181 tcagggggtg gggcttcccc gaccgggctg cgtttcccgc gtgcccggct gggtgctgtg
      241 agtccctaca aacaccctcc gcgccctccc ccaggcagcc aaggatgacc accctcacgc
      301 gccaagacct caacttcggc caagtggtgg ccgacgtgct ctccgagttc ctggaggtgg
      361 ccgtgcactt gatcctctat gtgcgcgagg tctacccggt gggcatcttt cagaagcgca
      421 agaagtacaa cgtgccggtt cagatgtcct gccacccaga gctgaaccag tacatccagg
      481 acacacttca ctgcgtcaaa ccactcctgg agaagaacga tgtggagaag gtggtggtgg
      541 tgattttgga taaggaacac cgcccagtgg agaagtttgt ctttgagatc actcagccac
      601 ccttgctgtc catcaattca gactccctcc tgtctcatgt ggagcagctg cttcgagcct
      661 tcattcttaa gattagtgtg tgtgacgctg tcctcgacca taatcctcca ggctgcacgt
      721 ttacagttct cgtgcacaca agagaagctg ccactcggaa catggagaag atacaggtca
      781 tcaaggactt cccctggatc ctggcagatg agcaagatgt ccacatgcat gatccccggt
      841 tgatacccct gaaaaccatg acttcggaca ttttaaagat gcaactttac gtagaagagc
      901 gagctcataa aaacagctga gggcacctct gtcaccagac gcccagccat cccactctgg
      961 gacccaggcc caggacagta ctgcagggcc ccagactcca agtgctctta ttgccttgac
     1021 gtgtggccgt ccctccggtc aggctgctca gccctgcttg ccttcgtgag gcagccttcc
     1081 cgggagccga gggaaggatc ccaggacaga cggccatttc tcagcggcct ccagggctca
     1141 gctcacactg tccacctgaa atactgtgcc gtgtgttatc gttaataaag tggccccgag
     1201 ggctgaccgc attgtcgtta accgaa
//
