LOCUS       NM_139337               1244 bp    mRNA    linear   ROD 22-SEP-2024
DEFINITION  Rattus norvegicus mono-ADP ribosylhydrolase 1 (Macrod1), mRNA.
ACCESSION   NM_139337
VERSION     NM_139337.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1244)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1244)
  AUTHORS   Barkauskaite,E., Jankevicius,G. and Ahel,I.
  TITLE     Structures and Mechanisms of Enzymes Employed in the Synthesis and
            Degradation of PARP-Dependent Protein ADP-Ribosylation
  JOURNAL   Mol Cell 58 (6), 935-946 (2015)
   PUBMED   26091342
  REMARK    Review article
REFERENCE   3  (bases 1 to 1244)
  AUTHORS   Rosenthal,F., Feijs,K.L., Frugier,E., Bonalli,M., Forst,A.H.,
            Imhof,R., Winkler,H.C., Fischer,D., Caflisch,A., Hassa,P.O.,
            Luscher,B. and Hottiger,M.O.
  TITLE     Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases
  JOURNAL   Nat Struct Mol Biol 20 (4), 502-507 (2013)
   PUBMED   23474714
REFERENCE   4  (bases 1 to 1244)
  AUTHORS   Jankevicius,G., Hassler,M., Golia,B., Rybin,V., Zacharias,M.,
            Timinszky,G. and Ladurner,A.G.
  TITLE     A family of macrodomain proteins reverses cellular
            mono-ADP-ribosylation
  JOURNAL   Nat Struct Mol Biol 20 (4), 508-514 (2013)
   PUBMED   23474712
REFERENCE   5  (bases 1 to 1244)
  AUTHORS   Chen,D., Vollmar,M., Rossi,M.N., Phillips,C., Kraehenbuehl,R.,
            Slade,D., Mehrotra,P.V., von Delft,F., Crosthwaite,S.K.,
            Gileadi,O., Denu,J.M. and Ahel,I.
  TITLE     Identification of macrodomain proteins as novel O-acetyl-ADP-ribose
            deacetylases
  JOURNAL   J Biol Chem 286 (15), 13261-13271 (2011)
   PUBMED   21257746
REFERENCE   6  (bases 1 to 1244)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 1244)
  AUTHORS   Han,W.D., Mu,Y.M., Lu,X.C., Xu,Z.M., Li,X.J., Yu,L., Song,H.J.,
            Li,M., Lu,J.M., Zhao,Y.L. and Pan,C.Y.
  TITLE     Up-regulation of LRP16 mRNA by 17beta-estradiol through activation
            of estrogen receptor alpha (ERalpha), but not ERbeta, and promotion
            of human breast cancer MCF-7 cell proliferation: a preliminary
            report
  JOURNAL   Endocr Relat Cancer 10 (2), 217-224 (2003)
   PUBMED   12790785
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Feb 9, 2022 this sequence version replaced NM_139337.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF404762.1, AF419856.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-375               JAXUCZ010000001.1  213675477-213675851
            376-477             JAXUCZ010000001.1  213683245-213683346
            478-594             JAXUCZ010000001.1  213684042-213684158
            595-624             JAXUCZ010000001.1  213802791-213802820
            625-741             JAXUCZ010000001.1  213814516-213814632
            742-863             JAXUCZ010000001.1  213814985-213815106
            864-894             JAXUCZ010000001.1  213815189-213815219
            895-968             JAXUCZ010000001.1  213815335-213815408
            969-1050            JAXUCZ010000001.1  213815689-213815770
            1051-1085           JAXUCZ010000001.1  213815847-213815881
            1086-1244           JAXUCZ010000001.1  213816053-213816211
FEATURES             Location/Qualifiers
     source          1..1244
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1244
                     /gene="Macrod1"
                     /gene_synonym="Lrp16"
                     /note="mono-ADP ribosylhydrolase 1"
                     /db_xref="GeneID:246233"
                     /db_xref="RGD:628701"
     exon            1..375
                     /gene="Macrod1"
                     /gene_synonym="Lrp16"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..1055
                     /gene="Macrod1"
                     /gene_synonym="Lrp16"
                     /EC_number="3.1.1.106"
                     /note="MACRO domain-containing protein 1; [Protein
                     ADP-ribosylglutamate] hydrolase; O-acetyl-ADP-ribose
                     deacetylase MACROD1; [Protein ADP-ribosylaspartate]
                     hydrolase MACROD1; [Protein ADP-ribosylglutamate]
                     hydrolase MACROD1; MACRO domain containing 1"
                     /codon_start=1
                     /product="ADP-ribose glycohydrolase MACROD1"
                     /protein_id="NP_647553.2"
                     /db_xref="GeneID:246233"
                     /db_xref="RGD:628701"
                     /translation="MSLQSQVSGRLAQLRVAGQLLVSPRPWPGRSAGGPRPRGSAYGP
                     LVALGQHGYCAWPSAGVGAWGAAGRGAWVRTWAPLAMAAKVDLSTSTDWKEAKSFLKG
                     LSDKQREEHYFCKDFIKLKKIPMWKETAKGLAGKVENPKYKKDKQLNEKISLFRGDIT
                     KLEVDAIVNAANNSLLGGGGVDGCIHRAAGSLLTDECRTLQNCETGKAKITCGYRLPA
                     KHVIHTVGPIAVGQPTASQAAELRSCYLSSLDLLLEHRLRSVAFPCISTGVFGYPNEE
                     AAEVVLATLREWLEQHKDKVDRLIICVFLEKDEGIYQERLPHYFPVA"
     exon            376..477
                     /gene="Macrod1"
                     /gene_synonym="Lrp16"
                     /inference="alignment:Splign:2.1.0"
     exon            478..594
                     /gene="Macrod1"
                     /gene_synonym="Lrp16"
                     /inference="alignment:Splign:2.1.0"
     exon            595..624
                     /gene="Macrod1"
                     /gene_synonym="Lrp16"
                     /inference="alignment:Splign:2.1.0"
     exon            625..741
                     /gene="Macrod1"
                     /gene_synonym="Lrp16"
                     /inference="alignment:Splign:2.1.0"
     exon            742..863
                     /gene="Macrod1"
                     /gene_synonym="Lrp16"
                     /inference="alignment:Splign:2.1.0"
     exon            864..894
                     /gene="Macrod1"
                     /gene_synonym="Lrp16"
                     /inference="alignment:Splign:2.1.0"
     exon            895..968
                     /gene="Macrod1"
                     /gene_synonym="Lrp16"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1050
                     /gene="Macrod1"
                     /gene_synonym="Lrp16"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1085
                     /gene="Macrod1"
                     /gene_synonym="Lrp16"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1244
                     /gene="Macrod1"
                     /gene_synonym="Lrp16"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtaaataagg gaccgagcgc gactctccag agcaccgtaa atagagtccg agtgggcggg
       61 gagcagcccg gcaccgcctg ctcatgtcgc tgcagagcca agtgtccggc cgcctggcac
      121 agctgcgcgt ggcggggcag ctgctggtct ccccgcgccc ctggcccggc cgctcggcgg
      181 gtggcccgcg gccccgtggc agtgcgtacg gtcccctggt ggcgctgggc cagcacggct
      241 actgcgcgtg gccttcggcg ggagttgggg cgtggggggc ggcagggcgt ggagcctggg
      301 tgcgcacctg ggcccccctg gccatggccg cgaaggtgga cctgagcacc tccaccgact
      361 ggaaggaggc caaatccttt ctgaagggcc tgagtgacaa gcagagggag gaacattact
      421 tctgcaagga tttcattaag ctgaagaaga tccccatgtg gaaggagaca gcaaaagggc
      481 tggctgggaa ggtggagaac cccaagtata agaaggacaa gcagctgaat gagaaaatct
      541 ccctgttccg tggggacatc accaagctgg aggtggatgc cattgtcaat gctgccaaca
      601 actccctgct tggaggcgga ggggtggacg gctgcattca tcgggccgcg ggatccctcc
      661 tgacggacga atgccgcacc ctgcagaact gcgagaccgg caaagccaag atcacttgcg
      721 gctatcggct gccagctaag catgtcatcc acacggtggg gcccatcgcc gtgggccaac
      781 ccactgccag ccaggcggct gaactccgca gctgctactt gagcagcctg gacctgctgc
      841 tggagcaccg gctgcgatcg gtggctttcc catgcatctc cacaggcgtg tttggctacc
      901 ccaatgagga ggctgcggag gtagtgctag ctacgctgcg cgaatggctg gagcagcaca
      961 aggacaaggt ggatcggctc atcatctgtg tgttcctgga gaaggacgag ggcatttacc
     1021 aggagcgcct gccccattat ttcccagtag cctgaggctc ccactgccca ccctgaacag
     1081 gactgaccca cctgggcctg gaggacctcg ttctcagctc tgagaggtct cagaagcctg
     1141 caacttgttc cagcctggcc acagcagggt tctgccctca ccccgagcct gtcctgccct
     1201 gcctttaaga agcctcctaa taaagctgtc tggttcagcc ctca
//
