LOCUS       NM_017182               1861 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus macroH2A.1 histone (Macroh2a1), mRNA.
ACCESSION   NM_017182
VERSION     NM_017182.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1861)
  AUTHORS   Ramamoorthy,M. and Smith,S.
  TITLE     Loss of ATRX Suppresses Resolution of Telomere Cohesion to Control
            Recombination in ALT Cancer Cells
  JOURNAL   Cancer Cell 28 (3), 357-369 (2015)
   PUBMED   26373281
REFERENCE   2  (bases 1 to 1861)
  AUTHORS   Podrini,C., Koffas,A., Chokshi,S., Vinciguerra,M., Lelliott,C.J.,
            White,J.K., Adissu,H.A., Williams,R. and Greco,A.
  TITLE     MacroH2A1 isoforms are associated with epigenetic markers for
            activation of lipogenic genes in fat-induced steatosis
  JOURNAL   FASEB J 29 (5), 1676-1687 (2015)
   PUBMED   25526730
REFERENCE   3  (bases 1 to 1861)
  AUTHORS   Weber,C.M. and Henikoff,S.
  TITLE     Histone variants: dynamic punctuation in transcription
  JOURNAL   Genes Dev 28 (7), 672-682 (2014)
   PUBMED   24696452
  REMARK    Review article
REFERENCE   4  (bases 1 to 1861)
  AUTHORS   Cong,R., Das,S., Douet,J., Wong,J., Buschbeck,M., Mongelard,F. and
            Bouvet,P.
  TITLE     macroH2A1 histone variant represses rDNA transcription
  JOURNAL   Nucleic Acids Res 42 (1), 181-192 (2014)
   PUBMED   24071584
REFERENCE   5  (bases 1 to 1861)
  AUTHORS   Barrero,M.J., Sese,B., Marti,M. and Izpisua Belmonte,J.C.
  TITLE     Macro histone variants are critical for the differentiation of
            human pluripotent cells
  JOURNAL   J Biol Chem 288 (22), 16110-16116 (2013)
   PUBMED   23595991
REFERENCE   6  (bases 1 to 1861)
  AUTHORS   Ganesan,S., Silver,D.P., Greenberg,R.A., Avni,D., Drapkin,R.,
            Miron,A., Mok,S.C., Randrianarison,V., Brodie,S., Salstrom,J.,
            Rasmussen,T.P., Klimke,A., Marrese,C., Marahrens,Y., Deng,C.X.,
            Feunteun,J. and Livingston,D.M.
  TITLE     BRCA1 supports XIST RNA concentration on the inactive X chromosome
  JOURNAL   Cell 111 (3), 393-405 (2002)
   PUBMED   12419249
REFERENCE   7  (bases 1 to 1861)
  AUTHORS   Chadwick,B.P. and Willard,H.F.
  TITLE     Cell cycle-dependent localization of macroH2A in chromatin of the
            inactive X chromosome
  JOURNAL   J Cell Biol 157 (7), 1113-1123 (2002)
   PUBMED   12082075
REFERENCE   8  (bases 1 to 1861)
  AUTHORS   Chadwick,B.P. and Willard,H.F.
  TITLE     Histone H2A variants and the inactive X chromosome: identification
            of a second macroH2A variant
  JOURNAL   Hum Mol Genet 10 (10), 1101-1113 (2001)
   PUBMED   11331621
REFERENCE   9  (bases 1 to 1861)
  AUTHORS   Pehrson,J.R., Costanzi,C. and Dharia,C.
  TITLE     Developmental and tissue expression patterns of histone macroH2A1
            subtypes
  JOURNAL   J Cell Biochem 65 (1), 107-113 (1997)
   PUBMED   9138085
REFERENCE   10 (bases 1 to 1861)
  AUTHORS   Pehrson,J.R. and Fried,V.A.
  TITLE     MacroH2A, a core histone containing a large nonhistone region
  JOURNAL   Science 257 (5075), 1398-1400 (1992)
   PUBMED   1529340
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On May 20, 2021 this sequence version replaced NM_017182.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089093.1, U79139.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               JAXUCZ010000017.1  8484550-8484721
            173-377             JAXUCZ010000017.1  8491085-8491289
            378-484             JAXUCZ010000017.1  8515488-8515594
            485-682             JAXUCZ010000017.1  8515936-8516133
            683-790             JAXUCZ010000017.1  8523308-8523415
            791-890             JAXUCZ010000017.1  8529362-8529461
            891-980             JAXUCZ010000017.1  8535354-8535443
            981-1155            JAXUCZ010000017.1  8537287-8537461
            1156-1861           JAXUCZ010000017.1  8546563-8547268
FEATURES             Location/Qualifiers
     source          1..1861
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..1861
                     /gene="Macroh2a1"
                     /gene_synonym="H2A.y; H2A/y; H2afy; mH2A1"
                     /note="macroH2A.1 histone"
                     /db_xref="GeneID:29384"
                     /db_xref="RGD:621462"
     exon            1..172
                     /gene="Macroh2a1"
                     /gene_synonym="H2A.y; H2A/y; H2afy; mH2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            173..377
                     /gene="Macroh2a1"
                     /gene_synonym="H2A.y; H2A/y; H2afy; mH2A1"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..1321
                     /gene="Macroh2a1"
                     /gene_synonym="H2A.y; H2A/y; H2afy; mH2A1"
                     /note="histone macroH2A1; H2A histone family, member Y"
                     /codon_start=1
                     /product="core histone macro-H2A.1"
                     /protein_id="NP_058878.1"
                     /db_xref="GeneID:29384"
                     /db_xref="RGD:621462"
                     /translation="MSSRGGKKKSTKTSRSAKAGVIFPVGRMLRYIKKGHPKYRIGVG
                     APVYMAAVLEYLTAEILELAGNAARDNKKGRVTPRHILLAVANDEELNQLLKGVTIAS
                     GGVLPNIHPELLAKKRGSKGKLEAIITPPPAKKAKSPSQKKPVAKKTGGKKGARKSKK
                     QGEVSKAASADSTTEGAPTDGFTVLSTKSLFLGQKLNLIHSEISNLAGFEVEAIINPT
                     NADIDLKDDLGSTLEKKGGKEFVEAVLELRKKNGPLEVAGAAVSAGHGLPAKFVIHCN
                     SPVWGADKCEELLEKTVKNCLALADDRKLKSIAFPSIGSGRNGFPKQTAAQLILKAIS
                     SYFVSTMSSSIKTVYFVLFDSESIGIYVQEMAKLDAN"
     exon            378..484
                     /gene="Macroh2a1"
                     /gene_synonym="H2A.y; H2A/y; H2afy; mH2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            485..682
                     /gene="Macroh2a1"
                     /gene_synonym="H2A.y; H2A/y; H2afy; mH2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            683..790
                     /gene="Macroh2a1"
                     /gene_synonym="H2A.y; H2A/y; H2afy; mH2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            791..890
                     /gene="Macroh2a1"
                     /gene_synonym="H2A.y; H2A/y; H2afy; mH2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            891..980
                     /gene="Macroh2a1"
                     /gene_synonym="H2A.y; H2A/y; H2afy; mH2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1155
                     /gene="Macroh2a1"
                     /gene_synonym="H2A.y; H2A/y; H2afy; mH2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1861
                     /gene="Macroh2a1"
                     /gene_synonym="H2A.y; H2A/y; H2afy; mH2A1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggggccgcc gcgagtggtt ccagttcact ggttccagcg gagccgggcg gagggcgcga
       61 gcgcgggacg cgcgggcggg aagcgaggag gcgtgggcgg gcaggcagga gtgcggagcg
      121 gaccggcgca agaggccgac cgggctcggg cccctcaccg tgcagccgcc cgtgagcttg
      181 ctgatctgtt tctggggccg tcgccatgtc gagccgtggt gggaagaaga aatccaccaa
      241 gacctcccgg tcagccaagg ccggggtcat cttccccgtg ggacggatgc tgcggtacat
      301 caagaaaggc caccctaagt atcggatcgg agtgggggcg cctgtgtaca tggctgccgt
      361 actggaatac ctgaccgctg agatcctgga gctggccggc aatgcagcga gagacaacaa
      421 gaaggggcgg gtcacaccgc ggcacatcct gttagcagtg gccaatgatg aggagctaaa
      481 ccagctgcta aaaggagtca ccatagccag tgggggcgtg ttgccgaaca tccatcctga
      541 gttgctagcg aagaaacgag gatccaaggg aaaattggaa gccatcatca cgcctccacc
      601 agccaaaaag gccaagtctc catcccagaa gaagccagtg gctaagaaaa caggaggcaa
      661 gaaaggggcc cggaagtcta agaagcaggg agaagtcagc aaggcagcca gcgcagacag
      721 tacaacggag ggcgcgccta cagacggctt tactgtcctc tctaccaaga gcctcttcct
      781 cggccagaag ctgaacctta ttcacagtga aatcagtaat ttagccggct ttgaggtgga
      841 ggccataatc aatcctacca atgctgacat tgaccttaaa gatgacctag gaagcacact
      901 ggagaagaaa ggtggcaagg agtttgtaga agctgttctg gaacttcgga aaaagaatgg
      961 gcccttggaa gtagctggag ctgctgttag tgcaggccac ggcctgcctg ccaagtttgt
     1021 gatccactgt aacagtcctg tctggggcgc agacaaatgt gaagaacttc tagaaaagac
     1081 ggtgaaaaac tgcctggctc tagctgatga cagaaagctg aagtccatcg ccttcccgtc
     1141 tattggcagt ggcaggaacg ggttcccgaa gcagacagcc gcccaactca ttctgaaggc
     1201 catctccagc tactttgtgt ccactatgtc gtcctccatc aaaactgtgt actttgtgct
     1261 ttttgacagt gagagcatag gcatctacgt gcaggaaatg gccaaactgg atgccaacta
     1321 ggccagcgtt ccctagagcc agcacatgtc gtggccccca cctccaactg gaaagaaaga
     1381 aaaaaaaaga aaaaaatccc ctcggctctt atggggaggt gggggctcct ttccttttca
     1441 gttctgctca tctaggggaa ataaggtttt ggtttccggt ttgattgttt ttggccttct
     1501 acaatgtttt ctgttagcac tgatagctgg cattgtcctt gctaagcact gcgttccaga
     1561 ccgtgtctga cttagttaac ctaggagatt ttatagtttt actttaatga agtcctgatt
     1621 aacacagagc agtggagaga ccgtgcccct gtgtcagcag cagcagcagc agcagcagga
     1681 agccccgttt gtaacgcgtg ttgtggtgct ttactgtaca cccagtggcg ttctttttac
     1741 tattacggtt tttccccctc agaagagaaa aaaaaatcat aaaatttgca acagacctaa
     1801 cttttgttta cttttttgtc ttaatgatag atttgaaaat gaaaaatgtt aaaaaaaaaa
     1861 a
//
