LOCUS       NM_001109387            2612 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus mitotic arrest deficient 1 like 1 (Mad1l1), mRNA.
ACCESSION   NM_001109387 XM_001055286
VERSION     NM_001109387.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2612)
  AUTHORS   Yachie,N., Petsalaki,E., Mellor,J.C., Weile,J., Jacob,Y., Verby,M.,
            Ozturk,S.B., Li,S., Cote,A.G., Mosca,R., Knapp,J.J., Ko,M., Yu,A.,
            Gebbia,M., Sahni,N., Yi,S., Tyagi,T., Sheykhkarimli,D., Roth,J.F.,
            Wong,C., Musa,L., Snider,J., Liu,Y.C., Yu,H., Braun,P.,
            Stagljar,I., Hao,T., Calderwood,M.A., Pelletier,L., Aloy,P.,
            Hill,D.E., Vidal,M. and Roth,F.P.
  TITLE     Pooled-matrix protein interaction screens using Barcode Fusion
            Genetics
  JOURNAL   Mol Syst Biol 12 (4), 863 (2016)
   PUBMED   27107012
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2612)
  AUTHORS   Kim,S., Sun,H., Tomchick,D.R., Yu,H. and Luo,X.
  TITLE     Structure of human Mad1 C-terminal domain reveals its involvement
            in kinetochore targeting
  JOURNAL   Proc Natl Acad Sci U S A 109 (17), 6549-6554 (2012)
   PUBMED   22493223
REFERENCE   3  (bases 1 to 2612)
  AUTHORS   Yeh,P.C., Yeh,C.C., Chen,Y.C. and Juang,Y.L.
  TITLE     RED, a spindle pole-associated protein, is required for kinetochore
            localization of MAD1, mitotic progression, and activation of the
            spindle assembly checkpoint
  JOURNAL   J Biol Chem 287 (15), 11704-11716 (2012)
   PUBMED   22351768
REFERENCE   4  (bases 1 to 2612)
  AUTHORS   Hached,K., Xie,S.Z., Buffin,E., Cladiere,D., Rachez,C., Sacras,M.,
            Sorger,P.K. and Wassmann,K.
  TITLE     Mps1 at kinetochores is essential for female mouse meiosis I
  JOURNAL   Development 138 (11), 2261-2271 (2011)
   PUBMED   21558374
REFERENCE   5  (bases 1 to 2612)
  AUTHORS   Nakano,H., Funasaka,T., Hashizume,C. and Wong,R.W.
  TITLE     Nucleoporin translocated promoter region (Tpr) associates with
            dynein complex, preventing chromosome lagging formation during
            mitosis
  JOURNAL   J Biol Chem 285 (14), 10841-10849 (2010)
   PUBMED   20133940
REFERENCE   6  (bases 1 to 2612)
  AUTHORS   Jeganathan,K., Malureanu,L., Baker,D.J., Abraham,S.C. and van
            Deursen,J.M.
  TITLE     Bub1 mediates cell death in response to chromosome missegregation
            and acts to suppress spontaneous tumorigenesis
  JOURNAL   J Cell Biol 179 (2), 255-267 (2007)
   PUBMED   17938250
REFERENCE   7  (bases 1 to 2612)
  AUTHORS   Zuccolo,M., Alves,A., Galy,V., Bolhy,S., Formstecher,E., Racine,V.,
            Sibarita,J.B., Fukagawa,T., Shiekhattar,R., Yen,T. and Doye,V.
  TITLE     The human Nup107-160 nuclear pore subcomplex contributes to proper
            kinetochore functions
  JOURNAL   EMBO J 26 (7), 1853-1864 (2007)
   PUBMED   17363900
REFERENCE   8  (bases 1 to 2612)
  AUTHORS   Zhang,D., Yin,S., Jiang,M.X., Ma,W., Hou,Y., Liang,C.G., Yu,L.Z.,
            Wang,W.H. and Sun,Q.Y.
  TITLE     Cytoplasmic dynein participates in meiotic checkpoint inactivation
            in mouse oocytes by transporting cytoplasmic mitotic
            arrest-deficient (Mad) proteins from kinetochores to spindle poles
  JOURNAL   Reproduction 133 (4), 685-695 (2007)
   PUBMED   17504913
REFERENCE   9  (bases 1 to 2612)
  AUTHORS   Rudolph,B., Hueber,A.O. and Evan,G.I.
  TITLE     Expression of Mad1 in T cells leads to reduced thymic cellularity
            and impaired mitogen-induced proliferation
  JOURNAL   Oncogene 20 (10), 1164-1175 (2001)
   PUBMED   11313860
REFERENCE   10 (bases 1 to 2612)
  AUTHORS   Wang,Y., Toury,R., Hauchecorne,M. and Balmain,N.
  TITLE     Expression and subcellular localization of the Myc superfamily
            proteins: c-Myc, Max, Mad1 and Mxi1 in the epiphyseal plate
            cartilage chondrocytes of growing rats
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 43 (2), 175-188 (1997)
   PUBMED   9130602
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474012.1.
            
            On Oct 4, 2007 this sequence version replaced XM_001055286.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132291,
                              SAMD00132292 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2612
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q11"
     gene            1..2612
                     /gene="Mad1l1"
                     /note="mitotic arrest deficient 1 like 1"
                     /db_xref="GeneID:680006"
                     /db_xref="RGD:1596881"
     exon            1..44
                     /gene="Mad1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            45..204
                     /gene="Mad1l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..2208
                     /gene="Mad1l1"
                     /note="MAD1 mitotic arrest deficient like 1"
                     /codon_start=1
                     /product="mitotic spindle assembly checkpoint protein
                     MAD1"
                     /protein_id="NP_001102857.1"
                     /db_xref="GeneID:680006"
                     /db_xref="RGD:1596881"
                     /translation="MEDLGENTTVLSTLRSLNNFISQRMEGASGLDVSTSASGSLQKQ
                     YEQNMQLEERAEQIRSKSYLIQVEREKMQMELSHKRARVELERAASTNARNYEREVDR
                     NQELLARIRQLQEREAAAEEKMREQLERHRLCKQSLDAASQQLREREDGLAAARETIS
                     SLKGRVSELQLSAMDQKVQVKRLESEKQELKEQLELQQRKWQEANQKIQELQASQEER
                     TDQEQKIKDLEQKLCLQEQDAAVVKSMKSELLRLPRMERELKRLREENTHLREMRETN
                     GLLTEELEGLQRKLGRQEKMQEALVDLELEKEKLLAKLQSWEKLDQTMGLNLRTPEDL
                     SRFVIELQQRELALKEKNSSITSSARGLEKAQQQLQDEVRQVNAQLLEERKKRETHEA
                     LARRLQKRNALLTKERDGMRAILGSYDSELTQAEYSPQLTQRMWEAEDMVQKVHAHSS
                     EMEAQLSQALEELGVQKQRADTLEMELKMLRAQTSSAEASFPFCKEEVDALRLKVEEL
                     EGERSRLEQEKQALEMQMERLTLQGDYNQSRTKVLHMSLNPASMARQRQREDHDRLQE
                     ECERLRGLVHALERGGPIPADLEAASSLPSSKEVAELRKQVESAELKNQRLKEVFQTK
                     IQEFRKVCYTLTGYQIDVTTESQYRLTSRYAEHQTDCLIFKATGPSGSKMQLLETEFS
                     RSVPELIELHLLQQDSIPAFLSALTIELFSRQTSV"
     exon            205..345
                     /gene="Mad1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            346..525
                     /gene="Mad1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            526..650
                     /gene="Mad1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            651..732
                     /gene="Mad1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            733..863
                     /gene="Mad1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            864..978
                     /gene="Mad1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1040
                     /gene="Mad1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1127
                     /gene="Mad1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1272
                     /gene="Mad1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1413
                     /gene="Mad1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1470
                     /gene="Mad1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1559
                     /gene="Mad1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1650
                     /gene="Mad1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1858
                     /gene="Mad1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..2049
                     /gene="Mad1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..2612
                     /gene="Mad1l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggagatctg agccgctgct gcagcactcg gctcctcaac tcgggagggt gaccatggaa
       61 gaccttgggg agaacaccac agtcctgtcc accctgagat ctctcaacaa cttcatttct
      121 cagcgaatgg agggagcatc aggcttggat gtgtccacat ctgcctcagg gtccctacag
      181 aagcagtatg aacagaacat gcagctggag gagagagcag agcagatccg ttcaaagtcc
      241 tacctcatcc aggtggagcg ggagaagatg cagatggagc tgagccacaa gagggctcgg
      301 gtggagctgg agagagcggc cagcaccaat gccaggaact atgagcgcga ggtggatcgc
      361 aaccaggaac tcctggcacg cattcggcag ctccaggagc gtgaggccgc agcagaagag
      421 aagatgcggg agcagctgga gcgccacagg ctgtgcaagc agagcctgga cgctgccagt
      481 cagcagctgc gggaacgaga ggatggcctg gctgcagcca gggagacgat tagttcattg
      541 aaggggcgag tctccgagct gcagttgagt gcgatggacc agaaggtaca ggtcaagcgc
      601 ctggagtctg agaagcagga gctgaaggag cagctggaac tgcagcagcg gaaatggcag
      661 gaggcaaatc agaagatcca ggagctacag gccagtcaag aagagagaac tgaccaggag
      721 cagaagatta aggacctgga gcagaagctg tgtctgcaag agcaggatgc agctgtggtg
      781 aagagcatga aatctgagct gttgcgactg cctcggatgg agcgtgagct aaagaggctg
      841 cgtgaggaga acactcatct aagggagatg agggagacca atgggctgct cacagaggag
      901 ctggaaggtc tgcagaggaa gctgggccgc caggagaaga tgcaggaagc tctggttgat
      961 ctggagttgg agaaggagaa gctgcttgca aagctgcaga gctgggagaa actggaccag
     1021 accatgggct tgaatctcag gactccagag gacctttcga ggttcgtgat tgagctgcag
     1081 cagcgagagc tggcgctgaa ggagaagaat agcagcatca ccagcagtgc ccggggtctg
     1141 gagaaggccc agcagcagct ccaggatgag gtccggcagg tcaatgcaca gctgctggaa
     1201 gagaggaaga agagggagac acatgaggca cttgcccgaa ggctccagaa gcgcaatgca
     1261 ttgctgacca aggagcgaga cggcatgcgc gccatcctgg gatcctacga cagtgagctg
     1321 acccaagctg agtactcgcc ccagcttaca cagcgcatgt gggaggctga ggacatggtt
     1381 cagaaggtgc atgcccacag ctcagagatg gaggctcagc tgtctcaggc cctggaagag
     1441 cttggggttc agaagcagag agctgacacg ctggagatgg agttgaagat gctgagggcc
     1501 cagacaagct cagccgaagc cagcttccca ttctgcaaag aggaggtgga tgcactcagg
     1561 ttgaaggtgg aggagctgga gggtgagcgg agccgtctgg aacaggaaaa gcaggctctg
     1621 gagatgcaga tggagagact aaccctacag ggtgactaca accagagtcg aaccaaagtg
     1681 ctacacatga gcctgaaccc ggctagcatg gccaggcagc gccagcgtga ggaccatgac
     1741 cggctgcagg aggaatgcga gcgcttacgg ggacttgtgc atgccctaga gagaggcggt
     1801 cccatccctg ctgacctgga ggctgcctcc agcctgccct catccaagga ggtggcagag
     1861 ctgcggaagc aggtagaaag cgctgagctg aagaaccagc ggctcaagga ggttttccag
     1921 accaagatcc aggagttccg caaggtttgc tacacactga ccggctacca gattgacgtg
     1981 accactgaga gccaataccg cctcacctcc cgatatgctg agcaccagac tgactgcctc
     2041 atcttcaagg ccacaggacc ctcgggctcc aaaatgcagc tgctggagac ggagttctcc
     2101 cgttcagtgc ctgagctcat tgagctgcac ctgctgcagc aggacagcat ccctgccttc
     2161 ctcagcgcgc tcaccataga gctgttcagc cgccagacct ctgtctagcc tcttcccatg
     2221 agcatccacg cctacagcca ctggacctcg gcctagccta tacctgcagc gtctcacatg
     2281 caaccctcag accttggcct agctcttggt cttccagaca gttacccaca tgtccccaaa
     2341 cccctttgct acccatagct gcatcatgtc acaaacacca ttcttgtccc tggccagcag
     2401 gagcaagctg ctggggatga ccaagccaga tcacacccca ccattctcct ctcctcccca
     2461 ccccatcgag ttctagggct gtactgtccc aaggtgtgcc cgtaccggcc catgtgctgg
     2521 ttgcttatgt cactttggtg gccagactgt ggcctgcgtc cacagtccca gcctgatgaa
     2581 ataaagtgct acatttatct tccctcccgg ga
//
