LOCUS       NM_001106594            1424 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus mitotic arrest deficient 2 like 1 (Mad2l1), mRNA.
ACCESSION   NM_001106594 XM_001061025 XM_216161
VERSION     NM_001106594.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1424)
  AUTHORS   Koban,F. and Freissmuth,M.
  TITLE     The cell cycle protein MAD2 facilitates endocytosis of the
            serotonin transporter in the neuronal soma
  JOURNAL   EMBO Rep 24 (10), e53408 (2023)
   PUBMED   37530743
  REMARK    GeneRIF: The cell cycle protein MAD2 facilitates endocytosis of the
            serotonin transporter in the neuronal soma.
REFERENCE   2  (bases 1 to 1424)
  AUTHORS   Zhu,M., Settele,F., Kotak,S., Sanchez-Pulido,L., Ehret,L.,
            Ponting,C.P., Gonczy,P. and Hoffmann,I.
  TITLE     MISP is a novel Plk1 substrate required for proper spindle
            orientation and mitotic progression
  JOURNAL   J Cell Biol 200 (6), 773-787 (2013)
   PUBMED   23509069
REFERENCE   3  (bases 1 to 1424)
  AUTHORS   Fava,L.L., Kaulich,M., Nigg,E.A. and Santamaria,A.
  TITLE     Probing the in vivo function of Mad1:C-Mad2 in the spindle assembly
            checkpoint
  JOURNAL   EMBO J 30 (16), 3322-3336 (2011)
   PUBMED   21772247
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1424)
  AUTHORS   Agarwal,N., Tochigi,Y., Adhikari,A.S., Cui,S., Cui,Y. and
            Iwakuma,T.
  TITLE     MTBP plays a crucial role in mitotic progression and chromosome
            segregation
  JOURNAL   Cell Death Differ 18 (7), 1208-1219 (2011)
   PUBMED   21274008
REFERENCE   5  (bases 1 to 1424)
  AUTHORS   Kim,S., Sun,H., Ball,H.L., Wassmann,K., Luo,X. and Yu,H.
  TITLE     Phosphorylation of the spindle checkpoint protein Mad2 regulates
            its conformational transition
  JOURNAL   Proc Natl Acad Sci U S A 107 (46), 19772-19777 (2010)
   PUBMED   21041666
REFERENCE   6  (bases 1 to 1424)
  AUTHORS   Pfleger,C.M., Salic,A., Lee,E. and Kirschner,M.W.
  TITLE     Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel
            mechanism for regulating Cdh1
  JOURNAL   Genes Dev 15 (14), 1759-1764 (2001)
   PUBMED   11459825
REFERENCE   7  (bases 1 to 1424)
  AUTHORS   Michel,L.S., Liberal,V., Chatterjee,A., Kirchwegger,R., Pasche,B.,
            Gerald,W., Dobles,M., Sorger,P.K., Murty,V.V. and Benezra,R.
  TITLE     MAD2 haplo-insufficiency causes premature anaphase and chromosome
            instability in mammalian cells
  JOURNAL   Nature 409 (6818), 355-359 (2001)
   PUBMED   11201745
REFERENCE   8  (bases 1 to 1424)
  AUTHORS   Kallio,M., Eriksson,J.E. and Gorbsky,G.J.
  TITLE     Differences in spindle association of the mitotic checkpoint
            protein Mad2 in mammalian spermatogenesis and oogenesis
  JOURNAL   Dev Biol 225 (1), 112-123 (2000)
   PUBMED   10964468
REFERENCE   9  (bases 1 to 1424)
  AUTHORS   Dobles,M., Liberal,V., Scott,M.L., Benezra,R. and Sorger,P.K.
  TITLE     Chromosome missegregation and apoptosis in mice lacking the mitotic
            checkpoint protein Mad2
  JOURNAL   Cell 101 (6), 635-645 (2000)
   PUBMED   10892650
REFERENCE   10 (bases 1 to 1424)
  AUTHORS   Li,Y. and Benezra,R.
  TITLE     Identification of a human mitotic checkpoint gene: hsMAD2
  JOURNAL   Science 274 (5285), 246-248 (1996)
   PUBMED   8824189
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474042.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001061025.1, XM_216161.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ222936.1, BP503907.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1424
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q31"
     gene            1..1424
                     /gene="Mad2l1"
                     /note="mitotic arrest deficient 2 like 1"
                     /db_xref="GeneID:297176"
                     /db_xref="RGD:1310889"
     exon            1..187
                     /gene="Mad2l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..732
                     /gene="Mad2l1"
                     /note="MAD2 (mitotic arrest deficient, homolog)-like 1;
                     MAD2 mitotic arrest deficient-like 1"
                     /codon_start=1
                     /product="mitotic spindle assembly checkpoint protein
                     MAD2A"
                     /protein_id="NP_001100064.1"
                     /db_xref="GeneID:297176"
                     /db_xref="RGD:1310889"
                     /translation="MAQQLARDQGITLRGSAEIVAEFFSFGINSILYQRGIYPSETFT
                     RVQKYGLTLLVTTDPELIKYLNNVVEQLKEWLYKCSVQKLVVVISNIESGEVLERWQF
                     DIECDKTAKEEGVRREKSQKAIQDEIRSVIRQITATVTFLPLLEVSCSFDLLIYTDKD
                     LVVPEKWEESGPQFITNSEEVRLRSFTTTIHKVNSMVAYKTPVSD"
     exon            188..334
                     /gene="Mad2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            335..455
                     /gene="Mad2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            456..559
                     /gene="Mad2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            560..739
                     /gene="Mad2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            740..1424
                     /gene="Mad2l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcgaccgg cgggattcgt agttactttt gaaccgggtg gcggggaata gctagaggag
       61 ccattagggc gccatctacg gaggggttga cagtgttctc cgttcgatct agtgatggca
      121 cagcagctcg cccgggacca aggcatcacc ctgcgtggga gcgcagaaat cgtcgccgag
      181 tttttttcat ttggcatcaa cagcattttg tatcagcgtg gcatttatcc gtcggaaacc
      241 tttactcgag tgcagaaata tggactcacc ttgcttgtaa ctactgaccc cgagctcata
      301 aagtatctca ataatgtggt agagcagcta aaagagtggt tgtacaagtg ctccgttcag
      361 aaactggtag tggtcatctc gaatattgaa agtggcgagg tccttgaaag atggcagttt
      421 gatattgagt gtgacaaaac ggccaaagaa gaaggtgttc gtagagaaaa gtcccagaaa
      481 gccatacagg atgaaatccg ttcagtgatc agacagatca cagccactgt gacatttcta
      541 ccactgttgg aggtttcttg ttcatttgat ctgctgattt atactgacaa agatttggtg
      601 gtacctgaaa agtgggaaga atcgggaccc cagtttatta ccaattctga agaagtccgt
      661 ctacgctcat tcactaccac aatccacaaa gtgaacagta tggtggccta caaaacacct
      721 gtcagtgact gaagagacgg ttcatttgat ctgctggttt atactgacaa agtttggttg
      781 tacttgaaaa gtgggaagag tcgggactcc agtttattac caattctgaa gaagtctgtc
      841 tacgctcatt tacgaccacc atccacaaag tgagtagtat ggtggcctac aaaacccatc
      901 aatgactgaa gaaacggtgc acaaatcatc cctcaccaca taataccttc tgctgtgttt
      961 atatttagat gcttctttat atcttggtta agattcttct aagctaaatc attaggcgaa
     1021 gtatttaact ttttaacaga agtttttcca tctacaatga ccatttttaa aggaattcat
     1081 tccacaatga atctgttagt tccccttaat aatggacagc actcttgttg actctatggt
     1141 aagtccagaa ggaacccaag aaatacaaca ataagacaca tttctgtcta tatagaccct
     1201 gtgttaaaat aaatggtaat tatttgattt tggtgtatat atcttgaact cacaaagcag
     1261 ttgatactgt ttaatttctg taataaagaa ctcttatttt aatgttttat aaaaatcaag
     1321 ctttaaatga cagtaataca aaaaattaac cctttgtgtt taaaatttgt gttacaatat
     1381 ctttgatatt taatttggtg ttaatacagt caaatacttc aatg
//
