LOCUS       NM_001135807            1983 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus macroH2A.2 histone (Macroh2a2), mRNA.
ACCESSION   NM_001135807 XM_001056152 XM_001056275 XM_001056330 XM_001056397
            XM_342138
VERSION     NM_001135807.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1983)
  AUTHORS   Weber CM and Henikoff S.
  TITLE     Histone variants: dynamic punctuation in transcription
  JOURNAL   Genes Dev 28 (7), 672-682 (2014)
   PUBMED   24696452
  REMARK    Review article
REFERENCE   2  (bases 1 to 1983)
  AUTHORS   Cong R, Das S, Douet J, Wong J, Buschbeck M, Mongelard F and Bouvet
            P.
  TITLE     macroH2A1 histone variant represses rDNA transcription
  JOURNAL   Nucleic Acids Res 42 (1), 181-192 (2014)
   PUBMED   24071584
REFERENCE   3  (bases 1 to 1983)
  AUTHORS   Barrero MJ, Sese B, Marti M and Izpisua Belmonte JC.
  TITLE     Macro histone variants are critical for the differentiation of
            human pluripotent cells
  JOURNAL   J Biol Chem 288 (22), 16110-16116 (2013)
   PUBMED   23595991
REFERENCE   4  (bases 1 to 1983)
  AUTHORS   Gaspar-Maia A, Qadeer ZA, Hasson D, Ratnakumar K, Leu NA, Leroy G,
            Liu S, Costanzi C, Valle-Garcia D, Schaniel C, Lemischka I, Garcia
            B, Pehrson JR and Bernstein E.
  TITLE     MacroH2A histone variants act as a barrier upon reprogramming
            towards pluripotency
  JOURNAL   Nat Commun 4, 1565 (2013)
   PUBMED   23463008
  REMARK    Erratum:[Nat Commun. 2013;4:2090]
REFERENCE   5  (bases 1 to 1983)
  AUTHORS   Buschbeck M, Uribesalgo I, Wibowo I, Rue P, Martin D, Gutierrez A,
            Morey L, Guigo R, Lopez-Schier H and Di Croce L.
  TITLE     The histone variant macroH2A is an epigenetic regulator of key
            developmental genes
  JOURNAL   Nat Struct Mol Biol 16 (10), 1074-1079 (2009)
   PUBMED   19734898
REFERENCE   6  (bases 1 to 1983)
  AUTHORS   Dejardin J and Kingston RE.
  TITLE     Purification of proteins associated with specific genomic Loci
  JOURNAL   Cell 136 (1), 175-186 (2009)
   PUBMED   19135898
REFERENCE   7  (bases 1 to 1983)
  AUTHORS   Chadwick BP and Willard HF.
  TITLE     Histone H2A variants and the inactive X chromosome: identification
            of a second macroH2A variant
  JOURNAL   Hum Mol Genet 10 (10), 1101-1113 (2001)
   PUBMED   11331621
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC161981.1.
            
            On or before Oct 16, 2008 this sequence version replaced
            XM_342138.3, XM_001056397.1, XM_001056275.1, XM_001056330.1,
            XM_001056152.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC161981.1, SRR8487230.24571.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1983
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     gene            1..1983
                     /gene="Macroh2a2"
                     /gene_synonym="H2afy2; RGD1561371"
                     /note="macroH2A.2 histone"
                     /db_xref="GeneID:361844"
                     /db_xref="RGD:1561371"
     exon            1..129
                     /gene="Macroh2a2"
                     /gene_synonym="H2afy2; RGD1561371"
                     /inference="alignment:Splign:2.1.0"
     exon            130..359
                     /gene="Macroh2a2"
                     /gene_synonym="H2afy2; RGD1561371"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..1306
                     /gene="Macroh2a2"
                     /gene_synonym="H2afy2; RGD1561371"
                     /note="H2A histone family, member Y2"
                     /codon_start=1
                     /product="core histone macro-H2A.2"
                     /protein_id="NP_001129279.1"
                     /db_xref="GeneID:361844"
                     /db_xref="RGD:1561371"
                     /translation="MSGRSGKKKMSKLSRSARAGVIFPVGRLMRYLKKGTFKYRISVG
                     APVYMAAVIEYLAAEILELAGNAARDNKKARIAPRHILLAVANDEELNQLLKGVTIAS
                     GGVLPRIHPELLAKKRGTKGKSETILSPPPEKRGRKAASGKKGGKKSKATKPRTSKKS
                     KAKDSDKEGTSNSTSEDGPGDGFTILSSKSLVLGQKLSLTQSDISHIGSMRVEGIVHP
                     TTAEIDLKEEIGKALEKAGGKEFLETVKELRKSQGPLEVAEAAVSQSSGLAAKFVIHC
                     HIPQWGSDKCEEQLEETIKNCLSAAEDKKLKSVAFPPFPSGRNCFPKQTAAQVTLKAI
                     SAHFDDSSSSSLKNVYFLLFDSESIGIYVQEMAKLDTK"
     exon            360..466
                     /gene="Macroh2a2"
                     /gene_synonym="H2afy2; RGD1561371"
                     /inference="alignment:Splign:2.1.0"
     exon            467..664
                     /gene="Macroh2a2"
                     /gene_synonym="H2afy2; RGD1561371"
                     /inference="alignment:Splign:2.1.0"
     exon            665..775
                     /gene="Macroh2a2"
                     /gene_synonym="H2afy2; RGD1561371"
                     /inference="alignment:Splign:2.1.0"
     exon            776..875
                     /gene="Macroh2a2"
                     /gene_synonym="H2afy2; RGD1561371"
                     /inference="alignment:Splign:2.1.0"
     exon            876..965
                     /gene="Macroh2a2"
                     /gene_synonym="H2afy2; RGD1561371"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1140
                     /gene="Macroh2a2"
                     /gene_synonym="H2afy2; RGD1561371"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1961
                     /gene="Macroh2a2"
                     /gene_synonym="H2afy2; RGD1561371"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacacgcaca gatacaaccc caagaaaggc agggtcctgc ccggcaccgg cggcacgcgg
       61 gccgaacctg cggccgggat tggcgcgcac taggccaccg ggcgcccgga gcccgcggtg
      121 cagcaccagt attgtttagt gccaagagac cactctgtca gcaagctgag aggaaaactg
      181 cggcaagatg tcaggccgga gcgggaagaa gaaaatgtct aagctgtctc ggtcagccag
      241 ggccggggtc atctttccag tagggcggtt gatgcgctac ctgaagaaag gaactttcaa
      301 gtaccggatc agcgtgggtg ctccagtcta catggctgca gtcattgagt acctggcagc
      361 ggaaatccta gagttggctg ggaacgctgc gagggacaac aagaaggccc ggatagcccc
      421 cagacacatc ctgctggccg ttgccaacga tgaggagctc aaccagttgc tgaaaggagt
      481 gaccatcgcc agtgggggtg tcttgcccag aattcacccc gaactgttgg ccaaaaagcg
      541 agggaccaaa ggcaagtcag aaaccatcct ctccccaccc ccagagaaaa gaggaaggaa
      601 ggccgcatca ggcaagaagg ggggtaagaa atccaaggcc actaagccgc ggacgtccaa
      661 gaagtccaaa gccaaggaca gcgataaaga aggaacatcg aattccacct cagaagacgg
      721 gccgggggat ggctttacca tcctgtcttc gaagagcctc gttctggggc agaagctgtc
      781 cctgacccag agtgacatca gccacatcgg ctccatgagg gtggagggca tcgtccaccc
      841 aaccacagcc gaaatcgacc tcaaggaaga gataggtaaa gccttggaaa aggccggggg
      901 taaagagttc ttggaaacag taaaggagct tcgcaagtcc caaggccctt tggaagttgc
      961 cgaagctgcc gtcagccaat ccagtggact cgcagccaag tttgtcatcc actgtcacat
     1021 cccccagtgg ggctccgaca aatgtgaaga acagctggaa gagaccatca aaaactgcct
     1081 gtccgcagcc gaggacaaga agcttaaatc tgtcgccttc ccaccgttcc ccagtggcag
     1141 aaactgcttt cccaaacaga cggccgccca agtgaccctc aaggccatct cggcccactt
     1201 cgacgactcg agctcatcct cgctgaagaa tgtgtacttc ctgctcttcg acagcgagag
     1261 cattggcatc tacgtgcagg agatggccaa actggacacc aagtagctcc ccagcgggga
     1321 aggaggaggg tcagtgtgat gtcacaagag cgggggtttt attttttaaa aggattgcag
     1381 aaggctgaca gggcatggga gcagagggtg gctgagaggg tgagcggagg cagcaggagc
     1441 aggtcctgcc tgcctgggga aggggcccgg tgcattttat actctttaca aagggcctct
     1501 tccacaatta accaggtctc caccagaggt ttctttccat gtgttttttc ttcctgttgt
     1561 tttagaactt tttttaaaac aaacataaaa atagacttcg tttagattta tagcattgac
     1621 ttttacaatc tctctctctc tctctctctt acacacacac acacacacac acacacacac
     1681 acacacacac acacacagaa tctgttcaaa tttcctatgt ctttggttcc tccttttttc
     1741 caagggaaga gggcgtgact gtcaaaccta ggtatactgg ctgtctccct cagtggagag
     1801 aagatgagaa aaacatctcg gggtgctttt ctgttatagg gtccccccct gacgcctaaa
     1861 atatttgtaa ctacacccaa aagggttttg cttcgggatt tttgtttgtt tgtttttgtt
     1921 tttttaaaga aaaagaaaaa atgagaagaa aaaaaataaa aaaaaaaaaa aaaaaaaaaa
     1981 aaa
//
